#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q66K89	uniprotkb:Q9NS23-2	intact:EBI-1227043|uniprotkb:A8K2R4|uniprotkb:O00146|ensembl:ENSP00000301727	intact:EBI-438698|intact:EBI-8557945|intact:MINT-1919550|ensembl:ENSP00000352323	psi-mi:e4f1_human(display_long)|uniprotkb:E4F1(gene name)|psi-mi:E4F1(display_short)|uniprotkb:E4F(gene name synonym)|uniprotkb:Putative E3 ubiquitin-protein ligase E4F1(gene name synonym)|uniprotkb:E4F transcription factor 1(gene name synonym)|uniprotkb:Transcription factor E4F(gene name synonym)|uniprotkb:p120E4F(gene name synonym)|uniprotkb:p50E4F(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase E4F1(gene name synonym)	psi-mi:q9ns23-2(display_long)|uniprotkb:RASSF1A(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fenton et al. (2004)	pubmed:14729613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1227055	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001275705.1|refseq:NP_001275707.1|refseq:NP_004415.3|ensembl:ENSP00000301727|ensembl:ENSG00000167967(gene)|ensembl:ENST00000301727(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006260"(DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016740"(transferase activity)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q66K89	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000359365(transcript)|uniprotkb:Q9NS23-2(isoform-parent)	-	-	isoform-comment:Produced by alternative splicing of isoform D.	author-identifiers:PREY protein NP_004415|caution:"Isoform C of RASS1F as described by the authors lacks 119 aa at the N-terminus as compared to RASSF1A and did not interact with E4F1 (461-784). Note that the isoform C of RASS1F described in the UniProtKB entry Q9NS23 does not conform with the isoform described by the authors."|caution:"The authors state E4F is 683 aa in length, whereas the protein they reference (NP_004415) is 784 aa, as is the corresponding UniProtKB entry. The predicted C-terminal zinc finger range for NP_004415 is aa 416-595. The range given above for E4FDelta is approximate only as precise mapping was not possible as the sequence of E4FDelta was not provided."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/04/05	2014/10/16	rogid:WkZmCgVg25mO8Gd8Bl0Nax4dVXE9606	rogid:fnCwaMSu8L2xdeP+tZBG+FLFTPg9606	intact-crc:238E1E38ED27563D|rigid:/PChRgLjLEeClbqfvqIKab23oLk	false	sufficient binding region:416..416-784..784	necessary binding region:1-119	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NS23-2	uniprotkb:Q13043	intact:EBI-438698|intact:EBI-8557945|intact:MINT-1919550|ensembl:ENSP00000352323	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:q9ns23-2(display_long)|uniprotkb:RASSF1A(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fenton et al. (2004)	pubmed:14729613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1227062	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000359365(transcript)|uniprotkb:Q9NS23-2(isoform-parent)	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	-	isoform-comment:Produced by alternative splicing of isoform D.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/04/05	2014/10/16	rogid:fnCwaMSu8L2xdeP+tZBG+FLFTPg9606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:3F3ED6AF055F2724|rigid:Z0OAgP15uLhCcCKntyRm+Rovq8Y	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NS23-2	uniprotkb:Q13188	intact:EBI-438698|intact:EBI-8557945|intact:MINT-1919550|ensembl:ENSP00000352323	intact:EBI-992580|uniprotkb:Q15445|uniprotkb:Q15801|uniprotkb:Q96FM6|uniprotkb:A8K722|ensembl:ENSP00000390500|uniprotkb:B3KYA7	psi-mi:q9ns23-2(display_long)|uniprotkb:RASSF1A(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:stk3_human(display_long)|uniprotkb:STE20-like kinase MST2(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-1(gene name synonym)|uniprotkb:STK3(gene name)|psi-mi:STK3(display_short)|uniprotkb:MST2(gene name synonym)|uniprotkb:KRS1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fenton et al. (2004)	pubmed:14729613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1227066	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000359365(transcript)|uniprotkb:Q9NS23-2(isoform-parent)	refseq:NP_001243241.1|refseq:NP_006272.2|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR036674|mint:Q13188|rcsb pdb:3WWS|rcsb pdb:4HKD|rcsb pdb:4L0N|rcsb pdb:4LG4|rcsb pdb:4LGD|rcsb pdb:4OH9|rcsb pdb:5BRM|rcsb pdb:5DH3|rcsb pdb:6AO5|rcsb pdb:6AR2|reactome:R-HSA-2028269|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0106311"|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000104375(gene)|ensembl:ENST00000419617(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001841"(neural tube formation)|go:"GO:0003157"(endocardium development)|dip:DIP-36128N	-	isoform-comment:Produced by alternative splicing of isoform D.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/04/05	2014/10/16	rogid:fnCwaMSu8L2xdeP+tZBG+FLFTPg9606	rogid:slrC4Ax6263chBC1DJygdoExuCc9606	intact-crc:0F9C7B1464C90331|rigid:4o7fLIkXIyqV1hIVTVFJm28dddI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q66K89	uniprotkb:Q9NS23-2	intact:EBI-1227043|uniprotkb:A8K2R4|uniprotkb:O00146|ensembl:ENSP00000301727	intact:EBI-438698|intact:EBI-8557945|intact:MINT-1919550|ensembl:ENSP00000352323	psi-mi:e4f1_human(display_long)|uniprotkb:E4F1(gene name)|psi-mi:E4F1(display_short)|uniprotkb:E4F(gene name synonym)|uniprotkb:Putative E3 ubiquitin-protein ligase E4F1(gene name synonym)|uniprotkb:E4F transcription factor 1(gene name synonym)|uniprotkb:Transcription factor E4F(gene name synonym)|uniprotkb:p120E4F(gene name synonym)|uniprotkb:p50E4F(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase E4F1(gene name synonym)	psi-mi:q9ns23-2(display_long)|uniprotkb:RASSF1A(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fenton et al. (2004)	pubmed:14729613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1227084	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001275705.1|refseq:NP_001275707.1|refseq:NP_004415.3|ensembl:ENSP00000301727|ensembl:ENSG00000167967(gene)|ensembl:ENST00000301727(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006260"(DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016740"(transferase activity)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q66K89	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000359365(transcript)|uniprotkb:Q9NS23-2(isoform-parent)	-	-	isoform-comment:Produced by alternative splicing of isoform D.	author-identifiers:PREY protein NP_004415|figure legend:1 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/05	2014/10/16	rogid:WkZmCgVg25mO8Gd8Bl0Nax4dVXE9606	rogid:fnCwaMSu8L2xdeP+tZBG+FLFTPg9606	intact-crc:BE05EEF0970FF909|rigid:/PChRgLjLEeClbqfvqIKab23oLk	false	sufficient binding region:416..416-784..784|ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NS23-2	uniprotkb:Q66K89	intact:EBI-438698|intact:EBI-8557945|intact:MINT-1919550|ensembl:ENSP00000352323	intact:EBI-1227043|uniprotkb:A8K2R4|uniprotkb:O00146|ensembl:ENSP00000301727	psi-mi:q9ns23-2(display_long)|uniprotkb:RASSF1A(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:e4f1_human(display_long)|uniprotkb:E4F1(gene name)|psi-mi:E4F1(display_short)|uniprotkb:E4F(gene name synonym)|uniprotkb:Putative E3 ubiquitin-protein ligase E4F1(gene name synonym)|uniprotkb:E4F transcription factor 1(gene name synonym)|uniprotkb:Transcription factor E4F(gene name synonym)|uniprotkb:p120E4F(gene name synonym)|uniprotkb:p50E4F(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase E4F1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fenton et al. (2004)	pubmed:14729613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1227096	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000359365(transcript)|uniprotkb:Q9NS23-2(isoform-parent)	refseq:NP_001275705.1|refseq:NP_001275707.1|refseq:NP_004415.3|ensembl:ENSP00000301727|ensembl:ENSG00000167967(gene)|ensembl:ENST00000301727(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006260"(DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016740"(transferase activity)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q66K89	-	isoform-comment:Produced by alternative splicing of isoform D.	-	author-identifiers:BAIT protein NP_004415|figure legend:1 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/05	2014/10/16	rogid:fnCwaMSu8L2xdeP+tZBG+FLFTPg9606	rogid:WkZmCgVg25mO8Gd8Bl0Nax4dVXE9606	intact-crc:D0D9B780F570FAE4|rigid:/PChRgLjLEeClbqfvqIKab23oLk	false	myc tag:?-?	sufficient binding region:416..416-784..784|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q66K89	uniprotkb:Q9NS23-2	intact:EBI-1227043|uniprotkb:A8K2R4|uniprotkb:O00146|ensembl:ENSP00000301727	intact:EBI-438698|intact:EBI-8557945|intact:MINT-1919550|ensembl:ENSP00000352323	psi-mi:e4f1_human(display_long)|uniprotkb:E4F1(gene name)|psi-mi:E4F1(display_short)|uniprotkb:E4F(gene name synonym)|uniprotkb:Putative E3 ubiquitin-protein ligase E4F1(gene name synonym)|uniprotkb:E4F transcription factor 1(gene name synonym)|uniprotkb:Transcription factor E4F(gene name synonym)|uniprotkb:p120E4F(gene name synonym)|uniprotkb:p50E4F(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase E4F1(gene name synonym)	psi-mi:q9ns23-2(display_long)|uniprotkb:RASSF1A(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fenton et al. (2004)	pubmed:14729613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1227165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001275705.1|refseq:NP_001275707.1|refseq:NP_004415.3|ensembl:ENSP00000301727|ensembl:ENSG00000167967(gene)|ensembl:ENST00000301727(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006260"(DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016740"(transferase activity)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q66K89	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000359365(transcript)|uniprotkb:Q9NS23-2(isoform-parent)	-	-	isoform-comment:Produced by alternative splicing of isoform D.	author-identifiers:PREY protein NP_004415|figure legend:1 C, 4 A|caution:"The range for E4F is approximate only. It is based on the end of the fourth C-terminal zinc finger (found using zinc finger consensus sequence CX2-4C....HX2-4H) and the next 26 aa (as the deletion analysis reveals the 26 aa after the end of this fourth zinc finger are required to bind.)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/05	2014/10/16	rogid:WkZmCgVg25mO8Gd8Bl0Nax4dVXE9606	rogid:fnCwaMSu8L2xdeP+tZBG+FLFTPg9606	intact-crc:5C8238063411AEA3|rigid:/PChRgLjLEeClbqfvqIKab23oLk	false	ha tag:?-?|necessary binding region:571..571-597..597	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NS23-2	uniprotkb:Q66K89	intact:EBI-438698|intact:EBI-8557945|intact:MINT-1919550|ensembl:ENSP00000352323	intact:EBI-1227043|uniprotkb:A8K2R4|uniprotkb:O00146|ensembl:ENSP00000301727	psi-mi:q9ns23-2(display_long)|uniprotkb:RASSF1A(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:e4f1_human(display_long)|uniprotkb:E4F1(gene name)|psi-mi:E4F1(display_short)|uniprotkb:E4F(gene name synonym)|uniprotkb:Putative E3 ubiquitin-protein ligase E4F1(gene name synonym)|uniprotkb:E4F transcription factor 1(gene name synonym)|uniprotkb:Transcription factor E4F(gene name synonym)|uniprotkb:p120E4F(gene name synonym)|uniprotkb:p50E4F(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase E4F1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fenton et al. (2004)	pubmed:14729613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1227187	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000359365(transcript)|uniprotkb:Q9NS23-2(isoform-parent)	refseq:NP_001275705.1|refseq:NP_001275707.1|refseq:NP_004415.3|ensembl:ENSP00000301727|ensembl:ENSG00000167967(gene)|ensembl:ENST00000301727(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006260"(DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016740"(transferase activity)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q66K89	-	isoform-comment:Produced by alternative splicing of isoform D.	-	figure legend:2 A|delivery method:Q66K89; Q9NS23 transfection|expression level:Q66K89; Q9NS23 over-expressed|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2007/04/05	2014/10/16	rogid:fnCwaMSu8L2xdeP+tZBG+FLFTPg9606	rogid:WkZmCgVg25mO8Gd8Bl0Nax4dVXE9606	intact-crc:65E14C3D612DFB6D|rigid:/PChRgLjLEeClbqfvqIKab23oLk	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q66K89	uniprotkb:Q9NS23-2	intact:EBI-1227043|uniprotkb:A8K2R4|uniprotkb:O00146|ensembl:ENSP00000301727	intact:EBI-438698|intact:EBI-8557945|intact:MINT-1919550|ensembl:ENSP00000352323	psi-mi:e4f1_human(display_long)|uniprotkb:E4F1(gene name)|psi-mi:E4F1(display_short)|uniprotkb:E4F(gene name synonym)|uniprotkb:Putative E3 ubiquitin-protein ligase E4F1(gene name synonym)|uniprotkb:E4F transcription factor 1(gene name synonym)|uniprotkb:Transcription factor E4F(gene name synonym)|uniprotkb:p120E4F(gene name synonym)|uniprotkb:p50E4F(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase E4F1(gene name synonym)	psi-mi:q9ns23-2(display_long)|uniprotkb:RASSF1A(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fenton et al. (2004)	pubmed:14729613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1227207	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001275705.1|refseq:NP_001275707.1|refseq:NP_004415.3|ensembl:ENSP00000301727|ensembl:ENSG00000167967(gene)|ensembl:ENST00000301727(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006260"(DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016740"(transferase activity)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q66K89	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000359365(transcript)|uniprotkb:Q9NS23-2(isoform-parent)	-	-	isoform-comment:Produced by alternative splicing of isoform D.	figure legend:2 A|delivery method:Q66K89; Q9NS23 transfection|expression level:Q66K89; Q9NS23 over-expressed|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2007/04/05	2014/10/16	rogid:WkZmCgVg25mO8Gd8Bl0Nax4dVXE9606	rogid:fnCwaMSu8L2xdeP+tZBG+FLFTPg9606	intact-crc:3D7A7E8B361A1D65|rigid:/PChRgLjLEeClbqfvqIKab23oLk	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q66K89	uniprotkb:Q9NS23-2	intact:EBI-1227043|uniprotkb:A8K2R4|uniprotkb:O00146|ensembl:ENSP00000301727	intact:EBI-438698|intact:EBI-8557945|intact:MINT-1919550|ensembl:ENSP00000352323	psi-mi:e4f1_human(display_long)|uniprotkb:E4F1(gene name)|psi-mi:E4F1(display_short)|uniprotkb:E4F(gene name synonym)|uniprotkb:Putative E3 ubiquitin-protein ligase E4F1(gene name synonym)|uniprotkb:E4F transcription factor 1(gene name synonym)|uniprotkb:Transcription factor E4F(gene name synonym)|uniprotkb:p120E4F(gene name synonym)|uniprotkb:p50E4F(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase E4F1(gene name synonym)	psi-mi:q9ns23-2(display_long)|uniprotkb:RASSF1A(isoform synonym)|uniprotkb:RASSF1(gene name)|psi-mi:RASSF1(display_short)|uniprotkb:RDA32(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fenton et al. (2004)	pubmed:14729613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1228155	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001275705.1|refseq:NP_001275707.1|refseq:NP_004415.3|ensembl:ENSP00000301727|ensembl:ENSG00000167967(gene)|ensembl:ENST00000301727(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006260"(DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016740"(transferase activity)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q66K89	intact:EBI-367363(rsf1_human)|ensembl:ENSG00000068028(gene)|ensembl:ENST00000359365(transcript)|uniprotkb:Q9NS23-2(isoform-parent)	-	-	isoform-comment:Produced by alternative splicing of isoform D.	figure legend:2 B, C|inhibition:This interaction is inhibited by RASSF1A-siRNA.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-nci_h1792)|taxid:9606(Homo sapiens non-small cell lung adenocarcinoma cell line NCI-H1792)	-	2007/04/05	2014/10/16	rogid:WkZmCgVg25mO8Gd8Bl0Nax4dVXE9606	rogid:fnCwaMSu8L2xdeP+tZBG+FLFTPg9606	intact-crc:1E4E9702A6708659|rigid:/PChRgLjLEeClbqfvqIKab23oLk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)