#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P11344	uniprotkb:P11344	intact:EBI-821603|ensembl:ENSMUSP00000004770	intact:EBI-821603|ensembl:ENSMUSP00000004770	psi-mi:tyro_mouse(display_long)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:Albino locus protein(gene name synonym)|uniprotkb:Tyr(gene name)|psi-mi:Tyr(display_short)	psi-mi:tyro_mouse(display_long)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:Albino locus protein(gene name synonym)|uniprotkb:Tyr(gene name)|psi-mi:Tyr(display_short)	psi-mi:"MI:0071"(molecular sieving)	Jimenez-Cervantes et al. (1998)	pubmed:9918801|imex:IM-20074	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-821611|imex:IM-20074-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035791.1|ensembl:ENSMUSG00000004651(gene)|ensembl:ENSMUST00000004770(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-MMU-5662702	refseq:NP_035791.1|ensembl:ENSMUSG00000004651(gene)|ensembl:ENSMUST00000004770(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-MMU-5662702	go:"GO:0042803"(protein homodimerization activity)	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-b16)|taxid:10090(Mus musculus melanoma tumor maintained in mouse.)	-	2006/01/27	2014/10/16	rogid:RELxPvWYI7PD9JFDdMOVmQfJ54810090	rogid:RELxPvWYI7PD9JFDdMOVmQfJ54810090	intact-crc:ADF4E2386D4A3748|rigid:s9h0gdt79vPx6PNvAIQHKUYPNqw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07147	uniprotkb:P07147	intact:EBI-821614|ensembl:ENSMUSP00000006151|ensembl:ENSMUSP00000099895	intact:EBI-821614|ensembl:ENSMUSP00000006151|ensembl:ENSMUSP00000099895	psi-mi:tyrp1_mouse(display_long)|uniprotkb:Tyrosinase-related protein 1(gene name synonym)|uniprotkb:Catalase B(gene name synonym)|uniprotkb:Brown locus protein(gene name synonym)|uniprotkb:Tyrp1(gene name)|psi-mi:Tyrp1(display_short)|uniprotkb:Tyrp-1(gene name synonym)	psi-mi:tyrp1_mouse(display_long)|uniprotkb:Tyrosinase-related protein 1(gene name synonym)|uniprotkb:Catalase B(gene name synonym)|uniprotkb:Brown locus protein(gene name synonym)|uniprotkb:Tyrp1(gene name)|psi-mi:Tyrp1(display_short)|uniprotkb:Tyrp-1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Jimenez-Cervantes et al. (1998)	pubmed:9918801|imex:IM-20074	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-821623|imex:IM-20074-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112479.1|refseq:NP_001268943.1|refseq:NP_001268944.1|ensembl:ENSMUSG00000005994(gene)|ensembl:ENSMUST00000006151(transcript)|ensembl:ENSMUST00000102831(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006583"(melanin biosynthetic process from tyrosine)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043438"(acetoacetic acid metabolic process)|go:"GO:0043473"(pigmentation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0097708"(intracellular vesicle)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|rcsb pdb:6MP0|rcsb pdb:6MP1|reactome:R-MMU-5662702	refseq:NP_112479.1|refseq:NP_001268943.1|refseq:NP_001268944.1|ensembl:ENSMUSG00000005994(gene)|ensembl:ENSMUST00000006151(transcript)|ensembl:ENSMUST00000102831(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006583"(melanin biosynthetic process from tyrosine)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043438"(acetoacetic acid metabolic process)|go:"GO:0043473"(pigmentation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0097708"(intracellular vesicle)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|rcsb pdb:6MP0|rcsb pdb:6MP1|reactome:R-MMU-5662702	go:"GO:0042803"(protein homodimerization activity)	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-b16)|taxid:10090(Mus musculus melanoma tumor maintained in mouse.)	-	2006/01/27	2014/10/16	rogid:h8+d5jxCpz+Ak/25B8GjS/tOnwA10090	rogid:h8+d5jxCpz+Ak/25B8GjS/tOnwA10090	intact-crc:D0D47B4D0C33883E|rigid:tWGrFuZiqWsDbnMFPOJEjnUEG/8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07147	uniprotkb:P11344	intact:EBI-821614|ensembl:ENSMUSP00000006151|ensembl:ENSMUSP00000099895	intact:EBI-821603|ensembl:ENSMUSP00000004770	psi-mi:tyrp1_mouse(display_long)|uniprotkb:Tyrosinase-related protein 1(gene name synonym)|uniprotkb:Catalase B(gene name synonym)|uniprotkb:Brown locus protein(gene name synonym)|uniprotkb:Tyrp1(gene name)|psi-mi:Tyrp1(display_short)|uniprotkb:Tyrp-1(gene name synonym)	psi-mi:tyro_mouse(display_long)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:Albino locus protein(gene name synonym)|uniprotkb:Tyr(gene name)|psi-mi:Tyr(display_short)	psi-mi:"MI:0071"(molecular sieving)	Jimenez-Cervantes et al. (1998)	pubmed:9918801|imex:IM-20074	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-821626|imex:IM-20074-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112479.1|refseq:NP_001268943.1|refseq:NP_001268944.1|ensembl:ENSMUSG00000005994(gene)|ensembl:ENSMUST00000006151(transcript)|ensembl:ENSMUST00000102831(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006583"(melanin biosynthetic process from tyrosine)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043438"(acetoacetic acid metabolic process)|go:"GO:0043473"(pigmentation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0097708"(intracellular vesicle)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|rcsb pdb:6MP0|rcsb pdb:6MP1|reactome:R-MMU-5662702	refseq:NP_035791.1|ensembl:ENSMUSG00000004651(gene)|ensembl:ENSMUST00000004770(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-MMU-5662702	-	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-b16)|taxid:10090(Mus musculus melanoma tumor maintained in mouse.)	-	2006/01/27	2014/10/16	rogid:h8+d5jxCpz+Ak/25B8GjS/tOnwA10090	rogid:RELxPvWYI7PD9JFDdMOVmQfJ54810090	intact-crc:5C39CF746153C91E|rigid:8tMwCe77x07JAqXtD3LmQT7NLys	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07147	uniprotkb:P11344	intact:EBI-821614|ensembl:ENSMUSP00000006151|ensembl:ENSMUSP00000099895	intact:EBI-821603|ensembl:ENSMUSP00000004770	psi-mi:tyrp1_mouse(display_long)|uniprotkb:Tyrosinase-related protein 1(gene name synonym)|uniprotkb:Catalase B(gene name synonym)|uniprotkb:Brown locus protein(gene name synonym)|uniprotkb:Tyrp1(gene name)|psi-mi:Tyrp1(display_short)|uniprotkb:Tyrp-1(gene name synonym)	psi-mi:tyro_mouse(display_long)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:Albino locus protein(gene name synonym)|uniprotkb:Tyr(gene name)|psi-mi:Tyr(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Jimenez-Cervantes et al. (1998)	pubmed:9918801|imex:IM-20074	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-821637|imex:IM-20074-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112479.1|refseq:NP_001268943.1|refseq:NP_001268944.1|ensembl:ENSMUSG00000005994(gene)|ensembl:ENSMUST00000006151(transcript)|ensembl:ENSMUST00000102831(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006583"(melanin biosynthetic process from tyrosine)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043438"(acetoacetic acid metabolic process)|go:"GO:0043473"(pigmentation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0097708"(intracellular vesicle)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|rcsb pdb:6MP0|rcsb pdb:6MP1|reactome:R-MMU-5662702	refseq:NP_035791.1|ensembl:ENSMUSG00000004651(gene)|ensembl:ENSMUST00000004770(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-MMU-5662702	-	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-b16)|taxid:10090(Mus musculus melanoma tumor maintained in mouse.)	-	2006/01/27	2014/10/16	rogid:h8+d5jxCpz+Ak/25B8GjS/tOnwA10090	rogid:RELxPvWYI7PD9JFDdMOVmQfJ54810090	intact-crc:A674A3472AE3D92C|rigid:8tMwCe77x07JAqXtD3LmQT7NLys	false	dye label:?-?	fluorescein isothiocyanate label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)