#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q27368	uniprotkb:P23572	intact:EBI-108384|uniprotkb:O77035|uniprotkb:Q5U0Z6|ensemblmetazoa:FBpp0083516|ensemblmetazoa:FBpp0083517|ensemblmetazoa:FBpp0083518|ensemblmetazoa:FBpp0311985	intact:EBI-108689|intact:EBI-1627558|uniprotkb:A0ANT1|uniprotkb:Q86FT5|uniprotkb:Q86FT6|uniprotkb:Q86FT7|uniprotkb:Q86FT8|uniprotkb:Q86FT9|uniprotkb:Q9TX68|uniprotkb:Q9TX69|uniprotkb:Q9TX70|uniprotkb:Q9TX71|uniprotkb:Q9TX72|uniprotkb:Q9TX73|uniprotkb:Q9TX74|uniprotkb:Q9VKX5|ensemblmetazoa:FBpp0079641	psi-mi:e2f1_drome(display_long)|uniprotkb:E2f1(gene name)|psi-mi:E2f1(display_short)|uniprotkb:E2f(gene name synonym)|uniprotkb:dE2F(gene name synonym)|uniprotkb:CG6376(orf name)	psi-mi:cdk1_drome(display_long)|uniprotkb:Cdk1(gene name)|psi-mi:Cdk1(display_short)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:cdc2(gene name synonym)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:CG5363(orf name)	psi-mi:"MI:0096"(pull down)	Hayashi et al. (1999)	pubmed:10320477	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-871830	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524437.2|refseq:NP_732646.1|refseq:NP_732647.1|flybase:FBgn0011766|refseq:NP_001287455.1|dip:DIP-21076N|ensemblmetazoa:FBgn0011766(gene)|ensemblmetazoa:FBtr0084117(transcript)|ensemblmetazoa:FBtr0084118(transcript)|ensemblmetazoa:FBtr0084119(transcript)|ensemblmetazoa:FBtr0346157(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0007419"(ventral cord development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0035167"(larval lymph gland hemopoiesis)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045850"(positive regulation of nurse cell apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1900117"(regulation of execution phase of apoptosis)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|reactome:R-DME-68689|reactome:R-DME-68911|reactome:R-DME-8953750	refseq:NP_476797.1|flybase:FBgn0004106|dip:DIP-649N|ensemblmetazoa:FBgn0004106(gene)|ensemblmetazoa:FBtr0080051(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045169"(fusome)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P23572|reactome:R-DME-110056|reactome:R-DME-174048|reactome:R-DME-174184|reactome:R-DME-176408|reactome:R-DME-176412|reactome:R-DME-176417|reactome:R-DME-2500257|reactome:R-DME-2565942|reactome:R-DME-2995383|reactome:R-DME-3301854|reactome:R-DME-4419969|reactome:R-DME-5687128|reactome:R-DME-6804114|reactome:R-DME-68875|reactome:R-DME-69273|reactome:R-DME-69478|reactome:R-DME-75035|reactome:R-DME-8878166	-	-	-	figure legend:7A|caution:The Histidine tagged E2f was expressed in E coli in the presence of DP which could be the interacting molecule or an ancillary protein molecule.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/21	2014/10/16	rogid:iuWAVrB7ugwrZPPrJbYLNhkvS2A7227	rogid:WK4kxTRU/nlh6/LCeihCplHOZ2o7227	intact-crc:CD03686F7148234B|rigid:n9AlKqWi+ltq+BxmUqSrtsd6+cc	false	his tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14785	uniprotkb:Q27368	intact:EBI-240333|uniprotkb:Q8IGR7|uniprotkb:Q9VTP6|uniprotkb:Q9VTP7|ensemblmetazoa:FBpp0075807	intact:EBI-108384|uniprotkb:O77035|uniprotkb:Q5U0Z6|ensemblmetazoa:FBpp0083516|ensemblmetazoa:FBpp0083517|ensemblmetazoa:FBpp0083518|ensemblmetazoa:FBpp0311985	psi-mi:ccna_drome(display_long)|uniprotkb:CycA(gene name)|psi-mi:CycA(display_short)|uniprotkb:CG5940(orf name)	psi-mi:e2f1_drome(display_long)|uniprotkb:E2f1(gene name)|psi-mi:E2f1(display_short)|uniprotkb:E2f(gene name synonym)|uniprotkb:dE2F(gene name synonym)|uniprotkb:CG6376(orf name)	psi-mi:"MI:0096"(pull down)	Hayashi et al. (1999)	pubmed:10320477	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1209081	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524030.2|flybase:FBgn0000404|dip:DIP-22019N|ensemblmetazoa:FBgn0000404(gene)|ensemblmetazoa:FBtr0076075(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0035561"(regulation of chromatin binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045169"(fusome)|go:"GO:0045170"(spectrosome)|go:"GO:0045202"(synapse)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|mint:P14785|reactome:R-DME-1538133|reactome:R-DME-174184|reactome:R-DME-176408|reactome:R-DME-187577|reactome:R-DME-2559582|reactome:R-DME-2559586|reactome:R-DME-5689880|reactome:R-DME-6804116|reactome:R-DME-6804756|reactome:R-DME-68911|reactome:R-DME-68949|reactome:R-DME-69017|reactome:R-DME-69273|reactome:R-DME-69563|reactome:R-DME-69656	refseq:NP_524437.2|refseq:NP_732646.1|refseq:NP_732647.1|flybase:FBgn0011766|refseq:NP_001287455.1|dip:DIP-21076N|ensemblmetazoa:FBgn0011766(gene)|ensemblmetazoa:FBtr0084117(transcript)|ensemblmetazoa:FBtr0084118(transcript)|ensemblmetazoa:FBtr0084119(transcript)|ensemblmetazoa:FBtr0346157(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007307"(eggshell chorion gene amplification)|go:"GO:0007419"(ventral cord development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0035167"(larval lymph gland hemopoiesis)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0042023"(DNA endoreduplication)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045850"(positive regulation of nurse cell apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1900117"(regulation of execution phase of apoptosis)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|reactome:R-DME-68689|reactome:R-DME-68911|reactome:R-DME-8953750	-	-	-	figure legend:7A|caution:The Histidine tagged E2f was expressed in E coli in the presence of DP which could be the interacting molecule or an ancillary protein molecule.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/21	2014/10/16	rogid:Ym2ygZ2vFqtDFvZiyifYjRJ7K5c7227	rogid:iuWAVrB7ugwrZPPrJbYLNhkvS2A7227	intact-crc:12A25F64AE2A6666|rigid:WK3dOyxP/pSgy+jj4zLaS1nlJfg	false	35s radiolabel:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)