#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13585	uniprotkb:Q13585	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8550957|mint:MINT-2836076|imex:IM-11102-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836077(identity)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836078(identity)	-	comment:mint|function:Does not bind melatonin	comment:mint|function:Does not bind melatonin	figure legend:F1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	intact-crc:E369A313F6C03714|rigid:1Sj/8bfSFnF35SgezTez0hJvqls	false	yellow fluorescent protein tag:?-?(MINT-2836092)	flag tag:?-?(MINT-2836084)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04731	uniprotkb:Q13585	intact:EBI-8045030|uniprotkb:Q86YX5|intact:MINT-1781424|ensembl:ENSP00000290705	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	psi-mi:mt1a_human(display_long)|uniprotkb:MT1A(gene name)|psi-mi:MT1A(display_short)|uniprotkb:MT1S(gene name synonym)|uniprotkb:Metallothionein-IA(gene name synonym)	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8550997|mint:MINT-2836169|imex:IM-11102-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005937.2|ensembl:ENSG00000205362(gene)|ensembl:ENST00000290705(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P04731|reactome:R-HSA-5661231|mint:MINT-2836170(identity)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836178(identity)	-	comment:mint|function:Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids|comment:"Stoichiometry: 1.0"	comment:mint|function:Does not bind melatonin	figure legend:F1C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:OkjfxMNXEPwPs909UJCPAgr27709606	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	intact-crc:688C705EA7260E21|rigid:j3aO+0vvmg5i9gnK3MffBAYTaEU	false	flag tag:?-?(MINT-2836173)	yellow fluorescent protein tag:?-?(MINT-2836181)	1	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63096	uniprotkb:Q13585	intact:EBI-618639|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|uniprotkb:P04898|uniprotkb:P11015|uniprotkb:P31871|uniprotkb:Q5U074|uniprotkb:Q8TAN5|uniprotkb:Q9UGA4|uniprotkb:A8KA88|uniprotkb:B4E2V1|uniprotkb:C9J3A4	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	psi-mi:gnai1_human(display_long)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551035|mint:MINT-2836319|imex:IM-11102-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-418597|reactome:R-HSA-422356|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-418594|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENSG00000127955(gene)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P63096|rcsb pdb:1KJY|rcsb pdb:1Y3A|rcsb pdb:2G83|rcsb pdb:2GTP|rcsb pdb:2IK8|rcsb pdb:2OM2|rcsb pdb:2XNS|rcsb pdb:3ONW|rcsb pdb:3QE0|rcsb pdb:3QI2|rcsb pdb:3UMR|rcsb pdb:3UMS|rcsb pdb:4G5Q|rcsb pdb:5JS7|rcsb pdb:5JS8|rcsb pdb:5TDH|rcsb pdb:6CMO|rcsb pdb:6CRK|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6KPF|rcsb pdb:6KPG|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LML|rcsb pdb:6N4B|rcsb pdb:6OMM|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6QNO|rcsb pdb:6VU8|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7EB2|rcsb pdb:7JVR|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7O7F|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-400042|reactome:R-HSA-418555|refseq:NP_002060.4|refseq:NP_001243343.1|mint:MINT-2836328(identity)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836320(identity)	-	comment:"Stoichiometry: 1.0"	comment:mint|function:Does not bind melatonin|comment:"Stoichiometry: 1.0"	figure legend:F9A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	intact-crc:15DFE9547AA7A804|rigid:2LE9rjNw1fMX+hVzrCYEoi4L2L0	false	-	mutation decreasing interaction:1-349(MINT-2836381)|yellow fluorescent protein tag:?-?(MINT-2836326)	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63096	uniprotkb:P04731	intact:EBI-618639|ensembl:ENSP00000497051|ensembl:ENSP00000497179|ensembl:ENSP00000497260|ensembl:ENSP00000497315|ensembl:ENSP00000497379|ensembl:ENSP00000497717|ensembl:ENSP00000497754|ensembl:ENSP00000497760|ensembl:ENSP00000497765|ensembl:ENSP00000497773|ensembl:ENSP00000498091|ensembl:ENSP00000343027|ensembl:ENSP00000391439|ensembl:ENSP00000496800|ensembl:ENSP00000496829|uniprotkb:P04898|uniprotkb:P11015|uniprotkb:P31871|uniprotkb:Q5U074|uniprotkb:Q8TAN5|uniprotkb:Q9UGA4|uniprotkb:A8KA88|uniprotkb:B4E2V1|uniprotkb:C9J3A4	intact:EBI-8045030|uniprotkb:Q86YX5|intact:MINT-1781424|ensembl:ENSP00000290705	psi-mi:gnai1_human(display_long)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)	psi-mi:mt1a_human(display_long)|uniprotkb:MT1A(gene name)|psi-mi:MT1A(display_short)|uniprotkb:MT1S(gene name synonym)|uniprotkb:Metallothionein-IA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551057|mint:MINT-2836337|imex:IM-11102-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-418597|reactome:R-HSA-422356|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-418594|ensembl:ENST00000351004(transcript)|ensembl:ENST00000442586(transcript)|ensembl:ENST00000648098(transcript)|ensembl:ENSG00000127955(gene)|ensembl:ENST00000648306(transcript)|ensembl:ENST00000648412(transcript)|ensembl:ENST00000648476(transcript)|ensembl:ENST00000648663(transcript)|ensembl:ENST00000648832(transcript)|ensembl:ENST00000648877(transcript)|ensembl:ENST00000648953(transcript)|ensembl:ENST00000649225(transcript)|ensembl:ENST00000649267(transcript)|ensembl:ENST00000649487(transcript)|ensembl:ENST00000649796(transcript)|ensembl:ENST00000649855(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P63096|rcsb pdb:1KJY|rcsb pdb:1Y3A|rcsb pdb:2G83|rcsb pdb:2GTP|rcsb pdb:2IK8|rcsb pdb:2OM2|rcsb pdb:2XNS|rcsb pdb:3ONW|rcsb pdb:3QE0|rcsb pdb:3QI2|rcsb pdb:3UMR|rcsb pdb:3UMS|rcsb pdb:4G5Q|rcsb pdb:5JS7|rcsb pdb:5JS8|rcsb pdb:5TDH|rcsb pdb:6CMO|rcsb pdb:6CRK|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6KPF|rcsb pdb:6KPG|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LML|rcsb pdb:6N4B|rcsb pdb:6OMM|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6QNO|rcsb pdb:6VU8|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7EB2|rcsb pdb:7JVR|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7O7F|reactome:R-HSA-170670|reactome:R-HSA-392170|reactome:R-HSA-400042|reactome:R-HSA-418555|refseq:NP_002060.4|refseq:NP_001243343.1|mint:MINT-2836346(identity)	refseq:NP_005937.2|ensembl:ENSG00000205362(gene)|ensembl:ENST00000290705(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P04731|reactome:R-HSA-5661231|mint:MINT-2836338(identity)	-	comment:"Stoichiometry: 1.0"	comment:mint|function:Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids|comment:"Stoichiometry: 1.0"	figure legend:F9A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9606	rogid:OkjfxMNXEPwPs909UJCPAgr27709606	intact-crc:6E07EEFC540957D5|rigid:MRn4RVoiMX1TqwpOG/fNVYND79I	false	-	yellow fluorescent protein tag:?-?(MINT-2836341)	1	1	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02795	uniprotkb:Q13585	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551016|mint:MINT-2836197|imex:IM-11102-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N|mint:MINT-2836198(identity)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836207(identity)	-	comment:"Stoichiometry: 1.0"	comment:mint|function:Does not bind melatonin	figure legend:F1D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	intact-crc:95647088240C99ED|rigid:wcRNoB9T8KvEFKrU9T7fPz43h2Y	false	myc tag:?-?(MINT-2836205)	yellow fluorescent protein tag:?-?(MINT-2836211)	1	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13585	uniprotkb:Q13585	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551084|mint:MINT-2836103|imex:IM-11102-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836112(identity)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836104(identity)	-	comment:mint|function:Does not bind melatonin	comment:mint|function:Does not bind melatonin	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	intact-crc:685FFB434D00EFBC|rigid:1Sj/8bfSFnF35SgezTez0hJvqls	false	tag:?-?(MINT-2836118)	yellow fluorescent protein tag:?-?(MINT-2836110)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02795	uniprotkb:Q13585	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551102|mint:MINT-2836127|imex:IM-11102-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N|mint:MINT-2836128(identity)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836136(identity)	-	comment:"Stoichiometry: 1.0"	comment:mint|function:Does not bind melatonin	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	intact-crc:EC80099CB71CB905|rigid:wcRNoB9T8KvEFKrU9T7fPz43h2Y	false	yellow fluorescent protein tag:?-?(MINT-2836131)	tag:?-?(MINT-2836139)	1	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04731	uniprotkb:P49407	intact:EBI-8045030|uniprotkb:Q86YX5|intact:MINT-1781424|ensembl:ENSP00000290705	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	psi-mi:mt1a_human(display_long)|uniprotkb:MT1A(gene name)|psi-mi:MT1A(display_short)|uniprotkb:MT1S(gene name synonym)|uniprotkb:Metallothionein-IA(gene name synonym)	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551140|mint:MINT-2836265|imex:IM-11102-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005937.2|ensembl:ENSG00000205362(gene)|ensembl:ENST00000290705(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P04731|reactome:R-HSA-5661231|mint:MINT-2836266(identity)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N|mint:MINT-2836274(identity)	-	comment:mint|function:Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F9B|figure legend:F9C|comment:Dynamic recruitment of beta-arrestin 1 to MT1 was observed upon melatonin stimulation. Coexpression of Flag-GPR50 decreased the melatonin-induced BRET signal|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:OkjfxMNXEPwPs909UJCPAgr27709606	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	intact-crc:A9015C83EFFF2A4F|rigid:nX2tsTymg16By3nPnB27ye2BMp8	false	tag:?-?(MINT-2836269)	yellow fluorescent protein tag:?-?(MINT-2836277)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04731	uniprotkb:Q13585	intact:EBI-8045030|uniprotkb:Q86YX5|intact:MINT-1781424|ensembl:ENSP00000290705	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	psi-mi:mt1a_human(display_long)|uniprotkb:MT1A(gene name)|psi-mi:MT1A(display_short)|uniprotkb:MT1S(gene name synonym)|uniprotkb:Metallothionein-IA(gene name synonym)	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551121|mint:MINT-2836149|imex:IM-11102-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005937.2|ensembl:ENSG00000205362(gene)|ensembl:ENST00000290705(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P04731|reactome:R-HSA-5661231|mint:MINT-2836150(identity)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836158(identity)	-	comment:mint|function:Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids|comment:"Stoichiometry: 1.0"	comment:mint|function:Does not bind melatonin	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:OkjfxMNXEPwPs909UJCPAgr27709606	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	intact-crc:6321D89BB1B0D500|rigid:j3aO+0vvmg5i9gnK3MffBAYTaEU	false	yellow fluorescent protein tag:?-?(MINT-2836156)	tag:?-?(MINT-2836162)	1	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04731	uniprotkb:Q13585	intact:EBI-8045030|uniprotkb:Q86YX5|intact:MINT-1781424|ensembl:ENSP00000290705	intact:EBI-8550965|intact:MINT-2836359|uniprotkb:Q0VGG3|uniprotkb:Q3ZAR0|ensembl:ENSP00000218316	psi-mi:mt1a_human(display_long)|uniprotkb:MT1A(gene name)|psi-mi:MT1A(display_short)|uniprotkb:MT1S(gene name synonym)|uniprotkb:Metallothionein-IA(gene name synonym)	psi-mi:mtr1l_human(display_long)|uniprotkb:GPR50(gene name)|psi-mi:GPR50(display_short)|uniprotkb:G protein-coupled receptor 50(gene name synonym)|uniprotkb:H9(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Levoye et al. (2006)	mint:MINT-5218751|pubmed:16778767|imex:IM-11102	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8551172|mint:MINT-2836224|imex:IM-11102-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005937.2|ensembl:ENSG00000205362(gene)|ensembl:ENST00000290705(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P04731|reactome:R-HSA-5661231|mint:MINT-2836225(identity)	refseq:NP_004215.2|ensembl:ENSG00000102195(gene)|ensembl:ENST00000218316(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008502"(melatonin receptor activity)|interpro:IPR000025(Melatonin receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002280(Melatonin-related receptor type 1X)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13585|go:"GO:0005654"(nucleoplasm)|mint:MINT-2836233(identity)	-	comment:mint|function:Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids|comment:"Stoichiometry: 1.0"	comment:mint|function:Does not bind melatonin	figure legend:F7E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/07/26	2014/10/16	rogid:OkjfxMNXEPwPs909UJCPAgr27709606	rogid:qvZPAOucHhJ/X36FC96ZyJfk7nc9606	intact-crc:E54CC863AE1B1F65|rigid:j3aO+0vvmg5i9gnK3MffBAYTaEU	false	flag tag:?-?(MINT-2836228)	yellow fluorescent protein tag:?-?(MINT-2836236)	1	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0078"(nucleotide sequence identification)