#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q06455	uniprotkb:Q06455	intact:EBI-743342|uniprotkb:O14784|uniprotkb:Q06456|uniprotkb:Q14873|uniprotkb:Q16239|uniprotkb:Q16346|uniprotkb:Q16347|uniprotkb:Q6IBL1|uniprotkb:Q92479|uniprotkb:Q9BRZ0|ensembl:ENSP00000265814|ensembl:ENSP00000428543|ensembl:ENSP00000481112|ensembl:ENSP00000481315|ensembl:ENSP00000481799|uniprotkb:B7Z4P4|uniprotkb:E7EPN4|uniprotkb:Q6NXH1|uniprotkb:Q7Z4J5	intact:EBI-743342|uniprotkb:O14784|uniprotkb:Q06456|uniprotkb:Q14873|uniprotkb:Q16239|uniprotkb:Q16346|uniprotkb:Q16347|uniprotkb:Q6IBL1|uniprotkb:Q92479|uniprotkb:Q9BRZ0|ensembl:ENSP00000265814|ensembl:ENSP00000428543|ensembl:ENSP00000481112|ensembl:ENSP00000481315|ensembl:ENSP00000481799|uniprotkb:B7Z4P4|uniprotkb:E7EPN4|uniprotkb:Q6NXH1|uniprotkb:Q7Z4J5	psi-mi:mtg8_human(display_long)|uniprotkb:Protein MTG8(gene name synonym)|uniprotkb:Protein ETO(gene name synonym)|uniprotkb:Eight twenty one protein(gene name synonym)|uniprotkb:Cyclin-D-related protein(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 2(gene name synonym)|uniprotkb:RUNX1T1(gene name)|psi-mi:RUNX1T1(display_short)|uniprotkb:AML1T1(gene name synonym)|uniprotkb:CBFA2T1(gene name synonym)|uniprotkb:CDR(gene name synonym)|uniprotkb:ETO(gene name synonym)|uniprotkb:MTG8(gene name synonym)|uniprotkb:ZMYND2(gene name synonym)	psi-mi:mtg8_human(display_long)|uniprotkb:Protein MTG8(gene name synonym)|uniprotkb:Protein ETO(gene name synonym)|uniprotkb:Eight twenty one protein(gene name synonym)|uniprotkb:Cyclin-D-related protein(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 2(gene name synonym)|uniprotkb:RUNX1T1(gene name)|psi-mi:RUNX1T1(display_short)|uniprotkb:AML1T1(gene name synonym)|uniprotkb:CBFA2T1(gene name synonym)|uniprotkb:CDR(gene name synonym)|uniprotkb:ETO(gene name synonym)|uniprotkb:MTG8(gene name synonym)|uniprotkb:ZMYND2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Liu et al. (2006)	imex:IM-11855|pubmed:16616331	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1004888|rcsb pdb:1WQ6|imex:IM-11855-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185554.1|refseq:NP_001185555.1|refseq:NP_001185556.1|refseq:NP_001185557.1|refseq:NP_001185558.1|refseq:NP_001185559.1|refseq:NP_001185560.1|refseq:NP_001185561.1|refseq:NP_004340.1|refseq:NP_783552.1|refseq:NP_783553.1|refseq:NP_783554.1|ensembl:ENSG00000079102(gene)|ensembl:ENST00000265814(transcript)|ensembl:ENST00000523629(transcript)|ensembl:ENST00000613302(transcript)|ensembl:ENST00000614812(transcript)|ensembl:ENST00000617740(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|refseq:XP_011515653.1|refseq:XP_011515654.1|refseq:XP_011515655.1|interpro:IPR013290("Myeloid transforming gene on chromosome 8 (MTG8)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:Q06455|rcsb pdb:1WQ6|rcsb pdb:2DJ8|rcsb pdb:2H7B|rcsb pdb:2KNH|rcsb pdb:2KYG|rcsb pdb:2OD1|rcsb pdb:2ODD|rcsb pdb:2PP4|rcsb pdb:4JOL|refseq:NP_001185563.1|refseq:NP_001185562.1|refseq:NP_001185608.1|refseq:XP_006716739.1|refseq:XP_016869420.1|refseq:XP_016869421.1|refseq:XP_016869422.1|refseq:XP_016869423.1|refseq:XP_016869424.1|refseq:XP_016869425.1|refseq:XP_016869426.1|dip:DIP-29401N	refseq:NP_001185554.1|refseq:NP_001185555.1|refseq:NP_001185556.1|refseq:NP_001185557.1|refseq:NP_001185558.1|refseq:NP_001185559.1|refseq:NP_001185560.1|refseq:NP_001185561.1|refseq:NP_004340.1|refseq:NP_783552.1|refseq:NP_783553.1|refseq:NP_783554.1|ensembl:ENSG00000079102(gene)|ensembl:ENST00000265814(transcript)|ensembl:ENST00000523629(transcript)|ensembl:ENST00000613302(transcript)|ensembl:ENST00000614812(transcript)|ensembl:ENST00000617740(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|refseq:XP_011515653.1|refseq:XP_011515654.1|refseq:XP_011515655.1|interpro:IPR013290("Myeloid transforming gene on chromosome 8 (MTG8)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:Q06455|rcsb pdb:1WQ6|rcsb pdb:2DJ8|rcsb pdb:2H7B|rcsb pdb:2KNH|rcsb pdb:2KYG|rcsb pdb:2OD1|rcsb pdb:2ODD|rcsb pdb:2PP4|rcsb pdb:4JOL|refseq:NP_001185563.1|refseq:NP_001185562.1|refseq:NP_001185608.1|refseq:XP_006716739.1|refseq:XP_016869420.1|refseq:XP_016869421.1|refseq:XP_016869422.1|refseq:XP_016869423.1|refseq:XP_016869424.1|refseq:XP_016869425.1|refseq:XP_016869426.1|dip:DIP-29401N	-	-	-	comment:"Note the pdb entry refers to the Uniprot entry  Q06455 (resides 335-403). However, the authors refer to the numbering for AML1_ETO (480-551)."|comment:The protein crystallised has an extra ala-met-ala at the N-terminus.|figure legend:1, Table 1|3d-resolution:2.0 A|3d-r-factors:"R(%) 21.6; Rfree(%) 27.0"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2014/10/16	rogid:SMomKOZSbtqhKiAkkUkabKbC8/09606	rogid:SMomKOZSbtqhKiAkkUkabKbC8/09606	intact-crc:AA471B8744D3AB74|rigid:aDltnnFaBnAhJ1pmOPt3SBXnI38	false	L-selenomethionine:?-?|sufficient binding region:335-403	L-selenomethionine:?-?|sufficient binding region:335-403	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-11620908	intact:EBI-11620908	-	-	psi-mi:aml1_eto_chimera(display_short)|psi-mi:EBI-11620908(display_long)	psi-mi:aml1_eto_chimera(display_short)|psi-mi:EBI-11620908(display_long)	psi-mi:"MI:0027"(cosedimentation)	Liu et al. (2006)	imex:IM-11855|pubmed:16616331	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1004945|imex:IM-11855-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q01196(see-also)|uniprotkb:Q06455(see-also)	uniprotkb:Q01196(see-also)|uniprotkb:Q06455(see-also)	psi-mi:"MI:0469"(intact)	-	-	comment:"The Uniprot entry  Q06455 (resides 335-403)contains the  NHR2 domain as does the chimeric protein AML1_ETO."|figure legend:3 C, Table 2|comment:"The m4 (leu345gln-leu375glu-leu378lys-leu389gln) mutant was tetrameric at 20�C by analytical ultracentrifugation  (Table 2), but CD spectroscopy revealed that it was only  41% helical, suggesting that the m4 tetramer is significantly destabilized."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2016/03/10	rogid:qdAcaZFUs5eWXSLBdUyzMULIBuI9606	rogid:qdAcaZFUs5eWXSLBdUyzMULIBuI9606	intact-crc:E0FEEFB0C5434684|rigid:SIzwDG7TJqDcd1ITOxTaj2SXPlw	false	sufficient binding region:483-551|mutation disrupting interaction:493-493,505-505,508-508,509-509,523-523,526-526,537-537	sufficient binding region:483-551|mutation disrupting interaction:493-493,505-505,508-508,509-509,523-523,526-526,537-537	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-11620908	intact:EBI-11620908	-	-	psi-mi:aml1_eto_chimera(display_short)|psi-mi:EBI-11620908(display_long)	psi-mi:aml1_eto_chimera(display_short)|psi-mi:EBI-11620908(display_long)	psi-mi:"MI:0071"(molecular sieving)	Liu et al. (2006)	imex:IM-11855|pubmed:16616331	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1004975|imex:IM-11855-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q01196(see-also)|uniprotkb:Q06455(see-also)	uniprotkb:Q01196(see-also)|uniprotkb:Q06455(see-also)	go:"GO:0042802"(identical protein binding)	-	-	figure legend:3 A, E|comment:It is not clear whether the deletion of the NHR2 domain completely abolishes oligomerisation of AML1_ETO.|comment:The elution volume of the m4 mutant is in between that for AML1_ETO and the m7 mutant.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/04	2016/03/10	rogid:qdAcaZFUs5eWXSLBdUyzMULIBuI9606	rogid:qdAcaZFUs5eWXSLBdUyzMULIBuI9606	intact-crc:2B6E36F4E888840B|rigid:SIzwDG7TJqDcd1ITOxTaj2SXPlw	false	mutation decreasing interaction:493-493,505-505,508-508,509-509,523-523,526-526,537-537|mutation decreasing interaction:493-493,523-523,526-526,537-537|necessary binding region:453-453	mutation decreasing interaction:493-493,505-505,508-508,509-509,523-523,526-526,537-537|mutation decreasing interaction:493-493,523-523,526-526,537-537|necessary binding region:453-453	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)