#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q02574	uniprotkb:P38827	intact:EBI-10658|uniprotkb:P87260|uniprotkb:Q05887|ensemblfungi:YLR288C|uniprotkb:D6VYT4	intact:EBI-16977|uniprotkb:D3DL69|ensemblfungi:YHR119W	psi-mi:mec3_yeast(display_long)|uniprotkb:MEC3(gene name)|psi-mi:MEC3(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:YLR288C(locus name)|uniprotkb:L8003.15(orf name)|uniprotkb:PSO9(gene name synonym)	psi-mi:set1_yeast(display_long)|uniprotkb:SET1(gene name)|psi-mi:SET1(display_short)|uniprotkb:YTX1(gene name synonym)|uniprotkb:KMT2(gene name synonym)|uniprotkb:COMPASS component SET1(gene name synonym)|uniprotkb:SET domain-containing protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2(gene name synonym)|uniprotkb:YHR119W(locus name)	psi-mi:"MI:0018"(two hybrid)	Corda et al. (1999)	pubmed:9988274|imex:IM-19676	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-999828|imex:IM-19676-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013391.1|sgd:S000004279|ensemblfungi:YLR288C(gene)|ensemblfungi:YLR288C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006348"|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|reactome:R-SCE-176187|mint:Q02574|dip:DIP-1432N	ensemblfungi:YHR119W(gene)|ensemblfungi:YHR119W_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0006348"|go:"GO:0006479"(protein methylation)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0030437"(ascospore formation)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1903341"(regulation of meiotic DNA double-strand break formation)|go:"GO:1905088"(positive regulation of synaptonemal complex assembly)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017111(Histone H3-K4 methyltransferase Set1)|interpro:IPR024636|interpro:IPR024657|interpro:IPR044570|rcsb pdb:2J8A|rcsb pdb:6VEN|reactome:R-SCE-3214841|refseq:NP_011987.1|sgd:S000001161|dip:DIP-4616N|mint:P38827	-	crc64:4385CEFA9130FEA3	crc64:B7FA5D60F71063FD	figure legend:1A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/08/28	2014/10/16	rogid:LuYCya9O8z1Uw0xyfJnz3aowolg559292	rogid:QviRdWKz1+2O63RmD9p2MeyA9Jg559292	intact-crc:FF2B21C04F99A5A9|rigid:keQ7OeEUqJOxsan2Q1Wsnwg9BsM	false	binding-associated region:324-474	binding-associated region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02574	uniprotkb:P38827	intact:EBI-10658|uniprotkb:P87260|uniprotkb:Q05887|ensemblfungi:YLR288C|uniprotkb:D6VYT4	intact:EBI-16977|uniprotkb:D3DL69|ensemblfungi:YHR119W	psi-mi:mec3_yeast(display_long)|uniprotkb:MEC3(gene name)|psi-mi:MEC3(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:YLR288C(locus name)|uniprotkb:L8003.15(orf name)|uniprotkb:PSO9(gene name synonym)	psi-mi:set1_yeast(display_long)|uniprotkb:SET1(gene name)|psi-mi:SET1(display_short)|uniprotkb:YTX1(gene name synonym)|uniprotkb:KMT2(gene name synonym)|uniprotkb:COMPASS component SET1(gene name synonym)|uniprotkb:SET domain-containing protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2(gene name synonym)|uniprotkb:YHR119W(locus name)	psi-mi:"MI:0096"(pull down)	Corda et al. (1999)	pubmed:9988274|imex:IM-19676	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-999843|imex:IM-19676-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013391.1|sgd:S000004279|ensemblfungi:YLR288C(gene)|ensemblfungi:YLR288C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006348"|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|reactome:R-SCE-176187|mint:Q02574|dip:DIP-1432N	ensemblfungi:YHR119W(gene)|ensemblfungi:YHR119W_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0006348"|go:"GO:0006479"(protein methylation)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0030437"(ascospore formation)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1903341"(regulation of meiotic DNA double-strand break formation)|go:"GO:1905088"(positive regulation of synaptonemal complex assembly)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017111(Histone H3-K4 methyltransferase Set1)|interpro:IPR024636|interpro:IPR024657|interpro:IPR044570|rcsb pdb:2J8A|rcsb pdb:6VEN|reactome:R-SCE-3214841|refseq:NP_011987.1|sgd:S000001161|dip:DIP-4616N|mint:P38827	-	crc64:4385CEFA9130FEA3	crc64:B7FA5D60F71063FD	figure legend:1C|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/28	2014/10/16	rogid:LuYCya9O8z1Uw0xyfJnz3aowolg559292	rogid:QviRdWKz1+2O63RmD9p2MeyA9Jg559292	intact-crc:0C3135F23C6FDB95|rigid:keQ7OeEUqJOxsan2Q1Wsnwg9BsM	false	glutathione s tranferase tag:?-?	binding-associated region:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02574	uniprotkb:P38827	intact:EBI-10658|uniprotkb:P87260|uniprotkb:Q05887|ensemblfungi:YLR288C|uniprotkb:D6VYT4	intact:EBI-16977|uniprotkb:D3DL69|ensemblfungi:YHR119W	psi-mi:mec3_yeast(display_long)|uniprotkb:MEC3(gene name)|psi-mi:MEC3(display_short)|uniprotkb:PIP3(gene name synonym)|uniprotkb:YLR288C(locus name)|uniprotkb:L8003.15(orf name)|uniprotkb:PSO9(gene name synonym)	psi-mi:set1_yeast(display_long)|uniprotkb:SET1(gene name)|psi-mi:SET1(display_short)|uniprotkb:YTX1(gene name synonym)|uniprotkb:KMT2(gene name synonym)|uniprotkb:COMPASS component SET1(gene name synonym)|uniprotkb:SET domain-containing protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2(gene name synonym)|uniprotkb:YHR119W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Corda et al. (1999)	pubmed:9988274|imex:IM-19676	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-999858|imex:IM-19676-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013391.1|sgd:S000004279|ensemblfungi:YLR288C(gene)|ensemblfungi:YLR288C_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006348"|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|reactome:R-SCE-176187|mint:Q02574|dip:DIP-1432N	ensemblfungi:YHR119W(gene)|ensemblfungi:YHR119W_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0006348"|go:"GO:0006479"(protein methylation)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0030437"(ascospore formation)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043618"(regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1903341"(regulation of meiotic DNA double-strand break formation)|go:"GO:1905088"(positive regulation of synaptonemal complex assembly)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017111(Histone H3-K4 methyltransferase Set1)|interpro:IPR024636|interpro:IPR024657|interpro:IPR044570|rcsb pdb:2J8A|rcsb pdb:6VEN|reactome:R-SCE-3214841|refseq:NP_011987.1|sgd:S000001161|dip:DIP-4616N|mint:P38827	-	crc64:4385CEFA9130FEA3	crc64:B7FA5D60F71063FD	figure legend:1E|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/08/28	2014/10/16	rogid:LuYCya9O8z1Uw0xyfJnz3aowolg559292	rogid:QviRdWKz1+2O63RmD9p2MeyA9Jg559292	intact-crc:AC4F813868B67AE6|rigid:keQ7OeEUqJOxsan2Q1Wsnwg9BsM	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)