#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40073	uniprotkb:P25344	intact:EBI-18140|uniprotkb:D3DM24|ensemblfungi:YER118C	intact:EBI-18305|uniprotkb:D6VQY3|uniprotkb:Q3S1N2|ensemblfungi:YCL032W	psi-mi:sho1_yeast(display_long)|uniprotkb:YER118C(locus name)|uniprotkb:SHO1(gene name)|psi-mi:SHO1(display_short)|uniprotkb:SSU81(gene name synonym)|uniprotkb:Osmosensor SHO1(gene name synonym)|uniprotkb:Suppressor of SUA8-1 mutation(gene name synonym)|uniprotkb:Synthetic high osmolarity-sensitive protein 1(gene name synonym)	psi-mi:ste50_yeast(display_long)|uniprotkb:STE50(gene name)|psi-mi:STE50(display_short)|uniprotkb:YCL32W(orf name)|uniprotkb:YCL032W(locus name)	psi-mi:"MI:0096"(pull down)	Tatebayashi et al. (2006)	pubmed:16778768|imex:IM-11365|mint:MINT-5218754	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551648|mint:MINT-2835963|imex:IM-11365-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011043.1|sgd:S000000920|go:"GO:0005886"(plasma membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0043332"(mating projection tip)|go:"GO:0044697"(HICS complex)|go:"GO:0071944"(cell periphery)|interpro:IPR001452(Src homology-3)|interpro:IPR035522|interpro:IPR036028|ensemblfungi:YER118C(gene)|interpro:IPR039644|rcsb pdb:2VKN|ensemblfungi:YER118C_mRNA(transcript)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-2472N|mint:P40073|mint:MINT-2835975(identity)	refseq:NP_009898.1|sgd:S000000537|ensemblfungi:YCL032W(gene)|ensemblfungi:YCL032W_mRNA(transcript)|go:"GO:0000161"(osmosensory signaling MAPK cascade)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0032093"(SAM domain binding)|interpro:IPR000159(Ras-association)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR015316(Sterile alpha motif, Ste50p)|interpro:IPR029071|rcsb pdb:1UQV|rcsb pdb:1Z1V|dip:DIP-667N|mint:P25344|mint:MINT-2835964(identity)	-	crc64:E467A4D50AA3EDB6|comment:"Stoichiometry: 1.0"	crc64:EFC7D14F2940C779|comment:"Stoichiometry: 1.0"	figure legend:F5D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/07/26	2014/10/16	rogid:DPpJB36kZxbFXugXajgs899epuY559292	rogid:fiWecSMzcGUDfEIiL71V/nmjwwI559292	intact-crc:1C46C2B891686201|rigid:J75jiNKarPDc37USzKg90JxcHr0	false	mutation increasing interaction:342-342(MINT-2835991)|glutathione s tranferase tag:?-?(MINT-2835984)|mutation increasing interaction:346-346(MINT-2835994)|binding-associated region:145-367(MINT-2835976)	ha tag:?-?(MINT-2835973)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40073	uniprotkb:P25344	intact:EBI-18140|uniprotkb:D3DM24|ensemblfungi:YER118C	intact:EBI-18305|uniprotkb:D6VQY3|uniprotkb:Q3S1N2|ensemblfungi:YCL032W	psi-mi:sho1_yeast(display_long)|uniprotkb:YER118C(locus name)|uniprotkb:SHO1(gene name)|psi-mi:SHO1(display_short)|uniprotkb:SSU81(gene name synonym)|uniprotkb:Osmosensor SHO1(gene name synonym)|uniprotkb:Suppressor of SUA8-1 mutation(gene name synonym)|uniprotkb:Synthetic high osmolarity-sensitive protein 1(gene name synonym)	psi-mi:ste50_yeast(display_long)|uniprotkb:STE50(gene name)|psi-mi:STE50(display_short)|uniprotkb:YCL32W(orf name)|uniprotkb:YCL032W(locus name)	psi-mi:"MI:0096"(pull down)	Tatebayashi et al. (2006)	pubmed:16778768|imex:IM-11365|mint:MINT-5218754	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551616|mint:MINT-2835933|imex:IM-11365-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011043.1|sgd:S000000920|go:"GO:0005886"(plasma membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0043332"(mating projection tip)|go:"GO:0044697"(HICS complex)|go:"GO:0071944"(cell periphery)|interpro:IPR001452(Src homology-3)|interpro:IPR035522|interpro:IPR036028|ensemblfungi:YER118C(gene)|interpro:IPR039644|rcsb pdb:2VKN|ensemblfungi:YER118C_mRNA(transcript)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-2472N|mint:P40073|mint:MINT-2835935(identity)	refseq:NP_009898.1|sgd:S000000537|ensemblfungi:YCL032W(gene)|ensemblfungi:YCL032W_mRNA(transcript)|go:"GO:0000161"(osmosensory signaling MAPK cascade)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0032093"(SAM domain binding)|interpro:IPR000159(Ras-association)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR015316(Sterile alpha motif, Ste50p)|interpro:IPR029071|rcsb pdb:1UQV|rcsb pdb:1Z1V|dip:DIP-667N|mint:P25344|mint:MINT-2835934(identity)	-	crc64:E467A4D50AA3EDB6|comment:"Stoichiometry: 1.0"	crc64:EFC7D14F2940C779|comment:"Stoichiometry: 1.0"	figure legend:F5D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/07/26	2014/10/16	rogid:DPpJB36kZxbFXugXajgs899epuY559292	rogid:fiWecSMzcGUDfEIiL71V/nmjwwI559292	intact-crc:0894C94D53D09070|rigid:J75jiNKarPDc37USzKg90JxcHr0	false	binding-associated region:145-367(MINT-2835948)|ha tag:?-?(MINT-2835941)	glutathione s tranferase tag:?-?(MINT-2835952)|binding-associated region:1-236(MINT-2838555)|mutation increasing interaction:146-146(MINT-2835959)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23561	uniprotkb:P40073	intact:EBI-18259|uniprotkb:D6VZ00|ensemblfungi:YLR362W	intact:EBI-18140|uniprotkb:D3DM24|ensemblfungi:YER118C	psi-mi:ste11_yeast(display_long)|uniprotkb:STE11(gene name)|psi-mi:STE11(display_short)|uniprotkb:L8039.10(orf name)|uniprotkb:YLR362W(locus name)	psi-mi:sho1_yeast(display_long)|uniprotkb:YER118C(locus name)|uniprotkb:SHO1(gene name)|psi-mi:SHO1(display_short)|uniprotkb:SSU81(gene name synonym)|uniprotkb:Osmosensor SHO1(gene name synonym)|uniprotkb:Suppressor of SUA8-1 mutation(gene name synonym)|uniprotkb:Synthetic high osmolarity-sensitive protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tatebayashi et al. (2006)	pubmed:16778768|imex:IM-11365|mint:MINT-5218754	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551681|mint:MINT-2835999|imex:IM-11365-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013466.1|sgd:S000004354|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0032093"(SAM domain binding)|go:"GO:0035405"(histone-threonine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0071507"(pheromone response MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029458|rcsb pdb:1OW5|rcsb pdb:1X9X|reactome:R-SCE-2559580|ensemblfungi:YLR362W(gene)|ensemblfungi:YLR362W_mRNA(transcript)|go:"GO:0000161"(osmosensory signaling MAPK cascade)|go:"GO:0000196"(cell wall integrity MAPK cascade)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|dip:DIP-861N|mint:P23561|mint:MINT-2836000(identity)	refseq:NP_011043.1|sgd:S000000920|go:"GO:0005886"(plasma membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0043332"(mating projection tip)|go:"GO:0044697"(HICS complex)|go:"GO:0071944"(cell periphery)|interpro:IPR001452(Src homology-3)|interpro:IPR035522|interpro:IPR036028|ensemblfungi:YER118C(gene)|interpro:IPR039644|rcsb pdb:2VKN|ensemblfungi:YER118C_mRNA(transcript)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-2472N|mint:P40073|mint:MINT-2836008(identity)	-	crc64:E9E0DF27114EEEEF|comment:"Stoichiometry: 1.0"	crc64:E467A4D50AA3EDB6|comment:"Stoichiometry: 1.0"	figure legend:F5C|figure legend:F6C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/07/26	2014/10/16	rogid:KhdnSv61wKSQuH5bBkQS9yVxLns559292	rogid:DPpJB36kZxbFXugXajgs899epuY559292	intact-crc:76BEAA4CA420B57F|rigid:DItBtJnV6kKvUgDHQD2VryCOy9g	false	binding-associated region:82-412(MINT-2836061)|ha tag:?-?(MINT-2836003)	mutation increasing interaction:342-342(MINT-2836012)|glutathione s tranferase tag:?-?(MINT-2836020)|mutation increasing interaction:346-346(MINT-2836009)|binding-associated region:145-367(MINT-2836015)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23561	uniprotkb:P40073	intact:EBI-18259|uniprotkb:D6VZ00|ensemblfungi:YLR362W	intact:EBI-18140|uniprotkb:D3DM24|ensemblfungi:YER118C	psi-mi:ste11_yeast(display_long)|uniprotkb:STE11(gene name)|psi-mi:STE11(display_short)|uniprotkb:L8039.10(orf name)|uniprotkb:YLR362W(locus name)	psi-mi:sho1_yeast(display_long)|uniprotkb:YER118C(locus name)|uniprotkb:SHO1(gene name)|psi-mi:SHO1(display_short)|uniprotkb:SSU81(gene name synonym)|uniprotkb:Osmosensor SHO1(gene name synonym)|uniprotkb:Suppressor of SUA8-1 mutation(gene name synonym)|uniprotkb:Synthetic high osmolarity-sensitive protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tatebayashi et al. (2006)	pubmed:16778768|imex:IM-11365|mint:MINT-5218754	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551719|mint:MINT-2836031|imex:IM-11365-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013466.1|sgd:S000004354|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0032093"(SAM domain binding)|go:"GO:0035405"(histone-threonine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0071507"(pheromone response MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029458|rcsb pdb:1OW5|rcsb pdb:1X9X|reactome:R-SCE-2559580|ensemblfungi:YLR362W(gene)|ensemblfungi:YLR362W_mRNA(transcript)|go:"GO:0000161"(osmosensory signaling MAPK cascade)|go:"GO:0000196"(cell wall integrity MAPK cascade)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|dip:DIP-861N|mint:P23561|mint:MINT-2836032(identity)	refseq:NP_011043.1|sgd:S000000920|go:"GO:0005886"(plasma membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0043332"(mating projection tip)|go:"GO:0044697"(HICS complex)|go:"GO:0071944"(cell periphery)|interpro:IPR001452(Src homology-3)|interpro:IPR035522|interpro:IPR036028|ensemblfungi:YER118C(gene)|interpro:IPR039644|rcsb pdb:2VKN|ensemblfungi:YER118C_mRNA(transcript)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-2472N|mint:P40073|mint:MINT-2836040(identity)	-	crc64:E9E0DF27114EEEEF|comment:"Stoichiometry: 1.0"	crc64:E467A4D50AA3EDB6|comment:"Stoichiometry: 1.0"	figure legend:F6A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/07/26	2014/10/16	rogid:KhdnSv61wKSQuH5bBkQS9yVxLns559292	rogid:DPpJB36kZxbFXugXajgs899epuY559292	intact-crc:618200E5BE44FAB5|rigid:DItBtJnV6kKvUgDHQD2VryCOy9g	false	glutathione s tranferase tag:?-?(MINT-2836038)	mutation increasing interaction:342-342(MINT-2836051)|ha tag:?-?(MINT-2836044)|mutation increasing interaction:346-346(MINT-2836054)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23561	uniprotkb:P40073	intact:EBI-18259|uniprotkb:D6VZ00|ensemblfungi:YLR362W	intact:EBI-18140|uniprotkb:D3DM24|ensemblfungi:YER118C	psi-mi:ste11_yeast(display_long)|uniprotkb:STE11(gene name)|psi-mi:STE11(display_short)|uniprotkb:L8039.10(orf name)|uniprotkb:YLR362W(locus name)	psi-mi:sho1_yeast(display_long)|uniprotkb:YER118C(locus name)|uniprotkb:SHO1(gene name)|psi-mi:SHO1(display_short)|uniprotkb:SSU81(gene name synonym)|uniprotkb:Osmosensor SHO1(gene name synonym)|uniprotkb:Suppressor of SUA8-1 mutation(gene name synonym)|uniprotkb:Synthetic high osmolarity-sensitive protein 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tatebayashi et al. (2006)	pubmed:16778768|imex:IM-11365|mint:MINT-5218754	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551757|imex:IM-11365-5|mint:MINT-7721882	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013466.1|sgd:S000004354|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0032093"(SAM domain binding)|go:"GO:0035405"(histone-threonine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0071507"(pheromone response MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029458|rcsb pdb:1OW5|rcsb pdb:1X9X|reactome:R-SCE-2559580|ensemblfungi:YLR362W(gene)|ensemblfungi:YLR362W_mRNA(transcript)|go:"GO:0000161"(osmosensory signaling MAPK cascade)|go:"GO:0000196"(cell wall integrity MAPK cascade)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|dip:DIP-861N|mint:P23561|mint:MINT-7721889(identity)|uniprotkb:P23561(original identifier)	refseq:NP_011043.1|sgd:S000000920|go:"GO:0005886"(plasma membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0043332"(mating projection tip)|go:"GO:0044697"(HICS complex)|go:"GO:0071944"(cell periphery)|interpro:IPR001452(Src homology-3)|interpro:IPR035522|interpro:IPR036028|ensemblfungi:YER118C(gene)|interpro:IPR039644|rcsb pdb:2VKN|ensemblfungi:YER118C_mRNA(transcript)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-2472N|mint:P40073|mint:MINT-7721883(identity)|uniprotkb:P40073(original identifier)	-	crc64:E9E0DF27114EEEEF	crc64:E467A4D50AA3EDB6	figure legend:F5|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/07/26	2014/10/16	rogid:KhdnSv61wKSQuH5bBkQS9yVxLns559292	rogid:DPpJB36kZxbFXugXajgs899epuY559292	intact-crc:7C6F00A6AE1B7A9B|rigid:DItBtJnV6kKvUgDHQD2VryCOy9g	false	binding-associated region:340-413(MINT-7721892)	binding-associated region:303-360(MINT-7721886)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40073	uniprotkb:P25344	intact:EBI-18140|uniprotkb:D3DM24|ensemblfungi:YER118C	intact:EBI-18305|uniprotkb:D6VQY3|uniprotkb:Q3S1N2|ensemblfungi:YCL032W	psi-mi:sho1_yeast(display_long)|uniprotkb:YER118C(locus name)|uniprotkb:SHO1(gene name)|psi-mi:SHO1(display_short)|uniprotkb:SSU81(gene name synonym)|uniprotkb:Osmosensor SHO1(gene name synonym)|uniprotkb:Suppressor of SUA8-1 mutation(gene name synonym)|uniprotkb:Synthetic high osmolarity-sensitive protein 1(gene name synonym)	psi-mi:ste50_yeast(display_long)|uniprotkb:STE50(gene name)|psi-mi:STE50(display_short)|uniprotkb:YCL32W(orf name)|uniprotkb:YCL032W(locus name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tatebayashi et al. (2006)	pubmed:16778768|imex:IM-11365|mint:MINT-5218754	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551775|imex:IM-11365-6|mint:MINT-7721894	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011043.1|sgd:S000000920|go:"GO:0005886"(plasma membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0043332"(mating projection tip)|go:"GO:0044697"(HICS complex)|go:"GO:0071944"(cell periphery)|interpro:IPR001452(Src homology-3)|interpro:IPR035522|interpro:IPR036028|ensemblfungi:YER118C(gene)|interpro:IPR039644|rcsb pdb:2VKN|ensemblfungi:YER118C_mRNA(transcript)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-2472N|mint:P40073|mint:MINT-7721895(identity)|uniprotkb:P40073(original identifier)	refseq:NP_009898.1|sgd:S000000537|ensemblfungi:YCL032W(gene)|ensemblfungi:YCL032W_mRNA(transcript)|go:"GO:0000161"(osmosensory signaling MAPK cascade)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0032093"(SAM domain binding)|interpro:IPR000159(Ras-association)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR015316(Sterile alpha motif, Ste50p)|interpro:IPR029071|rcsb pdb:1UQV|rcsb pdb:1Z1V|dip:DIP-667N|mint:P25344|mint:MINT-7721901(identity)|uniprotkb:P25344(original identifier)	-	crc64:E467A4D50AA3EDB6	crc64:EFC7D14F2940C779	figure legend:F5|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/07/26	2014/10/16	rogid:DPpJB36kZxbFXugXajgs899epuY559292	rogid:fiWecSMzcGUDfEIiL71V/nmjwwI559292	intact-crc:157A97C5598C9AE5|rigid:J75jiNKarPDc37USzKg90JxcHr0	false	binding-associated region:303-360(MINT-7721898)	binding-associated region:149-235(MINT-7721904)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)