#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P38700	uniprotkb:P36000	intact:EBI-2705|uniprotkb:D3DKR4|ensemblfungi:YHL019C	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	psi-mi:apm2_yeast(display_long)|uniprotkb:APM2(gene name)|psi-mi:APM2(display_short)|uniprotkb:Adaptin-mu1-II(gene name synonym)|uniprotkb:YHL019C(locus name)	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560470|imex:IM-19316-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011844.1|sgd:S000001011|dip:DIP-1200N|mint:P38700|ensemblfungi:YHL019C(gene)|ensemblfungi:YHL019C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006897"(endocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR027200|interpro:IPR028565|interpro:IPR036168|reactome:R-SCE-8856825	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:7E216B11325EEE3C	crc64:89893945D4EC6C4A	figure legend:"Fig: 1E"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:dh+rB95eFgDQruQWkigoIiBW8+k559292	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	intact-crc:BCB65473A44A1341|rigid:EdZWiijiesxZiUyhI9y7kayTG0o	false	-	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00776	uniprotkb:P35181	intact:EBI-2624|uniprotkb:D6W3B0|ensemblfungi:YPL259C	intact:EBI-2612|uniprotkb:D6VYH5|ensemblfungi:YLR170C	psi-mi:ap1m1_yeast(display_long)|uniprotkb:APM1(gene name)|psi-mi:APM1(display_short)|uniprotkb:YAP54(gene name synonym)|uniprotkb:YPL259C(locus name)|uniprotkb:P0394(orf name)|uniprotkb:Mu1-I-adaptin(gene name synonym)|uniprotkb:"Mu(1)-adaptin"(gene name synonym)|uniprotkb:Golgi adaptor AP-1 54 kDa protein(gene name synonym)|uniprotkb:HA1 54 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP54(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP54(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1-I medium chain(gene name synonym)	psi-mi:ap1s1_yeast(display_long)|uniprotkb:APS1(gene name)|psi-mi:APS1(display_short)|uniprotkb:YAP19(gene name synonym)|uniprotkb:YLR170C(locus name)|uniprotkb:L9470.16(orf name)|uniprotkb:Sigma1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor AP-1 19 kDa adaptin(gene name synonym)|uniprotkb:HA1 19 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP19(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP19(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 sigma-1 small chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560512|imex:IM-19316-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015064.1|sgd:S000006180|dip:DIP-1198N|mint:Q00776|ensemblfungi:YPL259C(gene)|ensemblfungi:YPL259C_mRNA(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|reactome:R-SCE-432720|reactome:R-SCE-6798695	refseq:NP_013271.1|sgd:S000004160|dip:DIP-4806N|mint:P35181|ensemblfungi:YLR170C(gene)|ensemblfungi:YLR170C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|reactome:R-SCE-432720	-	crc64:C6B11153B845921C	crc64:1A584883F1DF815D	figure legend:"Fig: 1B & 1D"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:i+bg9eNIcUTBkm2e24EczcfL7AQ559292	rogid:MSl/Rj/unUQm0HSBgFC1jyYJpBM559292	intact-crc:B12554FF54BEEFC5|rigid:VMCq912d+abkH38Hc6gXj6jNZjE	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00776	uniprotkb:P36000	intact:EBI-2624|uniprotkb:D6W3B0|ensemblfungi:YPL259C	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	psi-mi:ap1m1_yeast(display_long)|uniprotkb:APM1(gene name)|psi-mi:APM1(display_short)|uniprotkb:YAP54(gene name synonym)|uniprotkb:YPL259C(locus name)|uniprotkb:P0394(orf name)|uniprotkb:Mu1-I-adaptin(gene name synonym)|uniprotkb:"Mu(1)-adaptin"(gene name synonym)|uniprotkb:Golgi adaptor AP-1 54 kDa protein(gene name synonym)|uniprotkb:HA1 54 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP54(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP54(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1-I medium chain(gene name synonym)	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560512|imex:IM-19316-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015064.1|sgd:S000006180|dip:DIP-1198N|mint:Q00776|ensemblfungi:YPL259C(gene)|ensemblfungi:YPL259C_mRNA(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|reactome:R-SCE-432720|reactome:R-SCE-6798695	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:C6B11153B845921C	crc64:89893945D4EC6C4A	figure legend:"Fig: 1B & 1D"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:i+bg9eNIcUTBkm2e24EczcfL7AQ559292	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	intact-crc:B12554FF54BEEFC5|rigid:VMCq912d+abkH38Hc6gXj6jNZjE	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35181	uniprotkb:Q00776	intact:EBI-2612|uniprotkb:D6VYH5|ensemblfungi:YLR170C	intact:EBI-2624|uniprotkb:D6W3B0|ensemblfungi:YPL259C	psi-mi:ap1s1_yeast(display_long)|uniprotkb:APS1(gene name)|psi-mi:APS1(display_short)|uniprotkb:YAP19(gene name synonym)|uniprotkb:YLR170C(locus name)|uniprotkb:L9470.16(orf name)|uniprotkb:Sigma1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor AP-1 19 kDa adaptin(gene name synonym)|uniprotkb:HA1 19 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP19(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP19(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 sigma-1 small chain(gene name synonym)	psi-mi:ap1m1_yeast(display_long)|uniprotkb:APM1(gene name)|psi-mi:APM1(display_short)|uniprotkb:YAP54(gene name synonym)|uniprotkb:YPL259C(locus name)|uniprotkb:P0394(orf name)|uniprotkb:Mu1-I-adaptin(gene name synonym)|uniprotkb:"Mu(1)-adaptin"(gene name synonym)|uniprotkb:Golgi adaptor AP-1 54 kDa protein(gene name synonym)|uniprotkb:HA1 54 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP54(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP54(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1-I medium chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560543|imex:IM-19316-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013271.1|sgd:S000004160|dip:DIP-4806N|mint:P35181|ensemblfungi:YLR170C(gene)|ensemblfungi:YLR170C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|reactome:R-SCE-432720	refseq:NP_015064.1|sgd:S000006180|dip:DIP-1198N|mint:Q00776|ensemblfungi:YPL259C(gene)|ensemblfungi:YPL259C_mRNA(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|reactome:R-SCE-432720|reactome:R-SCE-6798695	-	crc64:1A584883F1DF815D	crc64:C6B11153B845921C	figure legend:1 F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:MSl/Rj/unUQm0HSBgFC1jyYJpBM559292	rogid:i+bg9eNIcUTBkm2e24EczcfL7AQ559292	intact-crc:3FB11C3CDBBC862D|rigid:B+Btf47A0Fd5wHmKmGypfOd3OrA	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36000	uniprotkb:P38700	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	intact:EBI-2705|uniprotkb:D3DKR4|ensemblfungi:YHL019C	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:apm2_yeast(display_long)|uniprotkb:APM2(gene name)|psi-mi:APM2(display_short)|uniprotkb:Adaptin-mu1-II(gene name synonym)|uniprotkb:YHL019C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560569|imex:IM-19316-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_011844.1|sgd:S000001011|dip:DIP-1200N|mint:P38700|ensemblfungi:YHL019C(gene)|ensemblfungi:YHL019C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006897"(endocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR027200|interpro:IPR028565|interpro:IPR036168|reactome:R-SCE-8856825	-	crc64:89893945D4EC6C4A	crc64:7E216B11325EEE3C	figure legend:"Fig: 1F"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	rogid:dh+rB95eFgDQruQWkigoIiBW8+k559292	intact-crc:A0184F2DF32D9F66|rigid:+i4iBMZ5Wzx1LVHi3da/NBBKqmk	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36000	uniprotkb:P35181	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	intact:EBI-2612|uniprotkb:D6VYH5|ensemblfungi:YLR170C	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:ap1s1_yeast(display_long)|uniprotkb:APS1(gene name)|psi-mi:APS1(display_short)|uniprotkb:YAP19(gene name synonym)|uniprotkb:YLR170C(locus name)|uniprotkb:L9470.16(orf name)|uniprotkb:Sigma1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor AP-1 19 kDa adaptin(gene name synonym)|uniprotkb:HA1 19 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP19(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP19(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 sigma-1 small chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560569|imex:IM-19316-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_013271.1|sgd:S000004160|dip:DIP-4806N|mint:P35181|ensemblfungi:YLR170C(gene)|ensemblfungi:YLR170C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|reactome:R-SCE-432720	-	crc64:89893945D4EC6C4A	crc64:1A584883F1DF815D	figure legend:"Fig: 1F"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	rogid:MSl/Rj/unUQm0HSBgFC1jyYJpBM559292	intact-crc:A0184F2DF32D9F66|rigid:+i4iBMZ5Wzx1LVHi3da/NBBKqmk	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99186	uniprotkb:Q00381	intact:EBI-2715|uniprotkb:D6W205|ensemblfungi:YOL062C	intact:EBI-2608|uniprotkb:D6VWM9|ensemblfungi:YJR058C	psi-mi:ap2m_yeast(display_long)|uniprotkb:APM4(gene name)|psi-mi:APM4(display_short)|uniprotkb:YOL062C(locus name)|uniprotkb:O1210(orf name)|uniprotkb:Mu2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:Adaptin medium chain APM4(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:AMP1(gene name synonym)	psi-mi:ap2s_yeast(display_long)|uniprotkb:Sigma2-adaptin(gene name synonym)|uniprotkb:Adaptin small chain(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 17 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP17(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP17(gene name synonym)|uniprotkb:APS2(gene name)|psi-mi:APS2(display_short)|uniprotkb:YAP17(gene name synonym)|uniprotkb:YJR058C(locus name)|uniprotkb:J1720(orf name)|uniprotkb:Clathrin assembly protein 2 sigma small chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560596|imex:IM-19316-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014579.1|sgd:S000005423|ensemblfungi:YOL062C(gene)|ensemblfungi:YOL062C_mRNA(transcript)|go:"GO:0005829"(cytosol)|dip:DIP-5448N|mint:Q99186|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_012592.1|sgd:S000003819|dip:DIP-5093N|mint:Q00381|ensemblfungi:YJR058C(gene)|ensemblfungi:YJR058C_mRNA(transcript)|go:"GO:0005628"(prospore membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR027156|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:DCAF8F6BF8D43D45	crc64:DFFD1A567532AAD8	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:oOwUt1CP9SJ9yXKSrISVCBstBMg559292	rogid:7xDVm0qIX/o7sFOZZ4aILjLYh/s559292	intact-crc:DA56297F2D3EE60D|rigid:cJk5qw9C+sCHbWQXdQviPWDOIfk	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99186	uniprotkb:P27351	intact:EBI-2715|uniprotkb:D6W205|ensemblfungi:YOL062C	intact:EBI-2202|uniprotkb:D6VWH9|ensemblfungi:YJR005W	psi-mi:ap2m_yeast(display_long)|uniprotkb:APM4(gene name)|psi-mi:APM4(display_short)|uniprotkb:YOL062C(locus name)|uniprotkb:O1210(orf name)|uniprotkb:Mu2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:Adaptin medium chain APM4(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:AMP1(gene name synonym)	psi-mi:ap2b_yeast(display_long)|uniprotkb:APL1(gene name)|psi-mi:APL1(display_short)|uniprotkb:YAP80(gene name synonym)|uniprotkb:YJR005W(locus name)|uniprotkb:J1422(orf name)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta chain(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560596|imex:IM-19316-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014579.1|sgd:S000005423|ensemblfungi:YOL062C(gene)|ensemblfungi:YOL062C_mRNA(transcript)|go:"GO:0005829"(cytosol)|dip:DIP-5448N|mint:Q99186|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	sgd:S000003765|refseq:NP_012538.3|ensemblfungi:YJR005W(gene)|ensemblfungi:YJR005W_mRNA(transcript)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|dip:DIP-915N|mint:P27351|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:DCAF8F6BF8D43D45	crc64:556A8F3EF8B3930F	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:oOwUt1CP9SJ9yXKSrISVCBstBMg559292	rogid:l9nwflzNPx9ownQviK4kqMwKCh0559292	intact-crc:DA56297F2D3EE60D|rigid:cJk5qw9C+sCHbWQXdQviPWDOIfk	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22137	uniprotkb:P36000	intact:EBI-4766|uniprotkb:D6VTU9|ensemblfungi:YGL206C	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	psi-mi:clh_yeast(display_long)|uniprotkb:CHC1(gene name)|psi-mi:CHC1(display_short)|uniprotkb:YGL206C(locus name)	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560781|imex:IM-19316-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011309.1|sgd:S000003174|dip:DIP-2279N|mint:P22137|ensemblfungi:YGL206C(gene)|ensemblfungi:YGL206C_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030479"(actin cortical patch)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0071439"(clathrin complex)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:622F3083DF2FE315	crc64:89893945D4EC6C4A	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:SAN6H3nVFozXZyTiRLaljMcIKIA559292	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	intact-crc:986447E9CEE8E53B|rigid:kVvLoHPCTOrPWTLF2pDj5HdAOHo	false	-	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00381	uniprotkb:P27351	intact:EBI-2608|uniprotkb:D6VWM9|ensemblfungi:YJR058C	intact:EBI-2202|uniprotkb:D6VWH9|ensemblfungi:YJR005W	psi-mi:ap2s_yeast(display_long)|uniprotkb:Sigma2-adaptin(gene name synonym)|uniprotkb:Adaptin small chain(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 17 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP17(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP17(gene name synonym)|uniprotkb:APS2(gene name)|psi-mi:APS2(display_short)|uniprotkb:YAP17(gene name synonym)|uniprotkb:YJR058C(locus name)|uniprotkb:J1720(orf name)|uniprotkb:Clathrin assembly protein 2 sigma small chain(gene name synonym)	psi-mi:ap2b_yeast(display_long)|uniprotkb:APL1(gene name)|psi-mi:APL1(display_short)|uniprotkb:YAP80(gene name synonym)|uniprotkb:YJR005W(locus name)|uniprotkb:J1422(orf name)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta chain(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560647|imex:IM-19316-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012592.1|sgd:S000003819|dip:DIP-5093N|mint:Q00381|ensemblfungi:YJR058C(gene)|ensemblfungi:YJR058C_mRNA(transcript)|go:"GO:0005628"(prospore membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR027156|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	sgd:S000003765|refseq:NP_012538.3|ensemblfungi:YJR005W(gene)|ensemblfungi:YJR005W_mRNA(transcript)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|dip:DIP-915N|mint:P27351|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:DFFD1A567532AAD8	crc64:556A8F3EF8B3930F	figure legend:Fig. 1A & 1C|comment:This interaction requires the presence of Apl3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:7xDVm0qIX/o7sFOZZ4aILjLYh/s559292	rogid:l9nwflzNPx9ownQviK4kqMwKCh0559292	intact-crc:4521ED602053D17B|rigid:1w9yipjRirJLNYsWuZUkMPgvABQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35181	uniprotkb:P36000	intact:EBI-2612|uniprotkb:D6VYH5|ensemblfungi:YLR170C	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	psi-mi:ap1s1_yeast(display_long)|uniprotkb:APS1(gene name)|psi-mi:APS1(display_short)|uniprotkb:YAP19(gene name synonym)|uniprotkb:YLR170C(locus name)|uniprotkb:L9470.16(orf name)|uniprotkb:Sigma1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor AP-1 19 kDa adaptin(gene name synonym)|uniprotkb:HA1 19 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP19(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP19(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 sigma-1 small chain(gene name synonym)	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560675|imex:IM-19316-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013271.1|sgd:S000004160|dip:DIP-4806N|mint:P35181|ensemblfungi:YLR170C(gene)|ensemblfungi:YLR170C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|reactome:R-SCE-432720	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:1A584883F1DF815D	crc64:89893945D4EC6C4A	figure legend:Fig. 1C|comment:This interaction does not require the presence of Apl3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:MSl/Rj/unUQm0HSBgFC1jyYJpBM559292	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	intact-crc:97690B94288EA66E|rigid:gSVgM+GvP/MAC6Fq+wdtlFE9UFE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36000	uniprotkb:Q00381	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	intact:EBI-2608|uniprotkb:D6VWM9|ensemblfungi:YJR058C	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:ap2s_yeast(display_long)|uniprotkb:Sigma2-adaptin(gene name synonym)|uniprotkb:Adaptin small chain(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 17 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP17(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP17(gene name synonym)|uniprotkb:APS2(gene name)|psi-mi:APS2(display_short)|uniprotkb:YAP17(gene name synonym)|uniprotkb:YJR058C(locus name)|uniprotkb:J1720(orf name)|uniprotkb:Clathrin assembly protein 2 sigma small chain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560682|imex:IM-19316-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_012592.1|sgd:S000003819|dip:DIP-5093N|mint:Q00381|ensemblfungi:YJR058C(gene)|ensemblfungi:YJR058C_mRNA(transcript)|go:"GO:0005628"(prospore membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR027156|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:89893945D4EC6C4A	crc64:DFFD1A567532AAD8	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	rogid:7xDVm0qIX/o7sFOZZ4aILjLYh/s559292	intact-crc:E92FC7EB611D0473|rigid:/orUt/DX/lhav/yC/ty2kD2/jmQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36000	uniprotkb:Q12028	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	intact:EBI-33025|uniprotkb:D6W439|ensemblfungi:YPR029C	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:ap1g1_yeast(display_long)|uniprotkb:APL4(gene name)|psi-mi:APL4(display_short)|uniprotkb:Clathrin assembly protein complex 1 gamma large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large gamma chain(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:YPR029C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560682|imex:IM-19316-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_015354.1|sgd:S000006233|mint:Q12028|dip:DIP-3913N|ensemblfungi:YPR029C(gene)|ensemblfungi:YPR029C_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|reactome:R-SCE-432720	-	crc64:89893945D4EC6C4A	crc64:ABB619E9DC4F565C	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	rogid:nzjklmQlRHNY/Wqmrg6GbLG17e8559292	intact-crc:E92FC7EB611D0473|rigid:/orUt/DX/lhav/yC/ty2kD2/jmQ	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22137	uniprotkb:P36000	intact:EBI-4766|uniprotkb:D6VTU9|ensemblfungi:YGL206C	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	psi-mi:clh_yeast(display_long)|uniprotkb:CHC1(gene name)|psi-mi:CHC1(display_short)|uniprotkb:YGL206C(locus name)	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:"MI:0096"(pull down)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560750|imex:IM-19316-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011309.1|sgd:S000003174|dip:DIP-2279N|mint:P22137|ensemblfungi:YGL206C(gene)|ensemblfungi:YGL206C_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030479"(actin cortical patch)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0071439"(clathrin complex)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:622F3083DF2FE315	crc64:89893945D4EC6C4A	figure legend:Fig. 2A|comment:A C-terminal construct of APL2 was used to show the interaction because clathrin-binding sites in mammalian orthologs are located toward the C-termini.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/29	2014/10/16	rogid:SAN6H3nVFozXZyTiRLaljMcIKIA559292	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	intact-crc:32E1BED03FC94DA0|rigid:kVvLoHPCTOrPWTLF2pDj5HdAOHo	false	-	glutathione s tranferase tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36000	uniprotkb:P22137	intact:EBI-2206|uniprotkb:D6VX61|ensemblfungi:YKL135C	intact:EBI-4766|uniprotkb:D6VTU9|ensemblfungi:YGL206C	psi-mi:ap1b1_yeast(display_long)|uniprotkb:APL2(gene name)|psi-mi:APL2(display_short)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta-1 large chain(gene name synonym)|uniprotkb:Clathrin assembly protein large beta-1 chain(gene name synonym)|uniprotkb:YKL135C(locus name)	psi-mi:clh_yeast(display_long)|uniprotkb:CHC1(gene name)|psi-mi:CHC1(display_short)|uniprotkb:YGL206C(locus name)	psi-mi:"MI:0096"(pull down)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560775|imex:IM-19316-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012787.1|sgd:S000001618|dip:DIP-1199N|mint:P36000|ensemblfungi:YKL135C(gene)|ensemblfungi:YKL135C_mRNA(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030276"(clathrin binding)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856825|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_011309.1|sgd:S000003174|dip:DIP-2279N|mint:P22137|ensemblfungi:YGL206C(gene)|ensemblfungi:YGL206C_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030479"(actin cortical patch)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0071439"(clathrin complex)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:89893945D4EC6C4A	crc64:622F3083DF2FE315	figure legend:Fig. 2B|comment:A C-terminal construct of APL2 was used to show the interaction because clathrin-binding sites in mammalian orthologs are located toward the C-termini.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/29	2014/10/16	rogid:MKH8RySJV469TEWyuJCOuAitkJY559292	rogid:SAN6H3nVFozXZyTiRLaljMcIKIA559292	intact-crc:1FCD78EDB22CBBDA|rigid:kVvLoHPCTOrPWTLF2pDj5HdAOHo	false	glutathione s tranferase tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P13134	uniprotkb:P22137	intact:EBI-9658|ensemblfungi:YNL238W|uniprotkb:D6W0V5	intact:EBI-4766|uniprotkb:D6VTU9|ensemblfungi:YGL206C	psi-mi:kex2_yeast(display_long)|uniprotkb:KEX2(gene name)|psi-mi:KEX2(display_short)|uniprotkb:QDS1(gene name synonym)|uniprotkb:YNL238W(locus name)|uniprotkb:N1122(orf name)|uniprotkb:Protease KEX2(gene name synonym)|uniprotkb:Proteinase YSCF(gene name synonym)	psi-mi:clh_yeast(display_long)|uniprotkb:CHC1(gene name)|psi-mi:CHC1(display_short)|uniprotkb:YGL206C(locus name)	psi-mi:"MI:0091"(chromatography technology)	Yeung et al. (1999)	pubmed:10564262|imex:IM-19316	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1560794|imex:IM-19316-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002884(Proprotein convertase, P)|interpro:IPR008979(Galactose-binding like)|ensemblfungi:YNL238W(gene)|ensemblfungi:YNL238W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007323"(peptide pheromone maturation)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022398|interpro:IPR023827|interpro:IPR023828|interpro:IPR034182|interpro:IPR036852|rcsb pdb:1OT5|rcsb pdb:1R64|rcsb pdb:2ID4|refseq:NP_014161.1|sgd:S000005182|dip:DIP-6287N|mint:P13134	refseq:NP_011309.1|sgd:S000003174|dip:DIP-2279N|mint:P22137|ensemblfungi:YGL206C(gene)|ensemblfungi:YGL206C_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030479"(actin cortical patch)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0071439"(clathrin complex)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	crc64:5DCEEDADCF439C78	crc64:622F3083DF2FE315	figure legend:Fig. 5 & 9|comment:The interaction is not affected by the multiple deletions of Apl2, Apl4, Apm1 and Aps1 or of Apl1, Apl2 and Apl6.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/29	2014/10/16	rogid:DI29wdB9fSIOhlHVEuVoRiDbzl8559292	rogid:SAN6H3nVFozXZyTiRLaljMcIKIA559292	intact-crc:4A4B465166717325|rigid:hO7YoA+5EwS/Qbap+RiQ3rNPmtY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)