#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O35253	uniprotkb:Q9JIF0	intact:EBI-5274835|uniprotkb:O88709|ensembl:ENSMUSP00000026999|ensembl:ENSMUSP00000129322	intact:EBI-519055|uniprotkb:Q99LS4|ensembl:ENSMUSP00000103474	psi-mi:smad7_mouse(display_long)|uniprotkb:Smad7(gene name)|psi-mi:Smad7(display_short)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Madh8(gene name synonym)|uniprotkb:Mothers against decapentaplegic homolog 8(gene name synonym)|uniprotkb:SMAD family member 7(gene name synonym)	psi-mi:anm1_mouse(display_long)|uniprotkb:Prmt1(gene name)|psi-mi:Prmt1(display_short)|uniprotkb:Mrmt1(gene name synonym)|uniprotkb:Hrmt1l2(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Inamitsu et al. (2006)	pubmed:17118358|imex:IM-11005|mint:MINT-5219359	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7107723|mint:MINT-3981961|imex:IM-11005-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036125.1|refseq:XP_006525766.1|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1903043"(positive regulation of chondrocyte hypertrophy)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000317"(negative regulation of T-helper 17 type immune response)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35253|rcsb pdb:7CD1|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173796|reactome:R-MMU-5689880|ensembl:ENSMUSG00000025880(gene)|ensembl:ENSMUST00000026999(transcript)|ensembl:ENSMUST00000168918(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001657"(ureteric bud development)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034629"|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070411"(I-SMAD binding)|mint:MINT-3981962(identity)	ensembl:ENSMUSG00000109324(gene)|ensembl:ENSMUST00000107843(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016275"([cytochrome c]-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019919"(peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)|go:"GO:0030519"(snoRNP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035247"(peptidyl-arginine omega-N-methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q9JIF0|reactome:R-MMU-3214858|reactome:R-MMU-8936459|reactome:R-MMU-9009391|reactome:R-MMU-9018519|refseq:NP_062804.1|refseq:NP_001239405.1|mint:MINT-3981966(identity)	-	-	-	figure legend:F1A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/19	2014/10/16	rogid:3QfaoCXtWp+4BpA6Una+iIPCkEQ10090	rogid:r9A3nCdPjfUjlHiIDRqKxH5DumI10090	intact-crc:D6D6551614CB48AA|rigid:PodBswqlHve+rFjczpHzCR3nXp4	false	glutathione s tranferase tag:?-?(MINT-3981964)	glutathione s tranferase tag:?-?(MINT-3981968)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIF0	uniprotkb:O35182	intact:EBI-519055|uniprotkb:Q99LS4|ensembl:ENSMUSP00000103474	intact:EBI-4321242|uniprotkb:Q9CW62|ensembl:ENSMUSP00000036285	psi-mi:anm1_mouse(display_long)|uniprotkb:Prmt1(gene name)|psi-mi:Prmt1(display_short)|uniprotkb:Mrmt1(gene name synonym)|uniprotkb:Hrmt1l2(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)	psi-mi:smad6_mouse(display_long)|uniprotkb:Smad6(gene name)|psi-mi:Smad6(display_short)|uniprotkb:Madh6(gene name synonym)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Msmad6(gene name synonym)|uniprotkb:Mad homolog 7(gene name synonym)|uniprotkb:SMAD family member 6(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Inamitsu et al. (2006)	pubmed:17118358|imex:IM-11005|mint:MINT-5219359	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7107685|mint:MINT-3981919|imex:IM-11005-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000109324(gene)|ensembl:ENSMUST00000107843(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016275"([cytochrome c]-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019919"(peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)|go:"GO:0030519"(snoRNP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035247"(peptidyl-arginine omega-N-methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q9JIF0|reactome:R-MMU-3214858|reactome:R-MMU-8936459|reactome:R-MMU-9009391|reactome:R-MMU-9018519|refseq:NP_062804.1|refseq:NP_001239405.1|mint:MINT-3981921(identity)	refseq:NP_032568.3|refseq:XP_006510885.1|ensembl:ENSMUSG00000036867(gene)|ensembl:ENSMUST00000041029(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003170"(heart valve development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35182|reactome:R-MMU-201451|mint:MINT-3981920(identity)	-	-	-	figure legend:F1C|figure legend:F2A|figure legend:F1A|figure legend:F2C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/19	2014/10/16	rogid:r9A3nCdPjfUjlHiIDRqKxH5DumI10090	rogid:OUXf4eIz5T52+R67voHOPnyiIK410090	intact-crc:94DC0F3072F02283|rigid:meXivdMBQ1BrTjnwnbbdzFlLzZ0	false	glutathione s tranferase tag:?-?(MINT-3981950)	methylated residue:74-74(MINT-3981980)|glutathione s tranferase tag:?-?(MINT-3981954)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIF0	uniprotkb:O35182	intact:EBI-519055|uniprotkb:Q99LS4|ensembl:ENSMUSP00000103474	intact:EBI-4321242|uniprotkb:Q9CW62|ensembl:ENSMUSP00000036285	psi-mi:anm1_mouse(display_long)|uniprotkb:Prmt1(gene name)|psi-mi:Prmt1(display_short)|uniprotkb:Mrmt1(gene name synonym)|uniprotkb:Hrmt1l2(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)	psi-mi:smad6_mouse(display_long)|uniprotkb:Smad6(gene name)|psi-mi:Smad6(display_short)|uniprotkb:Madh6(gene name synonym)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Msmad6(gene name synonym)|uniprotkb:Mad homolog 7(gene name synonym)|uniprotkb:SMAD family member 6(gene name synonym)	psi-mi:"MI:0515"(methyltransferase assay)	Inamitsu et al. (2006)	pubmed:17118358|imex:IM-11005|mint:MINT-5219359	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7107760|mint:MINT-3981983|imex:IM-11005-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000109324(gene)|ensembl:ENSMUST00000107843(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016275"([cytochrome c]-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019919"(peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)|go:"GO:0030519"(snoRNP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035247"(peptidyl-arginine omega-N-methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q9JIF0|reactome:R-MMU-3214858|reactome:R-MMU-8936459|reactome:R-MMU-9009391|reactome:R-MMU-9018519|refseq:NP_062804.1|refseq:NP_001239405.1|mint:MINT-3981990(identity)	refseq:NP_032568.3|refseq:XP_006510885.1|ensembl:ENSMUSG00000036867(gene)|ensembl:ENSMUST00000041029(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003170"(heart valve development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35182|reactome:R-MMU-201451|mint:MINT-3981984(identity)	-	-	-	figure legend:F2D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/19	2014/10/16	rogid:r9A3nCdPjfUjlHiIDRqKxH5DumI10090	rogid:OUXf4eIz5T52+R67voHOPnyiIK410090	intact-crc:82E0B68DAA2154F2|rigid:meXivdMBQ1BrTjnwnbbdzFlLzZ0	false	glutathione s tranferase tag:?-?(MINT-3981992)	glutathione s tranferase tag:?-?(MINT-3981988)|methylated residue:74-74(MINT-3981985)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O35182	uniprotkb:Q9JIF0	intact:EBI-4321242|uniprotkb:Q9CW62|ensembl:ENSMUSP00000036285	intact:EBI-519055|uniprotkb:Q99LS4|ensembl:ENSMUSP00000103474	psi-mi:smad6_mouse(display_long)|uniprotkb:Smad6(gene name)|psi-mi:Smad6(display_short)|uniprotkb:Madh6(gene name synonym)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Msmad6(gene name synonym)|uniprotkb:Mad homolog 7(gene name synonym)|uniprotkb:SMAD family member 6(gene name synonym)	psi-mi:anm1_mouse(display_long)|uniprotkb:Prmt1(gene name)|psi-mi:Prmt1(display_short)|uniprotkb:Mrmt1(gene name synonym)|uniprotkb:Hrmt1l2(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Inamitsu et al. (2006)	pubmed:17118358|imex:IM-11005|mint:MINT-5219359	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7107805|mint:MINT-3981999|imex:IM-11005-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032568.3|refseq:XP_006510885.1|ensembl:ENSMUSG00000036867(gene)|ensembl:ENSMUST00000041029(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003170"(heart valve development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35182|reactome:R-MMU-201451|mint:MINT-3982000(identity)	ensembl:ENSMUSG00000109324(gene)|ensembl:ENSMUST00000107843(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016275"([cytochrome c]-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019919"(peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)|go:"GO:0030519"(snoRNP binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035247"(peptidyl-arginine omega-N-methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q9JIF0|reactome:R-MMU-3214858|reactome:R-MMU-8936459|reactome:R-MMU-9009391|reactome:R-MMU-9018519|refseq:NP_062804.1|refseq:NP_001239405.1|mint:MINT-3982006(identity)	-	-	-	figure legend:F3A|figure legend:F3B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/12/19	2014/10/16	rogid:OUXf4eIz5T52+R67voHOPnyiIK410090	rogid:r9A3nCdPjfUjlHiIDRqKxH5DumI10090	intact-crc:F3CB96690D2B92A1|rigid:meXivdMBQ1BrTjnwnbbdzFlLzZ0	false	binding-associated region:n-n(MINT-6949175)|flag tag:?-?(MINT-3982003)	ha tag:?-?(MINT-3982007)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CUN6	uniprotkb:O35182	intact:EBI-2348474|uniprotkb:Q3U412|uniprotkb:Q8K300|ensembl:ENSMUSP00000082827	intact:EBI-4321242|uniprotkb:Q9CW62|ensembl:ENSMUSP00000036285	psi-mi:smuf1_mouse(display_long)|uniprotkb:Smurf1(gene name)|psi-mi:Smurf1(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:smad6_mouse(display_long)|uniprotkb:Smad6(gene name)|psi-mi:Smad6(display_short)|uniprotkb:Madh6(gene name synonym)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Msmad6(gene name synonym)|uniprotkb:Mad homolog 7(gene name synonym)|uniprotkb:SMAD family member 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Inamitsu et al. (2006)	pubmed:17118358|imex:IM-11005|mint:MINT-5219359	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7107934|mint:MINT-3982302|imex:IM-11005-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033716.1|refseq:NP_083714.3|ensembl:ENSMUSG00000038780(gene)|ensembl:ENSMUST00000085684(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9CUN6|reactome:R-MMU-201451|reactome:R-MMU-2173791|reactome:R-MMU-4608870|reactome:R-MMU-5632684|reactome:R-MMU-8941858|reactome:R-MMU-983168|mint:MINT-3982308(identity)	refseq:NP_032568.3|refseq:XP_006510885.1|ensembl:ENSMUSG00000036867(gene)|ensembl:ENSMUST00000041029(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003170"(heart valve development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35182|reactome:R-MMU-201451|mint:MINT-3982303(identity)	-	-	-	figure legend:F4C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/12/19	2014/10/16	rogid:e/0b1gSRRvjn9kLgSmd2PBRU8Eo10090	rogid:OUXf4eIz5T52+R67voHOPnyiIK410090	intact-crc:BCE6C9A14992C2E8|rigid:c8jZkUwBHZ+xHfhDsw/8wZBJ4Bs	false	flag tag:?-?(MINT-3982309)	myc tag:?-?(MINT-3982304)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P36898	uniprotkb:O35182	intact:EBI-7107883|ensembl:ENSMUSP00000029948|ensembl:ENSMUSP00000096167|ensembl:ENSMUSP00000101837|ensembl:ENSMUSP00000101839|intact:MINT-124245|uniprotkb:Q3TRF2	intact:EBI-4321242|uniprotkb:Q9CW62|ensembl:ENSMUSP00000036285	psi-mi:bmr1b_mouse(display_long)|uniprotkb:Bmpr1b(gene name)|psi-mi:Bmpr1b(display_short)|uniprotkb:Acvrlk6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R6(gene name synonym)|uniprotkb:Activin receptor-like kinase 6(gene name synonym)	psi-mi:smad6_mouse(display_long)|uniprotkb:Smad6(gene name)|psi-mi:Smad6(display_short)|uniprotkb:Madh6(gene name synonym)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Msmad6(gene name synonym)|uniprotkb:Mad homolog 7(gene name synonym)|uniprotkb:SMAD family member 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Inamitsu et al. (2006)	pubmed:17118358|imex:IM-11005|mint:MINT-5219359	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7107876|mint:MINT-3982283|imex:IM-11005-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238303.1|refseq:XP_011238304.1|refseq:XP_006501006.1|refseq:XP_006501007.1|refseq:XP_006501002.1|refseq:XP_006501003.1|refseq:XP_006501005.1|ensembl:ENSMUSG00000052430(gene)|ensembl:ENSMUST00000029948(transcript)|ensembl:ENSMUST00000098568(transcript)|ensembl:ENSMUST00000106230(transcript)|ensembl:ENSMUST00000106232(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060348"(bone development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0071773"(cellular response to BMP stimulus)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36898|rcsb pdb:3EVS|reactome:R-MMU-201451|refseq:NP_001264149.1|refseq:NP_001264145.1|refseq:NP_001264146.1|refseq:NP_001264147.1|refseq:NP_031586.1|dip:DIP-252N|mint:MINT-3982290(identity)	refseq:NP_032568.3|refseq:XP_006510885.1|ensembl:ENSMUSG00000036867(gene)|ensembl:ENSMUST00000041029(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003170"(heart valve development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35182|reactome:R-MMU-201451|mint:MINT-3982284(identity)	-	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1	-	figure legend:F4B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/12/19	2014/10/16	rogid:hBx86trRoBai1kLICygtSQyHlQs10090	rogid:OUXf4eIz5T52+R67voHOPnyiIK410090	intact-crc:6CD03CB3B81DB9DE|rigid:iBnQJLtFS4Ll65yvW/hDy11+p68	false	v5 tag:?-?(MINT-3982291)	myc tag:?-?(MINT-3982287)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35182	uniprotkb:O88712	intact:EBI-4321242|uniprotkb:Q9CW62|ensembl:ENSMUSP00000036285	intact:EBI-604547|ensembl:ENSMUSP00000078682|uniprotkb:Q3TAT1|uniprotkb:Q3TDL5|uniprotkb:Q3TUM5|uniprotkb:Q91WI6|uniprotkb:Q91YX3|uniprotkb:Q9QYG2	psi-mi:smad6_mouse(display_long)|uniprotkb:Smad6(gene name)|psi-mi:Smad6(display_short)|uniprotkb:Madh6(gene name synonym)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Msmad6(gene name synonym)|uniprotkb:Mad homolog 7(gene name synonym)|uniprotkb:SMAD family member 6(gene name synonym)	psi-mi:ctbp1_mouse(display_long)|uniprotkb:Ctbp1(gene name)|psi-mi:Ctbp1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Inamitsu et al. (2006)	pubmed:17118358|imex:IM-11005|mint:MINT-5219359	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7107972|mint:MINT-3982318|imex:IM-11005-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032568.3|refseq:XP_006510885.1|ensembl:ENSMUSG00000036867(gene)|ensembl:ENSMUST00000041029(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003170"(heart valve development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046872"(metal ion binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035904"(aorta development)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070698"(type I activin receptor binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35182|reactome:R-MMU-201451|mint:MINT-3982324(identity)	go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0051726"(regulation of cell cycle)|ensembl:ENSMUSG00000037373(gene)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099526"(presynapse to nucleus signaling pathway)|ensembl:ENSMUST00000079746(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029752|go:"GO:0003682"(chromatin binding)|interpro:IPR029753|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR036291|go:"GO:0005737"(cytoplasm)|interpro:IPR043322|go:"GO:0006342"|mint:O88712|reactome:R-MMU-3769402|reactome:R-MMU-3899300|reactome:R-MMU-4641265|go:"GO:0008134"(transcription factor binding)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|refseq:NP_001185788.1|refseq:NP_001185789.1|refseq:NP_001185790.1|refseq:NP_038530.1|refseq:NP_001297464.1|dip:DIP-33907N|mint:MINT-3982319(identity)	-	-	-	figure legend:F4D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/12/19	2014/10/16	rogid:OUXf4eIz5T52+R67voHOPnyiIK410090	rogid:l2rq9ypazCscM/WbocEKgQZcEBo10090	intact-crc:38F70272DD48C2FE|rigid:shac2bvJef6umcG9aIPPPt4UmNI	false	flag tag:?-?(MINT-3982327)	myc tag:?-?(MINT-3982320)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)