#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P49799 uniprotkb:P10824 intact:EBI-1026423|ensembl:ENSRNOP00000003774 intact:EBI-1026411|uniprotkb:Q45QN2|ensembl:ENSRNOP00000074036 psi-mi:rgs4_rat(display_long)|uniprotkb:Rgs4(gene name)|psi-mi:Rgs4(display_short) psi-mi:gnai1_rat(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:Gnai1(gene name)|psi-mi:Gnai1(display_short)|uniprotkb:Gnai-1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Tesmer et al. (1997) pubmed:9108480 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1026434|rcsb pdb:1AGR - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000002773(gene)|ensembl:ENSRNOT00000003774(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|rgd:3567|refseq:NP_058910.1|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1900924"(negative regulation of glycine import across plasma membrane)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034952|interpro:IPR034953|interpro:IPR036305|rcsb pdb:1AGR|rcsb pdb:1EZT|rcsb pdb:1EZY|reactome:R-RNO-416476|reactome:R-RNO-418594|go:"GO:0043278"(response to morphine)|dip:DIP-6074N rgd:2713|refseq:NP_037277.1|ensembl:ENSRNOG00000057096(gene)|ensembl:ENSRNOT00000091004(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0099738"(cell cortex region)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P10824|rcsb pdb:1AGR|rcsb pdb:1AS0|go:"GO:0005634"(nucleus)|rcsb pdb:1AS2|rcsb pdb:1BH2|rcsb pdb:1BOF|rcsb pdb:1CIP|rcsb pdb:1FQJ|rcsb pdb:1FQK|rcsb pdb:1GDD|rcsb pdb:1GFI|rcsb pdb:1GG2|rcsb pdb:1GIA|rcsb pdb:1GIL|rcsb pdb:1GIT|rcsb pdb:1GP2|rcsb pdb:1SHZ|rcsb pdb:1SVK|rcsb pdb:1SVS|rcsb pdb:2BCJ|rcsb pdb:2ZJY|rcsb pdb:2ZJZ|rcsb pdb:3AH8|rcsb pdb:3D7M|rcsb pdb:3FFA|rcsb pdb:3FFB|rcsb pdb:3V00|rcsb pdb:4N0D|rcsb pdb:4N0E|rcsb pdb:4PAM|rcsb pdb:4PAN|rcsb pdb:4PAO|rcsb pdb:4PAQ|rcsb pdb:5KDL|rcsb pdb:5KDO|rcsb pdb:6M8H|rcsb pdb:6TYL|rcsb pdb:6UKT|rcsb pdb:6VMS|reactome:R-RNO-170670|reactome:R-RNO-392170|reactome:R-RNO-400042|reactome:R-RNO-418594|reactome:R-RNO-9009391|rcsb pdb:1AS3|dip:DIP-6073N - - - assembly:dimeric, multimeric|3d-r-factors:working 78.400%, free 70.900%|3d-resolution:2.8A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:s98H+VQ5SF3tM1eBpvlmrVYLeHg10116 rogid:4L9LLDHqr9N7S/GgFjFkDvaUQuY10116 intact-crc:7857C477CE8D6733|rigid:gGk4a2lC8eMnHf6R96oUnZaiGao false sufficient binding region:1-205 sufficient binding region:2-354 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)