#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6WKZ7 uniprotkb:P98078 intact:EBI-1391878|uniprotkb:Q7TSK5|uniprotkb:Q8BWC2|ensembl:ENSMUSP00000036923 intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1 psi-mi:nostn_mouse(display_long)|uniprotkb:Nostrin(gene name)|psi-mi:Nostrin(display_short)|uniprotkb:Daip2(gene name synonym)|uniprotkb:eNOS-trafficking inducer(gene name synonym)|uniprotkb:Nitric oxide synthase trafficker(gene name synonym)|uniprotkb:Disabled homolog 2-interacting protein 2(gene name synonym) psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Choi et al. (2005) pubmed:15596140|mint:MINT-5217405 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1391874 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_853525.3|ensembl:ENSMUSG00000034738(gene)|ensembl:ENSMUST00000041865(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028535|interpro:IPR031160|interpro:IPR035656|interpro:IPR036028|mint:Q6WKZ7|reactome:R-MMU-203641 refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828 - - - figure legend:1|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/09/05 2014/10/16 rogid:sYY/6zoWydoVacJ+I+OdFBAvFt810090 rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090 intact-crc:6C3FD6524B5BB0AC|rigid:pEICL4YzKe1EVwSQlTh/BtKihZg false - binding-associated region:487-720 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6WKZ7 uniprotkb:P98078 intact:EBI-1391878|uniprotkb:Q7TSK5|uniprotkb:Q8BWC2|ensembl:ENSMUSP00000036923 intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1 psi-mi:nostn_mouse(display_long)|uniprotkb:Nostrin(gene name)|psi-mi:Nostrin(display_short)|uniprotkb:Daip2(gene name synonym)|uniprotkb:eNOS-trafficking inducer(gene name synonym)|uniprotkb:Nitric oxide synthase trafficker(gene name synonym)|uniprotkb:Disabled homolog 2-interacting protein 2(gene name synonym) psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Choi et al. (2005) pubmed:15596140|mint:MINT-5217405 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1391905 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_853525.3|ensembl:ENSMUSG00000034738(gene)|ensembl:ENSMUST00000041865(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028535|interpro:IPR031160|interpro:IPR035656|interpro:IPR036028|mint:Q6WKZ7|reactome:R-MMU-203641 refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828 - - - figure legend:5|comment:Two bands have been detected using a polyclonal Dab2 antibody which have interpreted as Dab2 p96 and p67 isoforms.|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:10090(mouse-f9)|taxid:10090(Mus musculus) - 2007/09/05 2014/10/16 rogid:sYY/6zoWydoVacJ+I+OdFBAvFt810090 rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090 intact-crc:B7DAFACBBE928C15|rigid:pEICL4YzKe1EVwSQlTh/BtKihZg false binding-associated region:290-506 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)