#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P41005	uniprotkb:P78972	intact:EBI-1553555|ensemblfungi:"SPAC5D6.08c.1:pep"	intact:EBI-1252744|ensemblfungi:"SPAC821.08c.1:pep"	psi-mi:mes1_schpo(display_long)|uniprotkb:mes1(gene name)|psi-mi:mes1(display_short)|uniprotkb:SPAC5D6.08c(orf name)	psi-mi:slp1_schpo(display_long)|uniprotkb:slp1(gene name)|psi-mi:slp1(display_short)|uniprotkb:SPAC821.08c(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Izawa et al. (2005)	pubmed:15791259|imex:IM-19990	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1553553|imex:IM-19990-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_593361.1|ensemblfungi:SPAC5D6.08c(gene)|ensemblfungi:SPAC5D6.08c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|go:"GO:1905187"(negative regulation of metaphase/anaphase transition of meiosis I)|go:"GO:1990946"(meiosis I/meiosis II transition)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)	refseq:NP_593161.1|dip:DIP-38036N|reactome:R-SPO-141405|reactome:R-SPO-141430|reactome:R-SPO-983168|ensemblfungi:SPAC821.08c(gene)|ensemblfungi:SPAC821.08c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007049"(cell cycle)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0032153"(cell division site)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:1905188"(positive regulation of metaphase/anaphase transition of meiosis I)|go:"GO:1905191"(positive regulation of metaphase/anaphase transition of meiosis II)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|rcsb pdb:4AEZ|reactome:R-SPO-174113|reactome:R-SPO-5689880	-	-	crc64:52E021FD4EECE5DE	figure legend:Fig 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2007/11/08	2014/10/16	rogid:O2E9SdGKYr0KD9DTn4GJBMLhW5s284812	rogid:sOmydsidXVRfPZ9canW51eh9+Vc284812	intact-crc:5C45EC6A25372B06|rigid:k+fv1zgfr2uAKlATYJD8K8hCSQY	false	flag tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41005	uniprotkb:P78972	intact:EBI-1553555|ensemblfungi:"SPAC5D6.08c.1:pep"	intact:EBI-1252744|ensemblfungi:"SPAC821.08c.1:pep"	psi-mi:mes1_schpo(display_long)|uniprotkb:mes1(gene name)|psi-mi:mes1(display_short)|uniprotkb:SPAC5D6.08c(orf name)	psi-mi:slp1_schpo(display_long)|uniprotkb:slp1(gene name)|psi-mi:slp1(display_short)|uniprotkb:SPAC821.08c(orf name)	psi-mi:"MI:0096"(pull down)	Izawa et al. (2005)	pubmed:15791259|imex:IM-19990	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1553577|imex:IM-19990-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_593361.1|ensemblfungi:SPAC5D6.08c(gene)|ensemblfungi:SPAC5D6.08c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|go:"GO:1905187"(negative regulation of metaphase/anaphase transition of meiosis I)|go:"GO:1990946"(meiosis I/meiosis II transition)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)	refseq:NP_593161.1|dip:DIP-38036N|reactome:R-SPO-141405|reactome:R-SPO-141430|reactome:R-SPO-983168|ensemblfungi:SPAC821.08c(gene)|ensemblfungi:SPAC821.08c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007049"(cell cycle)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0032153"(cell division site)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:1905188"(positive regulation of metaphase/anaphase transition of meiosis I)|go:"GO:1905191"(positive regulation of metaphase/anaphase transition of meiosis II)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|rcsb pdb:4AEZ|reactome:R-SPO-174113|reactome:R-SPO-5689880	-	-	crc64:52E021FD4EECE5DE	figure legend:Fig 2e, 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/08	2014/10/16	rogid:O2E9SdGKYr0KD9DTn4GJBMLhW5s284812	rogid:sOmydsidXVRfPZ9canW51eh9+Vc284812	intact-crc:4E1CB3C73D4B7F9E|rigid:k+fv1zgfr2uAKlATYJD8K8hCSQY	false	glutathione s tranferase tag:n-n	ha tag:c-c|sufficient binding region:166-488	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10815	uniprotkb:P78972	intact:EBI-1187843|uniprotkb:Q9UU16|ensemblfungi:"SPBC582.03.1:pep"	intact:EBI-1252744|ensemblfungi:"SPAC821.08c.1:pep"	psi-mi:cg23_schpo(display_long)|uniprotkb:cdc13(gene name)|psi-mi:cdc13(display_short)|uniprotkb:SPBC582.03(orf name)	psi-mi:slp1_schpo(display_long)|uniprotkb:slp1(gene name)|psi-mi:slp1(display_short)|uniprotkb:SPAC821.08c(orf name)	psi-mi:"MI:0096"(pull down)	Izawa et al. (2005)	pubmed:15791259|imex:IM-19990	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1553588|imex:IM-19990-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595171.1|ensemblfungi:SPBC582.03(gene)|ensemblfungi:SPBC582.03.1(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0075297"(negative regulation of ascospore formation)|go:"GO:0140013"(meiotic nuclear division)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|go:"GO:0140445"(chromosome, telomeric repeat region)|dip:DIP-620N|reactome:R-SPO-69017|reactome:R-SPO-69202|reactome:R-SPO-5687128|reactome:R-SPO-5689880|reactome:R-SPO-68949|reactome:R-SPO-69656|reactome:R-SPO-75815|reactome:R-SPO-8951664|reactome:R-SPO-983168	refseq:NP_593161.1|dip:DIP-38036N|reactome:R-SPO-141405|reactome:R-SPO-141430|reactome:R-SPO-983168|ensemblfungi:SPAC821.08c(gene)|ensemblfungi:SPAC821.08c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007049"(cell cycle)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0032153"(cell division site)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:1905188"(positive regulation of metaphase/anaphase transition of meiosis I)|go:"GO:1905191"(positive regulation of metaphase/anaphase transition of meiosis II)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|rcsb pdb:4AEZ|reactome:R-SPO-174113|reactome:R-SPO-5689880	-	crc64:B2C267CF57F5FD36	crc64:52E021FD4EECE5DE	figure legend:Fig 2e, 4a, 4c|inhibition:This interaction is inhibited by mes1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/08	2014/10/16	rogid:18Ti7CkkGHpRMlPyXO+5ENZFIn4284812	rogid:sOmydsidXVRfPZ9canW51eh9+Vc284812	intact-crc:29597A7C732B33B6|rigid:waxQoaqOGU9iZAB3YTeJdzdypVQ	false	glutathione s tranferase tag:n-n	ha tag:c-c|sufficient binding region:166-488	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41005	uniprotkb:O94423	intact:EBI-1553555|ensemblfungi:"SPAC5D6.08c.1:pep"	intact:EBI-1252869|ensemblfungi:"SPBC1198.12.1:pep"	psi-mi:mes1_schpo(display_long)|uniprotkb:mes1(gene name)|psi-mi:mes1(display_short)|uniprotkb:SPAC5D6.08c(orf name)	psi-mi:mfr1_schpo(display_long)|uniprotkb:mfr1(gene name)|psi-mi:mfr1(display_short)|uniprotkb:SPBC1198.12(orf name)|uniprotkb:SPBC660.02(orf name)	psi-mi:"MI:0096"(pull down)	Izawa et al. (2005)	pubmed:15791259|imex:IM-19990	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1553598|imex:IM-19990-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_593361.1|ensemblfungi:SPAC5D6.08c(gene)|ensemblfungi:SPAC5D6.08c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|go:"GO:1905187"(negative regulation of metaphase/anaphase transition of meiosis I)|go:"GO:1990946"(meiosis I/meiosis II transition)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)	refseq:NP_595081.1|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|ensemblfungi:SPBC1198.12(gene)|ensemblfungi:SPBC1198.12.1(transcript)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0075296"(positive regulation of ascospore formation)|go:"GO:1905191"(positive regulation of metaphase/anaphase transition of meiosis II)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)	-	-	-	figure legend:Fig 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/08	2014/10/16	rogid:O2E9SdGKYr0KD9DTn4GJBMLhW5s284812	rogid:OdHdNPBYwC5cyD1NJ1H8IX5v9ao284812	intact-crc:091E7AD41AD174BB|rigid:VMrlSuagB38q1hj9nsQ5YmzKDZ4	false	glutathione s tranferase tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O94423	uniprotkb:P10815	intact:EBI-1252869|ensemblfungi:"SPBC1198.12.1:pep"	intact:EBI-1187843|uniprotkb:Q9UU16|ensemblfungi:"SPBC582.03.1:pep"	psi-mi:mfr1_schpo(display_long)|uniprotkb:mfr1(gene name)|psi-mi:mfr1(display_short)|uniprotkb:SPBC1198.12(orf name)|uniprotkb:SPBC660.02(orf name)	psi-mi:cg23_schpo(display_long)|uniprotkb:cdc13(gene name)|psi-mi:cdc13(display_short)|uniprotkb:SPBC582.03(orf name)	psi-mi:"MI:0096"(pull down)	Izawa et al. (2005)	pubmed:15791259|imex:IM-19990	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1553626|imex:IM-19990-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595081.1|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|ensemblfungi:SPBC1198.12(gene)|ensemblfungi:SPBC1198.12.1(transcript)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0075296"(positive regulation of ascospore formation)|go:"GO:1905191"(positive regulation of metaphase/anaphase transition of meiosis II)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)	refseq:NP_595171.1|ensemblfungi:SPBC582.03(gene)|ensemblfungi:SPBC582.03.1(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0075297"(negative regulation of ascospore formation)|go:"GO:0140013"(meiotic nuclear division)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|go:"GO:0140445"(chromosome, telomeric repeat region)|dip:DIP-620N|reactome:R-SPO-69017|reactome:R-SPO-69202|reactome:R-SPO-5687128|reactome:R-SPO-5689880|reactome:R-SPO-68949|reactome:R-SPO-69656|reactome:R-SPO-75815|reactome:R-SPO-8951664|reactome:R-SPO-983168	-	-	crc64:B2C267CF57F5FD36	figure legend:Fig 4c|inhibition:This interaction is inhibited by mes1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/08	2014/10/16	rogid:OdHdNPBYwC5cyD1NJ1H8IX5v9ao284812	rogid:18Ti7CkkGHpRMlPyXO+5ENZFIn4284812	intact-crc:8DD0B6219BAC6C64|rigid:yvNK+F0xFiF3prIsEL4mt4XsH3A	false	ha tag:c-c	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)