#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15156	uniprotkb:O15379	intact:EBI-867256	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short)	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867179|imex:IM-19113-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/02/27	2014/10/16	rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	intact-crc:6D772B71A58989D6|rigid:ul4Oc7nNN8kjfYrTNNYO0IZs8DQ	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UIS9	uniprotkb:O15379	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867192|imex:IM-19113-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253	-	-	-	comment:Integrity of the TRD domain was necessary for the interaction as R22A-I527R mutant showed a decrease in this interaction. I527 however could not be mapped to the UniProt entry.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/02/27	2014/10/16	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	intact-crc:1481837C66FB9409|rigid:tIYS95xCg+sYCxZXOK3eJeWzy9g	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15156	uniprotkb:Q9UIS9	intact:EBI-867256	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short)	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867274|imex:IM-19113-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	omim:102578(see-also)	-	-	delivery method:Q15156; Q9UIS9 transfection|antibodies:anti-PML PGM3|comment:This interaction persist in the presence of EtBr and is hence DNA independent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/02/27	2014/10/16	rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	intact-crc:618D9D735FD0C7E2|rigid:2gWPcpMUOjOhLrEQYlFBAtY3t0w	false	binding-associated region:c-c	mutation disrupting interaction:32-32	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15156	uniprotkb:Q9UIS9	intact:EBI-867256	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short)	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867314|imex:IM-19113-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	-	-	-	delivery method:Q15156; Q9UIS9 transfection|antibodies:anti-PML PGM3|inhibition:"Retinoic acid inhibits this interaction. CHEBI:15367"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/02/27	2014/10/16	rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	intact-crc:0F47913EB6439549|rigid:2gWPcpMUOjOhLrEQYlFBAtY3t0w	false	binding-associated region:395..395-797..797	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UIS9	uniprotkb:Q15156	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-867256	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867326|imex:IM-19113-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/02/27	2014/10/16	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606	intact-crc:DEBB19689D1E3B6D|rigid:Nrk1pAPDCusI+cinBLWI1udQ2iU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UIS9	uniprotkb:O15379	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867326|imex:IM-19113-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/02/27	2014/10/16	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	intact-crc:DEBB19689D1E3B6D|rigid:Nrk1pAPDCusI+cinBLWI1udQ2iU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UIS9	uniprotkb:P10276	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867347|imex:IM-19113-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/02/27	2014/10/16	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606	intact-crc:8E708D698F645EBE|rigid:cCoQNU+/YgFooab6Q0rSXx1M3N4	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:15367"	uniprotkb:Q15156	intact:EBI-980181	intact:EBI-867256	psi-mi:all-trans-retinoic acid(display_short)|psi-mi:"CHEBI:15367"(display_long)	psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-980189|imex:IM-19113-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)	-	-	-	delivery method:Q15156; Q9UIS9 transfection|antibodies:anti-PML PGM3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/02/27	2014/10/16	-	rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606	intact-crc:A15C849D9C86A3B8	false	-	binding-associated region:395..395-797..797	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15156	uniprotkb:Q9UIS9	intact:EBI-867256	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short)	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-980189|imex:IM-19113-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	-	-	-	delivery method:Q15156; Q9UIS9 transfection|antibodies:anti-PML PGM3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/02/27	2014/10/16	rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	intact-crc:A15C849D9C86A3B8	false	binding-associated region:395..395-797..797	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15379	uniprotkb:Q9UIS9	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Villa et al. (2006)	pubmed:16432238|imex:IM-19113	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867358|imex:IM-19113-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/27	2014/10/16	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	intact-crc:99BA3E6461F5C079|rigid:tIYS95xCg+sYCxZXOK3eJeWzy9g	false	glutathione s tranferase tag:?-?|necessary binding region:1-122	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)