#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15920	uniprotkb:P63034	intact:EBI-988456|uniprotkb:Q3U2X3|uniprotkb:Q9JHJ2|uniprotkb:A4FU82|uniprotkb:Q8VHU0|ensembl:ENSMUSP00000039737	intact:EBI-988425|uniprotkb:E9QJX3|uniprotkb:O89099|uniprotkb:P97695|uniprotkb:Q3UP39|ensembl:ENSMUSP00000051423	psi-mi:vpp2_mouse(display_long)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2(gene name synonym)|uniprotkb:"Lysosomal H(+)-transporting ATPase V0 subunit a2"(gene name synonym)|uniprotkb:Immune suppressor factor J6B7(gene name synonym)|uniprotkb:ShIF(gene name synonym)|uniprotkb:Atp6v0a2(gene name)|psi-mi:Atp6v0a2(display_short)|uniprotkb:Atp6n1b(gene name synonym)|uniprotkb:Tj6(gene name synonym)	psi-mi:cyh2_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:SEC7 homolog B(gene name synonym)|uniprotkb:Pscd2(gene name synonym)|uniprotkb:Cyth2(gene name)|psi-mi:Cyth2(display_short)|uniprotkb:Sec7b(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988454|imex:IM-14402-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038023(gene)|ensembl:ENSMUST00000037865(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043229"(intracellular organelle)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2LX4|reactome:R-MMU-1222556|reactome:R-MMU-917977|reactome:R-MMU-983712|reactome:R-MMU-77387|refseq:NP_035726.2	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030426"(growth cone)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1U27|rcsb pdb:1U29|reactome:R-MMU-6811438|ensembl:ENSMUSG00000003269(gene)|ensembl:ENSMUST00000056820(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|refseq:NP_001106171.1|refseq:NP_035311.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:3A, 3G, 4F|comment:Process is acidification dependent|antagonist:FCCP - an uncoupler of endosomal acidification|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-prox_tubule_cell)|taxid:10090(Mouse proximal tubule cells)	-	2006/08/15	2014/10/16	rogid:KGaTHpftl0KXCrQ2yCt5pvhoIkw10090	rogid:voVY4MdVAKJFC14a1Yn/9zYYPgQ10090	intact-crc:AA5017DA44DE7256|rigid:X9WcG0YjlVS6NRcuq319dQQjWAQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z1G3	uniprotkb:P62331	intact:EBI-772679|uniprotkb:Q91Z42|ensembl:ENSMUSP00000022904	intact:EBI-988682|uniprotkb:P26438|ensembl:ENSMUSP00000055862	psi-mi:vatc1_mouse(display_long)|uniprotkb:Vacuolar proton pump subunit C 1(gene name synonym)|uniprotkb:Atp6v1c1(gene name)|psi-mi:Atp6v1c1(display_short)|uniprotkb:Atp6c(gene name synonym)|uniprotkb:Vatc(gene name synonym)|uniprotkb:Atp6c1(gene name synonym)	psi-mi:arf6_mouse(display_long)|uniprotkb:Arf6(gene name)|psi-mi:Arf6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988710|imex:IM-14402-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079770.2|ensembl:ENSMUSG00000022295(gene)|ensembl:ENSMUST00000022904(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045177"(apical part of cell)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|reactome:R-MMU-1222556|reactome:R-MMU-77387|reactome:R-MMU-917977|reactome:R-MMU-9639288|reactome:R-MMU-983712	refseq:NP_031507.1|ensembl:ENSMUSG00000044147(gene)|ensembl:ENSMUST00000050063(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001889"(liver development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033028"(myeloid cell apoptotic process)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0043209"(myelin sheath)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0055037"(recycling endosome)|go:"GO:0006886"(intracellular protein transport)|reactome:R-MMU-8854214|reactome:R-MMU-8856828|reactome:R-MMU-8875656|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0090543"(Flemming body)|go:"GO:0097178"(ruffle assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR041838|mint:P62331|rcsb pdb:3VHX	psi-mi:"MI:0469"(intact)	-	-	figure legend:3I & 3J|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-prox_tubule_cell)|taxid:10090(Mouse proximal tubule cells)	-	2006/08/15	2014/10/16	rogid:aR9VQ/RGEGEDy6VkXw4nGQC6AFI10090	rogid:c+9TIZ6WGhwZzmFUnkW20tPjlC810090	intact-crc:71F52D65DDEB6152|rigid:yQTEytlmjDJhlNg8rmKYTuObkiU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15920	uniprotkb:P63034	intact:EBI-988456|uniprotkb:Q3U2X3|uniprotkb:Q9JHJ2|uniprotkb:A4FU82|uniprotkb:Q8VHU0|ensembl:ENSMUSP00000039737	intact:EBI-988425|uniprotkb:E9QJX3|uniprotkb:O89099|uniprotkb:P97695|uniprotkb:Q3UP39|ensembl:ENSMUSP00000051423	psi-mi:vpp2_mouse(display_long)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2(gene name synonym)|uniprotkb:"Lysosomal H(+)-transporting ATPase V0 subunit a2"(gene name synonym)|uniprotkb:Immune suppressor factor J6B7(gene name synonym)|uniprotkb:ShIF(gene name synonym)|uniprotkb:Atp6v0a2(gene name)|psi-mi:Atp6v0a2(display_short)|uniprotkb:Atp6n1b(gene name synonym)|uniprotkb:Tj6(gene name synonym)	psi-mi:cyh2_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:SEC7 homolog B(gene name synonym)|uniprotkb:Pscd2(gene name synonym)|uniprotkb:Cyth2(gene name)|psi-mi:Cyth2(display_short)|uniprotkb:Sec7b(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988490|imex:IM-14402-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038023(gene)|ensembl:ENSMUST00000037865(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043229"(intracellular organelle)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2LX4|reactome:R-MMU-1222556|reactome:R-MMU-917977|reactome:R-MMU-983712|reactome:R-MMU-77387|refseq:NP_035726.2	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030426"(growth cone)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1U27|rcsb pdb:1U29|reactome:R-MMU-6811438|ensembl:ENSMUSG00000003269(gene)|ensembl:ENSMUST00000056820(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|refseq:NP_001106171.1|refseq:NP_035311.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:3B|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/15	2014/10/16	rogid:KGaTHpftl0KXCrQ2yCt5pvhoIkw10090	rogid:voVY4MdVAKJFC14a1Yn/9zYYPgQ10090	intact-crc:A85D23CDBFD32138|rigid:X9WcG0YjlVS6NRcuq319dQQjWAQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63034	uniprotkb:P15920	intact:EBI-988425|uniprotkb:E9QJX3|uniprotkb:O89099|uniprotkb:P97695|uniprotkb:Q3UP39|ensembl:ENSMUSP00000051423	intact:EBI-988456|uniprotkb:Q3U2X3|uniprotkb:Q9JHJ2|uniprotkb:A4FU82|uniprotkb:Q8VHU0|ensembl:ENSMUSP00000039737	psi-mi:cyh2_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:SEC7 homolog B(gene name synonym)|uniprotkb:Pscd2(gene name synonym)|uniprotkb:Cyth2(gene name)|psi-mi:Cyth2(display_short)|uniprotkb:Sec7b(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener(gene name synonym)	psi-mi:vpp2_mouse(display_long)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2(gene name synonym)|uniprotkb:"Lysosomal H(+)-transporting ATPase V0 subunit a2"(gene name synonym)|uniprotkb:Immune suppressor factor J6B7(gene name synonym)|uniprotkb:ShIF(gene name synonym)|uniprotkb:Atp6v0a2(gene name)|psi-mi:Atp6v0a2(display_short)|uniprotkb:Atp6n1b(gene name synonym)|uniprotkb:Tj6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988518|imex:IM-14402-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030426"(growth cone)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1U27|rcsb pdb:1U29|reactome:R-MMU-6811438|ensembl:ENSMUSG00000003269(gene)|ensembl:ENSMUST00000056820(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|refseq:NP_001106171.1|refseq:NP_035311.1	ensembl:ENSMUSG00000038023(gene)|ensembl:ENSMUST00000037865(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043229"(intracellular organelle)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2LX4|reactome:R-MMU-1222556|reactome:R-MMU-917977|reactome:R-MMU-983712|reactome:R-MMU-77387|refseq:NP_035726.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:3C|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/15	2014/10/16	rogid:voVY4MdVAKJFC14a1Yn/9zYYPgQ10090	rogid:KGaTHpftl0KXCrQ2yCt5pvhoIkw10090	intact-crc:958AF30DA23A6D2D|rigid:X9WcG0YjlVS6NRcuq319dQQjWAQ	false	his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15920	uniprotkb:P63034	intact:EBI-988456|uniprotkb:Q3U2X3|uniprotkb:Q9JHJ2|uniprotkb:A4FU82|uniprotkb:Q8VHU0|ensembl:ENSMUSP00000039737	intact:EBI-988425|uniprotkb:E9QJX3|uniprotkb:O89099|uniprotkb:P97695|uniprotkb:Q3UP39|ensembl:ENSMUSP00000051423	psi-mi:vpp2_mouse(display_long)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2(gene name synonym)|uniprotkb:"Lysosomal H(+)-transporting ATPase V0 subunit a2"(gene name synonym)|uniprotkb:Immune suppressor factor J6B7(gene name synonym)|uniprotkb:ShIF(gene name synonym)|uniprotkb:Atp6v0a2(gene name)|psi-mi:Atp6v0a2(display_short)|uniprotkb:Atp6n1b(gene name synonym)|uniprotkb:Tj6(gene name synonym)	psi-mi:cyh2_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:SEC7 homolog B(gene name synonym)|uniprotkb:Pscd2(gene name synonym)|uniprotkb:Cyth2(gene name)|psi-mi:Cyth2(display_short)|uniprotkb:Sec7b(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988549|imex:IM-14402-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038023(gene)|ensembl:ENSMUST00000037865(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043229"(intracellular organelle)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2LX4|reactome:R-MMU-1222556|reactome:R-MMU-917977|reactome:R-MMU-983712|reactome:R-MMU-77387|refseq:NP_035726.2	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030426"(growth cone)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1U27|rcsb pdb:1U29|reactome:R-MMU-6811438|ensembl:ENSMUSG00000003269(gene)|ensembl:ENSMUST00000056820(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|refseq:NP_001106171.1|refseq:NP_035311.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:3D & 3E|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/15	2014/10/16	rogid:KGaTHpftl0KXCrQ2yCt5pvhoIkw10090	rogid:voVY4MdVAKJFC14a1Yn/9zYYPgQ10090	intact-crc:04549ACB36D2668A|rigid:X9WcG0YjlVS6NRcuq319dQQjWAQ	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:68..68-400	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63034	uniprotkb:P15920	intact:EBI-988425|uniprotkb:E9QJX3|uniprotkb:O89099|uniprotkb:P97695|uniprotkb:Q3UP39|ensembl:ENSMUSP00000051423	intact:EBI-988456|uniprotkb:Q3U2X3|uniprotkb:Q9JHJ2|uniprotkb:A4FU82|uniprotkb:Q8VHU0|ensembl:ENSMUSP00000039737	psi-mi:cyh2_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:SEC7 homolog B(gene name synonym)|uniprotkb:Pscd2(gene name synonym)|uniprotkb:Cyth2(gene name)|psi-mi:Cyth2(display_short)|uniprotkb:Sec7b(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener(gene name synonym)	psi-mi:vpp2_mouse(display_long)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2(gene name synonym)|uniprotkb:"Lysosomal H(+)-transporting ATPase V0 subunit a2"(gene name synonym)|uniprotkb:Immune suppressor factor J6B7(gene name synonym)|uniprotkb:ShIF(gene name synonym)|uniprotkb:Atp6v0a2(gene name)|psi-mi:Atp6v0a2(display_short)|uniprotkb:Atp6n1b(gene name synonym)|uniprotkb:Tj6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988577|imex:IM-14402-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030426"(growth cone)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|rcsb pdb:1U27|rcsb pdb:1U29|reactome:R-MMU-6811438|ensembl:ENSMUSG00000003269(gene)|ensembl:ENSMUST00000056820(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|refseq:NP_001106171.1|refseq:NP_035311.1	ensembl:ENSMUSG00000038023(gene)|ensembl:ENSMUST00000037865(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043229"(intracellular organelle)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2LX4|reactome:R-MMU-1222556|reactome:R-MMU-917977|reactome:R-MMU-983712|reactome:R-MMU-77387|refseq:NP_035726.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:3F|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/08/15	2014/10/16	rogid:voVY4MdVAKJFC14a1Yn/9zYYPgQ10090	rogid:KGaTHpftl0KXCrQ2yCt5pvhoIkw10090	intact-crc:A58EDD53641A4B2A|rigid:X9WcG0YjlVS6NRcuq319dQQjWAQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y487	uniprotkb:Q99418	intact:EBI-988630|ensembl:ENSP00000332247|uniprotkb:Q6NUM0|uniprotkb:A8K026	intact:EBI-448974|intact:EBI-1760516|uniprotkb:Q8IXY9|uniprotkb:Q92958|intact:EBI-1965579|uniprotkb:A8K8P0|ensembl:ENSP00000493357	psi-mi:vpp2_human(display_long)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2(gene name synonym)|uniprotkb:"Lysosomal H(+)-transporting ATPase V0 subunit a2"(gene name synonym)|uniprotkb:TJ6(gene name synonym)|uniprotkb:ATP6V0A2(gene name)|psi-mi:ATP6V0A2(display_short)	psi-mi:cyh2_human(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener(gene name synonym)|uniprotkb:ARF exchange factor(gene name synonym)|uniprotkb:CYTH2(gene name)|psi-mi:CYTH2(display_short)|uniprotkb:ARNO(gene name synonym)|uniprotkb:PSCD2L(gene name synonym)|uniprotkb:PSCD2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988639|imex:IM-14402-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185344(gene)|ensembl:ENST00000330342(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006955"(immune response)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|mint:Q9Y487|refseq:NP_036595.2|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-983712	refseq:NP_004219.3|refseq:NP_059431.1|dip:DIP-31598N|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|mint:Q99418|rcsb pdb:1PBV|rcsb pdb:1R8M|rcsb pdb:1R8Q|rcsb pdb:1R8S|rcsb pdb:1S9D|rcsb pdb:4JMI|rcsb pdb:4JMO|rcsb pdb:4JWL|rcsb pdb:4JXH|rcsb pdb:4L5M|rcsb pdb:4Z21|reactome:R-HSA-6811438|ensembl:ENSG00000105443(gene)|ensembl:ENST00000641098(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3G|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/08/15	2014/10/16	rogid:I4UxvwiAe4ObvfgL15K2lzNKuOA9606	rogid:wGF6f2/B1HkGHOB/juI9LS1N/ww9606	intact-crc:6B2261B4A10340A7|rigid:iWUJcO6wBgEZw9phhuQ7a0qL5uc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P21283	uniprotkb:P62330	intact:EBI-988663|ensembl:ENSP00000379203|ensembl:ENSP00000430282	intact:EBI-638181|uniprotkb:P26438|ensembl:ENSP00000298316|intact:EBI-2802827|uniprotkb:Q6FGZ2	psi-mi:vatc1_human(display_long)|uniprotkb:Vacuolar proton pump subunit C 1(gene name synonym)|uniprotkb:ATP6V1C1(gene name)|psi-mi:ATP6V1C1(display_short)|uniprotkb:ATP6C(gene name synonym)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VATC(gene name synonym)	psi-mi:arf6_human(display_long)|uniprotkb:ARF6(gene name)|psi-mi:ARF6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988700|imex:IM-14402-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001686.1|go:"GO:0005886"(plasma membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045177"(apical part of cell)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|ensembl:ENSG00000155097(gene)|ensembl:ENST00000395862(transcript)|ensembl:ENST00000518738(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005215"(transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)	refseq:NP_001654.1|ensembl:ENSG00000165527(gene)|ensembl:ENST00000298316(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001889"(liver development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033028"(myeloid cell apoptotic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0090543"(Flemming body)|go:"GO:0097178"(ruffle assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR041838|rcsb pdb:1E0S|rcsb pdb:2A5D|rcsb pdb:2A5F|rcsb pdb:2A5G|rcsb pdb:2BAO|rcsb pdb:2BAU|rcsb pdb:2J5X|rcsb pdb:2W83|rcsb pdb:3LVQ|rcsb pdb:3LVR|rcsb pdb:3N5C|rcsb pdb:3PCR|rcsb pdb:4FME|rcsb pdb:4KAX|rcsb pdb:6BBP|rcsb pdb:6BBQ|rcsb pdb:6PAU|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8875656|dip:DIP-33352N	psi-mi:"MI:0469"(intact)	-	-	figure legend:3I & 3J|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/08/15	2014/10/16	rogid:8Bvb2tq4GavkgDWnRGz7fb/eQh49606	rogid:c+9TIZ6WGhwZzmFUnkW20tPjlC89606	intact-crc:4AAEF58B74A646B9|rigid:jXAiyFLQHsPScMPKYexYmjLcrvA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y487	uniprotkb:Q99418	intact:EBI-988630|ensembl:ENSP00000332247|uniprotkb:Q6NUM0|uniprotkb:A8K026	intact:EBI-448974|intact:EBI-1760516|uniprotkb:Q8IXY9|uniprotkb:Q92958|intact:EBI-1965579|uniprotkb:A8K8P0|ensembl:ENSP00000493357	psi-mi:vpp2_human(display_long)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2(gene name synonym)|uniprotkb:"Lysosomal H(+)-transporting ATPase V0 subunit a2"(gene name synonym)|uniprotkb:TJ6(gene name synonym)|uniprotkb:ATP6V0A2(gene name)|psi-mi:ATP6V0A2(display_short)	psi-mi:cyh2_human(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 2(gene name synonym)|uniprotkb:ARF nucleotide-binding site opener(gene name synonym)|uniprotkb:ARF exchange factor(gene name synonym)|uniprotkb:CYTH2(gene name)|psi-mi:CYTH2(display_short)|uniprotkb:ARNO(gene name synonym)|uniprotkb:PSCD2L(gene name synonym)|uniprotkb:PSCD2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988653|imex:IM-14402-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185344(gene)|ensembl:ENST00000330342(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006955"(immune response)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|mint:Q9Y487|refseq:NP_036595.2|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-983712	refseq:NP_004219.3|refseq:NP_059431.1|dip:DIP-31598N|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|mint:Q99418|rcsb pdb:1PBV|rcsb pdb:1R8M|rcsb pdb:1R8Q|rcsb pdb:1R8S|rcsb pdb:1S9D|rcsb pdb:4JMI|rcsb pdb:4JMO|rcsb pdb:4JWL|rcsb pdb:4JXH|rcsb pdb:4L5M|rcsb pdb:4Z21|reactome:R-HSA-6811438|ensembl:ENSG00000105443(gene)|ensembl:ENST00000641098(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3G|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/08/15	2014/10/16	rogid:I4UxvwiAe4ObvfgL15K2lzNKuOA9606	rogid:wGF6f2/B1HkGHOB/juI9LS1N/ww9606	intact-crc:6278BAC5417D04FB|rigid:iWUJcO6wBgEZw9phhuQ7a0qL5uc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62330	uniprotkb:P21283	intact:EBI-638181|uniprotkb:P26438|ensembl:ENSP00000298316|intact:EBI-2802827|uniprotkb:Q6FGZ2	intact:EBI-988663|ensembl:ENSP00000379203|ensembl:ENSP00000430282	psi-mi:arf6_human(display_long)|uniprotkb:ARF6(gene name)|psi-mi:ARF6(display_short)	psi-mi:vatc1_human(display_long)|uniprotkb:Vacuolar proton pump subunit C 1(gene name synonym)|uniprotkb:ATP6V1C1(gene name)|psi-mi:ATP6V1C1(display_short)|uniprotkb:ATP6C(gene name synonym)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VATC(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988729|imex:IM-14402-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001654.1|ensembl:ENSG00000165527(gene)|ensembl:ENST00000298316(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001889"(liver development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033028"(myeloid cell apoptotic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0090543"(Flemming body)|go:"GO:0097178"(ruffle assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR041838|rcsb pdb:1E0S|rcsb pdb:2A5D|rcsb pdb:2A5F|rcsb pdb:2A5G|rcsb pdb:2BAO|rcsb pdb:2BAU|rcsb pdb:2J5X|rcsb pdb:2W83|rcsb pdb:3LVQ|rcsb pdb:3LVR|rcsb pdb:3N5C|rcsb pdb:3PCR|rcsb pdb:4FME|rcsb pdb:4KAX|rcsb pdb:6BBP|rcsb pdb:6BBQ|rcsb pdb:6PAU|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8875656|dip:DIP-33352N	refseq:NP_001686.1|go:"GO:0005886"(plasma membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045177"(apical part of cell)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|ensembl:ENSG00000155097(gene)|ensembl:ENST00000395862(transcript)|ensembl:ENST00000518738(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005215"(transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3I & 3J|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/08/15	2014/10/16	rogid:c+9TIZ6WGhwZzmFUnkW20tPjlC89606	rogid:8Bvb2tq4GavkgDWnRGz7fb/eQh49606	intact-crc:60CDE784569B46E0|rigid:jXAiyFLQHsPScMPKYexYmjLcrvA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62331	uniprotkb:P21283	intact:EBI-988682|uniprotkb:P26438|ensembl:ENSMUSP00000055862	intact:EBI-988663|ensembl:ENSP00000379203|ensembl:ENSP00000430282	psi-mi:arf6_mouse(display_long)|uniprotkb:Arf6(gene name)|psi-mi:Arf6(display_short)	psi-mi:vatc1_human(display_long)|uniprotkb:Vacuolar proton pump subunit C 1(gene name synonym)|uniprotkb:ATP6V1C1(gene name)|psi-mi:ATP6V1C1(display_short)|uniprotkb:ATP6C(gene name synonym)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VATC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-988676|imex:IM-14402-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031507.1|ensembl:ENSMUSG00000044147(gene)|ensembl:ENSMUST00000050063(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001889"(liver development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033028"(myeloid cell apoptotic process)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0043209"(myelin sheath)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0055037"(recycling endosome)|go:"GO:0006886"(intracellular protein transport)|reactome:R-MMU-8854214|reactome:R-MMU-8856828|reactome:R-MMU-8875656|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0090543"(Flemming body)|go:"GO:0097178"(ruffle assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR041838|mint:P62331|rcsb pdb:3VHX	refseq:NP_001686.1|go:"GO:0005886"(plasma membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045177"(apical part of cell)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|ensembl:ENSG00000155097(gene)|ensembl:ENST00000395862(transcript)|ensembl:ENST00000518738(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005215"(transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3H|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/08/15	2014/10/16	rogid:c+9TIZ6WGhwZzmFUnkW20tPjlC810090	rogid:8Bvb2tq4GavkgDWnRGz7fb/eQh49606	intact-crc:49B9BDE99EA1ED34|rigid:komzIKAjgUIDQD45YmRzh34V2xQ	false	ha tag:?-?	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62330	uniprotkb:P21283	intact:EBI-638181|uniprotkb:P26438|ensembl:ENSP00000298316|intact:EBI-2802827|uniprotkb:Q6FGZ2	intact:EBI-988663|ensembl:ENSP00000379203|ensembl:ENSP00000430282	psi-mi:arf6_human(display_long)|uniprotkb:ARF6(gene name)|psi-mi:ARF6(display_short)	psi-mi:vatc1_human(display_long)|uniprotkb:Vacuolar proton pump subunit C 1(gene name synonym)|uniprotkb:ATP6V1C1(gene name)|psi-mi:ATP6V1C1(display_short)|uniprotkb:ATP6C(gene name synonym)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VATC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1003831|imex:IM-14402-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001654.1|ensembl:ENSG00000165527(gene)|ensembl:ENST00000298316(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001889"(liver development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033028"(myeloid cell apoptotic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0090543"(Flemming body)|go:"GO:0097178"(ruffle assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR041838|rcsb pdb:1E0S|rcsb pdb:2A5D|rcsb pdb:2A5F|rcsb pdb:2A5G|rcsb pdb:2BAO|rcsb pdb:2BAU|rcsb pdb:2J5X|rcsb pdb:2W83|rcsb pdb:3LVQ|rcsb pdb:3LVR|rcsb pdb:3N5C|rcsb pdb:3PCR|rcsb pdb:4FME|rcsb pdb:4KAX|rcsb pdb:6BBP|rcsb pdb:6BBQ|rcsb pdb:6PAU|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8875656|dip:DIP-33352N	refseq:NP_001686.1|go:"GO:0005886"(plasma membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045177"(apical part of cell)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|ensembl:ENSG00000155097(gene)|ensembl:ENST00000395862(transcript)|ensembl:ENST00000518738(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005215"(transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3I, 3J|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mtc)|taxid:9606(Human  medullary thyroid carcinoma)	-	2006/08/15	2014/10/16	rogid:c+9TIZ6WGhwZzmFUnkW20tPjlC89606	rogid:8Bvb2tq4GavkgDWnRGz7fb/eQh49606	intact-crc:FCE5F9DE6487399E|rigid:jXAiyFLQHsPScMPKYexYmjLcrvA	false	-	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62330	uniprotkb:P21283	intact:EBI-638181|uniprotkb:P26438|ensembl:ENSP00000298316|intact:EBI-2802827|uniprotkb:Q6FGZ2	intact:EBI-988663|ensembl:ENSP00000379203|ensembl:ENSP00000430282	psi-mi:arf6_human(display_long)|uniprotkb:ARF6(gene name)|psi-mi:ARF6(display_short)	psi-mi:vatc1_human(display_long)|uniprotkb:Vacuolar proton pump subunit C 1(gene name synonym)|uniprotkb:ATP6V1C1(gene name)|psi-mi:ATP6V1C1(display_short)|uniprotkb:ATP6C(gene name synonym)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VATC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hurtado-Lorenzo et al. (2006)	imex:IM-14402|pubmed:16415858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1003847|imex:IM-14402-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001654.1|ensembl:ENSG00000165527(gene)|ensembl:ENST00000298316(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001889"(liver development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033028"(myeloid cell apoptotic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0090543"(Flemming body)|go:"GO:0097178"(ruffle assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR041838|rcsb pdb:1E0S|rcsb pdb:2A5D|rcsb pdb:2A5F|rcsb pdb:2A5G|rcsb pdb:2BAO|rcsb pdb:2BAU|rcsb pdb:2J5X|rcsb pdb:2W83|rcsb pdb:3LVQ|rcsb pdb:3LVR|rcsb pdb:3N5C|rcsb pdb:3PCR|rcsb pdb:4FME|rcsb pdb:4KAX|rcsb pdb:6BBP|rcsb pdb:6BBQ|rcsb pdb:6PAU|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8875656|dip:DIP-33352N	refseq:NP_001686.1|go:"GO:0005886"(plasma membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045177"(apical part of cell)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|ensembl:ENSG00000155097(gene)|ensembl:ENST00000395862(transcript)|ensembl:ENST00000518738(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005215"(transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3I, 3J|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/08/15	2014/10/16	rogid:c+9TIZ6WGhwZzmFUnkW20tPjlC89606	rogid:8Bvb2tq4GavkgDWnRGz7fb/eQh49606	intact-crc:6E303FCE6C4646AC|rigid:jXAiyFLQHsPScMPKYexYmjLcrvA	false	-	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)