#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97767	uniprotkb:Q62231	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	intact:EBI-1368483|uniprotkb:Q8CIL7|ensembl:ENSMUSP00000059026	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:six1_mouse(display_long)|uniprotkb:Six1(gene name)|psi-mi:Six1(display_short)|uniprotkb:Sine oculis homeobox homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Buller et al. (2001)	pubmed:11734542	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1368688	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	refseq:NP_033215.2|go:"GO:0001822"(kidney development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|ensembl:ENSMUSG00000051367(gene)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSMUST00000050029(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014857"(regulation of skeletal muscle cell proliferation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0021610"(facial nerve morphogenesis)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048538"(thymus development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061197"(fungiform papilla morphogenesis)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072172"(mesonephric tubule formation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1905243"(cellular response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031278|interpro:IPR031701	-	-	-	figure legend:1B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/07/11	2014/10/16	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	rogid:1H05OdwgQq632PL4a6wE9u1cFkM10090	intact-crc:A9F125E892F89115|rigid:EWry4Sz6H49XlC8nXnOfK0dKjxk	false	glutathione s tranferase tag:?-?|mutation disrupting interaction:486-486|binding-associated region:321-591|mutation disrupting interaction:330-330|mutation disrupting interaction:504-504	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97767	uniprotkb:Q62232	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	intact:EBI-1368736|uniprotkb:P70179|ensembl:ENSMUSP00000024947|ensembl:ENSMUSP00000125871	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:six2_mouse(display_long)|uniprotkb:Six2(gene name)|psi-mi:Six2(display_short)|uniprotkb:Sine oculis homeobox homolog 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Buller et al. (2001)	pubmed:11734542	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1368744	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	refseq:NP_035510.1|interpro:IPR031701|interpro:IPR017970|ensembl:ENSMUSG00000024134(gene)|ensembl:ENSMUST00000024947(transcript)|ensembl:ENSMUST00000163568(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0001822"(kidney development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0016477"(cell migration)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0072006"(nephron development)|go:"GO:0072028"(nephron morphogenesis)|go:"GO:0072038"(mesenchymal stem cell maintenance involved in nephron morphogenesis)|go:"GO:0072137"(condensed mesenchymal cell proliferation)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090189"(regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097168"(mesenchymal stem cell proliferation)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)	-	-	-	figure legend:1B	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/07/11	2014/10/16	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	rogid:+VNU0yexe/7PF/VqC2PNcmxgnvA10090	intact-crc:BBF81EEABDB90609|rigid:6uTakzcmlb1MMRH4NxPU6dqT4vc	false	mutation decreasing interaction:504-504|glutathione s tranferase tag:?-?|mutation decreasing interaction:486-486|binding-associated region:321-591|mutation decreasing interaction:330-330|mutation decreasing interaction:425-425	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62231	uniprotkb:P97767	intact:EBI-1368483|uniprotkb:Q8CIL7|ensembl:ENSMUSP00000059026	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	psi-mi:six1_mouse(display_long)|uniprotkb:Six1(gene name)|psi-mi:Six1(display_short)|uniprotkb:Sine oculis homeobox homolog 1(gene name synonym)	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Buller et al. (2001)	pubmed:11734542	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1368814	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033215.2|go:"GO:0001822"(kidney development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|ensembl:ENSMUSG00000051367(gene)|go:"GO:0010468"(regulation of gene expression)|ensembl:ENSMUST00000050029(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014857"(regulation of skeletal muscle cell proliferation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0021610"(facial nerve morphogenesis)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048538"(thymus development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061197"(fungiform papilla morphogenesis)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072172"(mesonephric tubule formation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1905243"(cellular response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031278|interpro:IPR031701	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	-	-	-	figure legend:2C, 3B, 3C|comment:Similar results have been obtained for using full length Eya1 or Eya1-domain fragment both with the respective mutations.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/07/11	2014/10/16	rogid:1H05OdwgQq632PL4a6wE9u1cFkM10090	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	intact-crc:BFDCD8A3FC4D5948|rigid:EWry4Sz6H49XlC8nXnOfK0dKjxk	false	his tag:?-?	binding-associated region:321-591|flag tag:?-?|mutation decreasing interaction:330-330|mutation decreasing interaction:486-486|mutation decreasing interaction:504-504	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62232	uniprotkb:P97767	intact:EBI-1368736|uniprotkb:P70179|ensembl:ENSMUSP00000024947|ensembl:ENSMUSP00000125871	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	psi-mi:six2_mouse(display_long)|uniprotkb:Six2(gene name)|psi-mi:Six2(display_short)|uniprotkb:Sine oculis homeobox homolog 2(gene name synonym)	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Buller et al. (2001)	pubmed:11734542	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1368825	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035510.1|interpro:IPR031701|interpro:IPR017970|ensembl:ENSMUSG00000024134(gene)|ensembl:ENSMUST00000024947(transcript)|ensembl:ENSMUST00000163568(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0001822"(kidney development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0016477"(cell migration)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0072006"(nephron development)|go:"GO:0072028"(nephron morphogenesis)|go:"GO:0072038"(mesenchymal stem cell maintenance involved in nephron morphogenesis)|go:"GO:0072137"(condensed mesenchymal cell proliferation)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090189"(regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097168"(mesenchymal stem cell proliferation)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	-	-	-	figure legend:2C, 3B, 3C|comment:Eya1 mutations glu330lys, ser454pro and leu472arg did not affect the interaction.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/07/11	2014/10/16	rogid:+VNU0yexe/7PF/VqC2PNcmxgnvA10090	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	intact-crc:9204A47D76FA76D7|rigid:6uTakzcmlb1MMRH4NxPU6dqT4vc	false	his tag:?-?	binding-associated region:321-591|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)