#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04070	uniprotkb:P51511	intact:EBI-1383018|uniprotkb:B4DPQ7|uniprotkb:Q15189|uniprotkb:Q15190|uniprotkb:Q16001|uniprotkb:Q53S74|uniprotkb:Q9UC55|ensembl:ENSP00000234071	intact:EBI-1383043|uniprotkb:A0A2U6|uniprotkb:Q14111|ensembl:ENSP00000219271	psi-mi:proc_human(display_long)|uniprotkb:PROC(gene name)|psi-mi:PROC(display_short)|uniprotkb:Autoprothrombin IIA(gene name synonym)|uniprotkb:Anticoagulant protein C(gene name synonym)|uniprotkb:Blood coagulation factor XIV(gene name synonym)	psi-mi:mmp15_human(display_long)|uniprotkb:MMP15(gene name)|psi-mi:MMP15(display_short)|uniprotkb:Membrane-type matrix metalloproteinase 2(gene name synonym)|uniprotkb:Membrane-type-2 matrix metalloproteinase(gene name synonym)|uniprotkb:SMCP-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Buisson-Legendre et al. (2004)	pubmed:15248212|imex:IM-19965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1383059|imex:IM-19965-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000303.1|ensembl:ENSG00000115718(gene)|ensembl:ENST00000234071(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050819"(negative regulation of coagulation)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035972|interpro:IPR043504|rcsb pdb:1AUT|rcsb pdb:1LQV|rcsb pdb:1PCU|rcsb pdb:2PCT|rcsb pdb:3F6U|rcsb pdb:3JTC|rcsb pdb:4DT7|rcsb pdb:6M3B|rcsb pdb:6M3C|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-381426|reactome:R-HSA-8957275	refseq:NP_002419.1|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR028729|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|mint:P51511|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|ensembl:ENSG00000102996(gene)|ensembl:ENST00000219271(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032355"(response to estradiol)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR000585(Hemopexin)|go:"GO:0005886"(plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486	omim:165720(primary-reference)	-	-	figure legend:3 D|comment:Both active and latent MMP-2 were coimmunoprecipitated with PC/APC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-synovial_fluid)|taxid:9606(Homo sapiens synovial fluid)	-	2007/08/15	2014/10/16	rogid:86Piqkh7WZbFPB5KRynsH2xThJU9606	rogid:PcbihFMCHtgwetE9vWK+sU1kBv89606	intact-crc:BFA2B4C32C657C12|rigid:IAPZY+KJVCNDhsZstYB5Y1bw0Rc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51511	uniprotkb:P04070	intact:EBI-1383043|uniprotkb:A0A2U6|uniprotkb:Q14111|ensembl:ENSP00000219271	intact:EBI-1383018|uniprotkb:B4DPQ7|uniprotkb:Q15189|uniprotkb:Q15190|uniprotkb:Q16001|uniprotkb:Q53S74|uniprotkb:Q9UC55|ensembl:ENSP00000234071	psi-mi:mmp15_human(display_long)|uniprotkb:MMP15(gene name)|psi-mi:MMP15(display_short)|uniprotkb:Membrane-type matrix metalloproteinase 2(gene name synonym)|uniprotkb:Membrane-type-2 matrix metalloproteinase(gene name synonym)|uniprotkb:SMCP-2(gene name synonym)	psi-mi:proc_human(display_long)|uniprotkb:PROC(gene name)|psi-mi:PROC(display_short)|uniprotkb:Autoprothrombin IIA(gene name synonym)|uniprotkb:Anticoagulant protein C(gene name synonym)|uniprotkb:Blood coagulation factor XIV(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Buisson-Legendre et al. (2004)	pubmed:15248212|imex:IM-19965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1383072|imex:IM-19965-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002419.1|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR021805|interpro:IPR024079|interpro:IPR028729|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|mint:P51511|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|ensembl:ENSG00000102996(gene)|ensembl:ENST00000219271(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032355"(response to estradiol)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR000585(Hemopexin)|go:"GO:0005886"(plasma membrane)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486	refseq:NP_000303.1|ensembl:ENSG00000115718(gene)|ensembl:ENST00000234071(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050819"(negative regulation of coagulation)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035972|interpro:IPR043504|rcsb pdb:1AUT|rcsb pdb:1LQV|rcsb pdb:1PCU|rcsb pdb:2PCT|rcsb pdb:3F6U|rcsb pdb:3JTC|rcsb pdb:4DT7|rcsb pdb:6M3B|rcsb pdb:6M3C|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-381426|reactome:R-HSA-8957275	omim:180300(primary-reference)	-	-	figure legend:3 D|comment:Both active and latent MMP-2 were coimmunoprecipitated with PC/APC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rheu_arth_syn_fluid)|taxid:9606(Homo sapiens rheumatoid arthritic synovial fluid)	-	2007/08/15	2014/10/16	rogid:PcbihFMCHtgwetE9vWK+sU1kBv89606	rogid:86Piqkh7WZbFPB5KRynsH2xThJU9606	intact-crc:1EB840225E16EF35|rigid:IAPZY+KJVCNDhsZstYB5Y1bw0Rc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)