#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26449	uniprotkb:P47074	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269141|imex:IM-19037-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	-	crc64:0BDFB8697935BCEB	crc64:36550249D81BB6D1	figure legend:Fig 4a, 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	rogid:lyE7pycs775JBy2fvm2J861azlg559292	intact-crc:8B5C9A0B9B761499|rigid:K7nkUD+vnRUMK4rkfjY9FQtfdpQ	false	-	sufficient binding region:308-409	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26309	uniprotkb:P47074	intact:EBI-4212|uniprotkb:D6VU31|ensemblfungi:YGL116W	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	psi-mi:cdc20_yeast(display_long)|uniprotkb:YGL116W(locus name)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:Cell division control protein 20(gene name synonym)	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269146|imex:IM-19037-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011399.1|sgd:S000003084|dip:DIP-982N|mint:P26309|ensemblfungi:YGL116W(gene)|ensemblfungi:YGL116W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|reactome:R-SCE-141405|reactome:R-SCE-141430|reactome:R-SCE-174113|reactome:R-SCE-983168	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	-	crc64:CCE7CD149C1F5ACF	crc64:36550249D81BB6D1	figure legend:Fig 4a, 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:8kkdOD/Z1G1Yf9TcjfvckVxhphk559292	rogid:lyE7pycs775JBy2fvm2J861azlg559292	intact-crc:979F4C50FCDE8A37|rigid:6YYLFVnQ6bVeNxIiGcf6DdQWF9g	false	-	sufficient binding region:1-237	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41695	uniprotkb:P26309	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	intact:EBI-4212|uniprotkb:D6VU31|ensemblfungi:YGL116W	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:cdc20_yeast(display_long)|uniprotkb:YGL116W(locus name)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:Cell division control protein 20(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269151|imex:IM-19037-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	refseq:NP_011399.1|sgd:S000003084|dip:DIP-982N|mint:P26309|ensemblfungi:YGL116W(gene)|ensemblfungi:YGL116W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|reactome:R-SCE-141405|reactome:R-SCE-141430|reactome:R-SCE-174113|reactome:R-SCE-983168	-	crc64:6D76FC980775D3F9	crc64:CCE7CD149C1F5ACF	figure legend:Fig 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rogid:8kkdOD/Z1G1Yf9TcjfvckVxhphk559292	intact-crc:42B87E0936A26A2F|rigid:vq0SudeRskgO3i6cwTpoa1uyz+8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41695	uniprotkb:P26449	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:"MI:0018"(two hybrid)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269155|imex:IM-19037-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	-	crc64:6D76FC980775D3F9	crc64:0BDFB8697935BCEB	figure legend:Fig 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	intact-crc:EC99BCF0088BA618|rigid:uPMpRTuexHAEMob+3KmUDHDObUs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47074	uniprotkb:P26449	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269169|imex:IM-19037-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	-	crc64:36550249D81BB6D1	crc64:0BDFB8697935BCEB	figure legend:Fig. 5A, 6B|comment:Using yeast strains lacking specifically lacking a checkpoint component, it was shown that none of the known checkpoint proteins are required for the Mad3p-Bub3p interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:lyE7pycs775JBy2fvm2J861azlg559292	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	intact-crc:3BBF3E826D645E72|rigid:K7nkUD+vnRUMK4rkfjY9FQtfdpQ	false	mutation decreasing interaction:382-382	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P47074	uniprotkb:P26309	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	intact:EBI-4212|uniprotkb:D6VU31|ensemblfungi:YGL116W	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:cdc20_yeast(display_long)|uniprotkb:YGL116W(locus name)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:Cell division control protein 20(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269178|imex:IM-19037-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	refseq:NP_011399.1|sgd:S000003084|dip:DIP-982N|mint:P26309|ensemblfungi:YGL116W(gene)|ensemblfungi:YGL116W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|reactome:R-SCE-141405|reactome:R-SCE-141430|reactome:R-SCE-174113|reactome:R-SCE-983168	-	crc64:36550249D81BB6D1	crc64:CCE7CD149C1F5ACF	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:lyE7pycs775JBy2fvm2J861azlg559292	rogid:8kkdOD/Z1G1Yf9TcjfvckVxhphk559292	intact-crc:24223A7FB9274760|rigid:6YYLFVnQ6bVeNxIiGcf6DdQWF9g	false	binding-associated region:156-159	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26449	uniprotkb:P47074	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269195|imex:IM-19037-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	-	crc64:0BDFB8697935BCEB	crc64:36550249D81BB6D1	figure legend:Fig 5d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/29	2014/10/16	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	rogid:lyE7pycs775JBy2fvm2J861azlg559292	intact-crc:A0D105DB1B1460E6|rigid:K7nkUD+vnRUMK4rkfjY9FQtfdpQ	false	radiolabel:?-?	sufficient binding region:176-409|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P47074	uniprotkb:P26449	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	intact:EBI-3830|uniprotkb:D6W292|ensemblfungi:YOR026W	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:bub3_yeast(display_long)|uniprotkb:OR26.16(orf name)|uniprotkb:YOR026W(locus name)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269212|imex:IM-19037-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	refseq:NP_014669.1|sgd:S000005552|reactome:R-SCE-141430|dip:DIP-1219N|ensemblfungi:YOR026W(gene)|ensemblfungi:YOR026W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:1U4C|rcsb pdb:1YFQ|rcsb pdb:2I3S|rcsb pdb:2I3T|rcsb pdb:4BL0	-	crc64:36550249D81BB6D1	crc64:0BDFB8697935BCEB	figure legend:Fig 6a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:lyE7pycs775JBy2fvm2J861azlg559292	rogid:y8P+TfgWS+dySWQDW7eo6YOGjwU559292	intact-crc:BF4EC4814EAF8875|rigid:K7nkUD+vnRUMK4rkfjY9FQtfdpQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40958	uniprotkb:P47074	intact:EBI-10362|ensemblfungi:YJL030W|uniprotkb:D6VWF2	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	psi-mi:mad2_yeast(display_long)|uniprotkb:MAD2(gene name)|psi-mi:MAD2(display_short)|uniprotkb:J1256(orf name)|uniprotkb:YJL030W(locus name)	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269217|imex:IM-19037-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003567|ensemblfungi:YJL030W(gene)|ensemblfungi:YJL030W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051312"(chromosome decondensation)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR027097|interpro:IPR036570|reactome:R-SCE-141405|reactome:R-SCE-141430|refseq:NP_012504.3|dip:DIP-815N|mint:P40958	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	go:"GO:0000082"(G1/S transition of mitotic cell cycle)	-	crc64:36550249D81BB6D1	figure legend:Fig 6a, 7a|comment:Interaction occurs when cells are in S and to a lesser extent G1 phase. Requires the presence of other check point proteins, with the exception of Bub2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:0pxFckODTcklkGn+JcczltjSHRU559292	rogid:lyE7pycs775JBy2fvm2J861azlg559292	intact-crc:77F9A44A46FF0E55|rigid:zBlp7VL20eeUxSDkp0U1etK/j2k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26309	uniprotkb:P47074	intact:EBI-4212|uniprotkb:D6VU31|ensemblfungi:YGL116W	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	psi-mi:cdc20_yeast(display_long)|uniprotkb:YGL116W(locus name)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:Cell division control protein 20(gene name synonym)	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269224|imex:IM-19037-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011399.1|sgd:S000003084|dip:DIP-982N|mint:P26309|ensemblfungi:YGL116W(gene)|ensemblfungi:YGL116W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|reactome:R-SCE-141405|reactome:R-SCE-141430|reactome:R-SCE-174113|reactome:R-SCE-983168	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	go:"GO:0000082"(G1/S transition of mitotic cell cycle)	crc64:CCE7CD149C1F5ACF	crc64:36550249D81BB6D1	figure legend:Fig 6a|comment:Interaction occurs when cells are in S and to a lesser extent G1 phase|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:8kkdOD/Z1G1Yf9TcjfvckVxhphk559292	rogid:lyE7pycs775JBy2fvm2J861azlg559292	intact-crc:9273FC8FC003C0CD|rigid:6YYLFVnQ6bVeNxIiGcf6DdQWF9g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26309	uniprotkb:P47074	intact:EBI-4212|uniprotkb:D6VU31|ensemblfungi:YGL116W	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	psi-mi:cdc20_yeast(display_long)|uniprotkb:YGL116W(locus name)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:Cell division control protein 20(gene name synonym)	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269232|imex:IM-19037-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011399.1|sgd:S000003084|dip:DIP-982N|mint:P26309|ensemblfungi:YGL116W(gene)|ensemblfungi:YGL116W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|reactome:R-SCE-141405|reactome:R-SCE-141430|reactome:R-SCE-174113|reactome:R-SCE-983168	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	-	crc64:CCE7CD149C1F5ACF	crc64:36550249D81BB6D1	figure legend:Fig 7a|comment:Interaction requires the presence of other checkpoint proteins, with the exception of Bub2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:8kkdOD/Z1G1Yf9TcjfvckVxhphk559292	rogid:lyE7pycs775JBy2fvm2J861azlg559292	intact-crc:A63E6F2361D5E44F|rigid:6YYLFVnQ6bVeNxIiGcf6DdQWF9g	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40958	uniprotkb:P26309	intact:EBI-10362|ensemblfungi:YJL030W|uniprotkb:D6VWF2	intact:EBI-4212|uniprotkb:D6VU31|ensemblfungi:YGL116W	psi-mi:mad2_yeast(display_long)|uniprotkb:MAD2(gene name)|psi-mi:MAD2(display_short)|uniprotkb:J1256(orf name)|uniprotkb:YJL030W(locus name)	psi-mi:cdc20_yeast(display_long)|uniprotkb:YGL116W(locus name)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:Cell division control protein 20(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269241|imex:IM-19037-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003567|ensemblfungi:YJL030W(gene)|ensemblfungi:YJL030W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051312"(chromosome decondensation)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR027097|interpro:IPR036570|reactome:R-SCE-141405|reactome:R-SCE-141430|refseq:NP_012504.3|dip:DIP-815N|mint:P40958	refseq:NP_011399.1|sgd:S000003084|dip:DIP-982N|mint:P26309|ensemblfungi:YGL116W(gene)|ensemblfungi:YGL116W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|reactome:R-SCE-141405|reactome:R-SCE-141430|reactome:R-SCE-174113|reactome:R-SCE-983168	-	-	crc64:CCE7CD149C1F5ACF	figure legend:Fig. 7B|comment:Interaction occurs in the absence of Mad3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:0pxFckODTcklkGn+JcczltjSHRU559292	rogid:8kkdOD/Z1G1Yf9TcjfvckVxhphk559292	intact-crc:E203AE7E333C1005|rigid:TMAeuLLYSIEy1s2XkGp4T/qzJhQ	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26309	uniprotkb:P40958	intact:EBI-4212|uniprotkb:D6VU31|ensemblfungi:YGL116W	intact:EBI-10362|ensemblfungi:YJL030W|uniprotkb:D6VWF2	psi-mi:cdc20_yeast(display_long)|uniprotkb:YGL116W(locus name)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:Cell division control protein 20(gene name synonym)	psi-mi:mad2_yeast(display_long)|uniprotkb:MAD2(gene name)|psi-mi:MAD2(display_short)|uniprotkb:J1256(orf name)|uniprotkb:YJL030W(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269249|imex:IM-19037-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011399.1|sgd:S000003084|dip:DIP-982N|mint:P26309|ensemblfungi:YGL116W(gene)|ensemblfungi:YGL116W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|reactome:R-SCE-141405|reactome:R-SCE-141430|reactome:R-SCE-174113|reactome:R-SCE-983168	sgd:S000003567|ensemblfungi:YJL030W(gene)|ensemblfungi:YJL030W_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051312"(chromosome decondensation)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR027097|interpro:IPR036570|reactome:R-SCE-141405|reactome:R-SCE-141430|refseq:NP_012504.3|dip:DIP-815N|mint:P40958	-	crc64:CCE7CD149C1F5ACF	-	figure legend:Fig. 7B|agonist:Nocodazole - induces spindle checkpoint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:8kkdOD/Z1G1Yf9TcjfvckVxhphk559292	rogid:0pxFckODTcklkGn+JcczltjSHRU559292	intact-crc:E33FBB27525E590A|rigid:DckVDJKotc+XfOeSR7QUGmkabs8	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26309	uniprotkb:P47074	intact:EBI-4212|uniprotkb:D6VU31|ensemblfungi:YGL116W	intact:EBI-10369|ensemblfungi:YJL013C|uniprotkb:D6VWG4	psi-mi:cdc20_yeast(display_long)|uniprotkb:YGL116W(locus name)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:Cell division control protein 20(gene name synonym)	psi-mi:mad3_yeast(display_long)|uniprotkb:MAD3(gene name)|psi-mi:MAD3(display_short)|uniprotkb:YJL013C(locus name)|uniprotkb:J1341(orf name)|uniprotkb:Mitotic MAD3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hardwick et al. (2000)	pubmed:10704439|imex:IM-19037	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1269249|imex:IM-19037-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011399.1|sgd:S000003084|dip:DIP-982N|mint:P26309|ensemblfungi:YGL116W(gene)|ensemblfungi:YGL116W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|reactome:R-SCE-141405|reactome:R-SCE-141430|reactome:R-SCE-174113|reactome:R-SCE-983168	sgd:S000003550|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|rcsb pdb:2I3T|ensemblfungi:YJL013C(gene)|ensemblfungi:YJL013C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0032837"(distributive segregation)|refseq:NP_012521.3|dip:DIP-1268N	-	crc64:CCE7CD149C1F5ACF	crc64:36550249D81BB6D1	figure legend:Fig. 7B|agonist:Nocodazole - induces spindle checkpoint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/06/29	2014/10/16	rogid:8kkdOD/Z1G1Yf9TcjfvckVxhphk559292	rogid:lyE7pycs775JBy2fvm2J861azlg559292	intact-crc:E33FBB27525E590A|rigid:DckVDJKotc+XfOeSR7QUGmkabs8	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)