#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99593-1 uniprotkb:P52952 intact:EBI-304423|ensembl:ENSP00000309913|ensembl:ENSP00000384152 intact:EBI-936601|uniprotkb:A8K3K0|uniprotkb:B4DNB6|uniprotkb:E9PBU6|ensembl:ENSP00000327758 psi-mi:q99593-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short) psi-mi:nkx25_human(display_long)|uniprotkb:NKX2-5(gene name)|psi-mi:NKX2-5(display_short)|uniprotkb:CSX(gene name synonym)|uniprotkb:NKX2.5(gene name synonym)|uniprotkb:NKX2E(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hiroi et al. (2001) pubmed:11431700 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1200045 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|intact:EBI-297043(tbx5_human) refseq:NP_001159647.1|refseq:NP_001159648.1|refseq:NP_004378.1|ensembl:ENSG00000183072(gene)|ensembl:ENST00000329198(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003285"(septum secundum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:3RKQ|rcsb pdb:4S0H|rcsb pdb:6WC2|rcsb pdb:6WC5|reactome:R-HSA-2032785|reactome:R-HSA-5578768 - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2007/02/07 2014/10/16 rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606 rogid:wLSYYxUoPmhRfcbEfCdGPPv4qCQ9606 intact-crc:8D9880AFD68CB723|rigid:eYXqkQFTCJuClkTRHA604JO5Jnw false - - - - psi-mi:"MI:0056"(full identification by DNA sequencing) psi-mi:"MI:0056"(full identification by DNA sequencing) uniprotkb:Q99593-1 uniprotkb:P52952 intact:EBI-304423|ensembl:ENSP00000309913|ensembl:ENSP00000384152 intact:EBI-936601|uniprotkb:A8K3K0|uniprotkb:B4DNB6|uniprotkb:E9PBU6|ensembl:ENSP00000327758 psi-mi:q99593-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short) psi-mi:nkx25_human(display_long)|uniprotkb:NKX2-5(gene name)|psi-mi:NKX2-5(display_short)|uniprotkb:CSX(gene name synonym)|uniprotkb:NKX2.5(gene name synonym)|uniprotkb:NKX2E(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hiroi et al. (2001) pubmed:11431700 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1200054 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|intact:EBI-297043(tbx5_human) refseq:NP_001159647.1|refseq:NP_001159648.1|refseq:NP_004378.1|ensembl:ENSG00000183072(gene)|ensembl:ENST00000329198(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003285"(septum secundum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:3RKQ|rcsb pdb:4S0H|rcsb pdb:6WC2|rcsb pdb:6WC5|reactome:R-HSA-2032785|reactome:R-HSA-5578768 - - - figure legend:1b taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2007/02/07 2014/10/16 rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606 rogid:wLSYYxUoPmhRfcbEfCdGPPv4qCQ9606 intact-crc:75FDA0B40BED1037|rigid:eYXqkQFTCJuClkTRHA604JO5Jnw false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P52952 uniprotkb:Q99593-1 intact:EBI-936601|uniprotkb:A8K3K0|uniprotkb:B4DNB6|uniprotkb:E9PBU6|ensembl:ENSP00000327758 intact:EBI-304423|ensembl:ENSP00000309913|ensembl:ENSP00000384152 psi-mi:nkx25_human(display_long)|uniprotkb:NKX2-5(gene name)|psi-mi:NKX2-5(display_short)|uniprotkb:CSX(gene name synonym)|uniprotkb:NKX2.5(gene name synonym)|uniprotkb:NKX2E(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:q99593-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hiroi et al. (2001) pubmed:11431700 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1200063 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159647.1|refseq:NP_001159648.1|refseq:NP_004378.1|ensembl:ENSG00000183072(gene)|ensembl:ENST00000329198(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003285"(septum secundum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:3RKQ|rcsb pdb:4S0H|rcsb pdb:6WC2|rcsb pdb:6WC5|reactome:R-HSA-2032785|reactome:R-HSA-5578768 ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|intact:EBI-297043(tbx5_human) - - - figure legend:1a taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2007/02/07 2014/10/16 rogid:wLSYYxUoPmhRfcbEfCdGPPv4qCQ9606 rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606 intact-crc:8D21F29E2F0D5AD6|rigid:eYXqkQFTCJuClkTRHA604JO5Jnw false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q99593-1 uniprotkb:P52952 intact:EBI-304423|ensembl:ENSP00000309913|ensembl:ENSP00000384152 intact:EBI-936601|uniprotkb:A8K3K0|uniprotkb:B4DNB6|uniprotkb:E9PBU6|ensembl:ENSP00000327758 psi-mi:q99593-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short) psi-mi:nkx25_human(display_long)|uniprotkb:NKX2-5(gene name)|psi-mi:NKX2-5(display_short)|uniprotkb:CSX(gene name synonym)|uniprotkb:NKX2.5(gene name synonym)|uniprotkb:NKX2E(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:"MI:0096"(pull down) Hiroi et al. (2001) pubmed:11431700 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1200078 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|intact:EBI-297043(tbx5_human) refseq:NP_001159647.1|refseq:NP_001159648.1|refseq:NP_004378.1|ensembl:ENSG00000183072(gene)|ensembl:ENST00000329198(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003285"(septum secundum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:3RKQ|rcsb pdb:4S0H|rcsb pdb:6WC2|rcsb pdb:6WC5|reactome:R-HSA-2032785|reactome:R-HSA-5578768 - - - figure legend:1c|comment:Coordinates of Nkx2-5 homeodomain region obtained from UniProt. taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/02/07 2014/10/16 rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606 rogid:wLSYYxUoPmhRfcbEfCdGPPv4qCQ9606 intact-crc:C23ADF82F3A4FF9B|rigid:eYXqkQFTCJuClkTRHA604JO5Jnw false 35s radiolabel:?-? glutathione s tranferase tag:?-?|sufficient binding region:138..138-197..197(IPR001356) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99593-1 uniprotkb:P52952 intact:EBI-304423|ensembl:ENSP00000309913|ensembl:ENSP00000384152 intact:EBI-936601|uniprotkb:A8K3K0|uniprotkb:B4DNB6|uniprotkb:E9PBU6|ensembl:ENSP00000327758 psi-mi:q99593-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short) psi-mi:nkx25_human(display_long)|uniprotkb:NKX2-5(gene name)|psi-mi:NKX2-5(display_short)|uniprotkb:CSX(gene name synonym)|uniprotkb:NKX2.5(gene name synonym)|uniprotkb:NKX2E(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:"MI:0096"(pull down) Hiroi et al. (2001) pubmed:11431700 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1200090 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|intact:EBI-297043(tbx5_human) refseq:NP_001159647.1|refseq:NP_001159648.1|refseq:NP_004378.1|ensembl:ENSG00000183072(gene)|ensembl:ENST00000329198(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003285"(septum secundum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:3RKQ|rcsb pdb:4S0H|rcsb pdb:6WC2|rcsb pdb:6WC5|reactome:R-HSA-2032785|reactome:R-HSA-5578768 - - - figure legend:1d taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/02/07 2014/10/16 rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606 rogid:wLSYYxUoPmhRfcbEfCdGPPv4qCQ9606 intact-crc:536805968AA53002|rigid:eYXqkQFTCJuClkTRHA604JO5Jnw false 35s radiolabel:?-?|necessary binding region:1-83 glutathione s tranferase tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-1200107 uniprotkb:Q99593-1 - intact:EBI-304423|ensembl:ENSP00000309913|ensembl:ENSP00000384152 psi-mi:nppa_human_dna(display_short)|psi-mi:EBI-1200107(display_long) psi-mi:q99593-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Hiroi et al. (2001) pubmed:11431700 taxid:-1(in vitro)|taxid:-1(In vitro) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1200109 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|intact:EBI-297043(tbx5_human) - - - figure legend:3b taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/02/07 2014/10/16 crc64:21DE2AE3628A0736 rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606 intact-crc:C7E66D6FBDF9953A false 32p radiolabel:?-? - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P52952 intact:EBI-1200107 intact:EBI-936601|uniprotkb:A8K3K0|uniprotkb:B4DNB6|uniprotkb:E9PBU6|ensembl:ENSP00000327758 - psi-mi:nkx25_human(display_long)|uniprotkb:NKX2-5(gene name)|psi-mi:NKX2-5(display_short)|uniprotkb:CSX(gene name synonym)|uniprotkb:NKX2.5(gene name synonym)|uniprotkb:NKX2E(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:nppa_human_dna(display_short)|psi-mi:EBI-1200107(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Hiroi et al. (2001) pubmed:11431700 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-1(in vitro)|taxid:-1(In vitro) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1200116 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) refseq:NP_001159647.1|refseq:NP_001159648.1|refseq:NP_004378.1|ensembl:ENSG00000183072(gene)|ensembl:ENST00000329198(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003285"(septum secundum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:3RKQ|rcsb pdb:4S0H|rcsb pdb:6WC2|rcsb pdb:6WC5|reactome:R-HSA-2032785|reactome:R-HSA-5578768 - - - - figure legend:3b taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/02/07 2014/10/16 rogid:wLSYYxUoPmhRfcbEfCdGPPv4qCQ9606 crc64:21DE2AE3628A0736 intact-crc:17562180F703AA97 false - 32p radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P52952 intact:EBI-1200107 intact:EBI-936601|uniprotkb:A8K3K0|uniprotkb:B4DNB6|uniprotkb:E9PBU6|ensembl:ENSP00000327758 - psi-mi:nkx25_human(display_long)|uniprotkb:NKX2-5(gene name)|psi-mi:NKX2-5(display_short)|uniprotkb:CSX(gene name synonym)|uniprotkb:NKX2.5(gene name synonym)|uniprotkb:NKX2E(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:nppa_human_dna(display_short)|psi-mi:EBI-1200107(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Hiroi et al. (2001) pubmed:11431700 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-1(in vitro)|taxid:-1(In vitro) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1200123 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) refseq:NP_001159647.1|refseq:NP_001159648.1|refseq:NP_004378.1|ensembl:ENSG00000183072(gene)|ensembl:ENST00000329198(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003285"(septum secundum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:3RKQ|rcsb pdb:4S0H|rcsb pdb:6WC2|rcsb pdb:6WC5|reactome:R-HSA-2032785|reactome:R-HSA-5578768 - - - - figure legend:3b taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/02/07 2014/10/16 rogid:wLSYYxUoPmhRfcbEfCdGPPv4qCQ9606 crc64:21DE2AE3628A0736 intact-crc:5377A0005A47DCBB false - 32p radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P52952 uniprotkb:Q99593-1 intact:EBI-936601|uniprotkb:A8K3K0|uniprotkb:B4DNB6|uniprotkb:E9PBU6|ensembl:ENSP00000327758 intact:EBI-304423|ensembl:ENSP00000309913|ensembl:ENSP00000384152 psi-mi:nkx25_human(display_long)|uniprotkb:NKX2-5(gene name)|psi-mi:NKX2-5(display_short)|uniprotkb:CSX(gene name synonym)|uniprotkb:NKX2.5(gene name synonym)|uniprotkb:NKX2E(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym) psi-mi:q99593-1(display_long)|uniprotkb:Long(isoform synonym)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Hiroi et al. (2001) pubmed:11431700 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1200123 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159647.1|refseq:NP_001159648.1|refseq:NP_004378.1|ensembl:ENSG00000183072(gene)|ensembl:ENST00000329198(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003285"(septum secundum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:3RKQ|rcsb pdb:4S0H|rcsb pdb:6WC2|rcsb pdb:6WC5|reactome:R-HSA-2032785|reactome:R-HSA-5578768 ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|intact:EBI-297043(tbx5_human) - - - figure legend:3b taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/02/07 2014/10/16 rogid:wLSYYxUoPmhRfcbEfCdGPPv4qCQ9606 rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606 intact-crc:5377A0005A47DCBB false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)