#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48356	uniprotkb:Q62077	intact:EBI-2257257|uniprotkb:O35686|uniprotkb:O54986|uniprotkb:Q61215|uniprotkb:Q64309|uniprotkb:Q9QWG3|uniprotkb:Q9QWV5|ensembl:ENSMUSP00000037385	intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1	psi-mi:lepr_mouse(display_long)|uniprotkb:Lepr(gene name)|psi-mi:Lepr(display_short)|uniprotkb:Db(gene name synonym)|uniprotkb:Obr(gene name synonym)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:B219(gene name synonym)	psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Montoye et al. (2006)	pubmed:16698021|imex:IM-11181|mint:MINT-5218643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8521211|mint:MINT-2573202|imex:IM-11181-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116371.1|refseq:NP_034834.1|refseq:NP_666258.2|dip:DIP-42763N|ensembl:ENSMUSG00000057722(gene)|ensembl:ENSMUST00000037552(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1904060"(negative regulation of locomotor rhythm)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|mint:P48356|mint:MINT-2573203(identity)	ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N|mint:MINT-2573204(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:"Analysis using the GGS-LR Y985 and GGS-LR Y1077 baits revealed that both preys only interact with the Y1077 motif (Fig. 3B)."|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2006/06/14	2014/10/16	rogid:jHA91jK8nehmfp3KPNSF/7QoMPs10090	rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090	intact-crc:1033BE964855806A|rigid:ChhCg6YPQeXlV0LJJQtSxh63WRs	false	tag:?-?(MINT-2576074)	tag:?-?(MINT-2576082)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48356	uniprotkb:O35718	intact:EBI-2257257|uniprotkb:O35686|uniprotkb:O54986|uniprotkb:Q61215|uniprotkb:Q64309|uniprotkb:Q9QWG3|uniprotkb:Q9QWV5|ensembl:ENSMUSP00000037385	intact:EBI-2659360|uniprotkb:Q3U7X5|uniprotkb:P97803|ensembl:ENSMUSP00000059129	psi-mi:lepr_mouse(display_long)|uniprotkb:Lepr(gene name)|psi-mi:Lepr(display_short)|uniprotkb:Db(gene name synonym)|uniprotkb:Obr(gene name synonym)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:B219(gene name synonym)	psi-mi:socs3_mouse(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:Protein EF-10(gene name synonym)|uniprotkb:Cis3(gene name synonym)|uniprotkb:Cish3(gene name synonym)|uniprotkb:Socs3(gene name)|psi-mi:Socs3(display_short)	psi-mi:"MI:0018"(two hybrid)	Montoye et al. (2006)	pubmed:16698021|imex:IM-11181|mint:MINT-5218643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8521232|mint:MINT-2576222|imex:IM-11181-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116371.1|refseq:NP_034834.1|refseq:NP_666258.2|dip:DIP-42763N|ensembl:ENSMUSG00000057722(gene)|ensembl:ENSMUST00000037552(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1904060"(negative regulation of locomotor rhythm)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|mint:P48356|mint:MINT-2576231(identity)	refseq:XP_011247009.1|refseq:NP_031733.1|ensembl:ENSMUSG00000053113(gene)|ensembl:ENSMUST00000054002(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O35718|rcsb pdb:2BBU|rcsb pdb:2HMH|rcsb pdb:2JZ3|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8849474|reactome:R-MMU-8951664|reactome:R-MMU-909733|reactome:R-MMU-9705462|reactome:R-MMU-983168|dip:DIP-29137N|mint:MINT-2576223(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:Interaction occurs also in TF1-M1-16 cells.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2006/06/14	2014/10/16	rogid:jHA91jK8nehmfp3KPNSF/7QoMPs10090	rogid:SFk8FM1xo7SkodsiFXZYzTbLrYg10090	intact-crc:59A09735C1F11297|rigid:1Ho914BBDE2fpOCOeNq+NmQjE3I	false	tag:?-?(MINT-2576237)	tag:?-?(MINT-2576229)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42230	uniprotkb:P48356	intact:EBI-617434|ensembl:ENSMUSP00000004145|ensembl:ENSMUSP00000102979	intact:EBI-2257257|uniprotkb:O35686|uniprotkb:O54986|uniprotkb:Q61215|uniprotkb:Q64309|uniprotkb:Q9QWG3|uniprotkb:Q9QWV5|ensembl:ENSMUSP00000037385	psi-mi:sta5a_mouse(display_long)|uniprotkb:Mammary gland factor(gene name synonym)|uniprotkb:Stat5a(gene name)|psi-mi:Stat5a(display_short)|uniprotkb:Mgf(gene name synonym)|uniprotkb:Mpf(gene name synonym)	psi-mi:lepr_mouse(display_long)|uniprotkb:Lepr(gene name)|psi-mi:Lepr(display_short)|uniprotkb:Db(gene name synonym)|uniprotkb:Obr(gene name synonym)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:B219(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Montoye et al. (2006)	pubmed:16698021|imex:IM-11181|mint:MINT-5218643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8521253|mint:MINT-2576447|imex:IM-11181-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004043(gene)|ensembl:ENSMUST00000004145(transcript)|ensembl:ENSMUST00000107356(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060376"(positive regulation of mast cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046543"(development of secondary female sexual characteristics)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42230|rcsb pdb:1Y1U|reactome:R-MMU-1251985|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_035618.1|refseq:XP_006532784.1|refseq:XP_006532785.1|refseq:XP_017169891.1|dip:DIP-897N|mint:MINT-2576448(identity)	refseq:NP_001116371.1|refseq:NP_034834.1|refseq:NP_666258.2|dip:DIP-42763N|ensembl:ENSMUSG00000057722(gene)|ensembl:ENSMUST00000037552(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1904060"(negative regulation of locomotor rhythm)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|mint:P48356|mint:MINT-2576456(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:"Analysis using the GGS-LR Y985 and GGS-LR Y1077 baits revealed that both preys only interact with the Y1077 motif (Fig. 3B)."|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2006/06/14	2014/10/16	rogid:Z/+QC7Q0bZ6GIEUJJbNEIyeu+xU10090	rogid:jHA91jK8nehmfp3KPNSF/7QoMPs10090	intact-crc:ADC7DC60C965BA73|rigid:06Fzcj9D4spNpfkPIXAObhkme8Q	false	tag:?-?(MINT-2576454)	tag:?-?(MINT-2576462)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JLY0	uniprotkb:P48356	intact:EBI-8500205|uniprotkb:Q8VEN5|intact:MINT-2577134|uniprotkb:Q9D2A0|ensembl:ENSMUSP00000064929|ensembl:ENSMUSP00000114993|ensembl:ENSMUSP00000118764	intact:EBI-2257257|uniprotkb:O35686|uniprotkb:O54986|uniprotkb:Q61215|uniprotkb:Q64309|uniprotkb:Q9QWG3|uniprotkb:Q9QWV5|ensembl:ENSMUSP00000037385	psi-mi:socs6_mouse(display_long)|uniprotkb:Socs6(gene name)|psi-mi:Socs6(display_short)|uniprotkb:Cis4(gene name synonym)|uniprotkb:Cish4(gene name synonym)|uniprotkb:Socs4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)	psi-mi:lepr_mouse(display_long)|uniprotkb:Lepr(gene name)|psi-mi:Lepr(display_short)|uniprotkb:Db(gene name synonym)|uniprotkb:Obr(gene name synonym)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:B219(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Montoye et al. (2006)	pubmed:16698021|imex:IM-11181|mint:MINT-5218643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8521293|mint:MINT-2577103|imex:IM-11181-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011245391.1|refseq:XP_011245392.1|refseq:NP_061291.2|refseq:XP_006526576.1|ensembl:ENSMUSG00000056153(gene)|ensembl:ENSMUST00000070116(transcript)|ensembl:ENSMUST00000123826(transcript)|ensembl:ENSMUST00000125362(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|interpro:IPR036860|interpro:IPR037345|mint:Q9JLY0|reactome:R-MMU-8951664|reactome:R-MMU-9706369|interpro:IPR001496(SOCS protein, C-terminal)|mint:MINT-2577104(identity)	refseq:NP_001116371.1|refseq:NP_034834.1|refseq:NP_666258.2|dip:DIP-42763N|ensembl:ENSMUSG00000057722(gene)|ensembl:ENSMUST00000037552(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1904060"(negative regulation of locomotor rhythm)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|mint:P48356|mint:MINT-2577115(identity)	-	function:"SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2006/06/14	2014/10/16	rogid:SDpUJXzmXmESUwVptgnLO/6AyoM10090	rogid:jHA91jK8nehmfp3KPNSF/7QoMPs10090	intact-crc:EEE0934B92A0C750|rigid:YLyaUPtlt4/55GE3grvdHS96yE4	false	tag:?-?(MINT-2577112)	tag:?-?(MINT-2577122)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48356	uniprotkb:O35717	intact:EBI-2257257|uniprotkb:O35686|uniprotkb:O54986|uniprotkb:Q61215|uniprotkb:Q64309|uniprotkb:Q9QWG3|uniprotkb:Q9QWV5|ensembl:ENSMUSP00000037385	intact:EBI-617349|ensembl:ENSMUSP00000020215|ensembl:ENSMUSP00000113378|ensembl:ENSMUSP00000129331|ensembl:ENSMUSP00000131875	psi-mi:lepr_mouse(display_long)|uniprotkb:Lepr(gene name)|psi-mi:Lepr(display_short)|uniprotkb:Db(gene name synonym)|uniprotkb:Obr(gene name synonym)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:B219(gene name synonym)	psi-mi:socs2_mouse(display_long)|uniprotkb:Cytokine-inducible SH2 protein 2(gene name synonym)|uniprotkb:Socs2(gene name)|psi-mi:Socs2(display_short)|uniprotkb:Cis2(gene name synonym)|uniprotkb:Cish2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Montoye et al. (2006)	pubmed:16698021|imex:IM-11181|mint:MINT-5218643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8521313|mint:MINT-2577149|imex:IM-11181-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116371.1|refseq:NP_034834.1|refseq:NP_666258.2|dip:DIP-42763N|ensembl:ENSMUSG00000057722(gene)|ensembl:ENSMUST00000037552(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1904060"(negative regulation of locomotor rhythm)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|mint:P48356|mint:MINT-2577158(identity)	ensembl:ENSMUSG00000020027(gene)|ensembl:ENSMUST00000020215(transcript)|ensembl:ENSMUST00000119917(transcript)|ensembl:ENSMUST00000170690(transcript)|ensembl:ENSMUST00000172070(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007595"(lactation)|go:"GO:0008269"(JAK pathway signal transduction adaptor activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060749"(mammary gland alveolus development)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028410|interpro:IPR035862|interpro:IPR036036|interpro:IPR036860|mint:O35717|reactome:R-MMU-8951664|reactome:R-MMU-9706369|refseq:XP_011241712.1|refseq:NP_001162126.1|refseq:NP_001162127.1|refseq:NP_001162128.1|refseq:NP_031732.1|mint:MINT-2577150(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2006/06/14	2014/10/16	rogid:jHA91jK8nehmfp3KPNSF/7QoMPs10090	rogid:m33nS0ixYDkwyJVqB7/Tmlum//g10090	intact-crc:2A1DBB751F594382|rigid:4WNuB7tvY2HBtwsICe1krwAiKjk	false	tag:?-?(MINT-2577165)	tag:?-?(MINT-2577156)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48356	uniprotkb:Q62225	intact:EBI-2257257|uniprotkb:O35686|uniprotkb:O54986|uniprotkb:Q61215|uniprotkb:Q64309|uniprotkb:Q9QWG3|uniprotkb:Q9QWV5|ensembl:ENSMUSP00000037385	intact:EBI-617489|ensembl:ENSMUSP00000082183|uniprotkb:Q3TC70	psi-mi:lepr_mouse(display_long)|uniprotkb:Lepr(gene name)|psi-mi:Lepr(display_short)|uniprotkb:Db(gene name synonym)|uniprotkb:Obr(gene name synonym)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:B219(gene name synonym)	psi-mi:cish_mouse(display_long)|uniprotkb:CIS-1(gene name synonym)|uniprotkb:Suppressor of cytokine signaling(gene name synonym)|uniprotkb:Cish(gene name)|psi-mi:Cish(display_short)|uniprotkb:Cis(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Montoye et al. (2006)	pubmed:16698021|imex:IM-11181|mint:MINT-5218643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8521273|mint:MINT-2576912|imex:IM-11181-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116371.1|refseq:NP_034834.1|refseq:NP_666258.2|dip:DIP-42763N|ensembl:ENSMUSG00000057722(gene)|ensembl:ENSMUST00000037552(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1904060"(negative regulation of locomotor rhythm)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|mint:P48356|mint:MINT-2576913(identity)	ensembl:ENSMUSG00000032578(gene)|ensembl:ENSMUST00000085102(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028425|interpro:IPR035887|interpro:IPR036036|interpro:IPR036860|mint:Q62225|reactome:R-MMU-8951664|refseq:NP_034025.1|refseq:NP_001304283.1|dip:DIP-907N|mint:MINT-2576921(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2006/06/14	2014/10/16	rogid:jHA91jK8nehmfp3KPNSF/7QoMPs10090	rogid:6VsFfr+LOZZOI8gwptkglukw3Mo10090	intact-crc:6EFC9F4404920DDB|rigid:WghuvRJ77EmGtNbNkqepHCvcSHk	false	tag:?-?(MINT-2576914)	tag:?-?(MINT-2576922)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VHQ2	uniprotkb:P48356	intact:EBI-8521341|uniprotkb:B1AQY1|uniprotkb:Q3UH08|intact:MINT-2577282|ensembl:ENSMUSP00000040896	intact:EBI-2257257|uniprotkb:O35686|uniprotkb:O54986|uniprotkb:Q61215|uniprotkb:Q64309|uniprotkb:Q9QWG3|uniprotkb:Q9QWV5|ensembl:ENSMUSP00000037385	psi-mi:socs7_mouse(display_long)|uniprotkb:Socs7(gene name)|psi-mi:Socs7(display_short)|uniprotkb:Cish7(gene name synonym)|uniprotkb:Nap4(gene name synonym)	psi-mi:lepr_mouse(display_long)|uniprotkb:Lepr(gene name)|psi-mi:Lepr(display_short)|uniprotkb:Db(gene name synonym)|uniprotkb:Obr(gene name synonym)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:B219(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Montoye et al. (2006)	pubmed:16698021|imex:IM-11181|mint:MINT-5218643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8521333|mint:MINT-2577205|imex:IM-11181-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_619598.1|ensembl:ENSMUSG00000038485(gene)|ensembl:ENSMUST00000045540(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028423|interpro:IPR035866|interpro:IPR036036|interpro:IPR036860|interpro:IPR037346|mint:Q8VHQ2|mint:MINT-2577225(identity)	refseq:NP_001116371.1|refseq:NP_034834.1|refseq:NP_666258.2|dip:DIP-42763N|ensembl:ENSMUSG00000057722(gene)|ensembl:ENSMUST00000037552(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1904060"(negative regulation of locomotor rhythm)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|mint:P48356|mint:MINT-2577234(identity)	-	function:Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2006/06/14	2014/10/16	rogid:3DqqkAke8wRMMSI2H8Opa7Y+hUo10090	rogid:jHA91jK8nehmfp3KPNSF/7QoMPs10090	intact-crc:B69DA2162EF8FEA4|rigid:kdvTIqJcB3qKvgvv977Q6q7UYZo	false	tag:?-?(MINT-2577229)	tag:?-?(MINT-2577235)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62077	uniprotkb:P48356	intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1	intact:EBI-2257257|uniprotkb:O35686|uniprotkb:O54986|uniprotkb:Q61215|uniprotkb:Q64309|uniprotkb:Q9QWG3|uniprotkb:Q9QWV5|ensembl:ENSMUSP00000037385	psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:lepr_mouse(display_long)|uniprotkb:Lepr(gene name)|psi-mi:Lepr(display_short)|uniprotkb:Db(gene name synonym)|uniprotkb:Obr(gene name synonym)|uniprotkb:OB receptor(gene name synonym)|uniprotkb:B219(gene name synonym)	psi-mi:"MI:0096"(pull down)	Montoye et al. (2006)	pubmed:16698021|imex:IM-11181|mint:MINT-5218643	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8521422|mint:MINT-2576732|imex:IM-11181-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N|mint:MINT-2576733(identity)	refseq:NP_001116371.1|refseq:NP_034834.1|refseq:NP_666258.2|dip:DIP-42763N|ensembl:ENSMUSG00000057722(gene)|ensembl:ENSMUST00000037552(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038021"(leptin receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044321"(response to leptin)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0051049"(regulation of transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903999"(negative regulation of eating behavior)|go:"GO:1904060"(negative regulation of locomotor rhythm)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015752(Leptin receptor)|interpro:IPR036116|interpro:IPR041182|mint:P48356|mint:MINT-2576741(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3C|comment:No detectable binding was observed with the non-phosphorylated peptides.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2006/06/14	2014/10/16	rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090	rogid:jHA91jK8nehmfp3KPNSF/7QoMPs10090	intact-crc:35A154C41ED19C91|rigid:ChhCg6YPQeXlV0LJJQtSxh63WRs	false	flag tag:?-?(MINT-2576739)|phosphorylated residue:1077-1077(MINT-2790473)|binding-associated region:1069-1085(MINT-2790471)	biotin tag:?-?(MINT-2576747)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)