#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O45406 uniprotkb:Q17635 intact:EBI-1175834|ensemblmetazoa:F26H11.1.1|ensemblmetazoa:F26H11.1.2 intact:EBI-314429|uniprotkb:Q23107|ensemblmetazoa:W01B6.9.1 psi-mi:kbp3_caeel(display_long)|uniprotkb:kbp-3(gene name)|psi-mi:kbp-3(display_short)|uniprotkb:F26H11.1(orf name) psi-mi:ndc80_caeel(display_long)|uniprotkb:ndc-80(gene name)|psi-mi:ndc-80(display_short)|uniprotkb:W01B6.9(orf name)|uniprotkb:Hec1 homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175852|imex:IM-12009-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_496993.1|wormbase:F26H11.1|ensemblmetazoa:F26H11.1.1(transcript)|ensemblmetazoa:F26H11.1.2(transcript)|ensemblmetazoa:WBGene00009179(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0031262"(Ndc80 complex) refseq:NP_501830.1|wormbase:W01B6.9|ensemblmetazoa:W01B6.9.1(transcript)|ensemblmetazoa:WBGene00003576(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|go:"GO:0030334"(regulation of cell migration)|dip:DIP-25850N go:"GO:0031262"(Ndc80 complex) - - figure legend:1 D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2014/10/16 rogid:qirHdE0d5GsHc7D5XlqZgH5kXMk6239 rogid:VqbUclU7wKvfpUfmJTQj3SosKtg6239 intact-crc:30F482C3B66DBC3A|rigid:mBr5zzvrQpqWjqshU6v+q0gaVIU false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O45406 uniprotkb:Q21952 intact:EBI-1175834|ensemblmetazoa:F26H11.1.1|ensemblmetazoa:F26H11.1.2 intact:EBI-326288|ensemblmetazoa:R12B2.4.1 psi-mi:kbp3_caeel(display_long)|uniprotkb:kbp-3(gene name)|psi-mi:kbp-3(display_short)|uniprotkb:F26H11.1(orf name) psi-mi:nuf2_caeel(display_long)|uniprotkb:R12B2.4(orf name)|uniprotkb:Kinetochore protein him-10(gene name synonym)|uniprotkb:Protein high incidence of males 10(gene name synonym)|uniprotkb:him-10(gene name)|psi-mi:him-10(display_short) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175852|imex:IM-12009-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_496993.1|wormbase:F26H11.1|ensemblmetazoa:F26H11.1.1(transcript)|ensemblmetazoa:F26H11.1.2(transcript)|ensemblmetazoa:WBGene00009179(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0031262"(Ndc80 complex) refseq:NP_498253.1|wormbase:R12B2.4|ensemblmetazoa:R12B2.4.1(transcript)|ensemblmetazoa:WBGene00001869(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|interpro:IPR005549(Nuf2)|interpro:IPR038275|dip:DIP-25404N go:"GO:0031262"(Ndc80 complex) - - figure legend:1 D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2014/10/16 rogid:qirHdE0d5GsHc7D5XlqZgH5kXMk6239 rogid:jGq4E8mXj7wTqWnEvuhDvjX2FxQ6239 intact-crc:30F482C3B66DBC3A|rigid:mBr5zzvrQpqWjqshU6v+q0gaVIU false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O45406 uniprotkb:Q9N2X3 intact:EBI-1175834|ensemblmetazoa:F26H11.1.1|ensemblmetazoa:F26H11.1.2 intact:EBI-1175844|ensemblmetazoa:Y92C3B.1.1 psi-mi:kbp3_caeel(display_long)|uniprotkb:kbp-3(gene name)|psi-mi:kbp-3(display_short)|uniprotkb:F26H11.1(orf name) psi-mi:q9n2x3_caeel(display_long)|uniprotkb:kbp-4(gene name)|psi-mi:kbp-4(display_short)|uniprotkb:CELE_Y92C3B.1(orf name)|uniprotkb:Y92C3B.1(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175852|imex:IM-12009-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_496993.1|wormbase:F26H11.1|ensemblmetazoa:F26H11.1.1(transcript)|ensemblmetazoa:F26H11.1.2(transcript)|ensemblmetazoa:WBGene00009179(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0031262"(Ndc80 complex) refseq:NP_497330.2|wormbase:Y92C3B.1|ensemblmetazoa:WBGene00022357(gene)|ensemblmetazoa:Y92C3B.1.1(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0031262"(Ndc80 complex) go:"GO:0031262"(Ndc80 complex) - - figure legend:1 D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2014/10/16 rogid:qirHdE0d5GsHc7D5XlqZgH5kXMk6239 rogid:ArHYGGXo4eybhrwSPsnHxrza6Pg6239 intact-crc:30F482C3B66DBC3A|rigid:mBr5zzvrQpqWjqshU6v+q0gaVIU false - his tag:?-? - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:O76406 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175966|imex:IM-12009-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) psi-mi:"MI:0469"(intact) - - figure legend:1 H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 intact-crc:7311F01E8BC44BEB|rigid:xzoQkRLAZ9yHBOfM7Z5zxpzK2LU false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q8MNT1 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175933|ensemblmetazoa:F26F4.13.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q8mnt1_caeel(display_long)|uniprotkb:kbp-2(gene name)|psi-mi:kbp-2(display_short)|uniprotkb:CELE_F26F4.13(orf name)|uniprotkb:F26F4.13(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175966|imex:IM-12009-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N interpro:IPR007128(Nnf1)|wormbase:F26F4.13|ensemblmetazoa:F26F4.13.1(transcript)|ensemblmetazoa:WBGene00017832(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0000818"(nuclear MIS12/MIND complex)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001333543.1 psi-mi:"MI:0469"(intact) - - figure legend:1 H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:Vpue/juDe4duVyAHaW5S+rEZZPY6239 intact-crc:7311F01E8BC44BEB|rigid:xzoQkRLAZ9yHBOfM7Z5zxpzK2LU false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q95QB8 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175928|ensemblmetazoa:R13F6.1.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q95qb8_caeel(display_long)|uniprotkb:kbp-1(gene name)|psi-mi:kbp-1(display_short)|uniprotkb:CELE_R13F6.1(orf name)|uniprotkb:R13F6.1(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175966|imex:IM-12009-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N wormbase:R13F6.1|ensemblmetazoa:R13F6.1.1(transcript)|ensemblmetazoa:WBGene00020064(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001293639.1 psi-mi:"MI:0469"(intact) - - figure legend:1 H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:M//0ApTdj9fnjaEAwjxvr02e6Us6239 intact-crc:7311F01E8BC44BEB|rigid:xzoQkRLAZ9yHBOfM7Z5zxpzK2LU false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q9N3R7 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175923|ensemblmetazoa:Y47G6A.24a.1|ensemblmetazoa:Y47G6A.24a.2 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q9n3r7_caeel(display_long)|uniprotkb:mis-12(gene name)|psi-mi:mis-12(display_short)|uniprotkb:CELE_Y47G6A.24(orf name)|uniprotkb:Y47G6A.24(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175966|imex:IM-12009-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_491184.1|wormbase:Y47G6A.24a|ensemblmetazoa:WBGene00021648(gene)|ensemblmetazoa:Y47G6A.24a.1(transcript)|ensemblmetazoa:Y47G6A.24a.2(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly) psi-mi:"MI:0469"(intact) - - figure legend:1 H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:EQD16Rq8ODi0DL8A2U5WQjJNJp86239 intact-crc:7311F01E8BC44BEB|rigid:xzoQkRLAZ9yHBOfM7Z5zxpzK2LU false - flag tag:?-? - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O76406 uniprotkb:Q8MNT1 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 intact:EBI-1175933|ensemblmetazoa:F26F4.13.1 psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:q8mnt1_caeel(display_long)|uniprotkb:kbp-2(gene name)|psi-mi:kbp-2(display_short)|uniprotkb:CELE_F26F4.13(orf name)|uniprotkb:F26F4.13(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179641|imex:IM-12009-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) interpro:IPR007128(Nnf1)|wormbase:F26F4.13|ensemblmetazoa:F26F4.13.1(transcript)|ensemblmetazoa:WBGene00017832(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0000818"(nuclear MIS12/MIND complex)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001333543.1 psi-mi:"MI:0469"(intact) - - figure legend:1 F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 rogid:Vpue/juDe4duVyAHaW5S+rEZZPY6239 intact-crc:CEBF0921F6119745|rigid:IVvf2aStoaMeduImuBp4G5ZSN3I false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O76406 uniprotkb:Q95QB8 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 intact:EBI-1175928|ensemblmetazoa:R13F6.1.1 psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:q95qb8_caeel(display_long)|uniprotkb:kbp-1(gene name)|psi-mi:kbp-1(display_short)|uniprotkb:CELE_R13F6.1(orf name)|uniprotkb:R13F6.1(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179641|imex:IM-12009-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) wormbase:R13F6.1|ensemblmetazoa:R13F6.1.1(transcript)|ensemblmetazoa:WBGene00020064(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001293639.1 psi-mi:"MI:0469"(intact) - - figure legend:1 F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 rogid:M//0ApTdj9fnjaEAwjxvr02e6Us6239 intact-crc:CEBF0921F6119745|rigid:IVvf2aStoaMeduImuBp4G5ZSN3I false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O76406 uniprotkb:Q9N3R7 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 intact:EBI-1175923|ensemblmetazoa:Y47G6A.24a.1|ensemblmetazoa:Y47G6A.24a.2 psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:q9n3r7_caeel(display_long)|uniprotkb:mis-12(gene name)|psi-mi:mis-12(display_short)|uniprotkb:CELE_Y47G6A.24(orf name)|uniprotkb:Y47G6A.24(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179641|imex:IM-12009-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) refseq:NP_491184.1|wormbase:Y47G6A.24a|ensemblmetazoa:WBGene00021648(gene)|ensemblmetazoa:Y47G6A.24a.1(transcript)|ensemblmetazoa:Y47G6A.24a.2(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly) psi-mi:"MI:0469"(intact) - - figure legend:1 F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 rogid:EQD16Rq8ODi0DL8A2U5WQjJNJp86239 intact-crc:CEBF0921F6119745|rigid:IVvf2aStoaMeduImuBp4G5ZSN3I false - flag tag:?-? - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q17635 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-314429|uniprotkb:Q23107|ensemblmetazoa:W01B6.9.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:ndc80_caeel(display_long)|uniprotkb:ndc-80(gene name)|psi-mi:ndc-80(display_short)|uniprotkb:W01B6.9(orf name)|uniprotkb:Hec1 homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179918|imex:IM-12009-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_501830.1|wormbase:W01B6.9|ensemblmetazoa:W01B6.9.1(transcript)|ensemblmetazoa:WBGene00003576(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|go:"GO:0030334"(regulation of cell migration)|dip:DIP-25850N psi-mi:"MI:0469"(intact) - - figure legend:2 B|comment:Densitometry revealed MIS-12 was present at a lower stoichiometry.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:VqbUclU7wKvfpUfmJTQj3SosKtg6239 intact-crc:33B353A67568D5A7|rigid:Rt8SuJlO/H+xzxcFWlIKD6aQiDo false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q21952 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-326288|ensemblmetazoa:R12B2.4.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:nuf2_caeel(display_long)|uniprotkb:R12B2.4(orf name)|uniprotkb:Kinetochore protein him-10(gene name synonym)|uniprotkb:Protein high incidence of males 10(gene name synonym)|uniprotkb:him-10(gene name)|psi-mi:him-10(display_short) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179918|imex:IM-12009-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_498253.1|wormbase:R12B2.4|ensemblmetazoa:R12B2.4.1(transcript)|ensemblmetazoa:WBGene00001869(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|interpro:IPR005549(Nuf2)|interpro:IPR038275|dip:DIP-25404N psi-mi:"MI:0469"(intact) - - figure legend:2 B|comment:Densitometry revealed MIS-12 was present at a lower stoichiometry.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:jGq4E8mXj7wTqWnEvuhDvjX2FxQ6239 intact-crc:33B353A67568D5A7|rigid:Rt8SuJlO/H+xzxcFWlIKD6aQiDo false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:O76406 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179918|imex:IM-12009-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) psi-mi:"MI:0469"(intact) - - figure legend:2 B|comment:Densitometry revealed MIS-12 was present at a lower stoichiometry.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 intact-crc:33B353A67568D5A7|rigid:Rt8SuJlO/H+xzxcFWlIKD6aQiDo false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q8MNT1 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175933|ensemblmetazoa:F26F4.13.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q8mnt1_caeel(display_long)|uniprotkb:kbp-2(gene name)|psi-mi:kbp-2(display_short)|uniprotkb:CELE_F26F4.13(orf name)|uniprotkb:F26F4.13(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179918|imex:IM-12009-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N interpro:IPR007128(Nnf1)|wormbase:F26F4.13|ensemblmetazoa:F26F4.13.1(transcript)|ensemblmetazoa:WBGene00017832(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0000818"(nuclear MIS12/MIND complex)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001333543.1 psi-mi:"MI:0469"(intact) - - figure legend:2 B|comment:Densitometry revealed MIS-12 was present at a lower stoichiometry.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:Vpue/juDe4duVyAHaW5S+rEZZPY6239 intact-crc:33B353A67568D5A7|rigid:Rt8SuJlO/H+xzxcFWlIKD6aQiDo false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q95QB8 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175928|ensemblmetazoa:R13F6.1.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q95qb8_caeel(display_long)|uniprotkb:kbp-1(gene name)|psi-mi:kbp-1(display_short)|uniprotkb:CELE_R13F6.1(orf name)|uniprotkb:R13F6.1(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179918|imex:IM-12009-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N wormbase:R13F6.1|ensemblmetazoa:R13F6.1.1(transcript)|ensemblmetazoa:WBGene00020064(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001293639.1 psi-mi:"MI:0469"(intact) - - figure legend:2 B|comment:Densitometry revealed MIS-12 was present at a lower stoichiometry.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:M//0ApTdj9fnjaEAwjxvr02e6Us6239 intact-crc:33B353A67568D5A7|rigid:Rt8SuJlO/H+xzxcFWlIKD6aQiDo false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q9N2X3 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175844|ensemblmetazoa:Y92C3B.1.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q9n2x3_caeel(display_long)|uniprotkb:kbp-4(gene name)|psi-mi:kbp-4(display_short)|uniprotkb:CELE_Y92C3B.1(orf name)|uniprotkb:Y92C3B.1(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179918|imex:IM-12009-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_497330.2|wormbase:Y92C3B.1|ensemblmetazoa:WBGene00022357(gene)|ensemblmetazoa:Y92C3B.1.1(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0031262"(Ndc80 complex) psi-mi:"MI:0469"(intact) - - figure legend:2 B|comment:Densitometry revealed MIS-12 was present at a lower stoichiometry.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:ArHYGGXo4eybhrwSPsnHxrza6Pg6239 intact-crc:33B353A67568D5A7|rigid:Rt8SuJlO/H+xzxcFWlIKD6aQiDo false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q9N3R7 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175923|ensemblmetazoa:Y47G6A.24a.1|ensemblmetazoa:Y47G6A.24a.2 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q9n3r7_caeel(display_long)|uniprotkb:mis-12(gene name)|psi-mi:mis-12(display_short)|uniprotkb:CELE_Y47G6A.24(orf name)|uniprotkb:Y47G6A.24(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179918|imex:IM-12009-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_491184.1|wormbase:Y47G6A.24a|ensemblmetazoa:WBGene00021648(gene)|ensemblmetazoa:Y47G6A.24a.1(transcript)|ensemblmetazoa:Y47G6A.24a.2(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly) psi-mi:"MI:0469"(intact) - - figure legend:2 B|comment:Densitometry revealed MIS-12 was present at a lower stoichiometry.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:EQD16Rq8ODi0DL8A2U5WQjJNJp86239 intact-crc:33B353A67568D5A7|rigid:Rt8SuJlO/H+xzxcFWlIKD6aQiDo false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O76406 uniprotkb:Q8MNT1 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 intact:EBI-1175933|ensemblmetazoa:F26F4.13.1 psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:q8mnt1_caeel(display_long)|uniprotkb:kbp-2(gene name)|psi-mi:kbp-2(display_short)|uniprotkb:CELE_F26F4.13(orf name)|uniprotkb:F26F4.13(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175914|imex:IM-12009-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) interpro:IPR007128(Nnf1)|wormbase:F26F4.13|ensemblmetazoa:F26F4.13.1(transcript)|ensemblmetazoa:WBGene00017832(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0000818"(nuclear MIS12/MIND complex)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001333543.1 psi-mi:"MI:0469"(intact) - - figure legend:S 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 rogid:Vpue/juDe4duVyAHaW5S+rEZZPY6239 intact-crc:E45793E9AF5DC816|rigid:IVvf2aStoaMeduImuBp4G5ZSN3I false his tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O76406 uniprotkb:Q95QB8 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 intact:EBI-1175928|ensemblmetazoa:R13F6.1.1 psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:q95qb8_caeel(display_long)|uniprotkb:kbp-1(gene name)|psi-mi:kbp-1(display_short)|uniprotkb:CELE_R13F6.1(orf name)|uniprotkb:R13F6.1(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175914|imex:IM-12009-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) wormbase:R13F6.1|ensemblmetazoa:R13F6.1.1(transcript)|ensemblmetazoa:WBGene00020064(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001293639.1 psi-mi:"MI:0469"(intact) - - figure legend:S 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 rogid:M//0ApTdj9fnjaEAwjxvr02e6Us6239 intact-crc:E45793E9AF5DC816|rigid:IVvf2aStoaMeduImuBp4G5ZSN3I false his tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O76406 uniprotkb:Q9N3R7 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 intact:EBI-1175923|ensemblmetazoa:Y47G6A.24a.1|ensemblmetazoa:Y47G6A.24a.2 psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:q9n3r7_caeel(display_long)|uniprotkb:mis-12(gene name)|psi-mi:mis-12(display_short)|uniprotkb:CELE_Y47G6A.24(orf name)|uniprotkb:Y47G6A.24(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1175914|imex:IM-12009-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) refseq:NP_491184.1|wormbase:Y47G6A.24a|ensemblmetazoa:WBGene00021648(gene)|ensemblmetazoa:Y47G6A.24a.1(transcript)|ensemblmetazoa:Y47G6A.24a.2(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly) psi-mi:"MI:0469"(intact) - - figure legend:S 1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 rogid:EQD16Rq8ODi0DL8A2U5WQjJNJp86239 intact-crc:E45793E9AF5DC816|rigid:IVvf2aStoaMeduImuBp4G5ZSN3I false his tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34278 uniprotkb:O76406 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176016|imex:IM-12009-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) psi-mi:"MI:0469"(intact) - - figure legend:S 1|comment:MIS-12 is reduced relative to other subunits in the purification with KNL-1-6XHis.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 intact-crc:DE8BFBE5862A4087|rigid:xzoQkRLAZ9yHBOfM7Z5zxpzK2LU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34278 uniprotkb:Q8MNT1 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175933|ensemblmetazoa:F26F4.13.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q8mnt1_caeel(display_long)|uniprotkb:kbp-2(gene name)|psi-mi:kbp-2(display_short)|uniprotkb:CELE_F26F4.13(orf name)|uniprotkb:F26F4.13(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176016|imex:IM-12009-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N interpro:IPR007128(Nnf1)|wormbase:F26F4.13|ensemblmetazoa:F26F4.13.1(transcript)|ensemblmetazoa:WBGene00017832(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0000818"(nuclear MIS12/MIND complex)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001333543.1 psi-mi:"MI:0469"(intact) - - figure legend:S 1|comment:MIS-12 is reduced relative to other subunits in the purification with KNL-1-6XHis.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:Vpue/juDe4duVyAHaW5S+rEZZPY6239 intact-crc:DE8BFBE5862A4087|rigid:xzoQkRLAZ9yHBOfM7Z5zxpzK2LU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34278 uniprotkb:Q95QB8 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175928|ensemblmetazoa:R13F6.1.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q95qb8_caeel(display_long)|uniprotkb:kbp-1(gene name)|psi-mi:kbp-1(display_short)|uniprotkb:CELE_R13F6.1(orf name)|uniprotkb:R13F6.1(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176016|imex:IM-12009-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N wormbase:R13F6.1|ensemblmetazoa:R13F6.1.1(transcript)|ensemblmetazoa:WBGene00020064(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly)|refseq:NP_001293639.1 psi-mi:"MI:0469"(intact) - - figure legend:S 1|comment:MIS-12 is reduced relative to other subunits in the purification with KNL-1-6XHis.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:M//0ApTdj9fnjaEAwjxvr02e6Us6239 intact-crc:DE8BFBE5862A4087|rigid:xzoQkRLAZ9yHBOfM7Z5zxpzK2LU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34278 uniprotkb:Q9N3R7 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175923|ensemblmetazoa:Y47G6A.24a.1|ensemblmetazoa:Y47G6A.24a.2 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:q9n3r7_caeel(display_long)|uniprotkb:mis-12(gene name)|psi-mi:mis-12(display_short)|uniprotkb:CELE_Y47G6A.24(orf name)|uniprotkb:Y47G6A.24(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176016|imex:IM-12009-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_491184.1|wormbase:Y47G6A.24a|ensemblmetazoa:WBGene00021648(gene)|ensemblmetazoa:Y47G6A.24a.1(transcript)|ensemblmetazoa:Y47G6A.24a.2(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0051382"(kinetochore assembly) psi-mi:"MI:0469"(intact) - - figure legend:S 1|comment:MIS-12 is reduced relative to other subunits in the purification with KNL-1-6XHis.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2016/12/06 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:EQD16Rq8ODi0DL8A2U5WQjJNJp86239 intact-crc:DE8BFBE5862A4087|rigid:xzoQkRLAZ9yHBOfM7Z5zxpzK2LU false - flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38991 uniprotkb:Q17635 intact:EBI-9319|ensemblfungi:YPL209C|uniprotkb:D6W3G1 intact:EBI-314429|uniprotkb:Q23107|ensemblmetazoa:W01B6.9.1 psi-mi:ipl1_yeast(display_long)|uniprotkb:IPL1(gene name)|psi-mi:IPL1(display_short)|uniprotkb:YPL209C(locus name)|uniprotkb:Aurora kinase(gene name synonym)|uniprotkb:Increase-in-ploidy protein 1(gene name synonym) psi-mi:ndc80_caeel(display_long)|uniprotkb:ndc-80(gene name)|psi-mi:ndc-80(display_short)|uniprotkb:W01B6.9(orf name)|uniprotkb:Hec1 homolog(gene name synonym) psi-mi:"MI:0415"(enzymatic study) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176131|imex:IM-12009-7 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YPL209C(gene)|ensemblfungi:YPL209C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0044774"(mitotic DNA integrity checkpoint signaling)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045144"(meiotic sister chromatid segregation)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901925"(negative regulation of protein import into nucleus during spindle assembly checkpoint)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|reactome:R-SCE-8854050|refseq:NP_015115.1|sgd:S000006130|dip:DIP-2771N|mint:P38991 refseq:NP_501830.1|wormbase:W01B6.9|ensemblmetazoa:W01B6.9.1(transcript)|ensemblmetazoa:WBGene00003576(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|go:"GO:0030334"(regulation of cell migration)|dip:DIP-25850N psi-mi:"MI:0469"(intact) - - figure legend:7 B|comment:NDC-80 was phosphorylated by Ipl1 when present as a constituent in the NDC-80 complex as well as when a constituent of the head dimer.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2014/10/16 rogid:hNg/pnDWxuP6BSpguV7aFh50wtE559292 rogid:VqbUclU7wKvfpUfmJTQj3SosKtg6239 intact-crc:403F676EFE939479|rigid:kAivHXaXUKf3uhmGMYTTbrTyGZU false - mutation disrupting interaction:8-8,18-18,44-44,51-51 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q21952 uniprotkb:Q17635 intact:EBI-326288|ensemblmetazoa:R12B2.4.1 intact:EBI-314429|uniprotkb:Q23107|ensemblmetazoa:W01B6.9.1 psi-mi:nuf2_caeel(display_long)|uniprotkb:R12B2.4(orf name)|uniprotkb:Kinetochore protein him-10(gene name synonym)|uniprotkb:Protein high incidence of males 10(gene name synonym)|uniprotkb:him-10(gene name)|psi-mi:him-10(display_short) psi-mi:ndc80_caeel(display_long)|uniprotkb:ndc-80(gene name)|psi-mi:ndc-80(display_short)|uniprotkb:W01B6.9(orf name)|uniprotkb:Hec1 homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176210|imex:IM-12009-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498253.1|wormbase:R12B2.4|ensemblmetazoa:R12B2.4.1(transcript)|ensemblmetazoa:WBGene00001869(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|interpro:IPR005549(Nuf2)|interpro:IPR038275|dip:DIP-25404N refseq:NP_501830.1|wormbase:W01B6.9|ensemblmetazoa:W01B6.9.1(transcript)|ensemblmetazoa:WBGene00003576(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|go:"GO:0030334"(regulation of cell migration)|dip:DIP-25850N go:"GO:0031262"(Ndc80 complex) - - figure legend:6 A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2014/10/16 rogid:jGq4E8mXj7wTqWnEvuhDvjX2FxQ6239 rogid:VqbUclU7wKvfpUfmJTQj3SosKtg6239 intact-crc:1972321EB95F56A4|rigid:eQ/v7LvX6T23ARRMMktRrL9TObY false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9BZD4 uniprotkb:O14777 intact:EBI-724102|ensembl:ENSP00000271452|ensembl:ENSP00000356875|uniprotkb:Q8WU69|uniprotkb:Q96HJ4|uniprotkb:Q96Q78 intact:EBI-715849|uniprotkb:Q6PJX2|ensembl:ENSP00000261597 psi-mi:nuf2_human(display_long)|uniprotkb:NUF2(gene name)|psi-mi:NUF2(display_short)|uniprotkb:CDCA1(gene name synonym)|uniprotkb:NUF2R(gene name synonym)|uniprotkb:Cell division cycle-associated protein 1(gene name synonym) psi-mi:ndc80_human(display_long)|uniprotkb:Kinetochore protein Hec1(gene name synonym)|uniprotkb:Kinetochore-associated protein 2(gene name synonym)|uniprotkb:Highly expressed in cancer protein(gene name synonym)|uniprotkb:Retinoblastoma-associated protein HEC(gene name synonym)|uniprotkb:NDC80(gene name)|psi-mi:NDC80(display_short)|uniprotkb:HEC(gene name synonym)|uniprotkb:KNTC2(gene name synonym)|uniprotkb:HEC1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176296|imex:IM-12009-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_113611.2|refseq:NP_663735.2|ensembl:ENSG00000143228(gene)|ensembl:ENST00000271452(transcript)|ensembl:ENST00000367900(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|interpro:IPR005549(Nuf2)|interpro:IPR038275|mint:Q9BZD4|rcsb pdb:2VE7|rcsb pdb:3IZ0|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0016020"(membrane)|dip:DIP-36119N refseq:NP_006092.1|ensembl:ENSG00000080986(gene)|ensembl:ENST00000261597(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016020"(membrane)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|interpro:IPR040967|mint:O14777|rcsb pdb:2IGP|rcsb pdb:2VE7|rcsb pdb:3IZ0|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-35100N go:"GO:0031262"(Ndc80 complex) - - figure legend:6 G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2015/02/12 rogid:jyetvY/NG1CPYYsx5DZ4dVEPdEY9606 rogid:5OsXbZPvJTMWPepp7M+AXlJUQ649606 intact-crc:95DBF77733F6623F|rigid:QDck69O6Ygx9r5MQJOySBevg8Kk false - his tag:?-? - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P34278 uniprotkb:Q17635 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-314429|uniprotkb:Q23107|ensemblmetazoa:W01B6.9.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:ndc80_caeel(display_long)|uniprotkb:ndc-80(gene name)|psi-mi:ndc-80(display_short)|uniprotkb:W01B6.9(orf name)|uniprotkb:Hec1 homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176356|imex:IM-12009-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_501830.1|wormbase:W01B6.9|ensemblmetazoa:W01B6.9.1(transcript)|ensemblmetazoa:WBGene00003576(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|go:"GO:0030334"(regulation of cell migration)|dip:DIP-25850N psi-mi:"MI:0469"(intact) - - figure legend:S2|comment:"This interaction occured under low salt (50 mM) conditions. Under high salt conditions (750 mM) HIM-10 did not co-fractionate with these proteins."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo) - 2006/12/05 2014/10/16 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:VqbUclU7wKvfpUfmJTQj3SosKtg6239 intact-crc:A443F8CC6F874FFD|rigid:kmR60gDH5RRPUmJmc4ZrnrOG/VA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34278 uniprotkb:Q21952 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-326288|ensemblmetazoa:R12B2.4.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:nuf2_caeel(display_long)|uniprotkb:R12B2.4(orf name)|uniprotkb:Kinetochore protein him-10(gene name synonym)|uniprotkb:Protein high incidence of males 10(gene name synonym)|uniprotkb:him-10(gene name)|psi-mi:him-10(display_short) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176356|imex:IM-12009-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_498253.1|wormbase:R12B2.4|ensemblmetazoa:R12B2.4.1(transcript)|ensemblmetazoa:WBGene00001869(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|interpro:IPR005549(Nuf2)|interpro:IPR038275|dip:DIP-25404N psi-mi:"MI:0469"(intact) - - figure legend:S2|comment:"This interaction occured under low salt (50 mM) conditions. Under high salt conditions (750 mM) HIM-10 did not co-fractionate with these proteins."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo) - 2006/12/05 2014/10/16 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:jGq4E8mXj7wTqWnEvuhDvjX2FxQ6239 intact-crc:A443F8CC6F874FFD|rigid:kmR60gDH5RRPUmJmc4ZrnrOG/VA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34278 uniprotkb:O76406 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176356|imex:IM-12009-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) psi-mi:"MI:0469"(intact) - - figure legend:S2|comment:"This interaction occured under low salt (50 mM) conditions. Under high salt conditions (750 mM) HIM-10 did not co-fractionate with these proteins."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo) - 2006/12/05 2014/10/16 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 intact-crc:A443F8CC6F874FFD|rigid:kmR60gDH5RRPUmJmc4ZrnrOG/VA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34278 uniprotkb:Q17635 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-314429|uniprotkb:Q23107|ensemblmetazoa:W01B6.9.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:ndc80_caeel(display_long)|uniprotkb:ndc-80(gene name)|psi-mi:ndc-80(display_short)|uniprotkb:W01B6.9(orf name)|uniprotkb:Hec1 homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176376|imex:IM-12009-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_501830.1|wormbase:W01B6.9|ensemblmetazoa:W01B6.9.1(transcript)|ensemblmetazoa:WBGene00003576(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|go:"GO:0030334"(regulation of cell migration)|dip:DIP-25850N go:"GO:0031262"(Ndc80 complex) - - figure legend:S2|comment:"This interaction occured under high salt conditions (750 mM) and unlike under low salt conditions (50 mM) HIM-10 did not co-fractionate with these proteins."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo) - 2006/12/05 2014/10/16 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:VqbUclU7wKvfpUfmJTQj3SosKtg6239 intact-crc:B7D5A2D5C560DF7B|rigid:0JAQU7KmBRJxAnotQ5FKe6gOQXw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P34278 uniprotkb:O76406 intact:EBI-313751|ensemblmetazoa:C02F5.1.1 intact:EBI-1175918|ensemblmetazoa:T10B5.6.1 psi-mi:knl1_caeel(display_long)|uniprotkb:C02F5.1(orf name)|uniprotkb:knl-1(gene name)|psi-mi:knl-1(display_short) psi-mi:o76406_caeel(display_long)|uniprotkb:knl-3(gene name)|psi-mi:knl-3(display_short)|uniprotkb:CELE_T10B5.6(orf name)|uniprotkb:T10B5.6(orf name) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1176376|imex:IM-12009-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498811.1|wormbase:C02F5.1|ensemblmetazoa:C02F5.1.1(transcript)|ensemblmetazoa:WBGene00002231(gene)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005694"(chromosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|dip:DIP-25115N refseq:NP_503520.1|wormbase:T10B5.6|ensemblmetazoa:T10B5.6.1(transcript)|ensemblmetazoa:WBGene00020392(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051382"(kinetochore assembly)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1905561"(positive regulation of kinetochore assembly) go:"GO:0031262"(Ndc80 complex) - - figure legend:S2|comment:"This interaction occured under high salt conditions (750 mM) and unlike under low salt conditions (50 mM) HIM-10 did not co-fractionate with these proteins."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo) - 2006/12/05 2014/10/16 rogid:3DFBj4SOezj3CRsizwC0biCAfUQ6239 rogid:YdVt0+9h0bkfHGwA9xNuJiWIimo6239 intact-crc:B7D5A2D5C560DF7B|rigid:0JAQU7KmBRJxAnotQ5FKe6gOQXw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q17635 uniprotkb:Q21952 intact:EBI-314429|uniprotkb:Q23107|ensemblmetazoa:W01B6.9.1 intact:EBI-326288|ensemblmetazoa:R12B2.4.1 psi-mi:ndc80_caeel(display_long)|uniprotkb:ndc-80(gene name)|psi-mi:ndc-80(display_short)|uniprotkb:W01B6.9(orf name)|uniprotkb:Hec1 homolog(gene name synonym) psi-mi:nuf2_caeel(display_long)|uniprotkb:R12B2.4(orf name)|uniprotkb:Kinetochore protein him-10(gene name synonym)|uniprotkb:Protein high incidence of males 10(gene name synonym)|uniprotkb:him-10(gene name)|psi-mi:him-10(display_short) psi-mi:"MI:0071"(molecular sieving) Cheeseman et al. (2006) imex:IM-12009|pubmed:17129783 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1179909|imex:IM-12009-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_501830.1|wormbase:W01B6.9|ensemblmetazoa:W01B6.9.1(transcript)|ensemblmetazoa:WBGene00003576(gene)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1901970"(positive regulation of mitotic sister chromatid separation)|go:"GO:1903394"(protein localization to kinetochore involved in kinetochore assembly)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905561"(positive regulation of kinetochore assembly)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|go:"GO:0030334"(regulation of cell migration)|dip:DIP-25850N refseq:NP_498253.1|wormbase:R12B2.4|ensemblmetazoa:R12B2.4.1(transcript)|ensemblmetazoa:WBGene00001869(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|interpro:IPR005549(Nuf2)|interpro:IPR038275|dip:DIP-25404N psi-mi:"MI:0469"(intact) - - figure legend:2 A gels 1, 5, 6, 7|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/12/05 2014/10/16 rogid:VqbUclU7wKvfpUfmJTQj3SosKtg6239 rogid:jGq4E8mXj7wTqWnEvuhDvjX2FxQ6239 intact-crc:665EF8DF652CF6FF|rigid:eQ/v7LvX6T23ARRMMktRrL9TObY false - - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining)