#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0071"(molecular sieving) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8165502|mint:MINT-2838787|imex:IM-13937-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838788(identity) mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI|mint:MINT-2838789(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" crc64:F6E377D8EA241B7D|comment:"Stoichiometry: 1.0" figure legend:F1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 intact-crc:2FFE80FE30E9AC0B|rigid:eIbrZ7ecp3UJuRjH3VW/ImoD/y4 false his tag:c-c(MINT-2838791) his tag:?-?(MINT-2838798) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37571 uniprotkb:P40396 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-8165548|ensemblbacteria:CAB12882|intact:MINT-2838890 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:comk_bacsu(display_long)|uniprotkb:comK(gene name)|psi-mi:comK(display_short)|uniprotkb:Competence protein K(gene name synonym)|uniprotkb:BSU10420(locus name) psi-mi:"MI:0071"(molecular sieving) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8165574|mint:MINT-2838916|imex:IM-13937-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838918(identity) refseq:WP_003245329.1|ensemblbacteria:BSU_10420(gene)|ensemblbacteria:CAB12882(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0030420"(establishment of competence for transformation)|refseq:NP_388923.1|mint:P40396|interpro:IPR010461(ComK)|mint:MINT-2838917(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" comment:mint|function:Intermediate regulatory gene required for the expression of the late competence genes comC, comE, comG and the bdbDC operon. Receives signals from srfA, and possibly other regulatory COM genes, and transduces these signals to the late COM genes|comment:"Stoichiometry: 1.0" figure legend:F4A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:3cBNdg4KkeIph/fw4hEkvl9exQM224308 intact-crc:D96FA24D227EE66C|rigid:6SfXtLGd1s4m7Z8I1uq2g2GzRZY false his tag:?-?(MINT-2838934) maltose binding protein tag:?-?(MINT-2838920) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0071"(molecular sieving) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8165574|mint:MINT-2838916|imex:IM-13937-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838918(identity) mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI|mint:MINT-2838919(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" crc64:F6E377D8EA241B7D|comment:"Stoichiometry: 1.0" figure legend:F4A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 intact-crc:D96FA24D227EE66C|rigid:6SfXtLGd1s4m7Z8I1uq2g2GzRZY false his tag:?-?(MINT-2838934) his tag:?-?(MINT-2838927) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37571 uniprotkb:P80244 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-8165631|ensemblbacteria:CAB15459|intact:MINT-2838977|uniprotkb:O08433 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:clpp_bacsu(display_long)|uniprotkb:clpP(gene name)|psi-mi:clpP(display_short)|uniprotkb:BSU34540(locus name)|uniprotkb:yvdN(gene name synonym)|uniprotkb:Endopeptidase Clp(gene name synonym)|uniprotkb:Caseinolytic protease(gene name synonym)|uniprotkb:Stress protein G7(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8165625|mint:MINT-2838953|imex:IM-13937-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838954(identity) refseq:WP_003228214.1|go:"GO:0004252"(serine-type endopeptidase activity)|ensemblbacteria:BSU_34540(gene)|ensemblbacteria:CAB15459(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|refseq:NP_391334.1|dip:DIP-43711N|mint:P80244|go:"GO:0005737"(cytoplasm)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|interpro:IPR001907(Peptidase S14, ClpP)|interpro:IPR018215|interpro:IPR023562|interpro:IPR029045|interpro:IPR033135|rcsb pdb:3KTG|rcsb pdb:3KTH|rcsb pdb:3KTI|rcsb pdb:3KTJ|rcsb pdb:3KTK|rcsb pdb:3TT6|rcsb pdb:3TT7|mint:MINT-2838968(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" crc64:5D4D4BD548DC45A0|comment:mint|function:"Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). ClpXP is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor rsiW. This results in the release of sigW and the transcription activation of the genes under the control of the sigma-W factor"|comment:"Stoichiometry: 1.0" figure legend:F4B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:3B0wNbPdwDnWeuHCReXF9FnchvY224308 intact-crc:690727719F6B5138|rigid:sqG6ArHBg18u8/jheJvl7fMvGFI false his tag:?-?(MINT-2838959) his tag:?-?(MINT-2838973) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0071"(molecular sieving) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8165625|mint:MINT-2838953|imex:IM-13937-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838954(identity) mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI|mint:MINT-2838961(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" crc64:F6E377D8EA241B7D|comment:"Stoichiometry: 1.0" figure legend:F4B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 intact-crc:690727719F6B5138|rigid:sqG6ArHBg18u8/jheJvl7fMvGFI false his tag:?-?(MINT-2838959) his tag:?-?(MINT-2838966) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0027"(cosedimentation) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8165688|mint:MINT-2838809|imex:IM-13937-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838817(identity) mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI|mint:MINT-2838810(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" crc64:F6E377D8EA241B7D|comment:"Stoichiometry: 1.0" figure legend:F2A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 intact-crc:80510131318B1E09|rigid:eIbrZ7ecp3UJuRjH3VW/ImoD/y4 false his tag:c-c(MINT-2838822) his tag:?-?(MINT-2838815) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0030"(cross-linking study) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8165743|mint:MINT-2838828|imex:IM-13937-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838829(identity) mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI|mint:MINT-2838836(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" crc64:F6E377D8EA241B7D|comment:"Stoichiometry: 1.0" figure legend:SF1A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 intact-crc:FDC9F3776CF8483A|rigid:eIbrZ7ecp3UJuRjH3VW/ImoD/y4 false his tag:c-c(MINT-2838830) his tag:?-?(MINT-2838837) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0040"(electron microscopy) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8165771|mint:MINT-2838847|imex:IM-13937-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838855(identity) mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI|mint:MINT-2838848(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" crc64:F6E377D8EA241B7D|comment:"Stoichiometry: 1.0" figure legend:SF1B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 intact-crc:4A0749F1C13C5AEB|rigid:eIbrZ7ecp3UJuRjH3VW/ImoD/y4 false his tag:c-c(MINT-2838860) his tag:?-?(MINT-2838853) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8165799|mint:MINT-2838869|imex:IM-13937-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838870(identity) mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI|mint:MINT-2838877(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" crc64:F6E377D8EA241B7D|comment:"Stoichiometry: 1.0" figure legend:F5|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 intact-crc:0BC486AA11839500|rigid:eIbrZ7ecp3UJuRjH3VW/ImoD/y4 false his tag:?-?(MINT-2838871) his tag:?-?(MINT-2838878) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P37571 uniprotkb:P40396 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-8165548|ensemblbacteria:CAB12882|intact:MINT-2838890 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:comk_bacsu(display_long)|uniprotkb:comK(gene name)|psi-mi:comK(display_short)|uniprotkb:Competence protein K(gene name synonym)|uniprotkb:BSU10420(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8165844|mint:MINT-2838912|imex:IM-13937-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838913(identity) refseq:WP_003245329.1|ensemblbacteria:BSU_10420(gene)|ensemblbacteria:CAB12882(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0030420"(establishment of competence for transformation)|refseq:NP_388923.1|mint:P40396|interpro:IPR010461(ComK)|mint:MINT-2838915(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" comment:mint|function:Intermediate regulatory gene required for the expression of the late competence genes comC, comE, comG and the bdbDC operon. Receives signals from srfA, and possibly other regulatory COM genes, and transduces these signals to the late COM genes|comment:"Stoichiometry: 1.0" comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:3cBNdg4KkeIph/fw4hEkvl9exQM224308 intact-crc:0AC9696F82D28604|rigid:6SfXtLGd1s4m7Z8I1uq2g2GzRZY false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P37571 uniprotkb:P37958 intact:EBI-7349302|intact:MINT-2838758|ensemblbacteria:CAB11862 intact:EBI-5254676|ensemblbacteria:CAB13009 psi-mi:clpc_bacsu(display_long)|uniprotkb:clpC(gene name)|psi-mi:clpC(display_short)|uniprotkb:mecB(gene name synonym)|uniprotkb:BSU00860(locus name) psi-mi:meca1_bacsu(display_long)|uniprotkb:mecA(gene name)|psi-mi:mecA(display_short)|uniprotkb:BSU11520(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Kirstein et al. (2006) pubmed:16525504|imex:IM-13937|mint:MINT-5218417 taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) taxid:224308(bacsu)|taxid:224308(Bacillus subtilis) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8165844|mint:MINT-2838912|imex:IM-13937-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_003235011.1|mint:P37571|refseq:NP_387967.1|ensemblbacteria:BSU_00860(gene)|ensemblbacteria:CAB11862(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0030420"(establishment of competence for transformation)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004176(Clp, N-terminal)|interpro:IPR018368|interpro:IPR019489|interpro:IPR027417|interpro:IPR028299|interpro:IPR036628|interpro:IPR041546|rcsb pdb:2K77|rcsb pdb:2Y1Q|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3PXG|rcsb pdb:3PXI|rcsb pdb:5HBN|dip:DIP-43708N|mint:MINT-2838913(identity) mint:P37958|refseq:NP_389034.1|refseq:WP_003245194.1|dip:DIP-43709N|ensemblbacteria:BSU_11520(gene)|ensemblbacteria:CAB13009(transcript)|go:"GO:0030420"(establishment of competence for transformation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042174"(negative regulation of sporulation resulting in formation of a cellular spore)|go:"GO:0045808"(negative regulation of establishment of competence for transformation)|interpro:IPR008681(Negative regulator of genetic competence)|interpro:IPR038471|rcsb pdb:2Y1R|rcsb pdb:3J3R|rcsb pdb:3J3S|rcsb pdb:3J3T|rcsb pdb:3J3U|rcsb pdb:3JTP|rcsb pdb:3PXG|rcsb pdb:3PXI|mint:MINT-2838914(identity) - crc64:9592231886C2E870|comment:mint|function:Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with mecA to negatively regulate comK|comment:"Stoichiometry: 1.0" crc64:F6E377D8EA241B7D|comment:"Stoichiometry: 1.0" comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/27 2014/10/16 rogid:INSVQnEvhBAzVoS515lg8hzqB1A224308 rogid:/v3HLyaYoX8Cpk8O6VhW7GtS8LM224308 intact-crc:0AC9696F82D28604|rigid:6SfXtLGd1s4m7Z8I1uq2g2GzRZY false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)