#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6BER6 uniprotkb:Q95Q17 intact:EBI-1533858|ensemblmetazoa:C24H11.9.1 intact:EBI-1533863|uniprotkb:Q9XWF7|ensemblmetazoa:Y54E5B.3b.1 psi-mi:med21_caeel(display_long)|uniprotkb:mdt-21(gene name)|psi-mi:mdt-21(display_short)|uniprotkb:C24H11.9(orf name)|uniprotkb:Mediator complex subunit 21(gene name synonym)|uniprotkb:CeSRB7(gene name synonym) psi-mi:med7_caeel(display_long)|uniprotkb:let-49(gene name)|psi-mi:let-49(display_short)|uniprotkb:mdt-7(gene name synonym)|uniprotkb:med-7(gene name synonym)|uniprotkb:Y54E5B.3(orf name)|uniprotkb:Mediator complex subunit 7(gene name synonym)|uniprotkb:CeMED7(gene name synonym)|uniprotkb:Lethal protein 49(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533856|imex:IM-19746-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021384|refseq:NP_001021184.1|wormbase:C24H11.9|interpro:IPR037212|ensemblmetazoa:C24H11.9.1(transcript)|ensemblmetazoa:WBGene00007704(gene)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex) refseq:NP_493585.1|refseq:NP_493586.1|wormbase:Y54E5B.3a|wormbase:Y54E5B.3b|interpro:IPR009244(MED7)|interpro:IPR037212|ensemblmetazoa:WBGene00002324(gene)|ensemblmetazoa:Y54E5B.3b.1(transcript)|go:"GO:0000003"(reproduction)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex) - - - figure legend:Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:FWa5qV3TCPgaDnH2xK3M++m4wEw6239 rogid:2vnSzQQim7krI84wwUv0n3B+TB86239 intact-crc:D0A51DACB7331A84|rigid:7OY5HImUgETKhwYzENRA9jaFa5M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P45966 uniprotkb:Q6BER6 intact:EBI-1533890|ensemblmetazoa:T09A5.6.1 intact:EBI-1533858|ensemblmetazoa:C24H11.9.1 psi-mi:med10_caeel(display_long)|uniprotkb:T09A5.6(orf name)|uniprotkb:mdt-10(gene name)|psi-mi:mdt-10(display_short)|uniprotkb:Mediator complex subunit 10(gene name synonym)|uniprotkb:CeMED10(gene name synonym)|uniprotkb:CeNUT2(gene name synonym) psi-mi:med21_caeel(display_long)|uniprotkb:mdt-21(gene name)|psi-mi:mdt-21(display_short)|uniprotkb:C24H11.9(orf name)|uniprotkb:Mediator complex subunit 21(gene name synonym)|uniprotkb:CeSRB7(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533901|imex:IM-19746-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:T09A5.6|interpro:IPR019145|refseq:NP_495650.2|ensemblmetazoa:T09A5.6.1(transcript)|ensemblmetazoa:WBGene00007014(gene)|go:"GO:0000785"(chromatin)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) interpro:IPR021384|refseq:NP_001021184.1|wormbase:C24H11.9|interpro:IPR037212|ensemblmetazoa:C24H11.9.1(transcript)|ensemblmetazoa:WBGene00007704(gene)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex) - - - figure legend:Fig 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:5RuS4RbyMC9tBlZ2U38GWc9CJBw6239 rogid:FWa5qV3TCPgaDnH2xK3M++m4wEw6239 intact-crc:3007757C359FD409|rigid:FYEPoA7asJzxZIB73J8CZJaZe74 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P45966 uniprotkb:Q95Q17 intact:EBI-1533890|ensemblmetazoa:T09A5.6.1 intact:EBI-1533863|uniprotkb:Q9XWF7|ensemblmetazoa:Y54E5B.3b.1 psi-mi:med10_caeel(display_long)|uniprotkb:T09A5.6(orf name)|uniprotkb:mdt-10(gene name)|psi-mi:mdt-10(display_short)|uniprotkb:Mediator complex subunit 10(gene name synonym)|uniprotkb:CeMED10(gene name synonym)|uniprotkb:CeNUT2(gene name synonym) psi-mi:med7_caeel(display_long)|uniprotkb:let-49(gene name)|psi-mi:let-49(display_short)|uniprotkb:mdt-7(gene name synonym)|uniprotkb:med-7(gene name synonym)|uniprotkb:Y54E5B.3(orf name)|uniprotkb:Mediator complex subunit 7(gene name synonym)|uniprotkb:CeMED7(gene name synonym)|uniprotkb:Lethal protein 49(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533901|imex:IM-19746-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:T09A5.6|interpro:IPR019145|refseq:NP_495650.2|ensemblmetazoa:T09A5.6.1(transcript)|ensemblmetazoa:WBGene00007014(gene)|go:"GO:0000785"(chromatin)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) refseq:NP_493585.1|refseq:NP_493586.1|wormbase:Y54E5B.3a|wormbase:Y54E5B.3b|interpro:IPR009244(MED7)|interpro:IPR037212|ensemblmetazoa:WBGene00002324(gene)|ensemblmetazoa:Y54E5B.3b.1(transcript)|go:"GO:0000003"(reproduction)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex) - - - figure legend:Fig 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:5RuS4RbyMC9tBlZ2U38GWc9CJBw6239 rogid:2vnSzQQim7krI84wwUv0n3B+TB86239 intact-crc:3007757C359FD409|rigid:FYEPoA7asJzxZIB73J8CZJaZe74 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P45966 uniprotkb:P16356 intact:EBI-1533890|ensemblmetazoa:T09A5.6.1 intact:EBI-1533906|uniprotkb:Q20090|ensemblmetazoa:F36A4.7.1|ensemblmetazoa:F36A4.7.2 psi-mi:med10_caeel(display_long)|uniprotkb:T09A5.6(orf name)|uniprotkb:mdt-10(gene name)|psi-mi:mdt-10(display_short)|uniprotkb:Mediator complex subunit 10(gene name synonym)|uniprotkb:CeMED10(gene name synonym)|uniprotkb:CeNUT2(gene name synonym) psi-mi:rpb1_caeel(display_long)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:ama-1(gene name)|psi-mi:ama-1(display_short)|uniprotkb:F36A4.7(orf name)|uniprotkb:rpb-1(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533901|imex:IM-19746-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:T09A5.6|interpro:IPR019145|refseq:NP_495650.2|ensemblmetazoa:T09A5.6.1(transcript)|ensemblmetazoa:WBGene00007014(gene)|go:"GO:0000785"(chromatin)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) reactome:R-CEL-5578749|refseq:NP_500523.4|reactome:R-CEL-674695|interpro:IPR038120|interpro:IPR038593|wormbase:F36A4.7|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|reactome:R-CEL-113418|reactome:R-CEL-6782135|reactome:R-CEL-6781823|reactome:R-CEL-6782210|reactome:R-CEL-6796648|reactome:R-CEL-6803529|reactome:R-CEL-6807505|reactome:R-CEL-72086|reactome:R-CEL-72163|reactome:R-CEL-72165|reactome:R-CEL-73776|reactome:R-CEL-73779|reactome:R-CEL-75953|reactome:R-CEL-75955|reactome:R-CEL-76042|reactome:R-CEL-77075|reactome:R-CEL-9018519|interpro:IPR042102|reactome:R-CEL-112382|ensemblmetazoa:F36A4.7.1(transcript)|ensemblmetazoa:WBGene00000123(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007369"(gastrulation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0035327"|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:2000543"(positive regulation of gastrulation)|ensemblmetazoa:F36A4.7.2(transcript) - - - figure legend:Fig 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:5RuS4RbyMC9tBlZ2U38GWc9CJBw6239 rogid:j1BypFz69JhWH82rWN0U4MuFeS46239 intact-crc:3007757C359FD409|rigid:FYEPoA7asJzxZIB73J8CZJaZe74 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9N337 uniprotkb:P16356 intact:EBI-1533827|uniprotkb:O18534|ensemblmetazoa:Y57E12AL.5.1 intact:EBI-1533906|uniprotkb:Q20090|ensemblmetazoa:F36A4.7.1|ensemblmetazoa:F36A4.7.2 psi-mi:med6_caeel(display_long)|uniprotkb:mdt-6(gene name)|psi-mi:mdt-6(display_short)|uniprotkb:med-6(gene name synonym)|uniprotkb:Y57E12AL.5(orf name)|uniprotkb:Mediator complex subunit 6(gene name synonym)|uniprotkb:CeMED6(gene name synonym)|uniprotkb:c-MED6(gene name synonym) psi-mi:rpb1_caeel(display_long)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:ama-1(gene name)|psi-mi:ama-1(display_short)|uniprotkb:F36A4.7(orf name)|uniprotkb:rpb-1(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533952|imex:IM-19746-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR038566|refseq:NP_504791.3|wormbase:Y57E12AL.5|interpro:IPR007018(MED6 mediator)|interpro:IPR016820(Mediator complex, subunit 6, metazoa/plant)|ensemblmetazoa:WBGene00003164(gene)|ensemblmetazoa:Y57E12AL.5.1(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex) reactome:R-CEL-5578749|refseq:NP_500523.4|reactome:R-CEL-674695|interpro:IPR038120|interpro:IPR038593|wormbase:F36A4.7|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|reactome:R-CEL-113418|reactome:R-CEL-6782135|reactome:R-CEL-6781823|reactome:R-CEL-6782210|reactome:R-CEL-6796648|reactome:R-CEL-6803529|reactome:R-CEL-6807505|reactome:R-CEL-72086|reactome:R-CEL-72163|reactome:R-CEL-72165|reactome:R-CEL-73776|reactome:R-CEL-73779|reactome:R-CEL-75953|reactome:R-CEL-75955|reactome:R-CEL-76042|reactome:R-CEL-77075|reactome:R-CEL-9018519|interpro:IPR042102|reactome:R-CEL-112382|ensemblmetazoa:F36A4.7.1(transcript)|ensemblmetazoa:WBGene00000123(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007369"(gastrulation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0035327"|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:2000543"(positive regulation of gastrulation)|ensemblmetazoa:F36A4.7.2(transcript) - - - figure legend:Fig 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:Nx/uz4CIDoiQtuqrMGybM0vySvE6239 rogid:j1BypFz69JhWH82rWN0U4MuFeS46239 intact-crc:2093236123EB6DFC|rigid:E9BX65YD5Hko6viP2CT1xvkVwhs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q95Q17 uniprotkb:Q6BER6 intact:EBI-1533863|uniprotkb:Q9XWF7|ensemblmetazoa:Y54E5B.3b.1 intact:EBI-1533858|ensemblmetazoa:C24H11.9.1 psi-mi:med7_caeel(display_long)|uniprotkb:let-49(gene name)|psi-mi:let-49(display_short)|uniprotkb:mdt-7(gene name synonym)|uniprotkb:med-7(gene name synonym)|uniprotkb:Y54E5B.3(orf name)|uniprotkb:Mediator complex subunit 7(gene name synonym)|uniprotkb:CeMED7(gene name synonym)|uniprotkb:Lethal protein 49(gene name synonym) psi-mi:med21_caeel(display_long)|uniprotkb:mdt-21(gene name)|psi-mi:mdt-21(display_short)|uniprotkb:C24H11.9(orf name)|uniprotkb:Mediator complex subunit 21(gene name synonym)|uniprotkb:CeSRB7(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533939|imex:IM-19746-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_493585.1|refseq:NP_493586.1|wormbase:Y54E5B.3a|wormbase:Y54E5B.3b|interpro:IPR009244(MED7)|interpro:IPR037212|ensemblmetazoa:WBGene00002324(gene)|ensemblmetazoa:Y54E5B.3b.1(transcript)|go:"GO:0000003"(reproduction)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex) interpro:IPR021384|refseq:NP_001021184.1|wormbase:C24H11.9|interpro:IPR037212|ensemblmetazoa:C24H11.9.1(transcript)|ensemblmetazoa:WBGene00007704(gene)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex) - - - figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:2vnSzQQim7krI84wwUv0n3B+TB86239 rogid:FWa5qV3TCPgaDnH2xK3M++m4wEw6239 intact-crc:E1DC3FF5103F3D87|rigid:FYEPoA7asJzxZIB73J8CZJaZe74 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q95Q17 uniprotkb:P16356 intact:EBI-1533863|uniprotkb:Q9XWF7|ensemblmetazoa:Y54E5B.3b.1 intact:EBI-1533906|uniprotkb:Q20090|ensemblmetazoa:F36A4.7.1|ensemblmetazoa:F36A4.7.2 psi-mi:med7_caeel(display_long)|uniprotkb:let-49(gene name)|psi-mi:let-49(display_short)|uniprotkb:mdt-7(gene name synonym)|uniprotkb:med-7(gene name synonym)|uniprotkb:Y54E5B.3(orf name)|uniprotkb:Mediator complex subunit 7(gene name synonym)|uniprotkb:CeMED7(gene name synonym)|uniprotkb:Lethal protein 49(gene name synonym) psi-mi:rpb1_caeel(display_long)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:ama-1(gene name)|psi-mi:ama-1(display_short)|uniprotkb:F36A4.7(orf name)|uniprotkb:rpb-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533939|imex:IM-19746-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_493585.1|refseq:NP_493586.1|wormbase:Y54E5B.3a|wormbase:Y54E5B.3b|interpro:IPR009244(MED7)|interpro:IPR037212|ensemblmetazoa:WBGene00002324(gene)|ensemblmetazoa:Y54E5B.3b.1(transcript)|go:"GO:0000003"(reproduction)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex) reactome:R-CEL-5578749|refseq:NP_500523.4|reactome:R-CEL-674695|interpro:IPR038120|interpro:IPR038593|wormbase:F36A4.7|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|reactome:R-CEL-113418|reactome:R-CEL-6782135|reactome:R-CEL-6781823|reactome:R-CEL-6782210|reactome:R-CEL-6796648|reactome:R-CEL-6803529|reactome:R-CEL-6807505|reactome:R-CEL-72086|reactome:R-CEL-72163|reactome:R-CEL-72165|reactome:R-CEL-73776|reactome:R-CEL-73779|reactome:R-CEL-75953|reactome:R-CEL-75955|reactome:R-CEL-76042|reactome:R-CEL-77075|reactome:R-CEL-9018519|interpro:IPR042102|reactome:R-CEL-112382|ensemblmetazoa:F36A4.7.1(transcript)|ensemblmetazoa:WBGene00000123(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007369"(gastrulation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0035327"|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:2000543"(positive regulation of gastrulation)|ensemblmetazoa:F36A4.7.2(transcript) - - - figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:2vnSzQQim7krI84wwUv0n3B+TB86239 rogid:j1BypFz69JhWH82rWN0U4MuFeS46239 intact-crc:E1DC3FF5103F3D87|rigid:FYEPoA7asJzxZIB73J8CZJaZe74 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q95Q17 uniprotkb:P45966 intact:EBI-1533863|uniprotkb:Q9XWF7|ensemblmetazoa:Y54E5B.3b.1 intact:EBI-1533890|ensemblmetazoa:T09A5.6.1 psi-mi:med7_caeel(display_long)|uniprotkb:let-49(gene name)|psi-mi:let-49(display_short)|uniprotkb:mdt-7(gene name synonym)|uniprotkb:med-7(gene name synonym)|uniprotkb:Y54E5B.3(orf name)|uniprotkb:Mediator complex subunit 7(gene name synonym)|uniprotkb:CeMED7(gene name synonym)|uniprotkb:Lethal protein 49(gene name synonym) psi-mi:med10_caeel(display_long)|uniprotkb:T09A5.6(orf name)|uniprotkb:mdt-10(gene name)|psi-mi:mdt-10(display_short)|uniprotkb:Mediator complex subunit 10(gene name synonym)|uniprotkb:CeMED10(gene name synonym)|uniprotkb:CeNUT2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533939|imex:IM-19746-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_493585.1|refseq:NP_493586.1|wormbase:Y54E5B.3a|wormbase:Y54E5B.3b|interpro:IPR009244(MED7)|interpro:IPR037212|ensemblmetazoa:WBGene00002324(gene)|ensemblmetazoa:Y54E5B.3b.1(transcript)|go:"GO:0000003"(reproduction)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex) wormbase:T09A5.6|interpro:IPR019145|refseq:NP_495650.2|ensemblmetazoa:T09A5.6.1(transcript)|ensemblmetazoa:WBGene00007014(gene)|go:"GO:0000785"(chromatin)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:2vnSzQQim7krI84wwUv0n3B+TB86239 rogid:5RuS4RbyMC9tBlZ2U38GWc9CJBw6239 intact-crc:E1DC3FF5103F3D87|rigid:FYEPoA7asJzxZIB73J8CZJaZe74 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9N337 uniprotkb:P16356 intact:EBI-1533827|uniprotkb:O18534|ensemblmetazoa:Y57E12AL.5.1 intact:EBI-1533906|uniprotkb:Q20090|ensemblmetazoa:F36A4.7.1|ensemblmetazoa:F36A4.7.2 psi-mi:med6_caeel(display_long)|uniprotkb:mdt-6(gene name)|psi-mi:mdt-6(display_short)|uniprotkb:med-6(gene name synonym)|uniprotkb:Y57E12AL.5(orf name)|uniprotkb:Mediator complex subunit 6(gene name synonym)|uniprotkb:CeMED6(gene name synonym)|uniprotkb:c-MED6(gene name synonym) psi-mi:rpb1_caeel(display_long)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:ama-1(gene name)|psi-mi:ama-1(display_short)|uniprotkb:F36A4.7(orf name)|uniprotkb:rpb-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533945|imex:IM-19746-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR038566|refseq:NP_504791.3|wormbase:Y57E12AL.5|interpro:IPR007018(MED6 mediator)|interpro:IPR016820(Mediator complex, subunit 6, metazoa/plant)|ensemblmetazoa:WBGene00003164(gene)|ensemblmetazoa:Y57E12AL.5.1(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex) reactome:R-CEL-5578749|refseq:NP_500523.4|reactome:R-CEL-674695|interpro:IPR038120|interpro:IPR038593|wormbase:F36A4.7|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|reactome:R-CEL-113418|reactome:R-CEL-6782135|reactome:R-CEL-6781823|reactome:R-CEL-6782210|reactome:R-CEL-6796648|reactome:R-CEL-6803529|reactome:R-CEL-6807505|reactome:R-CEL-72086|reactome:R-CEL-72163|reactome:R-CEL-72165|reactome:R-CEL-73776|reactome:R-CEL-73779|reactome:R-CEL-75953|reactome:R-CEL-75955|reactome:R-CEL-76042|reactome:R-CEL-77075|reactome:R-CEL-9018519|interpro:IPR042102|reactome:R-CEL-112382|ensemblmetazoa:F36A4.7.1(transcript)|ensemblmetazoa:WBGene00000123(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007369"(gastrulation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0035327"|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:2000543"(positive regulation of gastrulation)|ensemblmetazoa:F36A4.7.2(transcript) - - - figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:Nx/uz4CIDoiQtuqrMGybM0vySvE6239 rogid:j1BypFz69JhWH82rWN0U4MuFeS46239 intact-crc:336C6956C22A0219|rigid:E9BX65YD5Hko6viP2CT1xvkVwhs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6BER6 uniprotkb:Q9N337 intact:EBI-1533858|ensemblmetazoa:C24H11.9.1 intact:EBI-1533827|uniprotkb:O18534|ensemblmetazoa:Y57E12AL.5.1 psi-mi:med21_caeel(display_long)|uniprotkb:mdt-21(gene name)|psi-mi:mdt-21(display_short)|uniprotkb:C24H11.9(orf name)|uniprotkb:Mediator complex subunit 21(gene name synonym)|uniprotkb:CeSRB7(gene name synonym) psi-mi:med6_caeel(display_long)|uniprotkb:mdt-6(gene name)|psi-mi:mdt-6(display_short)|uniprotkb:med-6(gene name synonym)|uniprotkb:Y57E12AL.5(orf name)|uniprotkb:Mediator complex subunit 6(gene name synonym)|uniprotkb:CeMED6(gene name synonym)|uniprotkb:c-MED6(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533964|imex:IM-19746-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021384|refseq:NP_001021184.1|wormbase:C24H11.9|interpro:IPR037212|ensemblmetazoa:C24H11.9.1(transcript)|ensemblmetazoa:WBGene00007704(gene)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex) interpro:IPR038566|refseq:NP_504791.3|wormbase:Y57E12AL.5|interpro:IPR007018(MED6 mediator)|interpro:IPR016820(Mediator complex, subunit 6, metazoa/plant)|ensemblmetazoa:WBGene00003164(gene)|ensemblmetazoa:Y57E12AL.5.1(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex) - - - figure legend:Fig 2D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:FWa5qV3TCPgaDnH2xK3M++m4wEw6239 rogid:Nx/uz4CIDoiQtuqrMGybM0vySvE6239 intact-crc:06920CBD87E2AFE7|rigid:PbMqWi5ceUb5Va8Zp7x4reQ1ujs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6BER6 uniprotkb:P16356 intact:EBI-1533858|ensemblmetazoa:C24H11.9.1 intact:EBI-1533906|uniprotkb:Q20090|ensemblmetazoa:F36A4.7.1|ensemblmetazoa:F36A4.7.2 psi-mi:med21_caeel(display_long)|uniprotkb:mdt-21(gene name)|psi-mi:mdt-21(display_short)|uniprotkb:C24H11.9(orf name)|uniprotkb:Mediator complex subunit 21(gene name synonym)|uniprotkb:CeSRB7(gene name synonym) psi-mi:rpb1_caeel(display_long)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:ama-1(gene name)|psi-mi:ama-1(display_short)|uniprotkb:F36A4.7(orf name)|uniprotkb:rpb-1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Kwon et al. (1999) pubmed:10611325|imex:IM-19746 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1533964|imex:IM-19746-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021384|refseq:NP_001021184.1|wormbase:C24H11.9|interpro:IPR037212|ensemblmetazoa:C24H11.9.1(transcript)|ensemblmetazoa:WBGene00007704(gene)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex) reactome:R-CEL-5578749|refseq:NP_500523.4|reactome:R-CEL-674695|interpro:IPR038120|interpro:IPR038593|wormbase:F36A4.7|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|reactome:R-CEL-113418|reactome:R-CEL-6782135|reactome:R-CEL-6781823|reactome:R-CEL-6782210|reactome:R-CEL-6796648|reactome:R-CEL-6803529|reactome:R-CEL-6807505|reactome:R-CEL-72086|reactome:R-CEL-72163|reactome:R-CEL-72165|reactome:R-CEL-73776|reactome:R-CEL-73779|reactome:R-CEL-75953|reactome:R-CEL-75955|reactome:R-CEL-76042|reactome:R-CEL-77075|reactome:R-CEL-9018519|interpro:IPR042102|reactome:R-CEL-112382|ensemblmetazoa:F36A4.7.1(transcript)|ensemblmetazoa:WBGene00000123(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007369"(gastrulation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0035327"|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:2000543"(positive regulation of gastrulation)|ensemblmetazoa:F36A4.7.2(transcript) - - - figure legend:Fig 2D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2007/09/19 2014/10/16 rogid:FWa5qV3TCPgaDnH2xK3M++m4wEw6239 rogid:j1BypFz69JhWH82rWN0U4MuFeS46239 intact-crc:06920CBD87E2AFE7|rigid:PbMqWi5ceUb5Va8Zp7x4reQ1ujs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)