#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62820	uniprotkb:Q01968	intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604129|mint:MINT-2880667|imex:IM-11000-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N|mint:MINT-2880669(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2880668(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|figure legend:F1A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/09/04	2014/10/16	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:282D37BBAA833174|rigid:KnC6pjISlYVB1pP5xiiF0edogjk	false	tag:?-?(MINT-2882790)	tag:?-?(MINT-2882782)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P61006	uniprotkb:Q01968	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604278|mint:MINT-2882797|imex:IM-11000-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|mint:MINT-2882798(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2882805(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|figure legend:F1A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/09/04	2014/10/16	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:6121011B7415A2F9|rigid:zLOhPU/3clz4b/DwMXaeklcM50g	false	tandem tag:?-?(MINT-2882803)	tag:?-?(MINT-2882811)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20339	uniprotkb:Q01968	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604413|mint:MINT-2882874|imex:IM-11000-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-2882875(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2882882(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|figure legend:F2A|figure legend:F1A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/09/04	2014/10/16	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:A65AD2F886066CE0|rigid:VsOYV3iBGNV6Vbi4cZS8okKLfpU	false	tag:?-?(MINT-2882877)	tag:?-?(MINT-2882883)|binding-associated region:540-726(MINT-2882893)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P61106	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-1056404|uniprotkb:P35287|uniprotkb:Q5JVD4|uniprotkb:Q6Q7K5|uniprotkb:Q969L0|uniprotkb:Q9UI11|uniprotkb:B3KR31|ensembl:ENSP00000362946	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab14_human(display_long)|uniprotkb:RAB14(gene name)|psi-mi:RAB14(display_short)	psi-mi:"MI:0018"(two hybrid)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604321|mint:MINT-2882815|imex:IM-11000-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2882823(identity)	refseq:NP_057406.2|ensembl:ENSG00000119396(gene)|ensembl:ENST00000373840(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030702|mint:P61106|rcsb pdb:1Z0F|rcsb pdb:4D0G|rcsb pdb:4DRZ|reactome:R-HSA-1445148|reactome:R-HSA-1660499|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-42491N|mint:MINT-2882816(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|figure legend:F1A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:qFP8UXDCPt/RcLTWlZLaitH2LF49606	intact-crc:048E8A26B2C17295|rigid:a5kK0egUwx7bmKo2/NZtIoLuc44	false	tag:?-?(MINT-2882824)	tandem tag:?-?(MINT-2882818)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P20340	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604439|mint:MINT-2882900|imex:IM-11000-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2882908(identity)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2882901(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|figure legend:F2A|figure legend:F1A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	intact-crc:E3D3A9326D624D9E|rigid:VFbTbwuF3gzRFmIJ5v1ffOyH1is	false	tag:?-?(MINT-2882916)|binding-associated region:540-726(MINT-2882909)	myc tag:?-?(MINT-2882903)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P20340	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604494|mint:MINT-2882920|imex:IM-11000-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2882928(identity)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2882921(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|figure legend:F1D|figure legend:F1E|figure legend:F2B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	intact-crc:A83335CC48222E33|rigid:VFbTbwuF3gzRFmIJ5v1ffOyH1is	false	binding-associated region:616-631(MINT-2882940)	glutathione s tranferase tag:?-?(MINT-2882923)	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20339	uniprotkb:Q01968	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604546|mint:MINT-2882933|imex:IM-11000-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-2882934(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2882946(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|figure legend:F1D|figure legend:F1E|figure legend:F2B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:51903AE1B9B0D529|rigid:VsOYV3iBGNV6Vbi4cZS8okKLfpU	false	glutathione s tranferase tag:?-?(MINT-2882937)	binding-associated region:616-631(MINT-2882947)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P61106	uniprotkb:Q01968	intact:EBI-1056404|uniprotkb:P35287|uniprotkb:Q5JVD4|uniprotkb:Q6Q7K5|uniprotkb:Q969L0|uniprotkb:Q9UI11|uniprotkb:B3KR31|ensembl:ENSP00000362946	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab14_human(display_long)|uniprotkb:RAB14(gene name)|psi-mi:RAB14(display_short)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604588|mint:MINT-2882965|imex:IM-11000-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057406.2|ensembl:ENSG00000119396(gene)|ensembl:ENST00000373840(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030702|mint:P61106|rcsb pdb:1Z0F|rcsb pdb:4D0G|rcsb pdb:4DRZ|reactome:R-HSA-1445148|reactome:R-HSA-1660499|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-42491N|mint:MINT-2882966(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2882974(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|figure legend:F1D|figure legend:F1E|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:qFP8UXDCPt/RcLTWlZLaitH2LF49606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:CED75C60A543282B|rigid:a5kK0egUwx7bmKo2/NZtIoLuc44	false	glutathione s tranferase tag:?-?(MINT-2882972)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P61006	uniprotkb:Q01968	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604607|mint:MINT-2882984|imex:IM-11000-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|mint:MINT-2882985(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2882995(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|figure legend:F1D|figure legend:F1E|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:0FF29E7745A29DFE|rigid:zLOhPU/3clz4b/DwMXaeklcM50g	false	glutathione s tranferase tag:?-?(MINT-2882988)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q01968	uniprotkb:P62820	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604626|mint:MINT-2883000|imex:IM-11000-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883011(identity)	refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N|mint:MINT-2883003(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|figure legend:F1D|figure legend:F1E|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606	intact-crc:D820BA413FD4FD1E|rigid:KnC6pjISlYVB1pP5xiiF0edogjk	false	-	glutathione s tranferase tag:?-?(MINT-2883009)	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20340	uniprotkb:Q14203	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	intact:EBI-724352|uniprotkb:O95296|uniprotkb:Q9BRM9|uniprotkb:Q9UIU1|intact:EBI-28971695|ensembl:ENSP00000487279|uniprotkb:Q9UIU2|uniprotkb:E9PGE1|uniprotkb:G5E9H4|uniprotkb:Q6IQ37|intact:EBI-2560059|uniprotkb:B4DM45|uniprotkb:E9PFS5|uniprotkb:A8MY36|intact:EBI-10962300	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:dctn1_human(display_long)|uniprotkb:DCTN1(gene name)|psi-mi:DCTN1(display_short)|uniprotkb:150 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:DAP-150(gene name synonym)|uniprotkb:p150-glued(gene name synonym)|uniprotkb:p135(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604645|mint:MINT-2883031|imex:IM-11000-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2883032(identity)	refseq:NP_001128512.1|refseq:NP_001128513.1|refseq:NP_001177766.1|refseq:NP_004073.2|refseq:NP_075408.1|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-381038|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|reactome:R-HSA-380259|ensembl:ENSG00000204843(gene)|ensembl:ENST00000628224(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007097"(nuclear migration)|go:"GO:0007399"(nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048156"(tau protein binding)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061744"(motor behavior)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0099558"(maintenance of synapse structure)|go:"GO:0099738"(cell cortex region)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR022157|interpro:IPR036859|mint:Q14203|rcsb pdb:1TXQ|rcsb pdb:2COY|rcsb pdb:2HKN|rcsb pdb:2HKQ|rcsb pdb:2HL3|rcsb pdb:2HL5|rcsb pdb:2HQH|rcsb pdb:3E2U|rcsb pdb:3TQ7|reactome:R-HSA-2132295|reactome:R-HSA-2565942|reactome:R-HSA-3371497|ensembl:ENST00000394003|ensembl:ENSP00000377571|ensembl:ENST00000409240|ensembl:ENSP00000386406|ensembl:ENST00000409438|ensembl:ENSP00000387270|ensembl:ENST00000409567|ensembl:ENSP00000386843|ensembl:ENSP00000487279|ensembl:ENST00000633691|ensembl:ENSP00000487724|refseq:NP_001177765.1|dip:DIP-31365N|mint:MINT-2883047(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	rogid:PKchWdLWycCErGzSVMXq/xCQJRM9606	intact-crc:01A8487E481A45D6|rigid:9BTZ/uXD6D2WZh+sifGO13w+FI8	false	glutathione s tranferase tag:?-?(MINT-2883039)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q15075	uniprotkb:P20339	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604661|mint:MINT-2883035|imex:IM-11000-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2|mint:MINT-2883046(identity)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-2883037(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	intact-crc:B21EF47E214758C7|rigid:L3aFSzo30ZMUia8/Q+k8w3xzB0k	false	-	glutathione s tranferase tag:?-?(MINT-2883043)	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P62820	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604702|mint:MINT-2883227|imex:IM-11000-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883234(identity)	refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N|mint:MINT-2883228(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606	intact-crc:4B134FD995767722|rigid:KnC6pjISlYVB1pP5xiiF0edogjk	false	green fluorescent protein tag:?-?(MINT-2883250)|mutation disrupting interaction:564-564(MINT-2883241)	glutathione s tranferase tag:?-?(MINT-2883231)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20340	uniprotkb:Q01968	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604728|mint:MINT-2883260|imex:IM-11000-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2883280(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883261(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:7274250D3477F624|rigid:VFbTbwuF3gzRFmIJ5v1ffOyH1is	false	glutathione s tranferase tag:?-?(MINT-2883283)	mutation increasing interaction:526-526(MINT-2883292)|green fluorescent protein tag:?-?(MINT-2883276)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P20339	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604677|mint:MINT-2883194|imex:IM-11000-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883202(identity)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-2883195(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	intact-crc:812F9C23D0501E58|rigid:VsOYV3iBGNV6Vbi4cZS8okKLfpU	false	green fluorescent protein tag:?-?(MINT-2883211)|mutation increasing interaction:664-664(MINT-2883222)	glutathione s tranferase tag:?-?(MINT-2883198)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:Q00610	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604753|mint:MINT-2883302|imex:IM-11000-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883303(identity)	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424|mint:MINT-2883328(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	intact-crc:C5A4706636018177|rigid:dCc1XXFfjH0gtHzosft5HrDQhpY	false	green fluorescent protein tag:?-?(MINT-2883325)|mutation increasing interaction:526-526(MINT-2883307)	binding-associated region:1-579(MINT-2883336)|glutathione s tranferase tag:?-?(MINT-2883331)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20340	uniprotkb:Q01968	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604812|mint:MINT-2980764|imex:IM-11000-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2980765(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2980771(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:003CAD1145A90243|rigid:VFbTbwuF3gzRFmIJ5v1ffOyH1is	false	glutathione s tranferase tag:?-?(MINT-2980767)	mutation disrupting interaction:664-664(MINT-2980782)|green fluorescent protein tag:?-?(MINT-2980773)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P20340	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604879|mint:MINT-2980844|imex:IM-11000-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2980851(identity)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2980845(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	intact-crc:CA91AE710075942E|rigid:VFbTbwuF3gzRFmIJ5v1ffOyH1is	false	green fluorescent protein tag:?-?(MINT-2980853)|mutation decreasing interaction:568-568(MINT-2980878)	glutathione s tranferase tag:?-?(MINT-2980847)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P20340	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604853|mint:MINT-2980804|imex:IM-11000-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2980811(identity)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2980805(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	intact-crc:CA1BE706C8380411|rigid:VFbTbwuF3gzRFmIJ5v1ffOyH1is	false	green fluorescent protein tag:?-?(MINT-2980813)|mutation increasing interaction:606-606(MINT-2980830)	glutathione s tranferase tag:?-?(MINT-2980807)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P20340	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604937|mint:MINT-2980924|imex:IM-11000-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2980931(identity)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2980925(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	intact-crc:C5AC13EBD2733CAE|rigid:VFbTbwuF3gzRFmIJ5v1ffOyH1is	false	mutation decreasing interaction:555-555(MINT-2980938)|green fluorescent protein tag:?-?(MINT-2980933)	glutathione s tranferase tag:?-?(MINT-2980927)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P20340	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8604904|mint:MINT-2980884|imex:IM-11000-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2980891(identity)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2980885(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	intact-crc:364E720764DF3649|rigid:VFbTbwuF3gzRFmIJ5v1ffOyH1is	false	green fluorescent protein tag:?-?(MINT-2980893)|mutation disrupting interaction:564-564(MINT-2980906)	glutathione s tranferase tag:?-?(MINT-2980887)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q00610	uniprotkb:Q01968	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605029|mint:MINT-2980965|imex:IM-11000-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424|mint:MINT-2980966(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2980976(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:044679E8AEAC247F|rigid:dCc1XXFfjH0gtHzosft5HrDQhpY	false	glutathione s tranferase tag:?-?(MINT-2980968)|binding-associated region:1-579(MINT-2980973)	green fluorescent protein tag:?-?(MINT-2980979)|mutation increasing interaction:606-606(MINT-2980983)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:Q00610	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605060|mint:MINT-2980997|imex:IM-11000-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2981008(identity)	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424|mint:MINT-2980998(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5A|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	intact-crc:003F0C4381C3F44A|rigid:dCc1XXFfjH0gtHzosft5HrDQhpY	false	green fluorescent protein tag:?-?(MINT-2981011)|mutation decreasing interaction:555-555(MINT-2981021)	glutathione s tranferase tag:?-?(MINT-2981000)|binding-associated region:1-579(MINT-2981005)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20339	uniprotkb:Q01968	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605107|mint:MINT-2981030|imex:IM-11000-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-2981054(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2981031(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:F17A365F586240A5|rigid:VsOYV3iBGNV6Vbi4cZS8okKLfpU	false	glutathione s tranferase tag:?-?(MINT-2981056)	mutation decreasing interaction:555-555(MINT-2981038)|green fluorescent protein tag:?-?(MINT-2981033)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P20339	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605132|mint:MINT-2981062|imex:IM-11000-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2981063(identity)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-2981086(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	intact-crc:CE8B1917915EF384|rigid:VsOYV3iBGNV6Vbi4cZS8okKLfpU	false	mutation decreasing interaction:564-564(MINT-2981074)|green fluorescent protein tag:?-?(MINT-2981065)	glutathione s tranferase tag:?-?(MINT-2981088)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62820	uniprotkb:Q01968	intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605209|mint:MINT-2981127|imex:IM-11000-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N|mint:MINT-2981128(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2981134(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:CE1AC98D91A40C93|rigid:KnC6pjISlYVB1pP5xiiF0edogjk	false	glutathione s tranferase tag:?-?(MINT-2981130)	green fluorescent protein tag:?-?(MINT-2981137)|mutation increasing interaction:568-568(MINT-2981145)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62820	uniprotkb:Q01968	intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605235|mint:MINT-2981160|imex:IM-11000-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N|mint:MINT-2981161(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2981167(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:74E260915C4AC403|rigid:KnC6pjISlYVB1pP5xiiF0edogjk	false	glutathione s tranferase tag:?-?(MINT-2981163)	mutation disrupting interaction:555-555(MINT-2981174)|green fluorescent protein tag:?-?(MINT-2981170)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P20339	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605184|mint:MINT-2981094|imex:IM-11000-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2981095(identity)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-2981118(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	intact-crc:FE478BC58A64E825|rigid:VsOYV3iBGNV6Vbi4cZS8okKLfpU	false	mutation decreasing interaction:568-568(MINT-2981110)|green fluorescent protein tag:?-?(MINT-2981097)	glutathione s tranferase tag:?-?(MINT-2981120)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62820	uniprotkb:Q01968	intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605261|mint:MINT-2981180|imex:IM-11000-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N|mint:MINT-2981181(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2981187(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5B|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:963CAFEAB1C2F1EC|rigid:KnC6pjISlYVB1pP5xiiF0edogjk	false	glutathione s tranferase tag:?-?(MINT-2981183)	mutation disrupting interaction:664-664(MINT-2981194)|green fluorescent protein tag:?-?(MINT-2981190)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62820	uniprotkb:Q01968	intact:EBI-716845|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|uniprotkb:P11476|uniprotkb:Q6FIE7|ensembl:ENSP00000387286|ensembl:ENSP00000497078	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab1a_human(display_long)|uniprotkb:YPT1-related protein(gene name synonym)|uniprotkb:RAB1A(gene name)|psi-mi:RAB1A(display_short)|uniprotkb:RAB1(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605297|mint:MINT-2883082|imex:IM-11000-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004152.1|refseq:NP_056358.1|ensembl:ENSG00000138069(gene)|ensembl:ENST00000409784(transcript)|ensembl:ENST00000649427(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045296"(cadherin binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62820|rcsb pdb:2FOL|rcsb pdb:2WWX|rcsb pdb:3L0I|rcsb pdb:3SFV|rcsb pdb:3TKL|rcsb pdb:4FMB|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|rcsb pdb:4IRU|rcsb pdb:4JVS|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-1063N|mint:MINT-2883083(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883090(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1F|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf09606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:A613E4079E27CDC9|rigid:KnC6pjISlYVB1pP5xiiF0edogjk	false	glutathione s tranferase tag:?-?(MINT-2883088)	-	1	1	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01968	uniprotkb:P61106	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-1056404|uniprotkb:P35287|uniprotkb:Q5JVD4|uniprotkb:Q6Q7K5|uniprotkb:Q969L0|uniprotkb:Q9UI11|uniprotkb:B3KR31|ensembl:ENSP00000362946	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab14_human(display_long)|uniprotkb:RAB14(gene name)|psi-mi:RAB14(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605348|mint:MINT-2883141|imex:IM-11000-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883148(identity)	refseq:NP_057406.2|ensembl:ENSG00000119396(gene)|ensembl:ENST00000373840(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030702|mint:P61106|rcsb pdb:1Z0F|rcsb pdb:4D0G|rcsb pdb:4DRZ|reactome:R-HSA-1445148|reactome:R-HSA-1660499|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-42491N|mint:MINT-2883142(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1F|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:qFP8UXDCPt/RcLTWlZLaitH2LF49606	intact-crc:110C2373C6AC961C|rigid:a5kK0egUwx7bmKo2/NZtIoLuc44	false	-	glutathione s tranferase tag:?-?(MINT-2883145)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q01968	uniprotkb:P20339	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605314|mint:MINT-2883115|imex:IM-11000-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883122(identity)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-2883116(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1F|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	intact-crc:DFC94F417A66A436|rigid:VsOYV3iBGNV6Vbi4cZS8okKLfpU	false	-	glutathione s tranferase tag:?-?(MINT-2883119)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q01968	uniprotkb:P61006	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605365|mint:MINT-2883154|imex:IM-11000-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883161(identity)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|mint:MINT-2883155(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1F|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	intact-crc:BB22E5CD61656786|rigid:zLOhPU/3clz4b/DwMXaeklcM50g	false	-	glutathione s tranferase tag:?-?(MINT-2883158)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P20340	uniprotkb:Q01968	intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605331|mint:MINT-2883128|imex:IM-11000-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N|mint:MINT-2883129(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883135(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1F|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:668539BCFEEAB37A|rigid:VFbTbwuF3gzRFmIJ5v1ffOyH1is	false	glutathione s tranferase tag:?-?(MINT-2883132)	-	1	1	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20339	uniprotkb:Q01968	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Hyvola et al. (2006)	mint:MINT-5218938|pubmed:16902405|imex:IM-11000	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8605392|mint:MINT-2883167|imex:IM-11000-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231|mint:MINT-2883168(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-2883175(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:OCRL1 binds only to the active forms of the rab proteins.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2006/09/04	2014/10/16	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:F4DBB932B1AFFA76|rigid:VsOYV3iBGNV6Vbi4cZS8okKLfpU	false	myc tag:?-?(MINT-2883170)	-	1	1	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)