#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O16844 uniprotkb:P19538 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1393922 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N - - - figure legend:5 taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/09/11 2014/10/16 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 intact-crc:BC2988D6FDC05C5A|rigid:8zO1OasPbM30htcthuHAQTpVbqg false sufficient binding region:?-?|sufficient binding region:343-447|sufficient binding region:143-343 sufficient binding region:941-1396|sufficient binding region:1-620|sufficient binding region:941-1396 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O16844 uniprotkb:P23647 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7 psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name) psi-mi:"MI:0018"(two hybrid) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394147 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N - - - figure legend:5 taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/09/11 2014/10/16 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227 intact-crc:923F8CDC3E4D0948|rigid:bJKZP3SMTzOy8HkKRhCzyMFRo9s false sufficient binding region:?-? - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P23647 uniprotkb:P19538 intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394156 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N - - - figure legend:5 taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/09/11 2014/10/16 rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 intact-crc:685D7459C6763C1C|rigid:WNQgMeK//ptw2jJWqJcqucWKz7w false - sufficient binding region:941-1377 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O16844 uniprotkb:P19538 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394196 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N - - - figure legend:3A, 3B|comment:A dispersed N terminal and the CORD domain of Ci are involved in interaction with Cos. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/09/11 2014/10/16 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 intact-crc:4513DA37850D3889|rigid:8zO1OasPbM30htcthuHAQTpVbqg false - sufficient binding region:941-1396|sufficient binding region:1-440 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19538 uniprotkb:P23647 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394210 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N - - - figure legend:3C taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2007/09/11 2014/10/16 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227 intact-crc:231E00497AE05611|rigid:WNQgMeK//ptw2jJWqJcqucWKz7w false sufficient binding region:1-703|ha tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O16844 uniprotkb:P19538 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394215 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N - - - figure legend:3C taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2007/09/11 2014/10/16 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 intact-crc:9F7DFBF88B2C417A|rigid:8zO1OasPbM30htcthuHAQTpVbqg false flag tag:?-? sufficient binding region:1-703|necessary binding region:346-440|ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P19538 uniprotkb:O16844 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394753 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N - - - figure legend:6C, 6D taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2007/09/11 2014/10/16 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 intact-crc:1F7D7F4D6BAED72D|rigid:moestBHgxqZprcsCQvYHoD+c7HE false sufficient binding region:1-346,440-1377|sufficient binding region:1-941,1066-1377|ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P19538 uniprotkb:P23647 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394753 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N - - - figure legend:6C, 6D taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2007/09/11 2014/10/16 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227 intact-crc:1F7D7F4D6BAED72D|rigid:moestBHgxqZprcsCQvYHoD+c7HE false sufficient binding region:1-346,440-1377|sufficient binding region:1-941,1066-1377|ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P23647 uniprotkb:P19538 intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394800 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N - - - figure legend:6C, 6D taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2007/09/11 2014/10/16 rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 intact-crc:3428E8BDBDCD2201|rigid:WNQgMeK//ptw2jJWqJcqucWKz7w false flag tag:?-? sufficient binding region:941-1065|sufficient binding region:1-941,1066-1377|ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P19538 uniprotkb:O16844 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:"MI:0096"(pull down) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394602 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N - - - figure legend:6B taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/11 2014/10/16 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 intact-crc:40E7A898E1BD8E14|rigid:moestBHgxqZprcsCQvYHoD+c7HE false sufficient binding region:1-703|glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19538 uniprotkb:P23647 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name) psi-mi:"MI:0096"(pull down) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394602 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N - - - figure legend:6B taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/11 2014/10/16 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227 intact-crc:40E7A898E1BD8E14|rigid:moestBHgxqZprcsCQvYHoD+c7HE false sufficient binding region:1-703|glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19538 uniprotkb:O16844 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:"MI:0096"(pull down) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394643 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N - - - figure legend:6A taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/11 2014/10/16 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 intact-crc:8DD6FCE9BD689C16|rigid:moestBHgxqZprcsCQvYHoD+c7HE false sufficient binding region:1-703|glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19538 uniprotkb:P23647 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name) psi-mi:"MI:0096"(pull down) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394643 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N - - - figure legend:6A taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/11 2014/10/16 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227 intact-crc:8DD6FCE9BD689C16|rigid:moestBHgxqZprcsCQvYHoD+c7HE false sufficient binding region:1-703|glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19538 uniprotkb:P23647 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name) psi-mi:"MI:0096"(pull down) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394663 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N - - - figure legend:6A taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/11 2014/10/16 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227 intact-crc:3FC6022913ECAE24|rigid:WNQgMeK//ptw2jJWqJcqucWKz7w false sufficient binding region:1-703|glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O16844 uniprotkb:P19538 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:"MI:0096"(pull down) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1394676 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N - - - figure legend:6B taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/11 2014/10/16 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 intact-crc:73B6D800137FD5B1|rigid:8zO1OasPbM30htcthuHAQTpVbqg false 35s radiolabel:?-? sufficient binding region:1-703|glutathione s tranferase tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19538 uniprotkb:O16844 intact:EBI-94976|uniprotkb:O18525|uniprotkb:Q8T6T1|uniprotkb:Q9V4A8|ensemblmetazoa:FBpp0088245 intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854 psi-mi:ci_drome(display_long)|uniprotkb:ci(gene name)|psi-mi:ci(display_short)|uniprotkb:ci-D(gene name synonym)|uniprotkb:CG2125(orf name)|uniprotkb:ci form of 155 kDa(gene name synonym)|uniprotkb:ci full-length protein(gene name synonym) psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Wang et al. (2004) pubmed:15063184 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-1557350 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524617.3|flybase:FBgn0004859|ensemblmetazoa:FBgn0004859(gene)|ensemblmetazoa:FBtr0089178(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035017"(cuticle pattern formation)|go:"GO:0035217"(labial disc development)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000495"(regulation of cell proliferation involved in compound eye morphogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|rcsb pdb:3HQM|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-209446|reactome:R-DME-216119|reactome:R-DME-216167|reactome:R-DME-216217|reactome:R-DME-5610780|reactome:R-DME-5610785|reactome:R-DME-5610787|reactome:R-DME-5632684|go:"GO:0060914"(heart formation)|dip:DIP-121N refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N go:"GO:0005737"(cytoplasm) - - figure legend:2 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2007/09/11 2014/10/16 rogid:OECmiJznkWySH07yEHq3R8HSsAQ7227 rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227 intact-crc:1DB1C2E639550065|rigid:8zO1OasPbM30htcthuHAQTpVbqg false sufficient binding region:1-440|necessary binding region:346-440 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)