#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O89110	uniprotkb:Q61160	intact:EBI-851690|uniprotkb:O35669|ensembl:ENSMUSP00000027189|ensembl:ENSMUSP00000127375	intact:EBI-524415|uniprotkb:Q3TC37|uniprotkb:Q61082|ensembl:ENSMUSP00000033394	psi-mi:casp8_mouse(display_long)|uniprotkb:Casp8(gene name)|psi-mi:Casp8(display_short)	psi-mi:fadd_mouse(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:Fadd(gene name)|psi-mi:Fadd(display_short)|uniprotkb:Mort1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chang et al. (2006)	pubmed:16469705|imex:IM-11835	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851708|imex:IM-11835-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001073595.1|refseq:NP_033942.1|dip:DIP-37435N|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357905|reactome:R-MMU-5660668|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75108|reactome:R-MMU-75153|reactome:R-MMU-75157|reactome:R-MMU-75158|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:O89110|reactome:R-MMU-111465|reactome:R-MMU-140534|reactome:R-MMU-168638|reactome:R-MMU-2562578|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097342"(ripoptosome)|ensembl:ENSMUST00000027189(transcript)|ensembl:ENSMUST00000165549(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001841"(neural tube formation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016485"(protein processing)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030690"(Noc1p-Noc2p complex)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|ensembl:ENSMUSG00000026029(gene)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048738"(cardiac muscle tissue development)|reactome:R-MMU-264870	ensembl:ENSMUSG00000031077(gene)|ensembl:ENSMUST00000033394(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0044297"(cell body)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q61160|rcsb pdb:1FAD|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75157|reactome:R-MMU-75158|refseq:NP_034305.1|dip:DIP-34771N	imex:IM-1422(imex secondary)	-	-	comment:Very little pro-caspase-8 was brought down by the anti-FADD antibody in Jnk1 deficient livers, whereas pro-caspase-8 was readily detected in FADD immunoprecipitates from wt liver�especially after ConA administration.|agonist:ConA|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-liver)|taxid:10090(Mus musculus)	-	2006/02/13	2014/10/16	rogid:cugP6s7CldE0MbwvCxTcams7feA10090	rogid:0pzBrb1MrPRQ1IL9cdXg57tneNE10090	intact-crc:0622C59F9B2893DA|rigid:+UUdU6ChKUObtf7WAj7uh/MiQzY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61160	uniprotkb:O35732-1	intact:EBI-524415|uniprotkb:Q3TC37|uniprotkb:Q61082|ensembl:ENSMUSP00000033394	intact:EBI-851729|ensembl:ENSMUSP00000065107|ensembl:ENSMUSP00000109952	psi-mi:fadd_mouse(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:Fadd(gene name)|psi-mi:Fadd(display_short)|uniprotkb:Mort1(gene name synonym)	psi-mi:o35732-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:Cflar(gene name)|psi-mi:Cflar(display_short)|uniprotkb:Cash(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chang et al. (2006)	pubmed:16469705|imex:IM-11835	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851744|imex:IM-11835-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031077(gene)|ensembl:ENSMUST00000033394(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0044297"(cell body)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q61160|rcsb pdb:1FAD|reactome:R-MMU-140534|reactome:R-MMU-2562578|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75157|reactome:R-MMU-75158|refseq:NP_034305.1|dip:DIP-34771N	intact:EBI-851716(cflar_mouse)|ensembl:ENSMUSG00000026031(gene)|ensembl:ENSMUST00000069333(transcript)|ensembl:ENSMUST00000114313(transcript)	imex:IM-1420(imex secondary)	-	-	comment:Very little c-FLIP was brought down by the anti-FADD antibody in wild type livers, whereas it was readily detected in FADD immunoprecipitates from JNK deficient liver.|antagonist:ConA|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-liver)|taxid:10090(Mus musculus)	-	2006/02/13	2017/10/30	rogid:0pzBrb1MrPRQ1IL9cdXg57tneNE10090	rogid:lu98iTolU0X3KwcgkM7cOY8zsYo10090	intact-crc:C70D9F3A84F61554|rigid:W7nQhhJu6SCq09RFyC3AsEX05LQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8C863	uniprotkb:O35732-1	intact:EBI-851782|uniprotkb:O54971|ensembl:ENSMUSP00000029126|ensembl:ENSMUSP00000105307	intact:EBI-851729|ensembl:ENSMUSP00000065107|ensembl:ENSMUSP00000109952	psi-mi:itch_mouse(display_long)|uniprotkb:Itch(gene name)|psi-mi:Itch(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)	psi-mi:o35732-1(display_long)|uniprotkb:FLIP-L(isoform synonym)|uniprotkb:CASH alpha(isoform synonym)|uniprotkb:Cflar(gene name)|psi-mi:Cflar(display_short)|uniprotkb:Cash(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Usurpin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chang et al. (2006)	pubmed:16469705|imex:IM-11835	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851778|imex:IM-11835-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230641.1|refseq:NP_032421.2|dip:DIP-29318N|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q8C863|rcsb pdb:1YIU|rcsb pdb:2JO9|rcsb pdb:2JOC|rcsb pdb:5XMC|reactome:R-MMU-1253288|reactome:R-MMU-168638|reactome:R-MMU-2122948|reactome:R-MMU-5610780|reactome:R-MMU-5632684|reactome:R-MMU-8939236|reactome:R-MMU-983168|ensembl:ENSMUSG00000027598(gene)|ensembl:ENSMUST00000029126(transcript)|ensembl:ENSMUST00000109685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)	intact:EBI-851716(cflar_mouse)|ensembl:ENSMUSG00000026031(gene)|ensembl:ENSMUST00000069333(transcript)|ensembl:ENSMUST00000114313(transcript)	intact:EBI-852345(see-also)|imex:IM-1421(imex secondary)	-	-	comment:Itch does not interact with either the DED domain of cFLARlong or with the  cFLARshort isoform.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/13	2017/10/30	rogid:gDN+qYu3L0C2MzekQFRAtVwgceE10090	rogid:lu98iTolU0X3KwcgkM7cOY8zsYo10090	intact-crc:28DE61D21092C483|rigid:iSa3Oso/8Vdj4OUP1GnJWEDZ7lU	false	glutathione s tranferase tag:?-?	necessary binding region:230-481|his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)