#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15151	uniprotkb:P48729	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	intact:EBI-1383726|uniprotkb:Q96HD2|uniprotkb:Q5U046|uniprotkb:Q5U047|uniprotkb:Q6FGA2|uniprotkb:Q4JJA0|uniprotkb:Q9UDK3|intact:EBI-11048253|uniprotkb:D3DQG0|uniprotkb:D3DQG1|uniprotkb:Q71TU5|ensembl:ENSP00000367074	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:kc1a_human(display_long)|uniprotkb:CSNK1A1(gene name)|psi-mi:CSNK1A1(display_short)|uniprotkb:CK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8105981|mint:MINT-1958437|imex:IM-11079-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958439(identity)	refseq:NP_001020276.1|refseq:NP_001883.4|refseq:NP_001258670.1|refseq:NP_001258671.1|dip:DIP-40367N|ensembl:ENSG00000113712(gene)|ensembl:ENST00000377843(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904424"(regulation of GTP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P48729|rcsb pdb:5FQD|rcsb pdb:6GZD|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5635838|mint:MINT-1958438(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/05/26	2014/10/16	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	rogid:2rG1/sMVnsRKUEWsLhLAyHvqPnY9606	intact-crc:71EB83FD4272CEF4|rigid:yDkmqORp6cfv8y2+BKU8uW57tAg	false	flag tag:?-?(MINT-1958445)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q3YBA8	uniprotkb:O15151	intact:EBI-7852331|intact:MINT-1957887	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:q3yba8_human(display_long)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106037|mint:MINT-1958459|imex:IM-11079-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000308(14-3-3 protein)|mint:Q3YBA8|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1958460(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958466(identity)	-	comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/05/26	2014/10/16	rogid:DEBDUkJS35MS6W/Fm3ccbMKrFo49606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:C450259559D2EDB1|rigid:eL59el7/uxUll9lrB2YfxsnNt5Y	false	-	flag tag:?-?(MINT-1958472)	1	1	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3YBA8	uniprotkb:O15151	intact:EBI-7852331|intact:MINT-1957887	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:q3yba8_human(display_long)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106066|mint:MINT-1958477|imex:IM-11079-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000308(14-3-3 protein)|mint:Q3YBA8|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1958478(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958484(identity)	-	comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:Interaction increases when cells are treated with WCE.|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2006/05/26	2014/10/16	rogid:DEBDUkJS35MS6W/Fm3ccbMKrFo49606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:45E5357F9D761B95|rigid:eL59el7/uxUll9lrB2YfxsnNt5Y	false	-	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P31946	uniprotkb:O15151	intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106133|mint:MINT-1958529|imex:IM-11079-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N|mint:MINT-1958530(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958538(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2006/05/26	2014/10/16	rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:A08889EF1E1FC765|rigid:KAlXM2tlejsSK4d3uke24Va1z98	false	myc tag:?-?(MINT-1958536)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q3YBA8	uniprotkb:O15151	intact:EBI-7852331|intact:MINT-1957887	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:q3yba8_human(display_long)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106093|mint:MINT-1958505|imex:IM-11079-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000308(14-3-3 protein)|mint:Q3YBA8|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1958506(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958512(identity)	-	comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2006/05/26	2014/10/16	rogid:DEBDUkJS35MS6W/Fm3ccbMKrFo49606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:01315263F76FC34C|rigid:eL59el7/uxUll9lrB2YfxsnNt5Y	false	flag tag:?-?(MINT-1958525)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q04917	uniprotkb:O15151	intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106190|mint:MINT-1958584|imex:IM-11079-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N|mint:MINT-1958585(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958593(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2006/05/26	2014/10/16	rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:01A5A6E9798BC1BC|rigid:BjYBa1zhlaO3sgcBqH59LiwSh94	false	his tag:?-?(MINT-1958591)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:O15151	uniprotkb:P63104	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106171|mint:MINT-1958565|imex:IM-11079-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958574(identity)	ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N|mint:MINT-1958566(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2006/05/26	2014/10/16	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606	intact-crc:CD4CB132AFC933AA|rigid:dqpwowjuv0qkKCnGPWkYjerX9XI	false	-	myc tag:?-?(MINT-1958572)	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62258	uniprotkb:O15151	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106152|mint:MINT-1958547|imex:IM-11079-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-1958548(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958556(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2006/05/26	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:4BE4A7F55B793880|rigid:4l3a3SRnKYvjYAZ7m/a0Q0EGt78	false	his tag:?-?(MINT-1958554)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P61981	uniprotkb:O15151	intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106226|mint:MINT-1958602|imex:IM-11079-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N|mint:MINT-1958603(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958611(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2006/05/26	2014/10/16	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:B33F48F099B731F7|rigid:TMNPUCTWvBQhz98G6yPMFvUPCKo	false	flag tag:?-?(MINT-1958609)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q3YBA8	uniprotkb:O15151	intact:EBI-7852331|intact:MINT-1957887	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:q3yba8_human(display_long)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106262|mint:MINT-1958620|imex:IM-11079-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000308(14-3-3 protein)|mint:Q3YBA8|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1958621(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958629(identity)	-	comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2006/05/26	2014/10/16	rogid:DEBDUkJS35MS6W/Fm3ccbMKrFo49606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:53C2AB12DD982611|rigid:eL59el7/uxUll9lrB2YfxsnNt5Y	false	flag tag:?-?(MINT-1958627)	mutation disrupting interaction:367-367(MINT-1958645)|mutation decreasing interaction:369-369(MINT-1958648)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q3YBA8	uniprotkb:O15151	intact:EBI-7852331|intact:MINT-1957887	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:q3yba8_human(display_long)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106301|mint:MINT-1958651|imex:IM-11079-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000308(14-3-3 protein)|mint:Q3YBA8|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1958664(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958652(identity)	-	comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:The result showed that peptide with phosphorylated S367 specifically captured 14-3-3tau from the extract.|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/26	2014/10/16	rogid:DEBDUkJS35MS6W/Fm3ccbMKrFo49606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:E04CDB78054C8FDB|rigid:eL59el7/uxUll9lrB2YfxsnNt5Y	false	-	phosphorylated residue:367-367(MINT-2789387)|binding-associated region:364-372(MINT-1958690)	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:O00505	uniprotkb:O15151	intact:EBI-358297|intact:EBI-28976892|ensembl:ENSP00000261667|uniprotkb:O00191|uniprotkb:O43195|uniprotkb:Q96AA7|uniprotkb:Q5JVM9|intact:EBI-742146|uniprotkb:Q8IYQ9	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:ima4_human(display_long)|uniprotkb:KPNA3(gene name)|psi-mi:KPNA3(display_short)|uniprotkb:QIP2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)|uniprotkb:SRP1-gamma(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106326|mint:MINT-1958692|imex:IM-11079-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102753(gene)|ensembl:ENST00000261667(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0043657"(host cell)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000225(Armadillo)|refseq:NP_002258.2|ensembl:ENSP00000261667|dip:DIP-27586N|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00505|reactome:R-HSA-1169408|reactome:R-HSA-168276|mint:MINT-1958700(identity)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-1958693(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F7C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/26	2014/10/16	rogid:kx/oTYWMYG7dhwJHvr1POLD6FTU9606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:DC911CDC43FC4B85|rigid:AaCd0AeCZOyGhHLTWSzxNFwynD8	false	glutathione s tranferase tag:?-?(MINT-1958707)	mutation disrupting interaction:468-468(MINT-1958713)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P27348	uniprotkb:O15151	intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267	intact:EBI-398437|uniprotkb:Q32SL2|uniprotkb:Q6GS18|uniprotkb:Q8IV83|intact:EBI-3932059|uniprotkb:Q2M2Y2|intact:EBI-28988565|ensembl:ENSP00000356150	psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym)	psi-mi:mdm4_human(display_long)|uniprotkb:MDM4(gene name)|psi-mi:MDM4(display_short)|uniprotkb:MDMX(gene name synonym)|uniprotkb:p53-binding protein Mdm4(gene name synonym)|uniprotkb:Mdm2-like p53-binding protein(gene name synonym)|uniprotkb:Protein Mdmx(gene name synonym)|uniprotkb:Double minute 4 protein(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	LeBron et al. (2006)	pubmed:16511560|imex:IM-11079|mint:MINT-5218386	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8106358|mint:MINT-8007350|imex:IM-11079-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N|mint:MINT-8007351(identity)|uniprotkb:P27348(original identifier)	refseq:NP_002384.2|refseq:NP_001191101.1|refseq:NP_001191100.1|ensembl:ENSP00000356150|ensembl:ENST00000367183|ensembl:ENSP00000356151|ensembl:ENST00000454264|ensembl:ENSP00000396840|refseq:NP_001265445.1|refseq:NP_001265446.1|refseq:NP_001265447.1|refseq:NP_001265448.1|dip:DIP-24199N|reactome:R-HSA-69541|reactome:R-HSA-6804760|ensembl:ENSG00000198625(gene)|ensembl:ENST00000367182(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015458(MDM4/MDMX protein)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR036443|interpro:IPR036885|mint:O15151|rcsb pdb:2CR8|rcsb pdb:2MWY|rcsb pdb:2N06|rcsb pdb:2N0U|rcsb pdb:2N0W|rcsb pdb:2N14|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:2VYR|rcsb pdb:3DAB|rcsb pdb:3EQY|rcsb pdb:3FDO|rcsb pdb:3FE7|rcsb pdb:3FEA|rcsb pdb:3JZO|rcsb pdb:3JZP|rcsb pdb:3JZQ|rcsb pdb:3LBJ|rcsb pdb:3MQR|rcsb pdb:3U15|rcsb pdb:4RXZ|rcsb pdb:5MNJ|rcsb pdb:5UML|rcsb pdb:5VK1|rcsb pdb:6Q9Q|rcsb pdb:6Q9S|rcsb pdb:6Q9U|rcsb pdb:6Q9W|rcsb pdb:6Q9Y|rcsb pdb:7C3Q|rcsb pdb:7C3Y|rcsb pdb:7C44|rcsb pdb:7EL4|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|mint:MINT-8007354(identity)|uniprotkb:O15151(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2006/05/26	2014/10/16	rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606	rogid:zAL03wG+qlPT5folNjx1ZUJhx/A9606	intact-crc:DDE26F186B5F5E35|rigid:at0Z1+QupD7tYiKbR1HmuZ8fzsY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)