#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P21583 uniprotkb:P21583 intact:EBI-1379527|uniprotkb:A8K2Q4|uniprotkb:Q68DZ2|uniprotkb:Q7M4N8|uniprotkb:B7ZLM4|uniprotkb:A0AV09|uniprotkb:Q16487|uniprotkb:Q9UQK7|ensembl:ENSP00000495951 intact:EBI-1379527|uniprotkb:A8K2Q4|uniprotkb:Q68DZ2|uniprotkb:Q7M4N8|uniprotkb:B7ZLM4|uniprotkb:A0AV09|uniprotkb:Q16487|uniprotkb:Q9UQK7|ensembl:ENSP00000495951 psi-mi:scf_human(display_long)|uniprotkb:c-Kit ligand(gene name synonym)|uniprotkb:Stem cell factor(gene name synonym)|uniprotkb:Mast cell growth factor(gene name synonym)|uniprotkb:KITLG(gene name)|psi-mi:KITLG(display_short)|uniprotkb:MGF(gene name synonym)|uniprotkb:SCF(gene name synonym) psi-mi:scf_human(display_long)|uniprotkb:c-Kit ligand(gene name synonym)|uniprotkb:Stem cell factor(gene name synonym)|uniprotkb:Mast cell growth factor(gene name synonym)|uniprotkb:KITLG(gene name)|psi-mi:KITLG(display_short)|uniprotkb:MGF(gene name synonym)|uniprotkb:SCF(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Zhang et al. (2000) pubmed:10884405|imex:IM-19954 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1379647|wwpdb:1EXZ|imex:IM-19954-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000890.1|refseq:NP_003985.2|ensembl:ENSG00000049130(gene)|ensembl:ENST00000644744(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002763"(positive regulation of myeloid leukocyte differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005173"(stem cell factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|interpro:IPR003452(Stem cell factor)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1EXZ|rcsb pdb:1SCF|rcsb pdb:2E9W|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558 refseq:NP_000890.1|refseq:NP_003985.2|ensembl:ENSG00000049130(gene)|ensembl:ENST00000644744(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002763"(positive regulation of myeloid leukocyte differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005173"(stem cell factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|interpro:IPR003452(Stem cell factor)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1EXZ|rcsb pdb:1SCF|rcsb pdb:2E9W|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558 go:"GO:0042803"(protein homodimerization activity) - - figure legend:Table 1 and Figure 1|3d-resolution:2.30A|3d-r-factors:working 22.3%, free 29.4%|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/08/01 2014/10/16 rogid:lVHI+urdBzgi2jew8H1xhCNe7mg9606 rogid:lVHI+urdBzgi2jew8H1xhCNe7mg9606 intact-crc:B358904300957F25|rigid:DtIFQMkkH44xJC+7WD3ThU2e9j0 false sufficient binding region:1-141 sufficient binding region:1-141 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)