#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99MH6	uniprotkb:P51141	intact:EBI-1538321|uniprotkb:Q3TLD6|uniprotkb:Q8K200|uniprotkb:Q91Y46|ensembl:ENSMUSP00000034086	intact:EBI-1538407|uniprotkb:Q60868|uniprotkb:Q3U2D3|ensembl:ENSMUSP00000030948|ensembl:ENSMUSP00000133137	psi-mi:nkd1_mouse(display_long)|uniprotkb:Nkd1(gene name)|psi-mi:Nkd1(display_short)	psi-mi:dvl1_mouse(display_long)|uniprotkb:Dvl1(gene name)|psi-mi:Dvl1(display_short)|uniprotkb:Dvl(gene name synonym)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1538442|imex:IM-19535-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081556.3|ensembl:ENSMUSG00000031661(gene)|ensembl:ENSMUST00000034086(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901231"(positive regulation of non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:1901233"(negative regulation of convergent extension involved in axis elongation)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_034221.3|refseq:NP_001289271.1|dip:DIP-38263N|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048668"(collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060029"(convergent extension involved in organogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|rcsb pdb:1FSH|rcsb pdb:1MC7|rcsb pdb:2KAW|rcsb pdb:2MX6|rcsb pdb:3PZ8|reactome:R-MMU-201688|reactome:R-MMU-4086400|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5663220|ensembl:ENSMUSG00000029071(gene)|ensembl:ENSMUST00000030948(transcript)|ensembl:ENSMUST00000168552(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:liCzM7mnKqPRck5uBbY8CM5iyXQ10090	rogid:m61iD63WqE333GDlyLU6Mlnq50o10090	intact-crc:1D70A84349C62566|rigid:/e+Gpyx9LevZ2HySmNDouG1FByY	false	sufficient binding region:125-190	sufficient binding region:163-337	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8VE28	uniprotkb:P51141	intact:EBI-1538490|uniprotkb:Q3TYU5|uniprotkb:Q3UM34|uniprotkb:Q8C4J8|uniprotkb:Q91Y45|uniprotkb:Q9D7U9|ensembl:ENSMUSP00000022051	intact:EBI-1538407|uniprotkb:Q60868|uniprotkb:Q3U2D3|ensembl:ENSMUSP00000030948|ensembl:ENSMUSP00000133137	psi-mi:nkd2_mouse(display_long)|uniprotkb:Nkd2(gene name)|psi-mi:Nkd2(display_short)	psi-mi:dvl1_mouse(display_long)|uniprotkb:Dvl1(gene name)|psi-mi:Dvl1(display_short)|uniprotkb:Dvl(gene name synonym)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1538473|imex:IM-19535-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082462.3|refseq:NP_001334464.1|ensembl:ENSMUSG00000021567(gene)|ensembl:ENSMUST00000022051(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051117"(ATPase binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_034221.3|refseq:NP_001289271.1|dip:DIP-38263N|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048668"(collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060029"(convergent extension involved in organogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|rcsb pdb:1FSH|rcsb pdb:1MC7|rcsb pdb:2KAW|rcsb pdb:2MX6|rcsb pdb:3PZ8|reactome:R-MMU-201688|reactome:R-MMU-4086400|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5663220|ensembl:ENSMUSG00000029071(gene)|ensembl:ENSMUST00000030948(transcript)|ensembl:ENSMUST00000168552(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:YahIfIwWuxWNCTmkeFs9nSf8UWc10090	rogid:m61iD63WqE333GDlyLU6Mlnq50o10090	intact-crc:2875989A19CF27DF|rigid:3/M5BmmXBw/E4OO1TkzNQCs47mM	false	sufficient binding region:121-186	sufficient binding region:163-337	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51141	uniprotkb:Q9VVV9	intact:EBI-1538407|uniprotkb:Q60868|uniprotkb:Q3U2D3|ensembl:ENSMUSP00000030948|ensembl:ENSMUSP00000133137	intact:EBI-125843|intact:EBI-869341|uniprotkb:Q9NIH2|uniprotkb:Q9VVW0|uniprotkb:Q95RL6|ensemblmetazoa:FBpp0074806	psi-mi:dvl1_mouse(display_long)|uniprotkb:Dvl1(gene name)|psi-mi:Dvl1(display_short)|uniprotkb:Dvl(gene name synonym)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:nkd_drome(display_long)|uniprotkb:nkd(gene name)|psi-mi:nkd(display_short)|uniprotkb:CG11614(orf name)|uniprotkb:dNkd(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1538514|imex:IM-19535-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034221.3|refseq:NP_001289271.1|dip:DIP-38263N|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048668"(collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060029"(convergent extension involved in organogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|rcsb pdb:1FSH|rcsb pdb:1MC7|rcsb pdb:2KAW|rcsb pdb:2MX6|rcsb pdb:3PZ8|reactome:R-MMU-201688|reactome:R-MMU-4086400|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5663220|ensembl:ENSMUSG00000029071(gene)|ensembl:ENSMUST00000030948(transcript)|ensembl:ENSMUST00000168552(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_524788.2|flybase:FBgn0002945|ensemblmetazoa:FBgn0002945(gene)|ensemblmetazoa:FBtr0075039(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014018"(neuroblast fate specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR040140|go:"GO:0005829"(cytosol)|dip:DIP-20017N	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:m61iD63WqE333GDlyLU6Mlnq50o10090	rogid:yaaziXv2LEThet7ZTsI7idWJmhg7227	intact-crc:2139A1FA961E64F4|rigid:ZC01p/OO5U1lkzvgepK+xL5UKjM	false	sufficient binding region:163-337	sufficient binding region:177-253	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99MH6	uniprotkb:Q60838	intact:EBI-1538321|uniprotkb:Q3TLD6|uniprotkb:Q8K200|uniprotkb:Q91Y46|ensembl:ENSMUSP00000034086	intact:EBI-641940|uniprotkb:Q7TN14|ensembl:ENSMUSP00000099635|ensembl:ENSMUSP00000140073|ensembl:ENSMUSP00000019362	psi-mi:nkd1_mouse(display_long)|uniprotkb:Nkd1(gene name)|psi-mi:Nkd1(display_short)	psi-mi:dvl2_mouse(display_long)|uniprotkb:Dvl2(gene name)|psi-mi:Dvl2(display_short)|uniprotkb:DSH homolog 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543856|imex:IM-19535-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081556.3|ensembl:ENSMUSG00000031661(gene)|ensembl:ENSMUST00000034086(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901231"(positive regulation of non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:1901233"(negative regulation of convergent extension involved in axis elongation)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_031914.3|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q60838|rcsb pdb:3ML6|rcsb pdb:6VCC|reactome:R-MMU-201688|reactome:R-MMU-2028269|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5099900|reactome:R-MMU-5663220|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUST00000019362(transcript)|ensembl:ENSMUST00000102575(transcript)|ensembl:ENSMUST00000190940(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060029"(convergent extension involved in organogenesis)|ensembl:ENSMUSG00000020888(gene)|dip:DIP-29399N	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:liCzM7mnKqPRck5uBbY8CM5iyXQ10090	rogid:bFjXy0cGGbY8YE60qW3+0NLpqNs10090	intact-crc:850E8206B6106CAB|rigid:ko+YYwlImvPK9F3IevX049j25Sc	false	sufficient binding region:125-190	sufficient binding region:180-353	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99MH6	uniprotkb:Q61062	intact:EBI-1538321|uniprotkb:Q3TLD6|uniprotkb:Q8K200|uniprotkb:Q91Y46|ensembl:ENSMUSP00000034086	intact:EBI-1538450|uniprotkb:G5E820|ensembl:ENSMUSP00000003318	psi-mi:nkd1_mouse(display_long)|uniprotkb:Nkd1(gene name)|psi-mi:Nkd1(display_short)	psi-mi:dvl3_mouse(display_long)|uniprotkb:Dvl3(gene name)|psi-mi:Dvl3(display_short)|uniprotkb:DSH homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543864|imex:IM-19535-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081556.3|ensembl:ENSMUSG00000031661(gene)|ensembl:ENSMUST00000034086(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901231"(positive regulation of non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:1901233"(negative regulation of convergent extension involved in axis elongation)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_031915.2|ensembl:ENSMUSG00000003233(gene)|ensembl:ENSMUST00000003318(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|reactome:R-MMU-201688|reactome:R-MMU-4086400|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5663220	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:liCzM7mnKqPRck5uBbY8CM5iyXQ10090	rogid:+l0INmdRADXIgkikNBGmdG3UfiI10090	intact-crc:6535139E5F05B725|rigid:IGgfTOSnKXoXSZsbORdDNVO51wY	false	sufficient binding region:125-190	sufficient binding region:161-335	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99MH6	uniprotkb:P51140	intact:EBI-1538321|uniprotkb:Q3TLD6|uniprotkb:Q8K200|uniprotkb:Q91Y46|ensembl:ENSMUSP00000034086	intact:EBI-499383|ensemblmetazoa:FBpp0073310|uniprotkb:Q494J5|uniprotkb:Q9VYZ9	psi-mi:nkd1_mouse(display_long)|uniprotkb:Nkd1(gene name)|psi-mi:Nkd1(display_short)	psi-mi:dsh_drome(display_long)|uniprotkb:dsh(gene name)|psi-mi:dsh(display_short)|uniprotkb:CG18361(orf name)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543882|imex:IM-19535-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081556.3|ensembl:ENSMUSG00000031661(gene)|ensembl:ENSMUST00000034086(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901231"(positive regulation of non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:1901233"(negative regulation of convergent extension involved in axis elongation)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_511118.2|flybase:FBgn0000499|ensemblmetazoa:FBgn0000499(gene)|ensemblmetazoa:FBtr0073454(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001737"(establishment of imaginal disc-derived wing hair orientation)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007391"(dorsal closure)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035317"(imaginal disc-derived wing hair organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042067"(establishment of ommatidial planar polarity)|go:"GO:0045179"(apical cortex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048076"(regulation of compound eye pigmentation)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060914"(heart formation)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR026542|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-201688|reactome:R-DME-2028269|reactome:R-DME-209440|reactome:R-DME-350368|reactome:R-DME-350369|reactome:R-DME-350376|reactome:R-DME-350411|reactome:R-DME-350480|reactome:R-DME-4086400|reactome:R-DME-450728|reactome:R-DME-4608870|reactome:R-DME-4641258|reactome:R-DME-4641262|reactome:R-DME-5099900|reactome:R-DME-5663220|reactome:R-DME-8856825|reactome:R-DME-8856828|interpro:IPR038207	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:liCzM7mnKqPRck5uBbY8CM5iyXQ10090	rogid:zXo1t6bIifQ3/t3hf/MVeEuPw9A7227	intact-crc:48380417D5CEA469|rigid:mJ53wwKId5nQLE0vo7Jozs4zREY	false	sufficient binding region:125-190	sufficient binding region:167-338	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VVV9	uniprotkb:Q60838	intact:EBI-125843|intact:EBI-869341|uniprotkb:Q9NIH2|uniprotkb:Q9VVW0|uniprotkb:Q95RL6|ensemblmetazoa:FBpp0074806	intact:EBI-641940|uniprotkb:Q7TN14|ensembl:ENSMUSP00000099635|ensembl:ENSMUSP00000140073|ensembl:ENSMUSP00000019362	psi-mi:nkd_drome(display_long)|uniprotkb:nkd(gene name)|psi-mi:nkd(display_short)|uniprotkb:CG11614(orf name)|uniprotkb:dNkd(gene name synonym)	psi-mi:dvl2_mouse(display_long)|uniprotkb:Dvl2(gene name)|psi-mi:Dvl2(display_short)|uniprotkb:DSH homolog 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543890|imex:IM-19535-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524788.2|flybase:FBgn0002945|ensemblmetazoa:FBgn0002945(gene)|ensemblmetazoa:FBtr0075039(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014018"(neuroblast fate specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR040140|go:"GO:0005829"(cytosol)|dip:DIP-20017N	refseq:NP_031914.3|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q60838|rcsb pdb:3ML6|rcsb pdb:6VCC|reactome:R-MMU-201688|reactome:R-MMU-2028269|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5099900|reactome:R-MMU-5663220|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUST00000019362(transcript)|ensembl:ENSMUST00000102575(transcript)|ensembl:ENSMUST00000190940(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060029"(convergent extension involved in organogenesis)|ensembl:ENSMUSG00000020888(gene)|dip:DIP-29399N	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:yaaziXv2LEThet7ZTsI7idWJmhg7227	rogid:bFjXy0cGGbY8YE60qW3+0NLpqNs10090	intact-crc:B9478BBF69C82D39|rigid:yXImLjdwTb9xYe1dNJMKD2XJY0o	false	sufficient binding region:177-253	sufficient binding region:180-353	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61062	uniprotkb:Q9VVV9	intact:EBI-1538450|uniprotkb:G5E820|ensembl:ENSMUSP00000003318	intact:EBI-125843|intact:EBI-869341|uniprotkb:Q9NIH2|uniprotkb:Q9VVW0|uniprotkb:Q95RL6|ensemblmetazoa:FBpp0074806	psi-mi:dvl3_mouse(display_long)|uniprotkb:Dvl3(gene name)|psi-mi:Dvl3(display_short)|uniprotkb:DSH homolog 3(gene name synonym)	psi-mi:nkd_drome(display_long)|uniprotkb:nkd(gene name)|psi-mi:nkd(display_short)|uniprotkb:CG11614(orf name)|uniprotkb:dNkd(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543907|imex:IM-19535-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031915.2|ensembl:ENSMUSG00000003233(gene)|ensembl:ENSMUST00000003318(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|reactome:R-MMU-201688|reactome:R-MMU-4086400|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5663220	refseq:NP_524788.2|flybase:FBgn0002945|ensemblmetazoa:FBgn0002945(gene)|ensemblmetazoa:FBtr0075039(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014018"(neuroblast fate specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR040140|go:"GO:0005829"(cytosol)|dip:DIP-20017N	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:+l0INmdRADXIgkikNBGmdG3UfiI10090	rogid:yaaziXv2LEThet7ZTsI7idWJmhg7227	intact-crc:597C1A2780DDF6B7|rigid:PkPMJJ5+PoySykSggfp1ADQnGW0	false	sufficient binding region:161-335	sufficient binding region:177-253	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51140	uniprotkb:Q9VVV9	intact:EBI-499383|ensemblmetazoa:FBpp0073310|uniprotkb:Q494J5|uniprotkb:Q9VYZ9	intact:EBI-125843|intact:EBI-869341|uniprotkb:Q9NIH2|uniprotkb:Q9VVW0|uniprotkb:Q95RL6|ensemblmetazoa:FBpp0074806	psi-mi:dsh_drome(display_long)|uniprotkb:dsh(gene name)|psi-mi:dsh(display_short)|uniprotkb:CG18361(orf name)	psi-mi:nkd_drome(display_long)|uniprotkb:nkd(gene name)|psi-mi:nkd(display_short)|uniprotkb:CG11614(orf name)|uniprotkb:dNkd(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543915|imex:IM-19535-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_511118.2|flybase:FBgn0000499|ensemblmetazoa:FBgn0000499(gene)|ensemblmetazoa:FBtr0073454(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001737"(establishment of imaginal disc-derived wing hair orientation)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007391"(dorsal closure)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035317"(imaginal disc-derived wing hair organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042067"(establishment of ommatidial planar polarity)|go:"GO:0045179"(apical cortex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048076"(regulation of compound eye pigmentation)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060914"(heart formation)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR026542|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-201688|reactome:R-DME-2028269|reactome:R-DME-209440|reactome:R-DME-350368|reactome:R-DME-350369|reactome:R-DME-350376|reactome:R-DME-350411|reactome:R-DME-350480|reactome:R-DME-4086400|reactome:R-DME-450728|reactome:R-DME-4608870|reactome:R-DME-4641258|reactome:R-DME-4641262|reactome:R-DME-5099900|reactome:R-DME-5663220|reactome:R-DME-8856825|reactome:R-DME-8856828|interpro:IPR038207	refseq:NP_524788.2|flybase:FBgn0002945|ensemblmetazoa:FBgn0002945(gene)|ensemblmetazoa:FBtr0075039(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014018"(neuroblast fate specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR040140|go:"GO:0005829"(cytosol)|dip:DIP-20017N	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:zXo1t6bIifQ3/t3hf/MVeEuPw9A7227	rogid:yaaziXv2LEThet7ZTsI7idWJmhg7227	intact-crc:74710DAE0A16E5FB|rigid:qoUlYlGzgebKrO0EZ0wUOiF2RZ4	false	sufficient binding region:167-338	sufficient binding region:177-253	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8VE28	uniprotkb:Q60838	intact:EBI-1538490|uniprotkb:Q3TYU5|uniprotkb:Q3UM34|uniprotkb:Q8C4J8|uniprotkb:Q91Y45|uniprotkb:Q9D7U9|ensembl:ENSMUSP00000022051	intact:EBI-641940|uniprotkb:Q7TN14|ensembl:ENSMUSP00000099635|ensembl:ENSMUSP00000140073|ensembl:ENSMUSP00000019362	psi-mi:nkd2_mouse(display_long)|uniprotkb:Nkd2(gene name)|psi-mi:Nkd2(display_short)	psi-mi:dvl2_mouse(display_long)|uniprotkb:Dvl2(gene name)|psi-mi:Dvl2(display_short)|uniprotkb:DSH homolog 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543923|imex:IM-19535-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082462.3|refseq:NP_001334464.1|ensembl:ENSMUSG00000021567(gene)|ensembl:ENSMUST00000022051(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051117"(ATPase binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_031914.3|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q60838|rcsb pdb:3ML6|rcsb pdb:6VCC|reactome:R-MMU-201688|reactome:R-MMU-2028269|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5099900|reactome:R-MMU-5663220|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUST00000019362(transcript)|ensembl:ENSMUST00000102575(transcript)|ensembl:ENSMUST00000190940(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060029"(convergent extension involved in organogenesis)|ensembl:ENSMUSG00000020888(gene)|dip:DIP-29399N	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:YahIfIwWuxWNCTmkeFs9nSf8UWc10090	rogid:bFjXy0cGGbY8YE60qW3+0NLpqNs10090	intact-crc:B00BB2DFE6196E12|rigid:B33UtiNyonkx+UKyXe6xSkgL80I	false	sufficient binding region:121-186	sufficient binding region:180-353	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8VE28	uniprotkb:Q61062	intact:EBI-1538490|uniprotkb:Q3TYU5|uniprotkb:Q3UM34|uniprotkb:Q8C4J8|uniprotkb:Q91Y45|uniprotkb:Q9D7U9|ensembl:ENSMUSP00000022051	intact:EBI-1538450|uniprotkb:G5E820|ensembl:ENSMUSP00000003318	psi-mi:nkd2_mouse(display_long)|uniprotkb:Nkd2(gene name)|psi-mi:Nkd2(display_short)	psi-mi:dvl3_mouse(display_long)|uniprotkb:Dvl3(gene name)|psi-mi:Dvl3(display_short)|uniprotkb:DSH homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543932|imex:IM-19535-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082462.3|refseq:NP_001334464.1|ensembl:ENSMUSG00000021567(gene)|ensembl:ENSMUST00000022051(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051117"(ATPase binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_031915.2|ensembl:ENSMUSG00000003233(gene)|ensembl:ENSMUST00000003318(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|reactome:R-MMU-201688|reactome:R-MMU-4086400|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5663220	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:YahIfIwWuxWNCTmkeFs9nSf8UWc10090	rogid:+l0INmdRADXIgkikNBGmdG3UfiI10090	intact-crc:503023470F0CB59C|rigid:Bq+xQdxrb067zyqExG6RwCT5sdY	false	sufficient binding region:121-186	sufficient binding region:161-335	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8VE28	uniprotkb:P51140	intact:EBI-1538490|uniprotkb:Q3TYU5|uniprotkb:Q3UM34|uniprotkb:Q8C4J8|uniprotkb:Q91Y45|uniprotkb:Q9D7U9|ensembl:ENSMUSP00000022051	intact:EBI-499383|ensemblmetazoa:FBpp0073310|uniprotkb:Q494J5|uniprotkb:Q9VYZ9	psi-mi:nkd2_mouse(display_long)|uniprotkb:Nkd2(gene name)|psi-mi:Nkd2(display_short)	psi-mi:dsh_drome(display_long)|uniprotkb:dsh(gene name)|psi-mi:dsh(display_short)|uniprotkb:CG18361(orf name)	psi-mi:"MI:0018"(two hybrid)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543950|imex:IM-19535-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082462.3|refseq:NP_001334464.1|ensembl:ENSMUSG00000021567(gene)|ensembl:ENSMUST00000022051(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051117"(ATPase binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_511118.2|flybase:FBgn0000499|ensemblmetazoa:FBgn0000499(gene)|ensemblmetazoa:FBtr0073454(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001737"(establishment of imaginal disc-derived wing hair orientation)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007391"(dorsal closure)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035317"(imaginal disc-derived wing hair organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042067"(establishment of ommatidial planar polarity)|go:"GO:0045179"(apical cortex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048076"(regulation of compound eye pigmentation)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060914"(heart formation)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR026542|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-201688|reactome:R-DME-2028269|reactome:R-DME-209440|reactome:R-DME-350368|reactome:R-DME-350369|reactome:R-DME-350376|reactome:R-DME-350411|reactome:R-DME-350480|reactome:R-DME-4086400|reactome:R-DME-450728|reactome:R-DME-4608870|reactome:R-DME-4641258|reactome:R-DME-4641262|reactome:R-DME-5099900|reactome:R-DME-5663220|reactome:R-DME-8856825|reactome:R-DME-8856828|interpro:IPR038207	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/26	2014/10/16	rogid:YahIfIwWuxWNCTmkeFs9nSf8UWc10090	rogid:zXo1t6bIifQ3/t3hf/MVeEuPw9A7227	intact-crc:7D3D34CE85C7A6D0|rigid:TBtrCZwHyeOO/DrfbN0GoKUiXGg	false	sufficient binding region:121-186	sufficient binding region:167-338	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51140	uniprotkb:Q9VVV9	intact:EBI-499383|ensemblmetazoa:FBpp0073310|uniprotkb:Q494J5|uniprotkb:Q9VYZ9	intact:EBI-125843|intact:EBI-869341|uniprotkb:Q9NIH2|uniprotkb:Q9VVW0|uniprotkb:Q95RL6|ensemblmetazoa:FBpp0074806	psi-mi:dsh_drome(display_long)|uniprotkb:dsh(gene name)|psi-mi:dsh(display_short)|uniprotkb:CG18361(orf name)	psi-mi:nkd_drome(display_long)|uniprotkb:nkd(gene name)|psi-mi:nkd(display_short)|uniprotkb:CG11614(orf name)|uniprotkb:dNkd(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1538541|imex:IM-19535-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_511118.2|flybase:FBgn0000499|ensemblmetazoa:FBgn0000499(gene)|ensemblmetazoa:FBtr0073454(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001737"(establishment of imaginal disc-derived wing hair orientation)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007391"(dorsal closure)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035317"(imaginal disc-derived wing hair organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042067"(establishment of ommatidial planar polarity)|go:"GO:0045179"(apical cortex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048076"(regulation of compound eye pigmentation)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060914"(heart formation)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR026542|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-201688|reactome:R-DME-2028269|reactome:R-DME-209440|reactome:R-DME-350368|reactome:R-DME-350369|reactome:R-DME-350376|reactome:R-DME-350411|reactome:R-DME-350480|reactome:R-DME-4086400|reactome:R-DME-450728|reactome:R-DME-4608870|reactome:R-DME-4641258|reactome:R-DME-4641262|reactome:R-DME-5099900|reactome:R-DME-5663220|reactome:R-DME-8856825|reactome:R-DME-8856828|interpro:IPR038207	refseq:NP_524788.2|flybase:FBgn0002945|ensemblmetazoa:FBgn0002945(gene)|ensemblmetazoa:FBtr0075039(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014018"(neuroblast fate specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR040140|go:"GO:0005829"(cytosol)|dip:DIP-20017N	-	-	-	figure legend:Fig 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/26	2014/10/16	rogid:zXo1t6bIifQ3/t3hf/MVeEuPw9A7227	rogid:yaaziXv2LEThet7ZTsI7idWJmhg7227	intact-crc:AE49F09C84AABCEF|rigid:qoUlYlGzgebKrO0EZ0wUOiF2RZ4	false	glutathione s tranferase tag:n-n	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99MH6	uniprotkb:P51140	intact:EBI-1538321|uniprotkb:Q3TLD6|uniprotkb:Q8K200|uniprotkb:Q91Y46|ensembl:ENSMUSP00000034086	intact:EBI-499383|ensemblmetazoa:FBpp0073310|uniprotkb:Q494J5|uniprotkb:Q9VYZ9	psi-mi:nkd1_mouse(display_long)|uniprotkb:Nkd1(gene name)|psi-mi:Nkd1(display_short)	psi-mi:dsh_drome(display_long)|uniprotkb:dsh(gene name)|psi-mi:dsh(display_short)|uniprotkb:CG18361(orf name)	psi-mi:"MI:0096"(pull down)	Wharton et al. (2001)	pubmed:11356022|imex:IM-19535	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1543960|imex:IM-19535-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081556.3|ensembl:ENSMUSG00000031661(gene)|ensembl:ENSMUST00000034086(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901231"(positive regulation of non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:1901233"(negative regulation of convergent extension involved in axis elongation)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_511118.2|flybase:FBgn0000499|ensemblmetazoa:FBgn0000499(gene)|ensemblmetazoa:FBtr0073454(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001737"(establishment of imaginal disc-derived wing hair orientation)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007391"(dorsal closure)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035317"(imaginal disc-derived wing hair organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042067"(establishment of ommatidial planar polarity)|go:"GO:0045179"(apical cortex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048076"(regulation of compound eye pigmentation)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|go:"GO:0060914"(heart formation)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR026542|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-201688|reactome:R-DME-2028269|reactome:R-DME-209440|reactome:R-DME-350368|reactome:R-DME-350369|reactome:R-DME-350376|reactome:R-DME-350411|reactome:R-DME-350480|reactome:R-DME-4086400|reactome:R-DME-450728|reactome:R-DME-4608870|reactome:R-DME-4641258|reactome:R-DME-4641262|reactome:R-DME-5099900|reactome:R-DME-5663220|reactome:R-DME-8856825|reactome:R-DME-8856828|interpro:IPR038207	-	-	-	figure legend:Fig 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/26	2014/10/16	rogid:liCzM7mnKqPRck5uBbY8CM5iyXQ10090	rogid:zXo1t6bIifQ3/t3hf/MVeEuPw9A7227	intact-crc:6D49F301D9B77E3C|rigid:mJ53wwKId5nQLE0vo7Jozs4zREY	false	35s radiolabel:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)