#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P52946	uniprotkb:Q6ZWS8	intact:EBI-7128945|ensembl:ENSMUSP00000082729|uniprotkb:Q3ZB03|intact:MINT-3982089	intact:EBI-7128920|ensembl:ENSMUSP00000103350|ensembl:ENSMUSP00000103352|uniprotkb:Q3TLC2|uniprotkb:Q5ST07|intact:MINT-3982111|uniprotkb:Q76LV9	psi-mi:pdx1_mouse(display_long)|uniprotkb:Pdx1(gene name)|psi-mi:Pdx1(display_short)|uniprotkb:Ipf1(gene name synonym)|uniprotkb:Insulin promoter factor 1(gene name synonym)|uniprotkb:Islet/duodenum homeobox 1(gene name synonym)|uniprotkb:Somatostatin-transactivating factor 1(gene name synonym)	psi-mi:spop_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)|uniprotkb:Pcif1(gene name synonym)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:PDX-1 C-terminal-interacting factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2006)	pubmed:17126328|imex:IM-11120|mint:MINT-5219381	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7129009|mint:MINT-3982129|imex:IM-11120-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029644(gene)|ensembl:ENSMUST00000085591(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0031016"(pancreas development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033273"(response to vitamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043201"(response to leucine)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051594"(detection of glucose)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070542"(response to fatty acid)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR017995|interpro:IPR020479|mint:P52946|go:"GO:0030073"(insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010157"(response to chlorate)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016607"(nuclear speck)|refseq:NP_032840.1|mint:MINT-3982130(identity)	refseq:XP_006532755.1|ensembl:ENSMUSG00000057522(gene)|ensembl:ENSMUST00000107722(transcript)|ensembl:ENSMUST00000107724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:Q6ZWS8|reactome:R-MMU-5632684|refseq:NP_079563.2|dip:DIP-43930N|mint:MINT-3982131(identity)	-	comment:mint|function:Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'|comment:homomint	comment:mint|function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-min6)|taxid:10090(Mouse-pancreatic insulinoma cells)	-	2006/12/19	2014/10/16	rogid:CHitZAkwvBAI2ercpQQzvn5ROvQ10090	rogid:PC9ofpvk14xwTnnqT590/YRnx/410090	intact-crc:0B5BB9484BA9355D|rigid:CossEKcc/hDZtaQ8m9adBSHRcLY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZWS8	uniprotkb:P52946	intact:EBI-7128920|ensembl:ENSMUSP00000103350|ensembl:ENSMUSP00000103352|uniprotkb:Q3TLC2|uniprotkb:Q5ST07|intact:MINT-3982111|uniprotkb:Q76LV9	intact:EBI-7128945|ensembl:ENSMUSP00000082729|uniprotkb:Q3ZB03|intact:MINT-3982089	psi-mi:spop_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)|uniprotkb:Pcif1(gene name synonym)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:PDX-1 C-terminal-interacting factor 1(gene name synonym)	psi-mi:pdx1_mouse(display_long)|uniprotkb:Pdx1(gene name)|psi-mi:Pdx1(display_short)|uniprotkb:Ipf1(gene name synonym)|uniprotkb:Insulin promoter factor 1(gene name synonym)|uniprotkb:Islet/duodenum homeobox 1(gene name synonym)|uniprotkb:Somatostatin-transactivating factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2006)	pubmed:17126328|imex:IM-11120|mint:MINT-5219381	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7129259|mint:MINT-3982142|imex:IM-11120-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006532755.1|ensembl:ENSMUSG00000057522(gene)|ensembl:ENSMUST00000107722(transcript)|ensembl:ENSMUST00000107724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:Q6ZWS8|reactome:R-MMU-5632684|refseq:NP_079563.2|dip:DIP-43930N|mint:MINT-3982146(identity)	ensembl:ENSMUSG00000029644(gene)|ensembl:ENSMUST00000085591(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0031016"(pancreas development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033273"(response to vitamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043201"(response to leucine)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051594"(detection of glucose)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070542"(response to fatty acid)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR017995|interpro:IPR020479|mint:P52946|go:"GO:0030073"(insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010157"(response to chlorate)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016607"(nuclear speck)|refseq:NP_032840.1|mint:MINT-3982143(identity)	-	comment:mint|function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3	comment:mint|function:Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'|comment:homomint	figure legend:F2D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/12/19	2014/10/16	rogid:PC9ofpvk14xwTnnqT590/YRnx/410090	rogid:CHitZAkwvBAI2ercpQQzvn5ROvQ10090	intact-crc:DB4A20CB43C4ADEE|rigid:CossEKcc/hDZtaQ8m9adBSHRcLY	false	-	mutation disrupting interaction:210-238(MINT-3982155)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15379	uniprotkb:Q9H4Z3	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	intact:EBI-5235470|uniprotkb:E1P5P1|uniprotkb:Q54AB9|uniprotkb:Q9NT85|intact:EBI-28969183|ensembl:ENSP00000361486	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:capam_human(display_long)|uniprotkb:PCIF1(gene name)|psi-mi:PCIF1(display_short)|uniprotkb:C20orf67(gene name synonym)|uniprotkb:CAPAM(gene name synonym)|uniprotkb:PPP1R121(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 121(gene name synonym)|uniprotkb:Cap-specific adenosine methyltransferase(gene name synonym)|uniprotkb:Phosphorylated CTD-interacting factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2006)	pubmed:17126328|imex:IM-11120|mint:MINT-5219381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7129275|mint:MINT-3982230|imex:IM-11120-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253|mint:MINT-3982231(identity)	ensembl:ENSP00000361486|refseq:XP_011527282.1|refseq:XP_011527283.1|refseq:NP_071387.1|refseq:XP_016883502.1|ensembl:ENSG00000100982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0017148"(negative regulation of translation)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0080009"(mRNA methylation)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR022035|interpro:IPR029048|interpro:IPR036020|interpro:IPR039881|mint:Q9H4Z3|rcsb pdb:2JX8|rcsb pdb:6IRV|rcsb pdb:6IRW|ensembl:ENST00000372409(transcript)|mint:MINT-3982236(identity)	-	-	-	figure legend:F5C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/12/19	2014/10/16	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	rogid:/LiqBpGc2Jxe9TaCJfYzM4oz/GM9606	intact-crc:7962277B4261FCDD|rigid:n9kD/UiAN/y4dPgrpf8qML8gG68	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZWS8	uniprotkb:P52946	intact:EBI-7128920|ensembl:ENSMUSP00000103350|ensembl:ENSMUSP00000103352|uniprotkb:Q3TLC2|uniprotkb:Q5ST07|intact:MINT-3982111|uniprotkb:Q76LV9	intact:EBI-7128945|ensembl:ENSMUSP00000082729|uniprotkb:Q3ZB03|intact:MINT-3982089	psi-mi:spop_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)|uniprotkb:Pcif1(gene name synonym)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:PDX-1 C-terminal-interacting factor 1(gene name synonym)	psi-mi:pdx1_mouse(display_long)|uniprotkb:Pdx1(gene name)|psi-mi:Pdx1(display_short)|uniprotkb:Ipf1(gene name synonym)|uniprotkb:Insulin promoter factor 1(gene name synonym)|uniprotkb:Islet/duodenum homeobox 1(gene name synonym)|uniprotkb:Somatostatin-transactivating factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Liu et al. (2006)	pubmed:17126328|imex:IM-11120|mint:MINT-5219381	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7129332|mint:MINT-3982159|imex:IM-11120-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006532755.1|ensembl:ENSMUSG00000057522(gene)|ensembl:ENSMUST00000107722(transcript)|ensembl:ENSMUST00000107724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:Q6ZWS8|reactome:R-MMU-5632684|refseq:NP_079563.2|dip:DIP-43930N|mint:MINT-3982160(identity)	ensembl:ENSMUSG00000029644(gene)|ensembl:ENSMUST00000085591(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0031016"(pancreas development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033273"(response to vitamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043201"(response to leucine)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051594"(detection of glucose)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070542"(response to fatty acid)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR017995|interpro:IPR020479|mint:P52946|go:"GO:0030073"(insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010157"(response to chlorate)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016607"(nuclear speck)|refseq:NP_032840.1|mint:MINT-3982164(identity)	-	comment:mint|function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3	comment:mint|function:Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'|comment:homomint	figure legend:F4B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/19	2014/10/16	rogid:PC9ofpvk14xwTnnqT590/YRnx/410090	rogid:CHitZAkwvBAI2ercpQQzvn5ROvQ10090	intact-crc:EE5FF6E708A5A7C1|rigid:CossEKcc/hDZtaQ8m9adBSHRcLY	false	binding-associated region:38-163(MINT-3982187)	binding-associated region:206-283(MINT-3982175)|glutathione s tranferase tag:?-?(MINT-3982173)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52946	uniprotkb:Q6ZWS8	intact:EBI-7128945|ensembl:ENSMUSP00000082729|uniprotkb:Q3ZB03|intact:MINT-3982089	intact:EBI-7128920|ensembl:ENSMUSP00000103350|ensembl:ENSMUSP00000103352|uniprotkb:Q3TLC2|uniprotkb:Q5ST07|intact:MINT-3982111|uniprotkb:Q76LV9	psi-mi:pdx1_mouse(display_long)|uniprotkb:Pdx1(gene name)|psi-mi:Pdx1(display_short)|uniprotkb:Ipf1(gene name synonym)|uniprotkb:Insulin promoter factor 1(gene name synonym)|uniprotkb:Islet/duodenum homeobox 1(gene name synonym)|uniprotkb:Somatostatin-transactivating factor 1(gene name synonym)	psi-mi:spop_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)|uniprotkb:Pcif1(gene name synonym)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:PDX-1 C-terminal-interacting factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Liu et al. (2006)	pubmed:17126328|imex:IM-11120|mint:MINT-5219381	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7129400|mint:MINT-3982191|imex:IM-11120-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029644(gene)|ensembl:ENSMUST00000085591(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0031016"(pancreas development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033273"(response to vitamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043201"(response to leucine)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051594"(detection of glucose)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070542"(response to fatty acid)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR017995|interpro:IPR020479|mint:P52946|go:"GO:0030073"(insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010157"(response to chlorate)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016607"(nuclear speck)|refseq:NP_032840.1|mint:MINT-3982198(identity)	refseq:XP_006532755.1|ensembl:ENSMUSG00000057522(gene)|ensembl:ENSMUST00000107722(transcript)|ensembl:ENSMUST00000107724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:Q6ZWS8|reactome:R-MMU-5632684|refseq:NP_079563.2|dip:DIP-43930N|mint:MINT-3982192(identity)	-	comment:mint|function:Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'|comment:homomint	comment:mint|function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/19	2014/10/16	rogid:CHitZAkwvBAI2ercpQQzvn5ROvQ10090	rogid:PC9ofpvk14xwTnnqT590/YRnx/410090	intact-crc:3C5C6B32AE51D882|rigid:CossEKcc/hDZtaQ8m9adBSHRcLY	false	binding-associated region:144-283(MINT-3982200)	glutathione s tranferase tag:?-?(MINT-3982210)|binding-associated region:38-163(MINT-3982194)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52946	uniprotkb:Q6ZWS8	intact:EBI-7128945|ensembl:ENSMUSP00000082729|uniprotkb:Q3ZB03|intact:MINT-3982089	intact:EBI-7128920|ensembl:ENSMUSP00000103350|ensembl:ENSMUSP00000103352|uniprotkb:Q3TLC2|uniprotkb:Q5ST07|intact:MINT-3982111|uniprotkb:Q76LV9	psi-mi:pdx1_mouse(display_long)|uniprotkb:Pdx1(gene name)|psi-mi:Pdx1(display_short)|uniprotkb:Ipf1(gene name synonym)|uniprotkb:Insulin promoter factor 1(gene name synonym)|uniprotkb:Islet/duodenum homeobox 1(gene name synonym)|uniprotkb:Somatostatin-transactivating factor 1(gene name synonym)	psi-mi:spop_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)|uniprotkb:Pcif1(gene name synonym)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:PDX-1 C-terminal-interacting factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Liu et al. (2006)	pubmed:17126328|imex:IM-11120|mint:MINT-5219381	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7129466|mint:MINT-3982213|imex:IM-11120-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029644(gene)|ensembl:ENSMUST00000085591(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030154"(cell differentiation)|go:"GO:0031016"(pancreas development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033273"(response to vitamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043201"(response to leucine)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051594"(detection of glucose)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070542"(response to fatty acid)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR017995|interpro:IPR020479|mint:P52946|go:"GO:0030073"(insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010157"(response to chlorate)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016607"(nuclear speck)|refseq:NP_032840.1|mint:MINT-3982222(identity)	refseq:XP_006532755.1|ensembl:ENSMUSG00000057522(gene)|ensembl:ENSMUST00000107722(transcript)|ensembl:ENSMUST00000107724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:Q6ZWS8|reactome:R-MMU-5632684|refseq:NP_079563.2|dip:DIP-43930N|mint:MINT-3982214(identity)	-	comment:mint|function:Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'|comment:homomint	comment:mint|function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/19	2014/10/16	rogid:CHitZAkwvBAI2ercpQQzvn5ROvQ10090	rogid:PC9ofpvk14xwTnnqT590/YRnx/410090	intact-crc:EE41E01D880B7A18|rigid:CossEKcc/hDZtaQ8m9adBSHRcLY	false	binding-associated region:144-283(MINT-3982224)	binding-associated region:190-294(MINT-3982218)|glutathione s tranferase tag:?-?(MINT-3982216)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)