#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8VDD9	uniprotkb:P35570	intact:EBI-1369766|uniprotkb:Q9ESL6|uniprotkb:Q3TS96|uniprotkb:Q80VI6|uniprotkb:Q9EPY1	intact:EBI-520230	psi-mi:phip_mouse(display_long)|uniprotkb:Phip1(gene name synonym)|uniprotkb:Phip(gene name)|psi-mi:Phip(display_short)|uniprotkb:Wdr11(gene name synonym)|uniprotkb:Ndrp(gene name synonym)|uniprotkb:IRS-1 PH domain-binding protein(gene name synonym)|uniprotkb:WD repeat-containing protein 11(gene name synonym)|uniprotkb:Neuronal differentiation-related protein(gene name synonym)	psi-mi:irs1_rat(display_long)|uniprotkb:pp185(gene name synonym)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Farhang-Fallah et al. (2000)	pubmed:11018022|imex:IM-19437	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1369776|imex:IM-19437-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR028738|interpro:IPR036322|interpro:IPR036427|mint:Q8VDD9|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013418	go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:5WRK|rcsb pdb:5WRL|rcsb pdb:5WRM|reactome:R-RNO-109704|reactome:R-RNO-112399|reactome:R-RNO-112412|reactome:R-RNO-1257604|reactome:R-RNO-1266695|reactome:R-RNO-198203|reactome:R-RNO-2428928|reactome:R-RNO-5673001|reactome:R-RNO-6811558|reactome:R-RNO-74713|reactome:R-RNO-74749|rgd:2922|refseq:NP_037101.1|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0090275"(negative regulation of somatostatin secretion)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071478"(cellular response to radiation)|mint:P35570|dip:DIP-664N	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/07/13	2014/10/16	rogid:Q3tjNzPTobuShNidgEYMDlV04s010090	rogid:SJ1RT9ubHcFhkPSArSJ6TsPIp0E10116	intact-crc:1D7813A82978E2EB|rigid:fxEQy7JUVoSpULeLzrNz1kbMxNs	false	-	binding-associated region:3-133	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VDD9	uniprotkb:P35570	intact:EBI-1369766|uniprotkb:Q9ESL6|uniprotkb:Q3TS96|uniprotkb:Q80VI6|uniprotkb:Q9EPY1	intact:EBI-520230	psi-mi:phip_mouse(display_long)|uniprotkb:Phip1(gene name synonym)|uniprotkb:Phip(gene name)|psi-mi:Phip(display_short)|uniprotkb:Wdr11(gene name synonym)|uniprotkb:Ndrp(gene name synonym)|uniprotkb:IRS-1 PH domain-binding protein(gene name synonym)|uniprotkb:WD repeat-containing protein 11(gene name synonym)|uniprotkb:Neuronal differentiation-related protein(gene name synonym)	psi-mi:irs1_rat(display_long)|uniprotkb:pp185(gene name synonym)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Farhang-Fallah et al. (2000)	pubmed:11018022|imex:IM-19437	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1369806|imex:IM-19437-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR028738|interpro:IPR036322|interpro:IPR036427|mint:Q8VDD9|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013418	go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:5WRK|rcsb pdb:5WRL|rcsb pdb:5WRM|reactome:R-RNO-109704|reactome:R-RNO-112399|reactome:R-RNO-112412|reactome:R-RNO-1257604|reactome:R-RNO-1266695|reactome:R-RNO-198203|reactome:R-RNO-2428928|reactome:R-RNO-5673001|reactome:R-RNO-6811558|reactome:R-RNO-74713|reactome:R-RNO-74749|rgd:2922|refseq:NP_037101.1|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0090275"(negative regulation of somatostatin secretion)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071478"(cellular response to radiation)|mint:P35570|dip:DIP-664N	-	-	-	figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/07/13	2014/10/16	rogid:Q3tjNzPTobuShNidgEYMDlV04s010090	rogid:SJ1RT9ubHcFhkPSArSJ6TsPIp0E10116	intact-crc:D63E5694E7F38635|rigid:fxEQy7JUVoSpULeLzrNz1kbMxNs	false	glutathione s tranferase tag:?-?|binding-associated region:924-1821	mutation disrupting interaction:106-106|necessary binding region:3-133(IPR001849)|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8VDD9	uniprotkb:P35569	intact:EBI-1369766|uniprotkb:Q9ESL6|uniprotkb:Q3TS96|uniprotkb:Q80VI6|uniprotkb:Q9EPY1	intact:EBI-400825	psi-mi:phip_mouse(display_long)|uniprotkb:Phip1(gene name synonym)|uniprotkb:Phip(gene name)|psi-mi:Phip(display_short)|uniprotkb:Wdr11(gene name synonym)|uniprotkb:Ndrp(gene name synonym)|uniprotkb:IRS-1 PH domain-binding protein(gene name synonym)|uniprotkb:WD repeat-containing protein 11(gene name synonym)|uniprotkb:Neuronal differentiation-related protein(gene name synonym)	psi-mi:irs1_mouse(display_long)|uniprotkb:Irs1(gene name)|psi-mi:Irs1(display_short)|uniprotkb:Irs-1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Farhang-Fallah et al. (2000)	pubmed:11018022|imex:IM-19437	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1369854|imex:IM-19437-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR028738|interpro:IPR036322|interpro:IPR036427|mint:Q8VDD9|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013418	refseq:NP_034700.2|mint:P35569|dip:DIP-32456N|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031000"(response to caffeine)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0090275"(negative regulation of somatostatin secretion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:1AYB|rcsb pdb:5AXI|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749	-	-	-	figure legend:4A|comment:Interaction was shown using antibody against IRS1 C-terminus. Stimulation with insulin did not change the interaction. Using an antibody against IRS1 PH-domain abolished the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2007/07/13	2014/10/16	rogid:Q3tjNzPTobuShNidgEYMDlV04s010090	rogid:S9ooRqBQ2LriTIe+f2hSyxU8oP010090	intact-crc:ABD43D8A1D999B5F|rigid:fkeVti2cw7ApIDCjzef/mMyYoKs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8VDD9	uniprotkb:P81122	intact:EBI-1369766|uniprotkb:Q9ESL6|uniprotkb:Q3TS96|uniprotkb:Q80VI6|uniprotkb:Q9EPY1	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	psi-mi:phip_mouse(display_long)|uniprotkb:Phip1(gene name synonym)|uniprotkb:Phip(gene name)|psi-mi:Phip(display_short)|uniprotkb:Wdr11(gene name synonym)|uniprotkb:Ndrp(gene name synonym)|uniprotkb:IRS-1 PH domain-binding protein(gene name synonym)|uniprotkb:WD repeat-containing protein 11(gene name synonym)|uniprotkb:Neuronal differentiation-related protein(gene name synonym)	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Farhang-Fallah et al. (2000)	pubmed:11018022|imex:IM-19437	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1369874|imex:IM-19437-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR028738|interpro:IPR036322|interpro:IPR036427|mint:Q8VDD9|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013418	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2007/07/13	2014/10/16	rogid:Q3tjNzPTobuShNidgEYMDlV04s010090	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	intact-crc:56EE44952BFD5B05|rigid:Zuwud7nvQ9Nna+7RcYH1oxn2U6k	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8VDD9	uniprotkb:Q28224	intact:EBI-1369766|uniprotkb:Q9ESL6|uniprotkb:Q3TS96|uniprotkb:Q80VI6|uniprotkb:Q9EPY1	intact:EBI-1369894	psi-mi:phip_mouse(display_long)|uniprotkb:Phip1(gene name synonym)|uniprotkb:Phip(gene name)|psi-mi:Phip(display_short)|uniprotkb:Wdr11(gene name synonym)|uniprotkb:Ndrp(gene name synonym)|uniprotkb:IRS-1 PH domain-binding protein(gene name synonym)|uniprotkb:WD repeat-containing protein 11(gene name synonym)|uniprotkb:Neuronal differentiation-related protein(gene name synonym)	psi-mi:irs1_chlae(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Farhang-Fallah et al. (2000)	pubmed:11018022|imex:IM-19437	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1369911|imex:IM-19437-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR028738|interpro:IPR036322|interpro:IPR036427|mint:Q8VDD9|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013418	interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR039011|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)	-	-	-	figure legend:5A|comment:Stimulation with insulin had no effect on the interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/07/13	2014/10/16	rogid:Q3tjNzPTobuShNidgEYMDlV04s010090	rogid:bNzEEs7b4+QxVVvcmWqZFyIsftY9534	intact-crc:1BDE38D45D5A77E0|rigid:M74/7jneRNo7VFgkKq0ojgacuRQ	false	ha tag:?-?|binding-associated region:927-1140	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)