#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32389	uniprotkb:P40573	intact:EBI-10757|uniprotkb:D6W176	intact:EBI-11503|uniprotkb:D6VVU7|ensemblfungi:YIR017C	psi-mi:met4_yeast(display_long)|uniprotkb:MET4(gene name)|psi-mi:MET4(display_short)|uniprotkb:YNL103W(locus name)|uniprotkb:N2177(orf name)|uniprotkb:Methionine-requiring protein 4(gene name synonym)	psi-mi:met28_yeast(display_long)|uniprotkb:MET28(gene name)|psi-mi:MET28(display_short)|uniprotkb:Methionine-requiring protein 28(gene name synonym)|uniprotkb:YIR017C(locus name)	psi-mi:"MI:0018"(two hybrid)	Kuras et al. (1996)	pubmed:8665859|imex:IM-19115	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-905812|imex:IM-19115-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005047|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0089713"(Cbf1-Met4-Met28 complex)|go:"GO:0000096"(sulfur amino acid metabolic process)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0042802"(identical protein binding)|refseq:NP_014296.4|mint:P32389|dip:DIP-2241N	ensemblfungi:YIR017C(gene)|ensemblfungi:YIR017C_mRNA(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0031335"(regulation of sulfur amino acid metabolic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0089713"(Cbf1-Met4-Met28 complex)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|refseq:NP_012282.3|sgd:S000001456|dip:DIP-2242N	-	crc64:D65745E1FA40C09D	-	comment:Interaction between Met4 and Met28 occurs via their leucine zipper regions|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/16	2014/10/16	rogid:SpxM+SnEmiw+uQlCEGZSto/zduw559292	rogid:vPHCC2NoSmWfllEyCnMu+sIrGko559292	intact-crc:06350EE83185B259|rigid:CkN9gLP5LnqtfdOh1pV3zfeChqM	false	necessary binding region:617-667	necessary binding region:140-167(IPR004827)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17106	uniprotkb:P32389	intact:EBI-4096|uniprotkb:Q6Q5N1|uniprotkb:P17623|uniprotkb:D6VWN1|ensemblfungi:YJR060W	intact:EBI-10757|uniprotkb:D6W176	psi-mi:cbf1_yeast(display_long)|uniprotkb:CEP1(gene name synonym)|uniprotkb:CP1(gene name synonym)|uniprotkb:CPF1(gene name synonym)|uniprotkb:J1730(orf name)|uniprotkb:YJR060W(locus name)|uniprotkb:CBF1(gene name)|psi-mi:CBF1(display_short)|uniprotkb:Centromere-binding factor 1(gene name synonym)|uniprotkb:Centromere promoter factor 1(gene name synonym)	psi-mi:met4_yeast(display_long)|uniprotkb:MET4(gene name)|psi-mi:MET4(display_short)|uniprotkb:YNL103W(locus name)|uniprotkb:N2177(orf name)|uniprotkb:Methionine-requiring protein 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kuras et al. (1996)	pubmed:8665859|imex:IM-19115	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-905831|imex:IM-19115-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012594.1|sgd:S000003821|dip:DIP-2239N|mint:P17106|ensemblfungi:YJR060W(gene)|ensemblfungi:YJR060W_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007059"(chromosome segregation)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0089713"(Cbf1-Met4-Met28 complex)|go:"GO:0098781"(ncRNA transcription)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638	sgd:S000005047|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0089713"(Cbf1-Met4-Met28 complex)|go:"GO:0000096"(sulfur amino acid metabolic process)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0042802"(identical protein binding)|refseq:NP_014296.4|mint:P32389|dip:DIP-2241N	-	-	crc64:D65745E1FA40C09D	comment:The Met4 leucine zipper region is required for its' interaction with Cbf1.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/16	2014/10/16	rogid:SjrIzQ9f1rrxeycid/060/5MRY8559292	rogid:SpxM+SnEmiw+uQlCEGZSto/zduw559292	intact-crc:162F704B9147949C|rigid:p/NRpRvNLqJ6YVhvf70OSNj3bwM	false	-	necessary binding region:617-667	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)