#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P93836	uniprotkb:P93836	intact:EBI-1251387|uniprotkb:F4IDP1|uniprotkb:O04330|uniprotkb:Q9SHK1|ensemblplants:AT1G06570.1	intact:EBI-1251387|uniprotkb:F4IDP1|uniprotkb:O04330|uniprotkb:Q9SHK1|ensemblplants:AT1G06570.1	psi-mi:hppd_arath(display_long)|uniprotkb:HPD(gene name)|psi-mi:HPD(display_short)|uniprotkb:4-hydroxyphenylpyruvic acid oxidase(gene name synonym)|uniprotkb:PDS1(gene name synonym)|uniprotkb:F12K11.9(orf name)|uniprotkb:At1g06570(locus name)	psi-mi:hppd_arath(display_long)|uniprotkb:HPD(gene name)|psi-mi:HPD(display_short)|uniprotkb:4-hydroxyphenylpyruvic acid oxidase(gene name synonym)|uniprotkb:PDS1(gene name synonym)|uniprotkb:F12K11.9(orf name)|uniprotkb:At1g06570(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Yang et al. (2004)	pubmed:15301540|imex:IM-19716	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1252226|imex:IM-19716-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR005956(4-hydroxyphenylpyruvate dioxygenase)|interpro:IPR004360(Glyoxalase/bleomycin resistance protein/dioxygenase)|rcsb pdb:1SP9|rcsb pdb:1SQD|rcsb pdb:1TFZ|rcsb pdb:1TG5|rcsb pdb:6JX9|interpro:IPR041735|interpro:IPR041736|rcsb pdb:5XGK|rcsb pdb:6ISD|interpro:IPR029068|refseq:NP_172144.3|interpro:IPR037523|rcsb pdb:5YWG|rcsb pdb:5YWH|rcsb pdb:5YWI|rcsb pdb:5YWK|rcsb pdb:5YY6|rcsb pdb:5YY7|rcsb pdb:6J63|ensemblplants:AT1G06570(gene)|ensemblplants:AT1G06570.1(transcript)|go:"GO:0003868"(4-hydroxyphenylpyruvate dioxygenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006559"(L-phenylalanine catabolic process)|go:"GO:0006572"(tyrosine catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6LGT|rcsb pdb:6M6D	interpro:IPR005956(4-hydroxyphenylpyruvate dioxygenase)|interpro:IPR004360(Glyoxalase/bleomycin resistance protein/dioxygenase)|rcsb pdb:1SP9|rcsb pdb:1SQD|rcsb pdb:1TFZ|rcsb pdb:1TG5|rcsb pdb:6JX9|interpro:IPR041735|interpro:IPR041736|rcsb pdb:5XGK|rcsb pdb:6ISD|interpro:IPR029068|refseq:NP_172144.3|interpro:IPR037523|rcsb pdb:5YWG|rcsb pdb:5YWH|rcsb pdb:5YWI|rcsb pdb:5YWK|rcsb pdb:5YY6|rcsb pdb:5YY7|rcsb pdb:6J63|ensemblplants:AT1G06570(gene)|ensemblplants:AT1G06570.1(transcript)|go:"GO:0003868"(4-hydroxyphenylpyruvate dioxygenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006559"(L-phenylalanine catabolic process)|go:"GO:0006572"(tyrosine catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6LGT|rcsb pdb:6M6D	go:"GO:0042803"(protein homodimerization activity)|wwpdb:1SP9(primary-reference)	-	-	3d-r-factors:Working R factor = 21.6 . Free R factor = 26.6.|3d-resolution:1.8 Angstroms.|3d-structure:The protein complex was homodimeric. It was not possible to distinguish between colbalt and iron ions within the protein structure , the active site metal ion cofactor is therefore referred to as 'M' by the authors. The metal ion in the AtHPPD structure is coordinated by His205, His287  Glu373,  and three water molecules forming an octahedral complex within the homodimer.|figure legend:Table 1 Figure 2a|comment:The protein was trucated by removal of 21 amino acids from the N terminus of the protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/14	2014/10/16	rogid:Pxrg8K2ZKqsVwgBWdNgJx+Bl23Q3702	rogid:Pxrg8K2ZKqsVwgBWdNgJx+Bl23Q3702	intact-crc:0F68ACB6FAECA2F1|rigid:PpBngPTSgdLY4dXfkHnwyntA/lQ	false	sufficient binding region:22-445	sufficient binding region:22-445	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:40290"	uniprotkb:P93836	intact:EBI-1255755|chebi:"CHEBI:38302"	intact:EBI-1251387|uniprotkb:F4IDP1|uniprotkb:O04330|uniprotkb:Q9SHK1|ensemblplants:AT1G06570.1	psi-mi:das869(display_short)|psi-mi:"CHEBI:40290"(display_long)	psi-mi:hppd_arath(display_long)|uniprotkb:HPD(gene name)|psi-mi:HPD(display_short)|uniprotkb:4-hydroxyphenylpyruvic acid oxidase(gene name synonym)|uniprotkb:PDS1(gene name synonym)|uniprotkb:F12K11.9(orf name)|uniprotkb:At1g06570(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Yang et al. (2004)	pubmed:15301540|imex:IM-19716	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1255758|wwpdb:1TFZ|imex:IM-19716-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR005956(4-hydroxyphenylpyruvate dioxygenase)|interpro:IPR004360(Glyoxalase/bleomycin resistance protein/dioxygenase)|rcsb pdb:1SP9|rcsb pdb:1SQD|rcsb pdb:1TFZ|rcsb pdb:1TG5|rcsb pdb:6JX9|interpro:IPR041735|interpro:IPR041736|rcsb pdb:5XGK|rcsb pdb:6ISD|interpro:IPR029068|refseq:NP_172144.3|interpro:IPR037523|rcsb pdb:5YWG|rcsb pdb:5YWH|rcsb pdb:5YWI|rcsb pdb:5YWK|rcsb pdb:5YY6|rcsb pdb:5YY7|rcsb pdb:6J63|ensemblplants:AT1G06570(gene)|ensemblplants:AT1G06570.1(transcript)|go:"GO:0003868"(4-hydroxyphenylpyruvate dioxygenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006559"(L-phenylalanine catabolic process)|go:"GO:0006572"(tyrosine catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6LGT|rcsb pdb:6M6D	go:"GO:0042803"(protein homodimerization activity)	comment:Experimental herbicides from the Dow AgroSciences collection.	-	3d-r-factors:Working R factor = 21.6 . Free R factor = 26.6.|3d-resolution:1.8 Angstroms.|3d-structure:The protein complex was homodimeric. It was not possible to distinguish between colbalt and iron ions within the protein structure , the active site metal ion cofactor is therefore referred to as 'M' by the authors. The metal ion in the AtHPPD structure is coordinated by His205, His287  Glu373,  and one water molecule and a  1,3-diketone moiety of the DAS869 inhibitor forming an octahedral complex within the homodimer.|figure legend:Table 1 Figure 2a|comment:The protein was trucated by removal of 21 amino acids from the N terminus of the protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/14	2014/10/16	-	rogid:Pxrg8K2ZKqsVwgBWdNgJx+Bl23Q3702	intact-crc:DD168476F7A5F97D	false	-	sufficient binding region:22-445|binding-associated region:360-360|binding-associated region:430-430	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:40290"	uniprotkb:P32755	intact:EBI-1255755|chebi:"CHEBI:38302"	intact:EBI-1255775|uniprotkb:O88655|ensembl:ENSRNOP00000001809	psi-mi:das869(display_short)|psi-mi:"CHEBI:40290"(display_long)	psi-mi:hppd_rat(display_long)|uniprotkb:Hpd(gene name)|psi-mi:Hpd(display_short)|uniprotkb:4-hydroxyphenylpyruvic acid oxidase(gene name synonym)|uniprotkb:F Alloantigen(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Yang et al. (2004)	pubmed:15301540|imex:IM-19716	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1255785|wwpdb:1SQI|imex:IM-19716-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:61974|refseq:NP_058929.1|ensembl:ENSRNOG00000001338(gene)|ensembl:ENSRNOT00000001809(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003868"(4-hydroxyphenylpyruvate dioxygenase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006559"(L-phenylalanine catabolic process)|go:"GO:0006572"(tyrosine catabolic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR004360(Glyoxalase/bleomycin resistance protein/dioxygenase)|interpro:IPR005956(4-hydroxyphenylpyruvate dioxygenase)|interpro:IPR029068|interpro:IPR037523|interpro:IPR041735|interpro:IPR041736|rcsb pdb:1SQI|reactome:R-RNO-8963684	go:"GO:0042803"(protein homodimerization activity)	comment:Experimental herbicides from the Dow AgroSciences collection.	-	3d-r-factors:Working R factor = 21.6 . Free R factor = 27.1|3d-resolution:2.15 Angstroms.|3d-structure:The protein complex was homodimeric. It was not possible to distinguish between colbalt and iron ions within the protein structure , the active site metal ion cofactor is therefore referred to as 'M' by the authors. The metal ion in the AtHPPD structure is coordinated by His183, His266  Glu349,  and one water molecule and a  1,3-diketone moiety of the DAS869 inhibitor forming an octahedral complex within the homodimer.|figure legend:Table 1 Figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/14	2014/10/16	-	rogid:MKrwssyMSIS+fqfHH2pDu1kOjv010116	intact-crc:A59680C54D570A0B	false	-	-	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:47147"	uniprotkb:P93836	intact:EBI-1255752|chebi:"CHEBI:38301"	intact:EBI-1251387|uniprotkb:F4IDP1|uniprotkb:O04330|uniprotkb:Q9SHK1|ensemblplants:AT1G06570.1	psi-mi:das645(display_short)|psi-mi:"CHEBI:47147"(display_long)	psi-mi:hppd_arath(display_long)|uniprotkb:HPD(gene name)|psi-mi:HPD(display_short)|uniprotkb:4-hydroxyphenylpyruvic acid oxidase(gene name synonym)|uniprotkb:PDS1(gene name synonym)|uniprotkb:F12K11.9(orf name)|uniprotkb:At1g06570(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Yang et al. (2004)	pubmed:15301540|imex:IM-19716	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1255795|wwpdb:1TG5|imex:IM-19716-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR005956(4-hydroxyphenylpyruvate dioxygenase)|interpro:IPR004360(Glyoxalase/bleomycin resistance protein/dioxygenase)|rcsb pdb:1SP9|rcsb pdb:1SQD|rcsb pdb:1TFZ|rcsb pdb:1TG5|rcsb pdb:6JX9|interpro:IPR041735|interpro:IPR041736|rcsb pdb:5XGK|rcsb pdb:6ISD|interpro:IPR029068|refseq:NP_172144.3|interpro:IPR037523|rcsb pdb:5YWG|rcsb pdb:5YWH|rcsb pdb:5YWI|rcsb pdb:5YWK|rcsb pdb:5YY6|rcsb pdb:5YY7|rcsb pdb:6J63|ensemblplants:AT1G06570(gene)|ensemblplants:AT1G06570.1(transcript)|go:"GO:0003868"(4-hydroxyphenylpyruvate dioxygenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006559"(L-phenylalanine catabolic process)|go:"GO:0006572"(tyrosine catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6LGT|rcsb pdb:6M6D	go:"GO:0042803"(protein homodimerization activity)	comment:Experimental herbicides from the Dow AgroSciences collection.	-	3d-r-factors:Working R factor = 18.8 . Free R factor = 23.4|3d-resolution:1.9 Angstroms.|figure legend:Table 1 Figure 7|comment:The HPPD protein was truncated by 21 N terminal amino acids|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/14	2014/10/16	-	rogid:Pxrg8K2ZKqsVwgBWdNgJx+Bl23Q3702	intact-crc:AD09A81376448CF0	false	-	-	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)