#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-1178037	uniprotkb:O75164	-	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	psi-mi:h3_peptide_1-10(display_short)|psi-mi:EBI-1178037(display_long)	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Huang et al. (2006)	pubmed:16601153|imex:IM-19699	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1178028|rcsb pdb:2gfa|imex:IM-19699-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:The AA 1- 10 consensus sequence found in most histone H3 proteins.|comment:Similar to P84244|comment:Similar to P84243	-	figure legend:2C, table S1|3d-resolution:2.1A|3d-r-factors:working 22.4, free 27.0|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/12	2014/10/16	rogid:awe4qgBC2v2dD6SIgP4/V9XnN+A9606	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	intact-crc:0C2AF83012D839ED|rigid:UflPZXsGMnasma6UOJTShcK86Ms	false	N6,N6,N6-trimethyl-L-lysine:4-4|N6,N6,N6-trimethyl-L-lysine:4-4|N6,N6,N6-trimethyl-L-lysine:4-4|sufficient binding region:1-1|sufficient binding region:2-2|sufficient binding region:3-3|sufficient binding region:5-5	sufficient binding region:895-1011(IPR002999)|sufficient binding region:967-967|sufficient binding region:973-973|sufficient binding region:932-932|sufficient binding region:942-942|sufficient binding region:945-945|sufficient binding region:940-940|sufficient binding region:937-937	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75164	intact:EBI-1178037	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	-	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:h3_peptide_1-10(display_short)|psi-mi:EBI-1178037(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Huang et al. (2006)	pubmed:16601153|imex:IM-19699	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1178238|imex:IM-19699-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	-	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:The AA 1- 10 consensus sequence found in most histone H3 proteins.|comment:Similar to P84244|comment:Similar to P84243	figure legend:3A, 3B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/12/12	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:awe4qgBC2v2dD6SIgP4/V9XnN+A9606	intact-crc:5D5191D857955A75|rigid:UflPZXsGMnasma6UOJTShcK86Ms	false	mutation disrupting interaction:967-967|mutation disrupting interaction:973-973|mutation decreasing interaction:945-945|sufficient binding region:895-1011	N6,N6,N6-trimethyl-L-lysine:4-4|mutation decreasing interaction:2-2|biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)