#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7KRW1	uniprotkb:Q9V3C1	intact:EBI-1011633|uniprotkb:Q7KRW0|uniprotkb:Q8IHG9|uniprotkb:Q8MQX1|uniprotkb:Q8T0E3|uniprotkb:Q8WRY2|uniprotkb:Q9VAK6|ensemblmetazoa:FBpp0089379	intact:EBI-169514|ensemblmetazoa:FBpp0087216|ensemblmetazoa:FBpp0304693	psi-mi:trc8_drome(display_long)|uniprotkb:Trc8(gene name)|psi-mi:Trc8(display_short)|uniprotkb:CG2304(orf name)	psi-mi:vhl_drome(display_long)|uniprotkb:Vhl(gene name)|psi-mi:Vhl(display_short)|uniprotkb:CG13221(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gemmill et al. (2002)	pubmed:12032852|imex:IM-19980	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1551639|imex:IM-19980-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0039668(gene)|ensemblmetazoa:FBtr0085432(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007418"(ventral midline development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|refseq:NP_733292.1|refseq:NP_733293.1|refseq:NP_996303.1|flybase:FBgn0039668|refseq:NP_001263070.1	ensemblmetazoa:FBtr0332420(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030891"(VCB complex)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0060438"(trachea development)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1900037"(regulation of cellular response to hypoxia)|interpro:IPR022772|interpro:IPR024053|interpro:IPR036208|interpro:IPR037140|reactome:R-DME-1234176|reactome:R-DME-8951664|reactome:R-DME-9706019|reactome:R-DME-983168|ensemblmetazoa:FBgn0041174(gene)|ensemblmetazoa:FBtr0088115(transcript)|refseq:NP_524986.1|flybase:FBgn0041174|refseq:NP_001260885.1	omim:608537(primary-reference)	-	-	figure legend:4 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/02	2014/10/16	rogid:h84JsRdSm6Of7reRs2lEWYf9RlM7227	rogid:dBU27j1KvlMnNDuNotuD0gr8hcQ7227	intact-crc:39F194A910A35748|rigid:SB6E947Ea1Mc5OyoGjuOnnjFyHQ	false	35s radiolabel:?-?|myc tag:?-?|sufficient binding region:578-809	ha tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q7KRW1	uniprotkb:Q9XZ58	intact:EBI-1011633|uniprotkb:Q7KRW0|uniprotkb:Q8IHG9|uniprotkb:Q8MQX1|uniprotkb:Q8T0E3|uniprotkb:Q8WRY2|uniprotkb:Q9VAK6|ensemblmetazoa:FBpp0089379	intact:EBI-97187|uniprotkb:Q7KN57|uniprotkb:Q9UB04|ensemblmetazoa:FBpp0082743	psi-mi:trc8_drome(display_long)|uniprotkb:Trc8(gene name)|psi-mi:Trc8(display_short)|uniprotkb:CG2304(orf name)	psi-mi:csn5_drome(display_long)|uniprotkb:CSN5(gene name)|psi-mi:CSN5(display_short)|uniprotkb:CG14884(orf name)|uniprotkb:quo(gene name synonym)|uniprotkb:JAB1 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gemmill et al. (2002)	pubmed:12032852|imex:IM-19980	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1551657|imex:IM-19980-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0039668(gene)|ensemblmetazoa:FBtr0085432(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007418"(ventral midline development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|refseq:NP_733292.1|refseq:NP_733293.1|refseq:NP_996303.1|flybase:FBgn0039668|refseq:NP_001263070.1	refseq:NP_477442.1|flybase:FBgn0027053|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-6781823|ensemblmetazoa:FBgn0027053(gene)|ensemblmetazoa:FBtr0083292(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007281"(germ cell development)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008347"(glial cell migration)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035204"(negative regulation of lamellocyte differentiation)|go:"GO:0035207"(negative regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0050821"(protein stabilization)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|reactome:R-DME-5696394|dip:DIP-22022N	-	-	-	figure legend:4 C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/02	2014/10/16	rogid:h84JsRdSm6Of7reRs2lEWYf9RlM7227	rogid:bvwuY3mncpz5R3dfJ+O9jMp9PhQ7227	intact-crc:332467A1FEE6531D|rigid:9YEQkMGyGi1nFELVch2wSQLXDwU	false	sufficient binding region:562-744|glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q7KRW1	uniprotkb:Q9V3C1	intact:EBI-1011633|uniprotkb:Q7KRW0|uniprotkb:Q8IHG9|uniprotkb:Q8MQX1|uniprotkb:Q8T0E3|uniprotkb:Q8WRY2|uniprotkb:Q9VAK6|ensemblmetazoa:FBpp0089379	intact:EBI-169514|ensemblmetazoa:FBpp0087216|ensemblmetazoa:FBpp0304693	psi-mi:trc8_drome(display_long)|uniprotkb:Trc8(gene name)|psi-mi:Trc8(display_short)|uniprotkb:CG2304(orf name)	psi-mi:vhl_drome(display_long)|uniprotkb:Vhl(gene name)|psi-mi:Vhl(display_short)|uniprotkb:CG13221(orf name)	psi-mi:"MI:0096"(pull down)	Gemmill et al. (2002)	pubmed:12032852|imex:IM-19980	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1551657|imex:IM-19980-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0039668(gene)|ensemblmetazoa:FBtr0085432(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007418"(ventral midline development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|refseq:NP_733292.1|refseq:NP_733293.1|refseq:NP_996303.1|flybase:FBgn0039668|refseq:NP_001263070.1	ensemblmetazoa:FBtr0332420(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030891"(VCB complex)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0060438"(trachea development)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1900037"(regulation of cellular response to hypoxia)|interpro:IPR022772|interpro:IPR024053|interpro:IPR036208|interpro:IPR037140|reactome:R-DME-1234176|reactome:R-DME-8951664|reactome:R-DME-9706019|reactome:R-DME-983168|ensemblmetazoa:FBgn0041174(gene)|ensemblmetazoa:FBtr0088115(transcript)|refseq:NP_524986.1|flybase:FBgn0041174|refseq:NP_001260885.1	-	-	-	figure legend:4 C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/02	2014/10/16	rogid:h84JsRdSm6Of7reRs2lEWYf9RlM7227	rogid:dBU27j1KvlMnNDuNotuD0gr8hcQ7227	intact-crc:332467A1FEE6531D|rigid:9YEQkMGyGi1nFELVch2wSQLXDwU	false	sufficient binding region:562-744|glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q7KRW1	uniprotkb:Q9V3C1	intact:EBI-1011633|uniprotkb:Q7KRW0|uniprotkb:Q8IHG9|uniprotkb:Q8MQX1|uniprotkb:Q8T0E3|uniprotkb:Q8WRY2|uniprotkb:Q9VAK6|ensemblmetazoa:FBpp0089379	intact:EBI-169514|ensemblmetazoa:FBpp0087216|ensemblmetazoa:FBpp0304693	psi-mi:trc8_drome(display_long)|uniprotkb:Trc8(gene name)|psi-mi:Trc8(display_short)|uniprotkb:CG2304(orf name)	psi-mi:vhl_drome(display_long)|uniprotkb:Vhl(gene name)|psi-mi:Vhl(display_short)|uniprotkb:CG13221(orf name)	psi-mi:"MI:0096"(pull down)	Gemmill et al. (2002)	pubmed:12032852|imex:IM-19980	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1551720|imex:IM-19980-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0039668(gene)|ensemblmetazoa:FBtr0085432(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007418"(ventral midline development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|refseq:NP_733292.1|refseq:NP_733293.1|refseq:NP_996303.1|flybase:FBgn0039668|refseq:NP_001263070.1	ensemblmetazoa:FBtr0332420(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030891"(VCB complex)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0060438"(trachea development)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1900037"(regulation of cellular response to hypoxia)|interpro:IPR022772|interpro:IPR024053|interpro:IPR036208|interpro:IPR037140|reactome:R-DME-1234176|reactome:R-DME-8951664|reactome:R-DME-9706019|reactome:R-DME-983168|ensemblmetazoa:FBgn0041174(gene)|ensemblmetazoa:FBtr0088115(transcript)|refseq:NP_524986.1|flybase:FBgn0041174|refseq:NP_001260885.1	-	-	-	figure legend:4 D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/02	2014/10/16	rogid:h84JsRdSm6Of7reRs2lEWYf9RlM7227	rogid:dBU27j1KvlMnNDuNotuD0gr8hcQ7227	intact-crc:4D51B3A79807ABC6|rigid:9YEQkMGyGi1nFELVch2wSQLXDwU	false	glutathione s tranferase tag:?-?|sufficient binding region:562-809	35s radiolabel:?-?|sufficient binding region:1-107	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q7KRW1	uniprotkb:Q9XZ58	intact:EBI-1011633|uniprotkb:Q7KRW0|uniprotkb:Q8IHG9|uniprotkb:Q8MQX1|uniprotkb:Q8T0E3|uniprotkb:Q8WRY2|uniprotkb:Q9VAK6|ensemblmetazoa:FBpp0089379	intact:EBI-97187|uniprotkb:Q7KN57|uniprotkb:Q9UB04|ensemblmetazoa:FBpp0082743	psi-mi:trc8_drome(display_long)|uniprotkb:Trc8(gene name)|psi-mi:Trc8(display_short)|uniprotkb:CG2304(orf name)	psi-mi:csn5_drome(display_long)|uniprotkb:CSN5(gene name)|psi-mi:CSN5(display_short)|uniprotkb:CG14884(orf name)|uniprotkb:quo(gene name synonym)|uniprotkb:JAB1 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gemmill et al. (2002)	pubmed:12032852|imex:IM-19980	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1551720|imex:IM-19980-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0039668(gene)|ensemblmetazoa:FBtr0085432(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007418"(ventral midline development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|refseq:NP_733292.1|refseq:NP_733293.1|refseq:NP_996303.1|flybase:FBgn0039668|refseq:NP_001263070.1	refseq:NP_477442.1|flybase:FBgn0027053|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-6781823|ensemblmetazoa:FBgn0027053(gene)|ensemblmetazoa:FBtr0083292(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007281"(germ cell development)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008347"(glial cell migration)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035204"(negative regulation of lamellocyte differentiation)|go:"GO:0035207"(negative regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0050821"(protein stabilization)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|reactome:R-DME-5696394|dip:DIP-22022N	-	-	-	figure legend:4 D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/02	2014/10/16	rogid:h84JsRdSm6Of7reRs2lEWYf9RlM7227	rogid:bvwuY3mncpz5R3dfJ+O9jMp9PhQ7227	intact-crc:4D51B3A79807ABC6|rigid:9YEQkMGyGi1nFELVch2wSQLXDwU	false	glutathione s tranferase tag:?-?|sufficient binding region:562-809	35s radiolabel:?-?|dansyl label:55-187	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8WU17	uniprotkb:P40337	intact:EBI-1551681|uniprotkb:O75485|uniprotkb:Q7LDL3|uniprotkb:B3KMD5|ensembl:ENSP00000304051	intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474	psi-mi:rn139_human(display_long)|uniprotkb:Translocation in renal carcinoma on chromosome 8 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF139(gene name synonym)|uniprotkb:RING finger protein 139(gene name synonym)|uniprotkb:RNF139(gene name)|psi-mi:RNF139(display_short)|uniprotkb:TRC8(gene name synonym)	psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gemmill et al. (2002)	pubmed:12032852|imex:IM-19980	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1551696|imex:IM-19980-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009149.2|ensembl:ENSG00000170881(gene)|ensembl:ENST00000303545(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|reactome:R-HSA-901032	rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N	omim:608537(primary-reference)	-	-	figure legend:4 F|delivery method:P40337 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/11/02	2014/10/16	rogid:LjH3X0GbTdHrU+hvPbJKZ3Bu9Jg9606	rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606	intact-crc:DEBA9C86246FA468|rigid:AeOZgcQMBF77UBcKSoR4uRIHQlw	false	-	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40337	uniprotkb:Q8WU17	intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474	intact:EBI-1551681|uniprotkb:O75485|uniprotkb:Q7LDL3|uniprotkb:B3KMD5|ensembl:ENSP00000304051	psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym)	psi-mi:rn139_human(display_long)|uniprotkb:Translocation in renal carcinoma on chromosome 8 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF139(gene name synonym)|uniprotkb:RING finger protein 139(gene name synonym)|uniprotkb:RNF139(gene name)|psi-mi:RNF139(display_short)|uniprotkb:TRC8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gemmill et al. (2002)	pubmed:12032852|imex:IM-19980	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1551704|imex:IM-19980-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N	refseq:NP_009149.2|ensembl:ENSG00000170881(gene)|ensembl:ENST00000303545(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|reactome:R-HSA-901032	omim:608537(primary-reference)	-	-	figure legend:4 F|delivery method:P40337; Q8WU17 transfection|comment:"GFP-TRC8 (aa 491-664) coimmunoprecipitated more VHL than endogenous TRC8 and GFP-TRC8 (aa547-584), encompassing the RING-H2 domain inhibited VHL coimmunoprecipitation."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/11/02	2014/10/16	rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606	rogid:LjH3X0GbTdHrU+hvPbJKZ3Bu9Jg9606	intact-crc:35B23EF8907AF4ED|rigid:AeOZgcQMBF77UBcKSoR4uRIHQlw	false	ha tag:?-?	green fluorescent protein tag:?-?|sufficient binding region:491-664	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92905	uniprotkb:P40337	intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512	intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474	psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym)	psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gemmill et al. (2002)	pubmed:12032852|imex:IM-19980	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1551755|imex:IM-19980-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664	rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N	-	-	-	figure legend:5 E|delivery method:P40337 transfection|stimulant:MG132 -  the amount of coprecipitated JAB1 was increased when cells were treated with the proteasome inhibitor MG132.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-786_o)|taxid:9606(Homo sapiens renal cell adenocarcinoma)	-	2007/11/02	2014/10/16	rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606	rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606	intact-crc:205E486F0398D807|rigid:rDuTXwjJ3pUc5wspylDCiyT22RY	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7KRW1	uniprotkb:Q9XZ58	intact:EBI-1011633|uniprotkb:Q7KRW0|uniprotkb:Q8IHG9|uniprotkb:Q8MQX1|uniprotkb:Q8T0E3|uniprotkb:Q8WRY2|uniprotkb:Q9VAK6|ensemblmetazoa:FBpp0089379	intact:EBI-97187|uniprotkb:Q7KN57|uniprotkb:Q9UB04|ensemblmetazoa:FBpp0082743	psi-mi:trc8_drome(display_long)|uniprotkb:Trc8(gene name)|psi-mi:Trc8(display_short)|uniprotkb:CG2304(orf name)	psi-mi:csn5_drome(display_long)|uniprotkb:CSN5(gene name)|psi-mi:CSN5(display_short)|uniprotkb:CG14884(orf name)|uniprotkb:quo(gene name synonym)|uniprotkb:JAB1 homolog(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gemmill et al. (2002)	pubmed:12032852|imex:IM-19980	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555603|imex:IM-19980-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0039668(gene)|ensemblmetazoa:FBtr0085432(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007418"(ventral midline development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR025754|refseq:NP_733292.1|refseq:NP_733293.1|refseq:NP_996303.1|flybase:FBgn0039668|refseq:NP_001263070.1	refseq:NP_477442.1|flybase:FBgn0027053|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-6781823|ensemblmetazoa:FBgn0027053(gene)|ensemblmetazoa:FBtr0083292(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007281"(germ cell development)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008347"(glial cell migration)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035204"(negative regulation of lamellocyte differentiation)|go:"GO:0035207"(negative regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0050821"(protein stabilization)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|reactome:R-DME-5696394|dip:DIP-22022N	-	-	-	figure legend:4 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/02	2014/10/16	rogid:h84JsRdSm6Of7reRs2lEWYf9RlM7227	rogid:bvwuY3mncpz5R3dfJ+O9jMp9PhQ7227	intact-crc:4ED1624B10B9D589|rigid:LXlUOzbYqHzK7pRv6F5HqKrKkAQ	false	sufficient binding region:277-744	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)