#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08032	uniprotkb:P53840	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	intact:EBI-28257|uniprotkb:D6W0S1|ensemblfungi:YNL273W	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:tof1_yeast(display_long)|uniprotkb:N0636(orf name)|uniprotkb:YNL273W(locus name)|uniprotkb:TOF1(gene name)|psi-mi:TOF1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katou et al. (2003)	pubmed:12944972|imex:IM-19948	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1378271|imex:IM-19948-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	sgd:S000005217|refseq:NP_014126.1|dip:DIP-4272N|mint:P53840|ensemblfungi:YNL273W(gene)|ensemblfungi:YNL273W_mRNA(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043111"(replication fork arrest)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0048478"(replication fork protection)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR006906(Timeless protein)|rcsb pdb:6SKL	-	crc64:6500DDD62EC4E8EE	crc64:CF8FEC33EE0088E9	figure legend:3a and b|comment:Interaction was observed preferentially in S phase.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/29	2014/10/16	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	rogid:+PvTDXPYcjJQn/GUfCpEtG7i4Q8559292	intact-crc:B919CE7F05517DA5|rigid:CMHiru66KPooueAjxi12C5PGdz0	false	ha tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P53840	uniprotkb:Q08032	intact:EBI-28257|uniprotkb:D6W0S1|ensemblfungi:YNL273W	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	psi-mi:tof1_yeast(display_long)|uniprotkb:N0636(orf name)|uniprotkb:YNL273W(locus name)|uniprotkb:TOF1(gene name)|psi-mi:TOF1(display_short)	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katou et al. (2003)	pubmed:12944972|imex:IM-19948	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1378280|imex:IM-19948-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005217|refseq:NP_014126.1|dip:DIP-4272N|mint:P53840|ensemblfungi:YNL273W(gene)|ensemblfungi:YNL273W_mRNA(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043111"(replication fork arrest)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0048478"(replication fork protection)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR006906(Timeless protein)|rcsb pdb:6SKL	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	-	crc64:CF8FEC33EE0088E9	crc64:6500DDD62EC4E8EE	figure legend:3a and b|comment:Interaction was observed preferentially in S phase.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/29	2014/10/16	rogid:+PvTDXPYcjJQn/GUfCpEtG7i4Q8559292	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	intact-crc:9FC2A3CB83F4BBDC|rigid:CMHiru66KPooueAjxi12C5PGdz0	false	flag tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P25588	uniprotkb:Q08032	intact:EBI-412442|uniprotkb:P25589|uniprotkb:P27513|uniprotkb:P87003|uniprotkb:Q07218|uniprotkb:Q8NIN2|uniprotkb:D6VQV6|ensemblfungi:YCL061C	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	psi-mi:mrc1_yeast(display_long)|uniprotkb:MRC1(gene name)|psi-mi:MRC1(display_short)|uniprotkb:YCL061C(locus name)|uniprotkb:YCL61C/YCL60C(orf name)|uniprotkb:DNA replication checkpoint mediator MRC1(gene name synonym)	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katou et al. (2003)	pubmed:12944972|imex:IM-19948	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1378289|imex:IM-19948-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009871.2|sgd:S000000566|ensemblfungi:YCL061C(gene)|ensemblfungi:YCL061C_mRNA(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0048478"(replication fork protection)|interpro:IPR018564|go:"GO:0000723"(telomere maintenance)|mint:P25588|dip:DIP-1017N	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	-	crc64:378345EE503FFA81	crc64:6500DDD62EC4E8EE	figure legend:3c|comment:Interaction was observed preferentially in S phase.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/29	2014/10/16	rogid:Sv9pZwka0vVslquPGLQ2N/R7W/w559292	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	intact-crc:67E6BFCFC68EB6A4|rigid:Q7HKpI42xfKPuSnT+zyAA4B72Qg	false	flag tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08032	uniprotkb:P25588	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	intact:EBI-412442|uniprotkb:P25589|uniprotkb:P27513|uniprotkb:P87003|uniprotkb:Q07218|uniprotkb:Q8NIN2|uniprotkb:D6VQV6|ensemblfungi:YCL061C	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:mrc1_yeast(display_long)|uniprotkb:MRC1(gene name)|psi-mi:MRC1(display_short)|uniprotkb:YCL061C(locus name)|uniprotkb:YCL61C/YCL60C(orf name)|uniprotkb:DNA replication checkpoint mediator MRC1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Katou et al. (2003)	pubmed:12944972|imex:IM-19948	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1378298|imex:IM-19948-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	refseq:NP_009871.2|sgd:S000000566|ensemblfungi:YCL061C(gene)|ensemblfungi:YCL061C_mRNA(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0048478"(replication fork protection)|interpro:IPR018564|go:"GO:0000723"(telomere maintenance)|mint:P25588|dip:DIP-1017N	-	crc64:6500DDD62EC4E8EE	crc64:378345EE503FFA81	figure legend:3c|comment:Interaction was observed preferentially in S phase.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/29	2014/10/16	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	rogid:Sv9pZwka0vVslquPGLQ2N/R7W/w559292	intact-crc:819F833C09B1AE9A|rigid:Q7HKpI42xfKPuSnT+zyAA4B72Qg	false	ha tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)