#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q24338	uniprotkb:Q94517	intact:EBI-88911|ensemblmetazoa:FBpp0079907	intact:EBI-302197|uniprotkb:O17429|uniprotkb:O77213|uniprotkb:Q9VZA1|ensemblmetazoa:FBpp0073173	psi-mi:esc_drome(display_long)|uniprotkb:esc(gene name)|psi-mi:esc(display_short)|uniprotkb:CG14941(orf name)|uniprotkb:Protein extra sex combs(gene name synonym)	psi-mi:hdac1_drome(display_long)|uniprotkb:HDAC1(gene name)|psi-mi:HDAC1(display_short)|uniprotkb:Rpd3(gene name synonym)|uniprotkb:CG7471(orf name)	psi-mi:"MI:0096"(pull down)	Furuyama et al. (2003)	pubmed:12533794|imex:IM-19923	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1204462|imex:IM-19923-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0000588(gene)|ensemblmetazoa:FBtr0080325(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006342"|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042802"(identical protein binding)|go:"GO:0048096"|go:"GO:0070734"(histone H3-K27 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q24338|go:"GO:0016458"(obsolete gene silencing)|refseq:NP_477431.1|flybase:FBgn0000588|dip:DIP-20069N	ensemblmetazoa:FBgn0015805(gene)|ensemblmetazoa:FBtr0073317(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005700"(polytene chromosome)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048477"(oogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0005705"(polytene chromosome interband)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006342"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070983"(dendrite guidance)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0031523"(Myb complex)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q94517|reactome:R-DME-1538133|reactome:R-DME-201722|reactome:R-DME-209394|reactome:R-DME-3214815|reactome:R-DME-3769402|reactome:R-DME-6804758|reactome:R-DME-8943724|reactome:R-DME-983231|refseq:NP_647918.2|flybase:FBgn0015805|dip:DIP-29512N	-	-	-	figure legend:4|complex-properties:This interaction was only observed in the large 2-3 MDa complex not in the smaller 600 KDa complex.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/20	2014/10/16	rogid:owOOCkwb0LdPVnElMax3J1OIkEE7227	rogid:HYHCai8wP8lueOr33vYY32w2pHU7227	intact-crc:7465DF1209FB5C20|rigid:+WiYXfDW6vcYL86J1Mpn/gDHxEQ	false	glutathione s tranferase tag:?-?|sufficient binding region:1-60	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24338	uniprotkb:Q24572	intact:EBI-88911|ensemblmetazoa:FBpp0079907	intact:EBI-75924|uniprotkb:A0AP04|uniprotkb:Q9VFB4|ensemblmetazoa:FBpp0082511	psi-mi:esc_drome(display_long)|uniprotkb:esc(gene name)|psi-mi:esc(display_short)|uniprotkb:CG14941(orf name)|uniprotkb:Protein extra sex combs(gene name synonym)	psi-mi:caf1_drome(display_long)|uniprotkb:Caf1-55(gene name)|psi-mi:Caf1-55(display_short)|uniprotkb:CAF-1(gene name synonym)|uniprotkb:Caf1(gene name synonym)|uniprotkb:Nucleosome-remodeling factor 55 kDa subunit(gene name synonym)|uniprotkb:CG4236(orf name)	psi-mi:"MI:0096"(pull down)	Furuyama et al. (2003)	pubmed:12533794|imex:IM-19923	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1204462|imex:IM-19923-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0000588(gene)|ensemblmetazoa:FBtr0080325(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006342"|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042802"(identical protein binding)|go:"GO:0048096"|go:"GO:0070734"(histone H3-K27 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q24338|go:"GO:0016458"(obsolete gene silencing)|refseq:NP_477431.1|flybase:FBgn0000588|dip:DIP-20069N	refseq:NP_524354.1|flybase:FBgn0263979|dip:DIP-23697N|ensemblmetazoa:FBgn0263979(gene)|ensemblmetazoa:FBtr0083052(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007379"(segment specification)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031523"(Myb complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q24572|rcsb pdb:2XYI|rcsb pdb:2YB8|rcsb pdb:2YBA|rcsb pdb:3C99|rcsb pdb:3C9C|reactome:R-DME-1538133|reactome:R-DME-2559580|reactome:R-DME-3214815|reactome:R-DME-6804758|reactome:R-DME-8943724|reactome:R-DME-8951664	-	-	-	figure legend:4|complex-properties:This interaction was only observed in the large 2-3 MDa complex not in the smaller 600 KDa complex.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/20	2014/10/16	rogid:owOOCkwb0LdPVnElMax3J1OIkEE7227	rogid:8/OL33qe/v2fpy7axUNyKWiIZt87227	intact-crc:7465DF1209FB5C20|rigid:+WiYXfDW6vcYL86J1Mpn/gDHxEQ	false	glutathione s tranferase tag:?-?|sufficient binding region:1-60	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42124	uniprotkb:Q24572	intact:EBI-112315|uniprotkb:Q9VTA3|uniprotkb:B7Z0G2|ensemblmetazoa:FBpp0076008|ensemblmetazoa:FBpp0271846	intact:EBI-75924|uniprotkb:A0AP04|uniprotkb:Q9VFB4|ensemblmetazoa:FBpp0082511	psi-mi:ez_drome(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:"E(z)"(gene name)|psi-mi:"E(z)"(display_short)|uniprotkb:CG6502(orf name)|uniprotkb:Protein enhancer of zeste(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)	psi-mi:caf1_drome(display_long)|uniprotkb:Caf1-55(gene name)|psi-mi:Caf1-55(display_short)|uniprotkb:CAF-1(gene name synonym)|uniprotkb:Caf1(gene name synonym)|uniprotkb:Nucleosome-remodeling factor 55 kDa subunit(gene name synonym)|uniprotkb:CG4236(orf name)	psi-mi:"MI:0096"(pull down)	Furuyama et al. (2003)	pubmed:12533794|imex:IM-19923	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1204474|imex:IM-19923-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524021.2|refseq:NP_001137932.1|flybase:FBgn0000629|dip:DIP-20386N|ensemblmetazoa:FBgn0000629(gene)|ensemblmetazoa:FBtr0076279(transcript)|ensemblmetazoa:FBtr0273338(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007411"(axon guidance)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016571"(histone methylation)|go:"GO:0022008"(neurogenesis)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:P42124|reactome:R-DME-2559580|reactome:R-DME-8943724	refseq:NP_524354.1|flybase:FBgn0263979|dip:DIP-23697N|ensemblmetazoa:FBgn0263979(gene)|ensemblmetazoa:FBtr0083052(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007379"(segment specification)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031523"(Myb complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q24572|rcsb pdb:2XYI|rcsb pdb:2YB8|rcsb pdb:2YBA|rcsb pdb:3C99|rcsb pdb:3C9C|reactome:R-DME-1538133|reactome:R-DME-2559580|reactome:R-DME-3214815|reactome:R-DME-6804758|reactome:R-DME-8943724|reactome:R-DME-8951664	-	-	-	figure legend:4|complex-properties:This interaction was only observed in the large 2-3 MDa complex not in the smaller 600 KDa complex.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/20	2014/10/16	rogid:SgDch3Z90h2XcA4b2MqjzZN+gSI7227	rogid:8/OL33qe/v2fpy7axUNyKWiIZt87227	intact-crc:4022E8F7C43F79DA|rigid:jTPcmAaKGejXIFaX+Lg++MfFd+s	false	glutathione s tranferase tag:?-?|sufficient binding region:1-73	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42124	uniprotkb:Q94517	intact:EBI-112315|uniprotkb:Q9VTA3|uniprotkb:B7Z0G2|ensemblmetazoa:FBpp0076008|ensemblmetazoa:FBpp0271846	intact:EBI-302197|uniprotkb:O17429|uniprotkb:O77213|uniprotkb:Q9VZA1|ensemblmetazoa:FBpp0073173	psi-mi:ez_drome(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:"E(z)"(gene name)|psi-mi:"E(z)"(display_short)|uniprotkb:CG6502(orf name)|uniprotkb:Protein enhancer of zeste(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)	psi-mi:hdac1_drome(display_long)|uniprotkb:HDAC1(gene name)|psi-mi:HDAC1(display_short)|uniprotkb:Rpd3(gene name synonym)|uniprotkb:CG7471(orf name)	psi-mi:"MI:0096"(pull down)	Furuyama et al. (2003)	pubmed:12533794|imex:IM-19923	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1204474|imex:IM-19923-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524021.2|refseq:NP_001137932.1|flybase:FBgn0000629|dip:DIP-20386N|ensemblmetazoa:FBgn0000629(gene)|ensemblmetazoa:FBtr0076279(transcript)|ensemblmetazoa:FBtr0273338(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007411"(axon guidance)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016571"(histone methylation)|go:"GO:0022008"(neurogenesis)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:P42124|reactome:R-DME-2559580|reactome:R-DME-8943724	ensemblmetazoa:FBgn0015805(gene)|ensemblmetazoa:FBtr0073317(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005700"(polytene chromosome)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048477"(oogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0005705"(polytene chromosome interband)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006342"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070983"(dendrite guidance)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0031523"(Myb complex)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q94517|reactome:R-DME-1538133|reactome:R-DME-201722|reactome:R-DME-209394|reactome:R-DME-3214815|reactome:R-DME-3769402|reactome:R-DME-6804758|reactome:R-DME-8943724|reactome:R-DME-983231|refseq:NP_647918.2|flybase:FBgn0015805|dip:DIP-29512N	-	-	-	figure legend:4|complex-properties:This interaction was only observed in the large 2-3 MDa complex not in the smaller 600 KDa complex.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/20	2014/10/16	rogid:SgDch3Z90h2XcA4b2MqjzZN+gSI7227	rogid:HYHCai8wP8lueOr33vYY32w2pHU7227	intact-crc:4022E8F7C43F79DA|rigid:jTPcmAaKGejXIFaX+Lg++MfFd+s	false	glutathione s tranferase tag:?-?|sufficient binding region:1-73	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24338	uniprotkb:P42124	intact:EBI-88911|ensemblmetazoa:FBpp0079907	intact:EBI-112315|uniprotkb:Q9VTA3|uniprotkb:B7Z0G2|ensemblmetazoa:FBpp0076008|ensemblmetazoa:FBpp0271846	psi-mi:esc_drome(display_long)|uniprotkb:esc(gene name)|psi-mi:esc(display_short)|uniprotkb:CG14941(orf name)|uniprotkb:Protein extra sex combs(gene name synonym)	psi-mi:ez_drome(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:"E(z)"(gene name)|psi-mi:"E(z)"(display_short)|uniprotkb:CG6502(orf name)|uniprotkb:Protein enhancer of zeste(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Furuyama et al. (2003)	pubmed:12533794|imex:IM-19923	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1204492|imex:IM-19923-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0000588(gene)|ensemblmetazoa:FBtr0080325(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006342"|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042802"(identical protein binding)|go:"GO:0048096"|go:"GO:0070734"(histone H3-K27 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q24338|go:"GO:0016458"(obsolete gene silencing)|refseq:NP_477431.1|flybase:FBgn0000588|dip:DIP-20069N	refseq:NP_524021.2|refseq:NP_001137932.1|flybase:FBgn0000629|dip:DIP-20386N|ensemblmetazoa:FBgn0000629(gene)|ensemblmetazoa:FBtr0076279(transcript)|ensemblmetazoa:FBtr0273338(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007411"(axon guidance)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016571"(histone methylation)|go:"GO:0022008"(neurogenesis)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:P42124|reactome:R-DME-2559580|reactome:R-DME-8943724	-	-	-	figure legend:6|expression level:Q24338 endogenous|complex-properties:About 600 kDa|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-embryo)|taxid:7227(drosophilla melanogaster embryo)	-	2007/02/20	2014/10/16	rogid:owOOCkwb0LdPVnElMax3J1OIkEE7227	rogid:SgDch3Z90h2XcA4b2MqjzZN+gSI7227	intact-crc:71FD6761B9167466|rigid:97CWoQ2IMfsQ4bSxZAjIKwtv42U	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42124	uniprotkb:Q24338	intact:EBI-112315|uniprotkb:Q9VTA3|uniprotkb:B7Z0G2|ensemblmetazoa:FBpp0076008|ensemblmetazoa:FBpp0271846	intact:EBI-88911|ensemblmetazoa:FBpp0079907	psi-mi:ez_drome(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:"E(z)"(gene name)|psi-mi:"E(z)"(display_short)|uniprotkb:CG6502(orf name)|uniprotkb:Protein enhancer of zeste(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)	psi-mi:esc_drome(display_long)|uniprotkb:esc(gene name)|psi-mi:esc(display_short)|uniprotkb:CG14941(orf name)|uniprotkb:Protein extra sex combs(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Furuyama et al. (2003)	pubmed:12533794|imex:IM-19923	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1204503|imex:IM-19923-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524021.2|refseq:NP_001137932.1|flybase:FBgn0000629|dip:DIP-20386N|ensemblmetazoa:FBgn0000629(gene)|ensemblmetazoa:FBtr0076279(transcript)|ensemblmetazoa:FBtr0273338(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007411"(axon guidance)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016571"(histone methylation)|go:"GO:0022008"(neurogenesis)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:P42124|reactome:R-DME-2559580|reactome:R-DME-8943724	ensemblmetazoa:FBgn0000588(gene)|ensemblmetazoa:FBtr0080325(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006342"|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042802"(identical protein binding)|go:"GO:0048096"|go:"GO:0070734"(histone H3-K27 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q24338|go:"GO:0016458"(obsolete gene silencing)|refseq:NP_477431.1|flybase:FBgn0000588|dip:DIP-20069N	-	-	-	figure legend:6|expression level:Q24338 over-expressed|complex-properties:About 600 KDa|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-embryo)|taxid:7227(drosophilla melanogaster embryo)	-	2007/02/20	2014/10/16	rogid:SgDch3Z90h2XcA4b2MqjzZN+gSI7227	rogid:owOOCkwb0LdPVnElMax3J1OIkEE7227	intact-crc:C61172491D1C6289|rigid:97CWoQ2IMfsQ4bSxZAjIKwtv42U	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)