#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10912	uniprotkb:P01241	intact:EBI-286316|uniprotkb:Q9HCX2|ensembl:ENSP00000230882|ensembl:ENSP00000442206|ensembl:ENSP00000478291|ensembl:ENSP00000478332|ensembl:ENSP00000479846|ensembl:ENSP00000482373	intact:EBI-1026046|uniprotkb:Q9HBZ1|uniprotkb:Q9UMJ7|uniprotkb:Q9UNL5|uniprotkb:Q14405|uniprotkb:Q16631|uniprotkb:Q5EB53|uniprotkb:A6NEF6|ensembl:ENSP00000312673	psi-mi:ghr_human(display_long)|uniprotkb:Somatotropin receptor(gene name synonym)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)	psi-mi:soma_human(display_long)|uniprotkb:GH1(gene name)|psi-mi:GH1(display_short)|uniprotkb:Growth hormone(gene name synonym)|uniprotkb:Pituitary growth hormone(gene name synonym)|uniprotkb:Growth hormone 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sundstrom et al. (1996)	pubmed:8943276	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1026225|rcsb pdb:1HWG	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000154.1|refseq:NP_001229328.1|refseq:NP_001229329.1|refseq:NP_001229330.1|refseq:NP_001229331.1|refseq:NP_001229332.1|refseq:NP_001229333.1|refseq:NP_001229334.1|refseq:NP_001229335.1|refseq:NP_001229389.1|refseq:NP_001229391.1|dip:DIP-630N|ensembl:ENSG00000112964(gene)|ensembl:ENST00000230882(transcript)|ensembl:ENST00000537449(transcript)|ensembl:ENST00000612382(transcript)|ensembl:ENST00000612626(transcript)|ensembl:ENST00000615111(transcript)|ensembl:ENST00000618088(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004903"(growth hormone receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032094"(response to food)|go:"GO:0032355"(response to estradiol)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043278"(response to morphine)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070195"(growth hormone receptor complex)|go:"GO:0070555"(response to interleukin-1)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|rcsb pdb:1A22|rcsb pdb:1AXI|rcsb pdb:1HWG|rcsb pdb:1HWH|rcsb pdb:1KF9|rcsb pdb:2AEW|rcsb pdb:3HHR|rcsb pdb:5OEK|rcsb pdb:5OHD|reactome:R-HSA-1170546|reactome:R-HSA-982772	refseq:NP_000506.2|refseq:NP_072053.1|ensembl:ENSG00000259384(gene)|ensembl:ENST00000323322(transcript)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005148"(prolactin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008083"(growth factor activity)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031904"(endosome lumen)|go:"GO:0032355"(response to estradiol)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0048513"(animal organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070195"(growth hormone receptor complex)|go:"GO:0070977"(bone maturation)|interpro:IPR001400(Somatotropin hormone)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018116|rcsb pdb:1A22|rcsb pdb:1AXI|rcsb pdb:1BP3|rcsb pdb:1HGU|rcsb pdb:1HUW|rcsb pdb:1HWG|rcsb pdb:1HWH|rcsb pdb:1KF9|rcsb pdb:3HHR|rcsb pdb:6QIO|reactome:R-HSA-1170546|reactome:R-HSA-422085|reactome:R-HSA-982772|refseq:NP_072054.1|dip:DIP-1022N	-	-	-	assembly:trimeric, multimeric|3d-r-factors:working 80.100%, free 71.300%|3d-resolution:2.5A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:BJvy3kRKyIQhPb9K64+bTaOUxhg9606	rogid:/wwYm28XFv1neYQcngRSejIdWFQ9606	intact-crc:FDF83A3C394D08A1|rigid:yDMoT3cuHk0jWxJEEFvJoYuJo5U	false	sufficient binding region:19-255	sufficient binding region:27-217	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10912	uniprotkb:P01241	intact:EBI-286316|uniprotkb:Q9HCX2|ensembl:ENSP00000230882|ensembl:ENSP00000442206|ensembl:ENSP00000478291|ensembl:ENSP00000478332|ensembl:ENSP00000479846|ensembl:ENSP00000482373	intact:EBI-1026046|uniprotkb:Q9HBZ1|uniprotkb:Q9UMJ7|uniprotkb:Q9UNL5|uniprotkb:Q14405|uniprotkb:Q16631|uniprotkb:Q5EB53|uniprotkb:A6NEF6|ensembl:ENSP00000312673	psi-mi:ghr_human(display_long)|uniprotkb:Somatotropin receptor(gene name synonym)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)	psi-mi:soma_human(display_long)|uniprotkb:GH1(gene name)|psi-mi:GH1(display_short)|uniprotkb:Growth hormone(gene name synonym)|uniprotkb:Pituitary growth hormone(gene name synonym)|uniprotkb:Growth hormone 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sundstrom et al. (1996)	pubmed:8943276	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1026236|rcsb pdb:1HWH	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000154.1|refseq:NP_001229328.1|refseq:NP_001229329.1|refseq:NP_001229330.1|refseq:NP_001229331.1|refseq:NP_001229332.1|refseq:NP_001229333.1|refseq:NP_001229334.1|refseq:NP_001229335.1|refseq:NP_001229389.1|refseq:NP_001229391.1|dip:DIP-630N|ensembl:ENSG00000112964(gene)|ensembl:ENST00000230882(transcript)|ensembl:ENST00000537449(transcript)|ensembl:ENST00000612382(transcript)|ensembl:ENST00000612626(transcript)|ensembl:ENST00000615111(transcript)|ensembl:ENST00000618088(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004903"(growth hormone receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032094"(response to food)|go:"GO:0032355"(response to estradiol)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043278"(response to morphine)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070195"(growth hormone receptor complex)|go:"GO:0070555"(response to interleukin-1)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|rcsb pdb:1A22|rcsb pdb:1AXI|rcsb pdb:1HWG|rcsb pdb:1HWH|rcsb pdb:1KF9|rcsb pdb:2AEW|rcsb pdb:3HHR|rcsb pdb:5OEK|rcsb pdb:5OHD|reactome:R-HSA-1170546|reactome:R-HSA-982772	refseq:NP_000506.2|refseq:NP_072053.1|ensembl:ENSG00000259384(gene)|ensembl:ENST00000323322(transcript)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005148"(prolactin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008083"(growth factor activity)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031904"(endosome lumen)|go:"GO:0032355"(response to estradiol)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0048513"(animal organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070195"(growth hormone receptor complex)|go:"GO:0070977"(bone maturation)|interpro:IPR001400(Somatotropin hormone)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018116|rcsb pdb:1A22|rcsb pdb:1AXI|rcsb pdb:1BP3|rcsb pdb:1HGU|rcsb pdb:1HUW|rcsb pdb:1HWG|rcsb pdb:1HWH|rcsb pdb:1KF9|rcsb pdb:3HHR|rcsb pdb:6QIO|reactome:R-HSA-1170546|reactome:R-HSA-422085|reactome:R-HSA-982772|refseq:NP_072054.1|dip:DIP-1022N	-	-	-	assembly:tetrameric, multimeric|3d-r-factors:working 78.500%, free 68.300%|3d-resolution:2.9A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:BJvy3kRKyIQhPb9K64+bTaOUxhg9606	rogid:/wwYm28XFv1neYQcngRSejIdWFQ9606	intact-crc:6C59C44AEFA3922A|rigid:yDMoT3cuHk0jWxJEEFvJoYuJo5U	false	sufficient binding region:19-255	sufficient binding region:27-217	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)