#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53199	uniprotkb:P29704	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-6865|uniprotkb:D3DLD8|ensemblfungi:YHR190W	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:fdft_yeast(display_long)|uniprotkb:"FPP:FPP farnesyltransferase"(gene name synonym)|uniprotkb:YHR190W(locus name)|uniprotkb:ERG9(gene name)|psi-mi:ERG9(display_short)|uniprotkb:Farnesyl-diphosphate farnesyltransferase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378406|imex:IM-19950-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	refseq:NP_012060.1|sgd:S000001233|dip:DIP-4576N|mint:P29704|ensemblfungi:YHR190W(gene)|ensemblfungi:YHR190W_mRNA(transcript)|go:"GO:0004310"(farnesyl-diphosphate farnesyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045338"(farnesyl diphosphate metabolic process)|go:"GO:0051996"(squalene synthase activity)|interpro:IPR002060(Squalene/phytoene synthase)|interpro:IPR006449(Farnesyl-diphosphate farnesyltransferase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR019845|interpro:IPR033904|interpro:IPR044844|reactome:R-SCE-191273	-	crc64:87CA8FF8D64B0327	-	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:lYDM8gN7ZuHFUP17Q3yyECIsJs8559292	intact-crc:7066E8B51C674199|rigid:06DqsmWMS3zvkZL/rp3A8RylU9Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32462	uniprotkb:P32476	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	intact:EBI-6545|uniprotkb:D6VUW0|ensemblfungi:YGR175C	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:erg1_yeast(display_long)|uniprotkb:YGR175C(locus name)|uniprotkb:ERG1(gene name)|psi-mi:ERG1(display_short)|uniprotkb:Squalene epoxidase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378426|imex:IM-19950-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_011691.1|sgd:S000003407|reactome:R-SCE-191273|dip:DIP-6325N|ensemblfungi:YGR175C(gene)|ensemblfungi:YGR175C_mRNA(transcript)|go:"GO:0004506"(squalene monooxygenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR013698(Squalene epoxidase)|interpro:IPR036188|interpro:IPR040125	-	crc64:B9368B004506C0F3	crc64:BBEFD766634855E8	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	rogid:vKJFukN2Wlwj1Rcv9t4zgCcCrJ4559292	intact-crc:B2A4ACEA05713E43|rigid:Cn5Qm58bx5vZG2nAykL9swvQFxE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53199	uniprotkb:P32476	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-6545|uniprotkb:D6VUW0|ensemblfungi:YGR175C	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:erg1_yeast(display_long)|uniprotkb:YGR175C(locus name)|uniprotkb:ERG1(gene name)|psi-mi:ERG1(display_short)|uniprotkb:Squalene epoxidase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378446|imex:IM-19950-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	refseq:NP_011691.1|sgd:S000003407|reactome:R-SCE-191273|dip:DIP-6325N|ensemblfungi:YGR175C(gene)|ensemblfungi:YGR175C_mRNA(transcript)|go:"GO:0004506"(squalene monooxygenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR013698(Squalene epoxidase)|interpro:IPR036188|interpro:IPR040125	-	crc64:87CA8FF8D64B0327	crc64:BBEFD766634855E8	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:vKJFukN2Wlwj1Rcv9t4zgCcCrJ4559292	intact-crc:D6734F5636979EAD|rigid:iCSj3aUec5vZzS1mL2WcFHTj7PA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32476	uniprotkb:P32352	intact:EBI-6545|uniprotkb:D6VUW0|ensemblfungi:YGR175C	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	psi-mi:erg1_yeast(display_long)|uniprotkb:YGR175C(locus name)|uniprotkb:ERG1(gene name)|psi-mi:ERG1(display_short)|uniprotkb:Squalene epoxidase(gene name synonym)	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378466|imex:IM-19950-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011691.1|sgd:S000003407|reactome:R-SCE-191273|dip:DIP-6325N|ensemblfungi:YGR175C(gene)|ensemblfungi:YGR175C_mRNA(transcript)|go:"GO:0004506"(squalene monooxygenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR013698(Squalene epoxidase)|interpro:IPR036188|interpro:IPR040125	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	-	crc64:BBEFD766634855E8	-	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:vKJFukN2Wlwj1Rcv9t4zgCcCrJ4559292	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	intact-crc:DF77EB2D9E00D6FC|rigid:koOMxNMWnOpTdnYDPDaBIlj6hpk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54781	uniprotkb:P32476	intact:EBI-6563|uniprotkb:D6VZI9|uniprotkb:E9P965|ensemblfungi:YMR015C	intact:EBI-6545|uniprotkb:D6VUW0|ensemblfungi:YGR175C	psi-mi:erg5_yeast(display_long)|uniprotkb:ERG5(gene name)|psi-mi:ERG5(display_short)|uniprotkb:CYP61(gene name synonym)|uniprotkb:YMR015C(locus name)|uniprotkb:YM9711.02C(orf name)|uniprotkb:C-22 sterol desaturase(gene name synonym)	psi-mi:erg1_yeast(display_long)|uniprotkb:YGR175C(locus name)|uniprotkb:ERG1(gene name)|psi-mi:ERG1(display_short)|uniprotkb:Squalene epoxidase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378486|imex:IM-19950-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013728.1|sgd:S000004617|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR036396|mint:P54781|ensemblfungi:YMR015C(gene)|ensemblfungi:YMR015C_mRNA(transcript)|go:"GO:0000249"(C-22 sterol desaturase activity)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)	refseq:NP_011691.1|sgd:S000003407|reactome:R-SCE-191273|dip:DIP-6325N|ensemblfungi:YGR175C(gene)|ensemblfungi:YGR175C_mRNA(transcript)|go:"GO:0004506"(squalene monooxygenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR013698(Squalene epoxidase)|interpro:IPR036188|interpro:IPR040125	-	-	crc64:BBEFD766634855E8	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ScwspGheTequLP3AGjoNZM3cp3E559292	rogid:vKJFukN2Wlwj1Rcv9t4zgCcCrJ4559292	intact-crc:292C8030FE6EE681|rigid:vdP+nzpkg/+G9hdFTGOStWSf93g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25340	uniprotkb:P32476	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	intact:EBI-6545|uniprotkb:D6VUW0|ensemblfungi:YGR175C	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:erg1_yeast(display_long)|uniprotkb:YGR175C(locus name)|uniprotkb:ERG1(gene name)|psi-mi:ERG1(display_short)|uniprotkb:Squalene epoxidase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378506|imex:IM-19950-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_011691.1|sgd:S000003407|reactome:R-SCE-191273|dip:DIP-6325N|ensemblfungi:YGR175C(gene)|ensemblfungi:YGR175C_mRNA(transcript)|go:"GO:0004506"(squalene monooxygenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR013698(Squalene epoxidase)|interpro:IPR036188|interpro:IPR040125	-	-	crc64:BBEFD766634855E8	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	rogid:vKJFukN2Wlwj1Rcv9t4zgCcCrJ4559292	intact-crc:B42B0E497220C491|rigid:n+hkKR6gl50qSTCE2vMOXJphD54	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:P38604	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378526|imex:IM-19950-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	-	-	-	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	intact-crc:3C9FFF50C4E53EED|rigid:E5tH8mOzF4BWtyBuYRdePZxwEuQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38604	uniprotkb:P10614	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378546|imex:IM-19950-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	-	-	-	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	intact-crc:57A32FD93C006E89|rigid:E5tH8mOzF4BWtyBuYRdePZxwEuQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53199	uniprotkb:P38604	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378566|imex:IM-19950-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	-	crc64:87CA8FF8D64B0327	-	comment:Strong interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	intact-crc:C28CB8DC25B1B64B|rigid:KSaHknnO91GoMipXpzhXhanC4EM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38604	uniprotkb:Q12452	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378571|imex:IM-19950-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	-	crc64:D9A0589C049D8C49	comment:Strong interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:EBD6A451BBD4ED9A|rigid:u3jQw0fgpffjVkoSOnsaZ3zvISM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12452	uniprotkb:P38604	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378576|imex:IM-19950-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	-	crc64:D9A0589C049D8C49	-	comment:Strong interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	intact-crc:BB5F5CB4EBB0A8E2|rigid:u3jQw0fgpffjVkoSOnsaZ3zvISM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29704	uniprotkb:P10614	intact:EBI-6865|uniprotkb:D3DLD8|ensemblfungi:YHR190W	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	psi-mi:fdft_yeast(display_long)|uniprotkb:"FPP:FPP farnesyltransferase"(gene name synonym)|uniprotkb:YHR190W(locus name)|uniprotkb:ERG9(gene name)|psi-mi:ERG9(display_short)|uniprotkb:Farnesyl-diphosphate farnesyltransferase(gene name synonym)	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378581|imex:IM-19950-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012060.1|sgd:S000001233|dip:DIP-4576N|mint:P29704|ensemblfungi:YHR190W(gene)|ensemblfungi:YHR190W_mRNA(transcript)|go:"GO:0004310"(farnesyl-diphosphate farnesyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045338"(farnesyl diphosphate metabolic process)|go:"GO:0051996"(squalene synthase activity)|interpro:IPR002060(Squalene/phytoene synthase)|interpro:IPR006449(Farnesyl-diphosphate farnesyltransferase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR019845|interpro:IPR033904|interpro:IPR044844|reactome:R-SCE-191273	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	-	-	-	comment:Strong interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:lYDM8gN7ZuHFUP17Q3yyECIsJs8559292	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	intact-crc:CE7E7384C8FF509F|rigid:jfWPNvjRYRF6mrRm/wnowvYg6iM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:P10614	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378586|imex:IM-19950-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	-	-	-	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	intact-crc:6F016C804C592001|rigid:X5FwejromHj1R6ymC2sBhVVkB68	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32462	uniprotkb:P10614	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378591|imex:IM-19950-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	-	crc64:B9368B004506C0F3	-	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	intact-crc:A811FD2F2591028D|rigid:+XQvITkTfJJaTTS9dvQMDy6YoaY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:P53045	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378596|imex:IM-19950-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	-	-	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:29B63E53BF5750E4|rigid:xCFzJReMghAla3qEPthz+t8TLbo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53045	uniprotkb:P10614	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378601|imex:IM-19950-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	-	-	-	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	intact-crc:31536E37FA2F3DBE|rigid:xCFzJReMghAla3qEPthz+t8TLbo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53199	uniprotkb:P10614	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378606|imex:IM-19950-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	-	crc64:87CA8FF8D64B0327	-	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	intact-crc:F99151689298A579|rigid:9O7GPmhiHeRCh0lhi+lxKVxAAO8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:Q12452	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378611|imex:IM-19950-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	-	crc64:D9A0589C049D8C49	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:816FC8328E153B1C|rigid:c4bZUxKPCq283lGKwPT+P77tfYo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12452	uniprotkb:P10614	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378616|imex:IM-19950-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	-	crc64:D9A0589C049D8C49	-	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	intact-crc:EA5318BB76F06B78|rigid:c4bZUxKPCq283lGKwPT+P77tfYo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:P10614	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378621|imex:IM-19950-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	-	crc64:F1BD39AFA180E367	-	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	intact-crc:254EA9B440534483|rigid:laHohyb506bbqfbjlIyNEqMes3A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:P10614	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378631|imex:IM-19950-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	-	crc64:F1BD39AFA180E367	-	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	intact-crc:7C0B78A01F9F681C|rigid:laHohyb506bbqfbjlIyNEqMes3A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:P25087	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378636|imex:IM-19950-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	-	-	crc64:C3A2B6DF2C14ED63	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	intact-crc:EB3B19C03B6176FA|rigid:/gFw74C+KIBmIoB3RpnoQ4KGwrQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:P25087	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378641|imex:IM-19950-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	-	-	crc64:C3A2B6DF2C14ED63	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	intact-crc:3275368DE1EAD868|rigid:/gFw74C+KIBmIoB3RpnoQ4KGwrQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:P32352	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378646|imex:IM-19950-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	-	-	-	comment:Weak interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	intact-crc:9D39536C32C6F10D|rigid:4cRpmuJD31WcRlxUEXhPhUoxuAY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10614	uniprotkb:P25340	intact:EBI-5127|uniprotkb:D3DKV1|ensemblfungi:YHR007C	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	psi-mi:cp51_yeast(display_long)|uniprotkb:ERG11(gene name)|psi-mi:ERG11(display_short)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450-LIA1(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:Cytochrome P450 51(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:YHR007C(locus name)	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378651|imex:IM-19950-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011871.1|sgd:S000001049|dip:DIP-7886N|mint:P10614|ensemblfungi:YHR007C(gene)|ensemblfungi:YHR007C_mRNA(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:4LXJ|rcsb pdb:5EQB|reactome:R-SCE-191273|reactome:R-SCE-211976	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	-	-	comment:Moderate interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:R1GrAV+7O8sKd+9XaZrXHg7H+h8559292	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	intact-crc:DF98522D39FF1035|rigid:Z7YbAdSr0cSe5xq6w3c/5fI+vmk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32462	uniprotkb:P32462	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378656|imex:IM-19950-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	crc64:B9368B004506C0F3	crc64:B9368B004506C0F3	comment:Strong interaction|comment:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	intact-crc:A39549C9F82CCD68|rigid:W/7mC80pLKxROqDQtIjP9LShlJo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32462	uniprotkb:P53199	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378661|imex:IM-19950-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	-	crc64:B9368B004506C0F3	crc64:87CA8FF8D64B0327	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	intact-crc:C7A6D07B28163A1D|rigid:6rt9G93KN4OKO8XtSq15L9P7zaM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53199	uniprotkb:P32462	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378666|imex:IM-19950-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	crc64:87CA8FF8D64B0327	crc64:B9368B004506C0F3	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	intact-crc:CB7F9A7731BA7BF7|rigid:6rt9G93KN4OKO8XtSq15L9P7zaM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32462	uniprotkb:Q12452	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378671|imex:IM-19950-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	crc64:B9368B004506C0F3	crc64:D9A0589C049D8C49	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:38220898391FDFD2|rigid:ccd1nkndk3tMp8D2tmxSBTrwCls	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P32462	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378676|imex:IM-19950-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	crc64:C3A2B6DF2C14ED63	crc64:B9368B004506C0F3	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	intact-crc:15397E059CDF5138|rigid:v1k0+0mLuu9UoljFkwa2CWrtVcs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32462	uniprotkb:P32352	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378681|imex:IM-19950-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	-	crc64:B9368B004506C0F3	-	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	intact-crc:C7C6AC5A13FA67C8|rigid:1nw6oQDShSPMiKRPfHKEnbQPLRE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32352	uniprotkb:P32462	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378686|imex:IM-19950-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	-	crc64:B9368B004506C0F3	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	intact-crc:B18BF23B342933F1|rigid:1nw6oQDShSPMiKRPfHKEnbQPLRE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32462	uniprotkb:P25340	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378691|imex:IM-19950-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	crc64:B9368B004506C0F3	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	intact-crc:7171EB26DF22AD30|rigid:FcFiWHo2PDV4Ckif6/yymoANpy0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29704	uniprotkb:P53045	intact:EBI-6865|uniprotkb:D3DLD8|ensemblfungi:YHR190W	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:fdft_yeast(display_long)|uniprotkb:"FPP:FPP farnesyltransferase"(gene name synonym)|uniprotkb:YHR190W(locus name)|uniprotkb:ERG9(gene name)|psi-mi:ERG9(display_short)|uniprotkb:Farnesyl-diphosphate farnesyltransferase(gene name synonym)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378696|imex:IM-19950-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012060.1|sgd:S000001233|dip:DIP-4576N|mint:P29704|ensemblfungi:YHR190W(gene)|ensemblfungi:YHR190W_mRNA(transcript)|go:"GO:0004310"(farnesyl-diphosphate farnesyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045338"(farnesyl diphosphate metabolic process)|go:"GO:0051996"(squalene synthase activity)|interpro:IPR002060(Squalene/phytoene synthase)|interpro:IPR006449(Farnesyl-diphosphate farnesyltransferase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR019845|interpro:IPR033904|interpro:IPR044844|reactome:R-SCE-191273	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	-	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:lYDM8gN7ZuHFUP17Q3yyECIsJs8559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:3D5B9319C8AE23F7|rigid:Ay6CmRXCXWjMvTf202lCxE46IV4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53045	uniprotkb:P32476	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	intact:EBI-6545|uniprotkb:D6VUW0|ensemblfungi:YGR175C	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:erg1_yeast(display_long)|uniprotkb:YGR175C(locus name)|uniprotkb:ERG1(gene name)|psi-mi:ERG1(display_short)|uniprotkb:Squalene epoxidase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378701|imex:IM-19950-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	refseq:NP_011691.1|sgd:S000003407|reactome:R-SCE-191273|dip:DIP-6325N|ensemblfungi:YGR175C(gene)|ensemblfungi:YGR175C_mRNA(transcript)|go:"GO:0004506"(squalene monooxygenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR013698(Squalene epoxidase)|interpro:IPR036188|interpro:IPR040125	-	-	crc64:BBEFD766634855E8	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	rogid:vKJFukN2Wlwj1Rcv9t4zgCcCrJ4559292	intact-crc:3F96E9BBA47D492F|rigid:+FaknZk/OEKRgjvwJer+9bEjI8k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53045	uniprotkb:P38604	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378707|imex:IM-19950-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	-	-	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	intact-crc:C3E9F4ED65205F56|rigid:9MMUsEgtCZ/B17g4pui44pnpLnA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53045	uniprotkb:P53045	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378869|imex:IM-19950-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	-	-	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:187FF28133151B2C|rigid:MiuOBZHKWj/WR8poXhyks5TiuL8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53199	uniprotkb:P53045	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378874|imex:IM-19950-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	crc64:87CA8FF8D64B0327	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:644C361D247E49FE|rigid:XZpxJAw0R3+oBMu9f7iGavpEpG0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53045	uniprotkb:Q12452	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378879|imex:IM-19950-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	-	crc64:D9A0589C049D8C49	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:15737FF3F7F25A5E|rigid:YznAGyPmy3A4hGgm21ECl+B9oYI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53045	uniprotkb:Q12452	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378884|imex:IM-19950-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	-	crc64:D9A0589C049D8C49	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:45FA8716A7961F26|rigid:YznAGyPmy3A4hGgm21ECl+B9oYI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:P53045	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378889|imex:IM-19950-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	crc64:F1BD39AFA180E367	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:DCA8AB27EFE5386E|rigid:JeixYwvITzqo+4oCYlHSugE19jM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53045	uniprotkb:P40030	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378894|imex:IM-19950-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	-	-	crc64:F1BD39AFA180E367	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	intact-crc:B7947BAE1700680A|rigid:JeixYwvITzqo+4oCYlHSugE19jM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P53045	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378899|imex:IM-19950-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	crc64:C3A2B6DF2C14ED63	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:949EBD7906190351|rigid:gvHkdP251UjEU0SXCucqw7BWXz4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53045	uniprotkb:P32352	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378909|imex:IM-19950-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	-	-	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	intact-crc:28C96123EB970CC2|rigid:s8PS2Us36lkf0ZwGmhiA6eeCtkU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32353	uniprotkb:P53045	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378914|imex:IM-19950-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	-	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:ACC3184DBE316402|rigid:VNsaXcvVsxt58yqVr5fHrJaFTjQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32353	uniprotkb:P53045	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378919|imex:IM-19950-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	-	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:14E0A5AACEF79F4C|rigid:VNsaXcvVsxt58yqVr5fHrJaFTjQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54781	uniprotkb:P53045	intact:EBI-6563|uniprotkb:D6VZI9|uniprotkb:E9P965|ensemblfungi:YMR015C	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:erg5_yeast(display_long)|uniprotkb:ERG5(gene name)|psi-mi:ERG5(display_short)|uniprotkb:CYP61(gene name synonym)|uniprotkb:YMR015C(locus name)|uniprotkb:YM9711.02C(orf name)|uniprotkb:C-22 sterol desaturase(gene name synonym)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378924|imex:IM-19950-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013728.1|sgd:S000004617|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR036396|mint:P54781|ensemblfungi:YMR015C(gene)|ensemblfungi:YMR015C_mRNA(transcript)|go:"GO:0000249"(C-22 sterol desaturase activity)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	-	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ScwspGheTequLP3AGjoNZM3cp3E559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:DD594AA09B218698|rigid:HoR4MWZGzKj4vRmC9d9Ip5WuZ5o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32352	uniprotkb:P53199	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378929|imex:IM-19950-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	-	-	crc64:87CA8FF8D64B0327	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	intact-crc:01D36BC5B44C5E0E|rigid:NjyYzS8tvIYnhW5Com6Q4kQdZOI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53199	uniprotkb:P25340	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378934|imex:IM-19950-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	crc64:87CA8FF8D64B0327	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	intact-crc:D9CC22BC1A3FAD95|rigid:IpaaXTwDPfjhRdXgNYDxbzRaKkM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53199	uniprotkb:P25340	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378939|imex:IM-19950-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	crc64:87CA8FF8D64B0327	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	intact-crc:C12972D85F47C0CF|rigid:IpaaXTwDPfjhRdXgNYDxbzRaKkM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12452	uniprotkb:P29704	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	intact:EBI-6865|uniprotkb:D3DLD8|ensemblfungi:YHR190W	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:fdft_yeast(display_long)|uniprotkb:"FPP:FPP farnesyltransferase"(gene name synonym)|uniprotkb:YHR190W(locus name)|uniprotkb:ERG9(gene name)|psi-mi:ERG9(display_short)|uniprotkb:Farnesyl-diphosphate farnesyltransferase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378944|imex:IM-19950-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	refseq:NP_012060.1|sgd:S000001233|dip:DIP-4576N|mint:P29704|ensemblfungi:YHR190W(gene)|ensemblfungi:YHR190W_mRNA(transcript)|go:"GO:0004310"(farnesyl-diphosphate farnesyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045338"(farnesyl diphosphate metabolic process)|go:"GO:0051996"(squalene synthase activity)|interpro:IPR002060(Squalene/phytoene synthase)|interpro:IPR006449(Farnesyl-diphosphate farnesyltransferase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR019845|interpro:IPR033904|interpro:IPR044844|reactome:R-SCE-191273	-	crc64:D9A0589C049D8C49	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	rogid:lYDM8gN7ZuHFUP17Q3yyECIsJs8559292	intact-crc:3B952E9CBD39B774|rigid:IlbvlGOQ6b+x/zoZNzOp8OPaDrc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53199	uniprotkb:Q12452	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378949|imex:IM-19950-52	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	crc64:87CA8FF8D64B0327	crc64:D9A0589C049D8C49	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:457CE16B85980D8D|rigid:6YwB6MunKnGwuWbl6RjtBj/ejNA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:Q12452	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378954|imex:IM-19950-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	crc64:F1BD39AFA180E367	crc64:D9A0589C049D8C49	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:9C1F2597DCE08974|rigid:R3ZBOLC0nzjtNyr4LOaPsRo4p9k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12452	uniprotkb:Q12452	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378959|imex:IM-19950-54	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	crc64:D9A0589C049D8C49	crc64:D9A0589C049D8C49	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:5D030051CF6057FB|rigid:CzN7Ps/JpGrHwxlfzAp6T9lKprs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:Q12452	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378965|imex:IM-19950-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	crc64:F1BD39AFA180E367	crc64:D9A0589C049D8C49	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:CC96DD728C84CC0C|rigid:R3ZBOLC0nzjtNyr4LOaPsRo4p9k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32353	uniprotkb:Q12452	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378970|imex:IM-19950-56	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	-	crc64:D9A0589C049D8C49	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:7FFC8CA6D0E8991C|rigid:nJc839fgyin0BoNiHyYhPuGUdxI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32353	uniprotkb:Q12452	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378975|imex:IM-19950-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	-	crc64:D9A0589C049D8C49	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:C13175413343A0E5|rigid:nJc839fgyin0BoNiHyYhPuGUdxI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54781	uniprotkb:Q12452	intact:EBI-6563|uniprotkb:D6VZI9|uniprotkb:E9P965|ensemblfungi:YMR015C	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	psi-mi:erg5_yeast(display_long)|uniprotkb:ERG5(gene name)|psi-mi:ERG5(display_short)|uniprotkb:CYP61(gene name synonym)|uniprotkb:YMR015C(locus name)|uniprotkb:YM9711.02C(orf name)|uniprotkb:C-22 sterol desaturase(gene name synonym)	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378980|imex:IM-19950-58	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013728.1|sgd:S000004617|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR036396|mint:P54781|ensemblfungi:YMR015C(gene)|ensemblfungi:YMR015C_mRNA(transcript)|go:"GO:0000249"(C-22 sterol desaturase activity)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	-	-	crc64:D9A0589C049D8C49	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ScwspGheTequLP3AGjoNZM3cp3E559292	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	intact-crc:D6236A58A10EC8A9|rigid:U0ILpRx7nT8kqZFTiwyCKIsgS+4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12452	uniprotkb:P25340	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378985|imex:IM-19950-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	crc64:D9A0589C049D8C49	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	intact-crc:1678FF5DA7752D15|rigid:O6rHxxR2mdTidhVIyggzOUcPRQU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29704	uniprotkb:P40030	intact:EBI-6865|uniprotkb:D3DLD8|ensemblfungi:YHR190W	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	psi-mi:fdft_yeast(display_long)|uniprotkb:"FPP:FPP farnesyltransferase"(gene name synonym)|uniprotkb:YHR190W(locus name)|uniprotkb:ERG9(gene name)|psi-mi:ERG9(display_short)|uniprotkb:Farnesyl-diphosphate farnesyltransferase(gene name synonym)	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378990|imex:IM-19950-60	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012060.1|sgd:S000001233|dip:DIP-4576N|mint:P29704|ensemblfungi:YHR190W(gene)|ensemblfungi:YHR190W_mRNA(transcript)|go:"GO:0004310"(farnesyl-diphosphate farnesyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045338"(farnesyl diphosphate metabolic process)|go:"GO:0051996"(squalene synthase activity)|interpro:IPR002060(Squalene/phytoene synthase)|interpro:IPR006449(Farnesyl-diphosphate farnesyltransferase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR019845|interpro:IPR033904|interpro:IPR044844|reactome:R-SCE-191273	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	-	-	crc64:F1BD39AFA180E367	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:lYDM8gN7ZuHFUP17Q3yyECIsJs8559292	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	intact-crc:ADCD4E87D456B410|rigid:ls/P+O4z8C/Zoir1gIOfXHfUXfE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38604	uniprotkb:P40030	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1378995|imex:IM-19950-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	-	-	crc64:F1BD39AFA180E367	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	intact-crc:537F297379D8C8B1|rigid:tc17W7GXSpLZsuQP0KbDbI5rTsE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:P32462	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379000|imex:IM-19950-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	crc64:F1BD39AFA180E367	crc64:B9368B004506C0F3	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	intact-crc:A23EEF95ACBBDB28|rigid:fBsuFKcvfoluEkyCBFYWOh3gyJU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53199	uniprotkb:P40030	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379005|imex:IM-19950-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	-	crc64:87CA8FF8D64B0327	crc64:F1BD39AFA180E367	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	intact-crc:C9A45F717E1A62EC|rigid:unniVckPlcEWWq3bzYu//wbKI2I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:P40030	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379010|imex:IM-19950-64	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	-	crc64:F1BD39AFA180E367	crc64:F1BD39AFA180E367	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	intact-crc:8C8DB41D8FE03702|rigid:3hb2p59xusQnbZBcLx+LI6drMgA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P40030	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379015|imex:IM-19950-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	-	crc64:C3A2B6DF2C14ED63	crc64:F1BD39AFA180E367	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	intact-crc:98662A9EF91D1736|rigid:Rgcbme6SGoRRa0F3nhvgKRqwrY0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:P25087	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379020|imex:IM-19950-66	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	-	crc64:F1BD39AFA180E367	crc64:C3A2B6DF2C14ED63	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	intact-crc:855F2D82D2B7EB36|rigid:Rgcbme6SGoRRa0F3nhvgKRqwrY0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:P32353	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379025|imex:IM-19950-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	-	crc64:F1BD39AFA180E367	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	intact-crc:00FD6229748BE671|rigid:qzgDma0bkcwuzUKCEghg/Mshu3o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40030	uniprotkb:P32352	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379030|imex:IM-19950-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	-	crc64:F1BD39AFA180E367	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	intact-crc:6643D45A46056708|rigid:FkaRTIxWV805f12J1w1iTB3ftoM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25340	uniprotkb:P40030	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	intact:EBI-22518|uniprotkb:D3DLU4|ensemblfungi:YER044C	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:erg28_yeast(display_long)|uniprotkb:YER044C(locus name)|uniprotkb:ERG28(gene name)|psi-mi:ERG28(display_short)|uniprotkb:BUD18(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379040|imex:IM-19950-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_010962.1|sgd:S000000846|dip:DIP-2672N|mint:P40030|ensemblfungi:YER044C(gene)|ensemblfungi:YER044C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0070988"(demethylation)|interpro:IPR005352(Erg28-like)	-	-	crc64:F1BD39AFA180E367	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	rogid:ZraMpueswAq72vwrFWF3rhIvH5M559292	intact-crc:80209F46CE1A2E71|rigid:X7JR8cmBTHtr1bkByGwZNWUVe5U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P29704	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-6865|uniprotkb:D3DLD8|ensemblfungi:YHR190W	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:fdft_yeast(display_long)|uniprotkb:"FPP:FPP farnesyltransferase"(gene name synonym)|uniprotkb:YHR190W(locus name)|uniprotkb:ERG9(gene name)|psi-mi:ERG9(display_short)|uniprotkb:Farnesyl-diphosphate farnesyltransferase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379045|imex:IM-19950-70	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	refseq:NP_012060.1|sgd:S000001233|dip:DIP-4576N|mint:P29704|ensemblfungi:YHR190W(gene)|ensemblfungi:YHR190W_mRNA(transcript)|go:"GO:0004310"(farnesyl-diphosphate farnesyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045338"(farnesyl diphosphate metabolic process)|go:"GO:0051996"(squalene synthase activity)|interpro:IPR002060(Squalene/phytoene synthase)|interpro:IPR006449(Farnesyl-diphosphate farnesyltransferase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR019845|interpro:IPR033904|interpro:IPR044844|reactome:R-SCE-191273	-	crc64:C3A2B6DF2C14ED63	-	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid:lYDM8gN7ZuHFUP17Q3yyECIsJs8559292	intact-crc:EBD546491BB1ACA9|rigid:WmFS5xPSnrXr4TRHoeSUKN1/L5o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P38604	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379050|imex:IM-19950-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	-	crc64:C3A2B6DF2C14ED63	-	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	intact-crc:E0464ECD9DAEDBC3|rigid:N3Adh9DLv2V3k9q4gpcgFxZGIao	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P53045	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379055|imex:IM-19950-72	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	-	crc64:C3A2B6DF2C14ED63	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	intact-crc:15C9F01CCE4F7CD1|rigid:gvHkdP251UjEU0SXCucqw7BWXz4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P53199	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379060|imex:IM-19950-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	-	crc64:C3A2B6DF2C14ED63	crc64:87CA8FF8D64B0327	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	intact-crc:6BF9D4C3A7557637|rigid:xRGdkaAuepGKUQH4maLiMm7PTWk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12452	uniprotkb:P25087	intact:EBI-38132|uniprotkb:D6VYA1|ensemblfungi:YLR100W	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	psi-mi:erg27_yeast(display_long)|uniprotkb:ERG27(gene name)|psi-mi:ERG27(display_short)|uniprotkb:YLR100W(locus name)	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379065|imex:IM-19950-74	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013201.1|sgd:S000004090|mint:Q12452|dip:DIP-1237N|ensemblfungi:YLR100W(gene)|ensemblfungi:YLR100W_mRNA(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|interpro:IPR038765|interpro:IPR042829	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	-	crc64:D9A0589C049D8C49	crc64:C3A2B6DF2C14ED63	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:O7stXbO9C0tvqJH/yjFPDMjib64559292	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	intact-crc:B7ADFCD8C83B51F2|rigid:GOmqIf1KbfoKJQ/vUqwyLkEiyGM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P25087	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379070|imex:IM-19950-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	-	crc64:C3A2B6DF2C14ED63	crc64:C3A2B6DF2C14ED63	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	intact-crc:891293272B4F94B6|rigid:YhUpUJdkaEfRvVIXLeqEGVW2sLM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P32353	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379075|imex:IM-19950-76	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	-	crc64:C3A2B6DF2C14ED63	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	intact-crc:395290FE0E60E046|rigid:Or96rKpeil+HIgnZ7yxz676WDYg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54781	uniprotkb:P25087	intact:EBI-6563|uniprotkb:D6VZI9|uniprotkb:E9P965|ensemblfungi:YMR015C	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	psi-mi:erg5_yeast(display_long)|uniprotkb:ERG5(gene name)|psi-mi:ERG5(display_short)|uniprotkb:CYP61(gene name synonym)|uniprotkb:YMR015C(locus name)|uniprotkb:YM9711.02C(orf name)|uniprotkb:C-22 sterol desaturase(gene name synonym)	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379080|imex:IM-19950-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013728.1|sgd:S000004617|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR036396|mint:P54781|ensemblfungi:YMR015C(gene)|ensemblfungi:YMR015C_mRNA(transcript)|go:"GO:0000249"(C-22 sterol desaturase activity)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	-	-	crc64:C3A2B6DF2C14ED63	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ScwspGheTequLP3AGjoNZM3cp3E559292	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	intact-crc:5A3E289DD44344EB|rigid:P598OelxvXBdU8kVy3vFyw5f5wE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25087	uniprotkb:P25340	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379085|imex:IM-19950-78	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	crc64:C3A2B6DF2C14ED63	-	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	intact-crc:BDB24B32E312365D|rigid:DugekThs9/GqiIcaDVu/As/j7T0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32352	uniprotkb:P25087	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	intact:EBI-6567|uniprotkb:D6VZG6|ensemblfungi:YML008C	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:erg6_yeast(display_long)|uniprotkb:ERG6(gene name)|psi-mi:ERG6(display_short)|uniprotkb:ISE1(gene name synonym)|uniprotkb:LIS1(gene name synonym)|uniprotkb:SED6(gene name synonym)|uniprotkb:YML008C(locus name)|uniprotkb:YM9571.10C(orf name)|uniprotkb:"Delta(24)-sterol C-methyltransferase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379090|imex:IM-19950-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	refseq:NP_013706.1|sgd:S000004467|mint:P25087|dip:DIP-3816N|ensemblfungi:YML008C(gene)|ensemblfungi:YML008C_mRNA(transcript)|go:"GO:0003838"(sterol 24-C-methyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR013705(Sterol methyltransferase C-terminal)|interpro:IPR029063|interpro:IPR030384	-	-	crc64:C3A2B6DF2C14ED63	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	rogid://B8LWgQFmbcX+wA6okkQ1DDrxY559292	intact-crc:559FF52561E39D11|rigid:fK/Y9QmIX8KS/i+sSEqswJLp8Ow	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32352	uniprotkb:P32352	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	intact:EBI-6550|uniprotkb:D6W027|ensemblfungi:YMR202W	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:erg2_yeast(display_long)|uniprotkb:ERG2(gene name)|psi-mi:ERG2(display_short)|uniprotkb:YMR202W(locus name)|uniprotkb:YM8325.03(orf name)|uniprotkb:Delta-8--delta-7 sterol isomerase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379095|imex:IM-19950-80	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	refseq:NP_013929.1|sgd:S000004815|dip:DIP-5068N|ensemblfungi:YMR202W(gene)|ensemblfungi:YMR202W_mRNA(transcript)|go:"GO:0000247"(C-8 sterol isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006716(ERG2 and sigma1 receptor-like)	-	-	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	rogid:IJt09jZ0mk1/kcaiFqrdSbQNmFQ559292	intact-crc:9C460C1C6606AD2B|rigid:APxML4F/xNBs4LV1FxdmY82Ee1E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32353	uniprotkb:P29704	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	intact:EBI-6865|uniprotkb:D3DLD8|ensemblfungi:YHR190W	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:fdft_yeast(display_long)|uniprotkb:"FPP:FPP farnesyltransferase"(gene name synonym)|uniprotkb:YHR190W(locus name)|uniprotkb:ERG9(gene name)|psi-mi:ERG9(display_short)|uniprotkb:Farnesyl-diphosphate farnesyltransferase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379206|imex:IM-19950-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	refseq:NP_012060.1|sgd:S000001233|dip:DIP-4576N|mint:P29704|ensemblfungi:YHR190W(gene)|ensemblfungi:YHR190W_mRNA(transcript)|go:"GO:0004310"(farnesyl-diphosphate farnesyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045338"(farnesyl diphosphate metabolic process)|go:"GO:0051996"(squalene synthase activity)|interpro:IPR002060(Squalene/phytoene synthase)|interpro:IPR006449(Farnesyl-diphosphate farnesyltransferase)|interpro:IPR008949(Terpenoid synthase)|interpro:IPR019845|interpro:IPR033904|interpro:IPR044844|reactome:R-SCE-191273	-	-	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	rogid:lYDM8gN7ZuHFUP17Q3yyECIsJs8559292	intact-crc:DFB3CFD83847B75C|rigid:GwSosLYbs3uRRLWBcR1m5PDnWu0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32353	uniprotkb:P38604	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379211|imex:IM-19950-82	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	-	-	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	intact-crc:A36264BC40CC92B9|rigid:xZOU6eAnwr6dFCY7TSxm7RtXAD4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32353	uniprotkb:P32462	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	intact:EBI-6502|uniprotkb:D6W0R4|ensemblfungi:YNL280C	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:erg24_yeast(display_long)|uniprotkb:ERG24(gene name)|psi-mi:ERG24(display_short)|uniprotkb:YNL280C(locus name)|uniprotkb:N0593(orf name)|uniprotkb:C-14 sterol reductase(gene name synonym)|uniprotkb:Sterol C14-reductase(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379216|imex:IM-19950-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	refseq:NP_014119.1|sgd:S000005224|reactome:R-SCE-191273|dip:DIP-5155N|reactome:R-SCE-2995383|ensemblfungi:YNL280C(gene)|ensemblfungi:YNL280C_mRNA(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0050613"(delta14-sterol reductase activity)|go:"GO:0050661"(NADP binding)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	-	crc64:B9368B004506C0F3	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	rogid:IqH7TFPkSUn6RV6CbGVyTM2YkhM559292	intact-crc:954766D65431CD25|rigid:sYmrup3CBcWSBJJqiL3RNOyuXsA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32353	uniprotkb:P53199	intact:EBI-6554|uniprotkb:D6VY58|ensemblfungi:YLR056W	intact:EBI-6514|uniprotkb:D6VUD7|ensemblfungi:YGL001C	psi-mi:erg3_yeast(display_long)|uniprotkb:SYR1(gene name synonym)|uniprotkb:L2150(orf name)|uniprotkb:YLR056W(locus name)|uniprotkb:ERG3(gene name)|psi-mi:ERG3(display_short)|uniprotkb:PSO6(gene name synonym)|uniprotkb:Sterol-C5-desaturase(gene name synonym)|uniprotkb:"Ergosterol Delta(5,6) desaturase"(gene name synonym)|uniprotkb:C-5 sterol desaturase(gene name synonym)	psi-mi:erg26_yeast(display_long)|uniprotkb:ERG26(gene name)|psi-mi:ERG26(display_short)|uniprotkb:C-3 sterol dehydrogenase(gene name synonym)|uniprotkb:C-4 decarboxylase(gene name synonym)|uniprotkb:"NAD(P)-dependent cholesterol dehydrogenase"(gene name synonym)|uniprotkb:YGL001C(locus name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379222|imex:IM-19950-84	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013157.1|sgd:S000004046|mint:P32353|dip:DIP-4136N|ensemblfungi:YLR056W(gene)|ensemblfungi:YLR056W_mRNA(transcript)|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0050046"("delta7-sterol 5(6)-desaturase activity")|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-6807047|reactome:R-SCE-6807062	refseq:NP_011514.1|sgd:S000002969|mint:P53199|dip:DIP-6786N|ensemblfungi:YGL001C(gene)|ensemblfungi:YGL001C_mRNA(transcript)|go:"GO:0000252"("C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity")|go:"GO:0003854"(3-beta-hydroxy-delta5-steroid dehydrogenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0047012"("sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity")|go:"GO:0102175"(3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)|go:"GO:0103066"("4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity")|go:"GO:0103067"("4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity")|interpro:IPR002225(3-beta hydroxysteroid dehydrogenase/isomerase)|interpro:IPR036291|reactome:R-SCE-191273|reactome:R-SCE-193048|reactome:R-SCE-193368|reactome:R-SCE-193775|reactome:R-SCE-193807|reactome:R-SCE-193993|reactome:R-SCE-194002	-	-	crc64:87CA8FF8D64B0327	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:zO926fj34KkGCJAI6vTmiICpUSc559292	rogid:ZN+ISnTNhtZIkk6fhxo0Sg0xErs559292	intact-crc:3DFAAF4C912CCD80|rigid:fcDkO+hteS+wzWuZvKOWc8UMSKk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54781	uniprotkb:P38604	intact:EBI-6563|uniprotkb:D6VZI9|uniprotkb:E9P965|ensemblfungi:YMR015C	intact:EBI-6572|uniprotkb:Q92327|uniprotkb:D3DL21|ensemblfungi:YHR072W	psi-mi:erg5_yeast(display_long)|uniprotkb:ERG5(gene name)|psi-mi:ERG5(display_short)|uniprotkb:CYP61(gene name synonym)|uniprotkb:YMR015C(locus name)|uniprotkb:YM9711.02C(orf name)|uniprotkb:C-22 sterol desaturase(gene name synonym)	psi-mi:erg7_yeast(display_long)|uniprotkb:Oxidosqualene--lanosterol cyclase(gene name synonym)|uniprotkb:2,3-epoxysqualene--lanosterol cyclase(gene name synonym)|uniprotkb:YHR072W(locus name)|uniprotkb:ERG7(gene name)|psi-mi:ERG7(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379229|imex:IM-19950-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013728.1|sgd:S000004617|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR036396|mint:P54781|ensemblfungi:YMR015C(gene)|ensemblfungi:YMR015C_mRNA(transcript)|go:"GO:0000249"(C-22 sterol desaturase activity)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)	refseq:NP_011939.2|sgd:S000001114|mint:P38604|dip:DIP-8319N|ensemblfungi:YHR072W(gene)|ensemblfungi:YHR072W_mRNA(transcript)|go:"GO:0000250"(lanosterol synthase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016104"(triterpenoid biosynthetic process)|go:"GO:0042300"(beta-amyrin synthase activity)|interpro:IPR002365(Terpene synthase)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR018333|interpro:IPR032696|interpro:IPR032697|reactome:R-SCE-191273	-	-	-	comment:Strong interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ScwspGheTequLP3AGjoNZM3cp3E559292	rogid:zqDPA3GvKWkMTmH97TcdF8HOHBU559292	intact-crc:B6BBF465BABF4848|rigid:YY0kGWIaHa5Youxjahvj4p+Bpjc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54781	uniprotkb:P25340	intact:EBI-6563|uniprotkb:D6VZI9|uniprotkb:E9P965|ensemblfungi:YMR015C	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	psi-mi:erg5_yeast(display_long)|uniprotkb:ERG5(gene name)|psi-mi:ERG5(display_short)|uniprotkb:CYP61(gene name synonym)|uniprotkb:YMR015C(locus name)|uniprotkb:YM9711.02C(orf name)|uniprotkb:C-22 sterol desaturase(gene name synonym)	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379234|imex:IM-19950-86	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013728.1|sgd:S000004617|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002403(Cytochrome P450, E-class, group IV)|interpro:IPR036396|mint:P54781|ensemblfungi:YMR015C(gene)|ensemblfungi:YMR015C_mRNA(transcript)|go:"GO:0000249"(C-22 sterol desaturase activity)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	-	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:ScwspGheTequLP3AGjoNZM3cp3E559292	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	intact-crc:2693EDDAD2C6D5B9|rigid:QQyrw+VSl6+OopSYd7jengWRwAQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25340	uniprotkb:P25340	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379239|imex:IM-19950-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	-	-	comment:Weak interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	intact-crc:82AB97F026419748|rigid:kUXqSr87tALf6eiQdhD6Sth8HTI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53045	uniprotkb:P25340	intact:EBI-6506|uniprotkb:D6VUJ5|uniprotkb:Q45U26|uniprotkb:E9P8T3|ensemblfungi:YGR060W	intact:EBI-6558|uniprotkb:D6VUC5|uniprotkb:E9P929|ensemblfungi:YGL012W	psi-mi:msmo_yeast(display_long)|uniprotkb:ERG25(gene name)|psi-mi:ERG25(display_short)|uniprotkb:FET6(gene name synonym)|uniprotkb:C-4 methylsterol oxidase(gene name synonym)|uniprotkb:Sterol-C4-methyl oxidase(gene name synonym)|uniprotkb:YGR060W(locus name)	psi-mi:erg4_yeast(display_long)|uniprotkb:ERG4(gene name)|psi-mi:ERG4(display_short)|uniprotkb:YGL012W(locus name)|uniprotkb:YGL022(orf name)|uniprotkb:"Sterol Delta(24(28))-reductase"(gene name synonym)|uniprotkb:"C-24(28) sterol reductase"(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mo et al. (2005)	pubmed:16300994|imex:IM-19950	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379244|imex:IM-19950-88	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003292|refseq:NP_011574.3|mint:P53045|dip:DIP-2799N|ensemblfungi:YGR060W(gene)|ensemblfungi:YGR060W_mRNA(transcript)|go:"GO:0000254"(C-4 methylsterol oxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR006694(Fatty acid hydroxylase)|reactome:R-SCE-191273|reactome:R-SCE-192105	refseq:NP_011503.1|sgd:S000002980|mint:P25340|dip:DIP-7177N|ensemblfungi:YGL012W(gene)|ensemblfungi:YGL012W_mRNA(transcript)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006696"(ergosterol biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|interpro:IPR001171(ERG4/ERG24 ergosterol biosynthesis protein)|interpro:IPR018083	-	-	-	comment:Moderate interaction|figure legend:Figs 3, 4, 5 and Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/30	2014/10/16	rogid:Ry0sO64GCCLYt4w5HaTb6IO+1+Y559292	rogid:BVxKi7zDnF20xAPBIry0VNTICCw559292	intact-crc:10B642D8D2E2B996|rigid:mk2Pvn3hQxa0wa0U1V+Uv1bjjD0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)