#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9C0H9 uniprotkb:Q61140 intact:EBI-1393949|uniprotkb:Q8N4W8|uniprotkb:Q75T46|ensembl:ENSP00000480869|ensembl:ENSP00000484715 intact:EBI-77088|uniprotkb:Q6PFF9|uniprotkb:Q60869|ensembl:ENSMUSP00000129584 psi-mi:srcn1_human(display_long)|uniprotkb:SRCIN1(gene name)|psi-mi:SRCIN1(display_short)|uniprotkb:KIAA1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:SNIP(gene name synonym) psi-mi:bcar1_mouse(display_long)|uniprotkb:Bcar1(gene name)|psi-mi:Bcar1(display_short)|uniprotkb:Cas(gene name synonym)|uniprotkb:Crkas(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:CRK-associated substrate(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1393943|imex:IM-19424-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079524.2|ensembl:ENSG00000273608(gene)|ensembl:ENSG00000277363(gene)|ensembl:ENST00000615049(transcript)|ensembl:ENST00000617146(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse)|interpro:IPR022782|interpro:IPR026727|mint:Q9C0H9|go:"GO:0030234"(enzyme regulator activity) refseq:NP_001185768.1|refseq:NP_034084.2|rcsb pdb:5W93|reactome:R-MMU-186763|reactome:R-MMU-372708|reactome:R-MMU-4420097|reactome:R-MMU-8849471|ensembl:ENSMUSG00000031955(gene)|ensembl:ENSMUST00000166232(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990859"(cellular response to endothelin)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:Q61140 - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/11 2018/04/06 rogid:6POWT5mqv6jfEOrlfFhjn1Aq5c49606 rogid:sbyvN4CE9k2skJV5C/LySCgu++E10090 intact-crc:67364C7BE1B78F6F|rigid:SRXrFOYgESeD3OI2EaMPGu+4cN8 false - binding-associated region:340-874|maltose binding protein tag:?-? - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q9C0H9 uniprotkb:P56945 intact:EBI-1393949|uniprotkb:Q8N4W8|uniprotkb:Q75T46|ensembl:ENSP00000480869|ensembl:ENSP00000484715 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 psi-mi:srcn1_human(display_long)|uniprotkb:SRCIN1(gene name)|psi-mi:SRCIN1(display_short)|uniprotkb:KIAA1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:SNIP(gene name synonym) psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1393984|imex:IM-19424-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079524.2|ensembl:ENSG00000273608(gene)|ensembl:ENSG00000277363(gene)|ensembl:ENST00000615049(transcript)|ensembl:ENST00000617146(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse)|interpro:IPR022782|interpro:IPR026727|mint:Q9C0H9|go:"GO:0030234"(enzyme regulator activity) refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 - - - figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ecv304)|taxid:9606(Human umbilical cord, endothelial ECV304) - 2007/09/11 2018/04/06 rogid:6POWT5mqv6jfEOrlfFhjn1Aq5c49606 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 intact-crc:60C931833AC5859D|rigid:uE02WGDp1sjzPBrVGb7ayUrmIxM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9C0H9 uniprotkb:P56945 intact:EBI-1393949|uniprotkb:Q8N4W8|uniprotkb:Q75T46|ensembl:ENSP00000480869|ensembl:ENSP00000484715 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 psi-mi:srcn1_human(display_long)|uniprotkb:SRCIN1(gene name)|psi-mi:SRCIN1(display_short)|uniprotkb:KIAA1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:SNIP(gene name synonym) psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1393988|imex:IM-19424-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079524.2|ensembl:ENSG00000273608(gene)|ensembl:ENSG00000277363(gene)|ensembl:ENST00000615049(transcript)|ensembl:ENST00000617146(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse)|interpro:IPR022782|interpro:IPR026727|mint:Q9C0H9|go:"GO:0030234"(enzyme regulator activity) refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 - - - figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ecv304)|taxid:9606(Human umbilical cord, endothelial ECV304) - 2007/09/11 2018/04/06 rogid:6POWT5mqv6jfEOrlfFhjn1Aq5c49606 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 intact-crc:4E4AE0748A824C83|rigid:uE02WGDp1sjzPBrVGb7ayUrmIxM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QWI6 uniprotkb:P56945 intact:EBI-775592|uniprotkb:O70298 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 psi-mi:srcn1_mouse(display_long)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym) psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-1393998|imex:IM-19424-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061361.2|interpro:IPR022782|interpro:IPR026727|mint:Q9QWI6|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse) refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/09/11 2014/10/16 rogid:M3+KJqcvaW0sMG63nFO9CXyjp9Q10090 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 intact-crc:6CF0A9FF6D1468C0|rigid:5qvKs6DvAmNZthflC4hCa2T0jg8 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9QWI6 uniprotkb:P46108 intact:EBI-775592|uniprotkb:O70298 intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791 psi-mi:srcn1_mouse(display_long)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym) psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-1393998|imex:IM-19424-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061361.2|interpro:IPR022782|interpro:IPR026727|mint:Q9QWI6|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse) ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422 - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/09/11 2014/10/16 rogid:M3+KJqcvaW0sMG63nFO9CXyjp9Q10090 rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606 intact-crc:6CF0A9FF6D1468C0|rigid:5qvKs6DvAmNZthflC4hCa2T0jg8 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P56945 uniprotkb:Q9QWI6 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 intact:EBI-775592|uniprotkb:O70298 psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:srcn1_mouse(display_long)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-1394006|imex:IM-19424-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 refseq:NP_061361.2|interpro:IPR022782|interpro:IPR026727|mint:Q9QWI6|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse) - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/09/11 2014/10/16 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 rogid:M3+KJqcvaW0sMG63nFO9CXyjp9Q10090 intact-crc:423737DCFDF4E26E|rigid:5qvKs6DvAmNZthflC4hCa2T0jg8 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P56945 uniprotkb:P46108 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791 psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-1394006|imex:IM-19424-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422 - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/09/11 2014/10/16 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606 intact-crc:423737DCFDF4E26E|rigid:5qvKs6DvAmNZthflC4hCa2T0jg8 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P46108 uniprotkb:P56945 intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym) psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1541867|imex:IM-19424-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422 refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/09/11 2014/10/16 rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 intact-crc:3464687BC83AD1E6|rigid:qZ4bbwgr47V8EHdiNJXa/5jmUOU false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9QWI6 uniprotkb:Q61140 intact:EBI-775592|uniprotkb:O70298 intact:EBI-77088|uniprotkb:Q6PFF9|uniprotkb:Q60869|ensembl:ENSMUSP00000129584 psi-mi:srcn1_mouse(display_long)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym) psi-mi:bcar1_mouse(display_long)|uniprotkb:Bcar1(gene name)|psi-mi:Bcar1(display_short)|uniprotkb:Cas(gene name synonym)|uniprotkb:Crkas(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:CRK-associated substrate(gene name synonym) psi-mi:"MI:0096"(pull down) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1394021|imex:IM-19424-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061361.2|interpro:IPR022782|interpro:IPR026727|mint:Q9QWI6|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse) refseq:NP_001185768.1|refseq:NP_034084.2|rcsb pdb:5W93|reactome:R-MMU-186763|reactome:R-MMU-372708|reactome:R-MMU-4420097|reactome:R-MMU-8849471|ensembl:ENSMUSG00000031955(gene)|ensembl:ENSMUST00000166232(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990859"(cellular response to endothelin)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:Q61140 - - - figure legend:5A|caution:The C-terminal of SNIP as given in the UnIProt database is longer than stated in the paper, nor can this difference be ascribed to any of the known isoforms.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/11 2014/10/16 rogid:M3+KJqcvaW0sMG63nFO9CXyjp9Q10090 rogid:sbyvN4CE9k2skJV5C/LySCgu++E10090 intact-crc:0926C615BCCC5BE7|rigid:VXMS28IA+/cpFAhfA/Vn1HF+6M0 false sufficient binding region:1006-1250|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QWI6 uniprotkb:Q61140 intact:EBI-775592|uniprotkb:O70298 intact:EBI-77088|uniprotkb:Q6PFF9|uniprotkb:Q60869|ensembl:ENSMUSP00000129584 psi-mi:srcn1_mouse(display_long)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym) psi-mi:bcar1_mouse(display_long)|uniprotkb:Bcar1(gene name)|psi-mi:Bcar1(display_short)|uniprotkb:Cas(gene name synonym)|uniprotkb:Crkas(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:CRK-associated substrate(gene name synonym) psi-mi:"MI:0096"(pull down) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1394049|imex:IM-19424-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061361.2|interpro:IPR022782|interpro:IPR026727|mint:Q9QWI6|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse) refseq:NP_001185768.1|refseq:NP_034084.2|rcsb pdb:5W93|reactome:R-MMU-186763|reactome:R-MMU-372708|reactome:R-MMU-4420097|reactome:R-MMU-8849471|ensembl:ENSMUSG00000031955(gene)|ensembl:ENSMUST00000166232(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990859"(cellular response to endothelin)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:Q61140 - - - figure legend:5D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/11 2014/10/16 rogid:M3+KJqcvaW0sMG63nFO9CXyjp9Q10090 rogid:sbyvN4CE9k2skJV5C/LySCgu++E10090 intact-crc:0763525D424E03ED|rigid:VXMS28IA+/cpFAhfA/Vn1HF+6M0 false - glutathione s tranferase tag:?-?|sufficient binding region:544-678 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QWI6 uniprotkb:P56945 intact:EBI-775592|uniprotkb:O70298 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 psi-mi:srcn1_mouse(display_long)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym) psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1394042|imex:IM-19424-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061361.2|interpro:IPR022782|interpro:IPR026727|mint:Q9QWI6|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse) refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 - - - figure legend:5C|comment:"A P140 deletion construct missing the c-terminus (aa 1006-1250) did not interact."|caution:The protein in UniProt is longer at the C-terminus than described in the paper|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/09/11 2014/10/16 rogid:M3+KJqcvaW0sMG63nFO9CXyjp9Q10090 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 intact-crc:79D36BF0261785BE|rigid:/h9rTuJaTSPKa9dxe/qE6MzzR5o false necessary binding region:1006-1250|myc tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9C0H9 uniprotkb:P56945 intact:EBI-1393949|uniprotkb:Q8N4W8|uniprotkb:Q75T46|ensembl:ENSP00000480869|ensembl:ENSP00000484715 intact:EBI-702093|uniprotkb:B4DIW5|uniprotkb:F8WA69|uniprotkb:Q6QEF7|uniprotkb:B7Z7X7|uniprotkb:F5GXV6|uniprotkb:B3KWD7|uniprotkb:B4DEV4|uniprotkb:B4DGB5|uniprotkb:E9PCL5|uniprotkb:E9PCV2|uniprotkb:F5GXA2|uniprotkb:F5H7Z0|intact:EBI-10963425|ensembl:ENSP00000162330 psi-mi:srcn1_human(display_long)|uniprotkb:SRCIN1(gene name)|psi-mi:SRCIN1(display_short)|uniprotkb:KIAA1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:SNIP(gene name synonym) psi-mi:bcar1_human(display_long)|uniprotkb:CRK-associated substrate(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:BCAR1(gene name)|psi-mi:BCAR1(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:CRKAS(gene name synonym)|uniprotkb:CASS1(gene name synonym)|uniprotkb:Cas scaffolding protein family member 1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Di et al. (2004) pubmed:14657239|imex:IM-19424 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-1394072|imex:IM-19424-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079524.2|ensembl:ENSG00000273608(gene)|ensembl:ENSG00000277363(gene)|ensembl:ENST00000615049(transcript)|ensembl:ENST00000617146(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse)|interpro:IPR022782|interpro:IPR026727|mint:Q9C0H9|go:"GO:0030234"(enzyme regulator activity) refseq:NP_001164185.1|refseq:NP_001164186.1|refseq:NP_001164187.1|refseq:NP_001164188.1|refseq:NP_001164189.1|refseq:NP_001164190.1|refseq:NP_001164191.1|refseq:NP_055382.2|refseq:XP_016879386.1|ensembl:ENSP00000162330|ensembl:ENST00000393420|ensembl:ENSP00000377072|ensembl:ENST00000393422|ensembl:ENSP00000377074|ensembl:ENST00000418647|ensembl:ENSP00000391669|ensembl:ENST00000420641|ensembl:ENSP00000392708|ensembl:ENST00000535626|ensembl:ENSP00000440370|ensembl:ENST00000538440|ensembl:ENSP00000443841|ensembl:ENST00000542031|ensembl:ENSP00000440415|dip:DIP-33855N|ensembl:ENSG00000050820(gene)|ensembl:ENST00000162330(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:P56945|rcsb pdb:1WYX|rcsb pdb:3T6G|rcsb pdb:5O2M|rcsb pdb:5O2P|rcsb pdb:5O2Q|reactome:R-HSA-186763|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471 go:"GO:0005737"(cytoplasm) - - figure legend:6|comment:Colocalization at cytoplasmic punctate structures. Upon treatment with PMA colocalization occurs at membrane ruffles. P140 is localized to actin cytoskeleton.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ecv304)|taxid:9606(Human umbilical cord, endothelial ECV304) - 2007/09/11 2018/04/06 rogid:6POWT5mqv6jfEOrlfFhjn1Aq5c49606 rogid:ssRxMtaHJrQ1lMJ02FpOh3xIaWY9606 intact-crc:A03BE3086BCFFA22|rigid:uE02WGDp1sjzPBrVGb7ayUrmIxM false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)