#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P22091 uniprotkb:P15806 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-81370|uniprotkb:Q3U153|uniprotkb:Q8CAH9|uniprotkb:Q8VCY4|uniprotkb:Q922S2|uniprotkb:Q99MB8|uniprotkb:Q9CYJ4|ensembl:ENSMUSP00000100983 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:tfe2_mouse(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006429|mint:MINT-2567725|imex:IM-10947-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2567726(identity) rcsb pdb:2QL2|reactome:R-MMU-525793|reactome:R-MMU-8939236|refseq:NP_001157620.1|refseq:NP_001157621.1|refseq:NP_001157623.1|refseq:NP_035678.3|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048468"(cell development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15806|ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105346(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|dip:DIP-30940N|mint:MINT-2567727(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:aMvLmcfudacIqIAxOSmbNPNjsc810090 intact-crc:51F69274D7082090|rigid:Dsr+1yEQaVf8snTGpNlVT0BJhtA false biotin tag:?-?(MINT-2567758) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:P25801 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-3903256|ensembl:ENSMUSP00000117703|ensembl:ENSMUSP00000128317 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:rbtn2_mouse(display_long)|uniprotkb:Lmo2(gene name)|psi-mi:Lmo2(display_short)|uniprotkb:Rbtn-2(gene name synonym)|uniprotkb:Rbtn2(gene name synonym)|uniprotkb:Rhom-2(gene name synonym)|uniprotkb:Cysteine-rich protein TTG-2(gene name synonym)|uniprotkb:LIM domain only protein 2(gene name synonym)|uniprotkb:T-cell translocation protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006569|mint:MINT-2567932|imex:IM-10947-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2567939(identity) refseq:NP_001135808.1|refseq:NP_001135809.1|dip:DIP-24247N|refseq:XP_006498883.1|ensembl:ENSMUSG00000032698(gene)|ensembl:ENSMUST00000123437(transcript)|ensembl:ENSMUST00000170926(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|interpro:IPR001781(Zinc finger, LIM-type)|mint:P25801|rcsb pdb:1J2O|rcsb pdb:2L6Y|rcsb pdb:2L6Z|go:"GO:0003682"(chromatin binding)|reactome:R-MMU-8939236|rcsb pdb:2LXD|mint:MINT-2567933(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:kIZ60YCK4hzGaxmi6+zOSaMDlNY10090 intact-crc:CE52179486A4A508|rigid:ntYgMRZGE9Wg247aORrPVBS0ym4 false biotin tag:?-?(MINT-2567945) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:Q60722 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-310070|uniprotkb:Q60721|uniprotkb:Q62211|uniprotkb:Q64072|uniprotkb:Q80UE8|ensembl:ENSMUSP00000077577|ensembl:ENSMUSP00000110631|ensembl:ENSMUSP00000110636 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:itf2_mouse(display_long)|uniprotkb:Tcf4(gene name)|psi-mi:Tcf4(display_short)|uniprotkb:Itf2(gene name synonym)|uniprotkb:Sef2(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:Class A helix-loop-helix transcription factor ME2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006552|mint:MINT-2567877|imex:IM-10947-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2567884(identity) refseq:NP_001077436.1|refseq:NP_038713.1|refseq:XP_006525809.1|refseq:XP_006525810.1|refseq:XP_006525813.1|refseq:XP_006525825.1|ensembl:ENSMUSG00000053477(gene)|ensembl:ENSMUST00000078486(transcript)|ensembl:ENSMUST00000114980(transcript)|ensembl:ENSMUST00000114985(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q60722|reactome:R-MMU-525793|go:"GO:0016525"(negative regulation of angiogenesis)|refseq:XP_017173346.1|dip:DIP-42841N|mint:MINT-2567878(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:o8X4UFFW9S6TNL/Ur0E/WC+b/8010090 intact-crc:5E9B065EB727AD00|rigid:YjvyHBE5AYKpendqYzDa9YKuLjc false biotin tag:?-?(MINT-2567885) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:Q61286 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006499|intact:MINT-2567849|uniprotkb:E9QPN4|ensembl:ENSMUSP00000139364|ensembl:ENSMUSP00000139365 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:htf4_mouse(display_long)|uniprotkb:Tcf12(gene name)|psi-mi:Tcf12(display_short)|uniprotkb:Alf1(gene name synonym)|uniprotkb:Meb(gene name synonym)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:Class A helix-loop-helix transcription factor ME1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006491|mint:MINT-2567833|imex:IM-10947-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2567840(identity) refseq:NP_035674.2|refseq:NP_001240794.1|refseq:XP_006511057.1|refseq:XP_006511060.1|dip:DIP-42840N|ensembl:ENSMUSG00000032228(gene)|ensembl:ENSMUST00000183404(transcript)|ensembl:ENSMUST00000184783(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q61286|reactome:R-MMU-525793|reactome:R-MMU-8939236|mint:MINT-2567834(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:mint|function:Binds specifically to oligomers of E-box motifs. May play important roles during development of the nervous system as well as in other organ systems|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:RaQpcfOvnDIORBP08og33dK901w10090 intact-crc:5E99E8FC878B3361|rigid:LTnZ2RORqozBZCU/4AIOZwoepVg false biotin tag:?-?(MINT-2567846) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:Q9CYZ8 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-309962|uniprotkb:Q99LX9|uniprotkb:B1B188|ensembl:ENSMUSP00000004094 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:ssbp2_mouse(display_long)|uniprotkb:Ssbp2(gene name)|psi-mi:Ssbp2(display_short)|uniprotkb:Ssdp2(gene name synonym)|uniprotkb:Sequence-specific single-stranded-DNA-binding protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006686|mint:MINT-2568084|imex:IM-10947-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568091(identity) refseq:NP_077148.1|refseq:NP_077234.2|ensembl:ENSMUSG00000003992(gene)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSMUST00000004094(transcript)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR008116(Sequence-specific single-strand DNA-binding protein)|mint:Q9CYZ8|mint:MINT-2568085(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:YUUExLJthieChUovaHvCaOJJZac10090 intact-crc:A6A2DD8D994C6820|rigid:BeURMDtEjDEwEwz/CemFONr4oCE false biotin tag:?-?(MINT-2568097) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:P17679 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-3903251|uniprotkb:Q3UIH9|uniprotkb:Q7TMX8|ensembl:ENSMUSP00000033502 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:gata1_mouse(display_long)|uniprotkb:Gata1(gene name)|psi-mi:Gata1(display_short)|uniprotkb:Gf-1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006602|mint:MINT-2567990|imex:IM-10947-32 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2567997(identity) refseq:XP_011245750.1|refseq:NP_032115.1|dip:DIP-40883N|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P17679|rcsb pdb:1GNF|rcsb pdb:1Y0J|rcsb pdb:2L5E|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:3VD6|rcsb pdb:3VEK|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-983231|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|ensembl:ENSMUSG00000031162(gene)|ensembl:ENSMUST00000033502(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|mint:MINT-2567991(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:zv2cIXaxDsuFj//cWvnvvL8jgiA10090 intact-crc:B3417180B79F0C3C|rigid:UEZUSew1EehVsPGFcA8XvCkMv8Q false biotin tag:?-?(MINT-2568003) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:P70662 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006586|mint:MINT-2567962|imex:IM-10947-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2567969(identity) ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-2567963(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090 intact-crc:BD9A81A279E0BD0A|rigid:YawXIQlQZpLZtnCbWn6qKEtriPM false biotin tag:?-?(MINT-2567970) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:Q9D032 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006619|intact:MINT-2568056|uniprotkb:Q9EQP3|uniprotkb:Q99LC6|ensembl:ENSMUSP00000030367 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:ssbp3_mouse(display_long)|uniprotkb:Ssbp3(gene name)|psi-mi:Ssbp3(display_short)|uniprotkb:Last(gene name synonym)|uniprotkb:Ssdp1(gene name synonym)|uniprotkb:Sequence-specific single-stranded-DNA-binding protein(gene name synonym)|uniprotkb:Lck-associated signal transducer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006652|mint:MINT-2568034|imex:IM-10947-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568041(identity) refseq:NP_940840.1|refseq:NP_076161.2|dip:DIP-42843N|ensembl:ENSMUSG00000061887(gene)|ensembl:ENSMUST00000030367(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0021501"(prechordal plate formation)|go:"GO:0021547"(midbrain-hindbrain boundary initiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048382"(mesendoderm development)|go:"GO:0060322"(head development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000744"(positive regulation of anterior head development)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR008116(Sequence-specific single-strand DNA-binding protein)|mint:Q9D032|mint:MINT-2568035(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:mint|function:"May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region"|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:GD7FO6kR/5WawTNP0MaDcmIf7f410090 intact-crc:A76A02B24CCF1B5B|rigid:30qSPO8aNA8Fxyuamgo8ll/+Z9w false biotin tag:?-?(MINT-2568042) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:O70374 uniprotkb:P22091 intact:EBI-8006755|intact:MINT-2568187|uniprotkb:Q6P288|uniprotkb:Q30BK8|uniprotkb:B2RRH8|ensembl:ENSMUSP00000043087 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 psi-mi:mtg8r_mouse(display_long)|uniprotkb:Cbfa2t2(gene name)|psi-mi:Cbfa2t2(display_short)|uniprotkb:Cbfa2t2h(gene name synonym)|uniprotkb:MTG8-like protein(gene name synonym)|uniprotkb:MTG8-related protein 1(gene name synonym)|uniprotkb:Mtgr1(gene name synonym) psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006787|mint:MINT-2568171|imex:IM-10947-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766448.1|refseq:NP_033953.1|refseq:XP_006498703.1|dip:DIP-62032N|ensembl:ENSMUSG00000038533(gene)|ensembl:ENSMUST00000045270(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013291("Myeloid transforming gene related protein-1 (MTGR1)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:O70374|rcsb pdb:5ECJ|mint:MINT-2568172(identity) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568178(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:CA4xMx/HKHH6tJ0ktwQaJfzaBUU10090 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 intact-crc:4869925803C41BF0|rigid:E5vqL3e4kYDeBRS39zVbAcjss1g false - biotin tag:?-?(MINT-2568184) 1 1 psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P22091 uniprotkb:O09106 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-301912|uniprotkb:P97476|ensembl:ENSMUSP00000099657 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:hdac1_mouse(display_long)|uniprotkb:Hdac1(gene name)|psi-mi:Hdac1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006804|mint:MINT-2568200|imex:IM-10947-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568207(identity) dip:DIP-31499N|ensembl:ENSMUSG00000028800(gene)|ensembl:ENSMUST00000102597(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|refseq:NP_032254.1|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O09106|reactome:R-MMU-1538133|reactome:R-MMU-201722|reactome:R-MMU-2173795|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-3769402|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8936459|reactome:R-MMU-8943724|reactome:R-MMU-9018519|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031000"(response to caffeine)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007492"(endoderm development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|mint:MINT-2568201(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:P7QV++FiMiNcabUkswbnNhGVU3410090 intact-crc:C468CE76FFBC823C|rigid:oh+LnjKScI3n8FpL7M7s28+zJfk false biotin tag:?-?(MINT-2568208) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:P70288 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-302251|uniprotkb:B2RRP3 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:hdac2_mouse(display_long)|uniprotkb:Hdac2(gene name)|psi-mi:Hdac2(display_short)|uniprotkb:Yy1bp(gene name synonym)|uniprotkb:YY1 transcription factor-binding protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006838|mint:MINT-2568242|imex:IM-10947-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568249(identity) go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|refseq:NP_032255.2|dip:DIP-32854N|mint:P70288|mint:MINT-2568243(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:bGLIDKTlyhBz40NViC8calRacZ010090 intact-crc:61FB964692E905DD|rigid:0CThnNIAzj7/pzDHvlX6vmJoHfk false biotin tag:?-?(MINT-2568255) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:O54972 uniprotkb:P22091 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006738|mint:MINT-2568125|imex:IM-10947-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)")|mint:MINT-2568126(identity) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568132(identity) - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein|comment:"Stoichiometry: 1.0" comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 intact-crc:DC8305AFDCBACB9D|rigid:SmzE2RmN7vKIa/9NFmTN4WdF300 false - biotin tag:?-?(MINT-2568133) 1 1 psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P22091 uniprotkb:P23475 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-822760|uniprotkb:Q3UJL8|uniprotkb:Q6GTV8|uniprotkb:Q8QZX7|uniprotkb:O88212|uniprotkb:Q62027|uniprotkb:Q62382|uniprotkb:Q62453 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:xrcc6_mouse(display_long)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Ku autoantigen protein p70 homolog(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:Xrcc6(gene name)|psi-mi:Xrcc6(display_short)|uniprotkb:G22p1(gene name synonym)|uniprotkb:Ku70(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006961|mint:MINT-2568431|imex:IM-10947-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568438(identity) mint:P23475|refseq:NP_034377.2|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|refseq:XP_006520505.1|refseq:XP_006520506.1|refseq:XP_011243758.1|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|go:"GO:0000723"(telomere maintenance)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|reactome:R-MMU-5693571|reactome:R-MMU-6798695|mint:MINT-2568432(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:/A6ygYkLE2FpziX/3fMu5IvG0iI10090 intact-crc:AEA7FCF1345F0107|rigid:h+E4qMerJxBIcwwpu+ZZIunjEyU false biotin tag:?-?(MINT-2568444) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:Q80YV3 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-2942477|uniprotkb:Q8C0Z5|uniprotkb:Q8K104 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:trrap_mouse(display_long)|uniprotkb:Trrap(gene name)|psi-mi:Trrap(display_short)|uniprotkb:Tra1 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006855|mint:MINT-2568279|imex:IM-10947-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568286(identity) go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000124"(SAGA complex)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|dip:DIP-29177N|mint:Q80YV3|mint:MINT-2568280(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:Interaction occurs only in induced cells|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:gB6vJ5mDsz4UFIbdOcUgzOlsqV810090 intact-crc:0B9F52A288BB8298|rigid:p5iNcNpiBvJSmf9CVsA0A/fUbC8 false biotin tag:?-?(MINT-2568287) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:Q3UE68 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006871|intact:MINT-2568379 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:q3ue68_mouse(display_long)|uniprotkb:Brd1(gene name)|psi-mi:Brd1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006888|mint:MINT-2568362|imex:IM-10947-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568369(identity) interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR019787|refseq:NP_001028446.2|interpro:IPR018359|interpro:IPR019542|interpro:IPR019786|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|mint:Q3UE68|interpro:IPR036427|go:"GO:0005634"(nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR042004|interpro:IPR042009|mint:MINT-2568363(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:mint|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:Interaction occurs only in induced cells|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:2P6tvdtKgbRQpPUt+uOejVzgY5o10090 intact-crc:C1D28A1C96AC573D|rigid:1QAa1GBJjb5BAuNJThGLrqIf+Xo false biotin tag:?-?(MINT-2568375) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:Q8VE37 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006911|intact:MINT-2568412|uniprotkb:Q3UDB6|ensembl:ENSMUSP00000081271|ensembl:ENSMUSP00000101571 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:rcc1_mouse(display_long)|uniprotkb:Rcc1(gene name)|psi-mi:Rcc1(display_short)|uniprotkb:Chc1(gene name synonym)|uniprotkb:Chromosome condensation protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006904|mint:MINT-2568392|imex:IM-10947-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568399(identity) refseq:NP_598639.1|ensembl:ENSMUSG00000028896(gene)|ensembl:ENSMUST00000084250(transcript)|ensembl:ENSMUST00000105951(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003682"(chromatin binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:Q8VE37|reactome:R-MMU-9615933|mint:MINT-2568393(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:mint|function:"Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA"|comment:"Stoichiometry: 1.0" figure legend:F1A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:6XZrAsHFmgggwcraXhckRs0N1xY10090 intact-crc:2D28D6FF83B01DE0|rigid:MOLq/FFJOy3Oxu5hGvuqt01+9kY false biotin tag:?-?(MINT-2568400) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:P11103 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-642213|uniprotkb:Q9JLX4|uniprotkb:Q9QVQ3 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:parp1_mouse(display_long)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Parp1(gene name)|psi-mi:Parp1(display_short)|uniprotkb:Adprp(gene name synonym)|uniprotkb:Adprt(gene name synonym)|uniprotkb:Adprt1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006977|mint:MINT-2568513|imex:IM-10947-34 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568520(identity) go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|reactome:R-MMU-110362|reactome:R-MMU-2173795|reactome:R-MMU-3108214|reactome:R-MMU-5685939|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0034644"(cellular response to UV)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071451"(cellular response to superoxide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903516"(regulation of single strand break repair)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1903827"|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:0070212"(protein poly-ADP-ribosylation)|mint:P11103|dip:DIP-39371N|mint:MINT-2568514(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:ZJY1aTtD8Cz198SVs9FDdUSli7s10090 intact-crc:EFF56510FB637E9A|rigid:piS/6OiktdgMe5HwMHJ5hAKcSuk false biotin tag:?-?(MINT-2568521) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:Q04750 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-6666222|ensembl:ENSMUSP00000105094|uniprotkb:A2A4B7 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:top1_mouse(display_long)|uniprotkb:Top1(gene name)|psi-mi:Top1(display_short)|uniprotkb:Top-1(gene name synonym)|uniprotkb:DNA topoisomerase I(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8006994|mint:MINT-2568559|imex:IM-10947-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568566(identity) ensembl:ENSMUSG00000070544(gene)|ensembl:ENSMUST00000109468(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000932"(P-body)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0003682"(chromatin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042493"|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097100"(supercoiled DNA binding)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR018521|interpro:IPR025834|interpro:IPR036202|reactome:R-MMU-4615885|mint:Q04750|refseq:NP_033434.2|mint:MINT-2568560(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:nY84yAtfGCI/k+B2u3mM151r+zU10090 intact-crc:1212DEF64F798F47|rigid:uVbRjblnHmrw64IRIvezD+V/3Lg false biotin tag:?-?(MINT-2568572) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P22091 uniprotkb:P15806 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-81370|uniprotkb:Q3U153|uniprotkb:Q8CAH9|uniprotkb:Q8VCY4|uniprotkb:Q922S2|uniprotkb:Q99MB8|uniprotkb:Q9CYJ4|ensembl:ENSMUSP00000100983 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:tfe2_mouse(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007042|mint:MINT-2568609|imex:IM-10947-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568616(identity) rcsb pdb:2QL2|reactome:R-MMU-525793|reactome:R-MMU-8939236|refseq:NP_001157620.1|refseq:NP_001157621.1|refseq:NP_001157623.1|refseq:NP_035678.3|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048468"(cell development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15806|ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105346(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|dip:DIP-30940N|mint:MINT-2568610(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:aMvLmcfudacIqIAxOSmbNPNjsc810090 intact-crc:36B8FDCA31FB1AA4|rigid:Dsr+1yEQaVf8snTGpNlVT0BJhtA false - - 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:P15806 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-81370|uniprotkb:Q3U153|uniprotkb:Q8CAH9|uniprotkb:Q8VCY4|uniprotkb:Q922S2|uniprotkb:Q99MB8|uniprotkb:Q9CYJ4|ensembl:ENSMUSP00000100983 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:tfe2_mouse(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007011|mint:MINT-2568577|imex:IM-10947-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568584(identity) rcsb pdb:2QL2|reactome:R-MMU-525793|reactome:R-MMU-8939236|refseq:NP_001157620.1|refseq:NP_001157621.1|refseq:NP_001157623.1|refseq:NP_035678.3|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048468"(cell development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15806|ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105346(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|dip:DIP-30940N|mint:MINT-2568578(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:aMvLmcfudacIqIAxOSmbNPNjsc810090 intact-crc:F74BCBB4CA4DC1C9|rigid:Dsr+1yEQaVf8snTGpNlVT0BJhtA false - - 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O54972 uniprotkb:Q60722 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-310070|uniprotkb:Q60721|uniprotkb:Q62211|uniprotkb:Q64072|uniprotkb:Q80UE8|ensembl:ENSMUSP00000077577|ensembl:ENSMUSP00000110631|ensembl:ENSMUSP00000110636 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:itf2_mouse(display_long)|uniprotkb:Tcf4(gene name)|psi-mi:Tcf4(display_short)|uniprotkb:Itf2(gene name synonym)|uniprotkb:Sef2(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:Class A helix-loop-helix transcription factor ME2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007127|mint:MINT-2570581|imex:IM-10947-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)")|mint:MINT-2570588(identity) refseq:NP_001077436.1|refseq:NP_038713.1|refseq:XP_006525809.1|refseq:XP_006525810.1|refseq:XP_006525813.1|refseq:XP_006525825.1|ensembl:ENSMUSG00000053477(gene)|ensembl:ENSMUST00000078486(transcript)|ensembl:ENSMUST00000114980(transcript)|ensembl:ENSMUST00000114985(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q60722|reactome:R-MMU-525793|go:"GO:0016525"(negative regulation of angiogenesis)|refseq:XP_017173346.1|dip:DIP-42841N|mint:MINT-2570582(identity) - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:o8X4UFFW9S6TNL/Ur0E/WC+b/8010090 intact-crc:D15623E90027DB5F|rigid:hjTCsVeaD/HjKFKMu/69/RFi7X0 false - - 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O54972 uniprotkb:P22091 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007099|mint:MINT-2570521|imex:IM-10947-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)")|mint:MINT-2570528(identity) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2570522(identity) - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein|comment:"Stoichiometry: 1.0" comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 intact-crc:BC77296E076D7B93|rigid:SmzE2RmN7vKIa/9NFmTN4WdF300 false - - 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:P70662 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007069|mint:MINT-2570077|imex:IM-10947-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2570084(identity) ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-2570078(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090 intact-crc:0BFD99AB5AD301EF|rigid:YawXIQlQZpLZtnCbWn6qKEtriPM false - - 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:P70662 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007056|mint:MINT-2568626|imex:IM-10947-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2568627(identity) ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-2568633(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090 intact-crc:8B1311E93EF543A5|rigid:YawXIQlQZpLZtnCbWn6qKEtriPM false - - 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:O54972 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007113|mint:MINT-2570563|imex:IM-10947-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2570570(identity) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)")|mint:MINT-2570564(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein|comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 intact-crc:7D841F10FCDBA0FE|rigid:SmzE2RmN7vKIa/9NFmTN4WdF300 false - - 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q60722 uniprotkb:P70662 intact:EBI-310070|uniprotkb:Q60721|uniprotkb:Q62211|uniprotkb:Q64072|uniprotkb:Q80UE8|ensembl:ENSMUSP00000077577|ensembl:ENSMUSP00000110631|ensembl:ENSMUSP00000110636 intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68 psi-mi:itf2_mouse(display_long)|uniprotkb:Tcf4(gene name)|psi-mi:Tcf4(display_short)|uniprotkb:Itf2(gene name synonym)|uniprotkb:Sef2(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:Class A helix-loop-helix transcription factor ME2(gene name synonym) psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007173|mint:MINT-2570733|imex:IM-10947-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001077436.1|refseq:NP_038713.1|refseq:XP_006525809.1|refseq:XP_006525810.1|refseq:XP_006525813.1|refseq:XP_006525825.1|ensembl:ENSMUSG00000053477(gene)|ensembl:ENSMUST00000078486(transcript)|ensembl:ENSMUST00000114980(transcript)|ensembl:ENSMUST00000114985(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q60722|reactome:R-MMU-525793|go:"GO:0016525"(negative regulation of angiogenesis)|refseq:XP_017173346.1|dip:DIP-42841N|mint:MINT-2570740(identity) ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-2570734(identity) - comment:"Stoichiometry: 1.0" - figure legend:F1B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:o8X4UFFW9S6TNL/Ur0E/WC+b/8010090 rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090 intact-crc:1DF9E60F463E3643|rigid:Q524rhwKe+6HtZH+cbF8Do4BjHI false - - 1 - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q60722 uniprotkb:P70662 intact:EBI-310070|uniprotkb:Q60721|uniprotkb:Q62211|uniprotkb:Q64072|uniprotkb:Q80UE8|ensembl:ENSMUSP00000077577|ensembl:ENSMUSP00000110631|ensembl:ENSMUSP00000110636 intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68 psi-mi:itf2_mouse(display_long)|uniprotkb:Tcf4(gene name)|psi-mi:Tcf4(display_short)|uniprotkb:Itf2(gene name synonym)|uniprotkb:Sef2(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:Class A helix-loop-helix transcription factor ME2(gene name synonym) psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007186|mint:MINT-2570965|imex:IM-10947-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001077436.1|refseq:NP_038713.1|refseq:XP_006525809.1|refseq:XP_006525810.1|refseq:XP_006525813.1|refseq:XP_006525825.1|ensembl:ENSMUSG00000053477(gene)|ensembl:ENSMUST00000078486(transcript)|ensembl:ENSMUST00000114980(transcript)|ensembl:ENSMUST00000114985(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q60722|reactome:R-MMU-525793|go:"GO:0016525"(negative regulation of angiogenesis)|refseq:XP_017173346.1|dip:DIP-42841N|mint:MINT-2570972(identity) ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-2570966(identity) - comment:"Stoichiometry: 1.0" - figure legend:F1B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:o8X4UFFW9S6TNL/Ur0E/WC+b/8010090 rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090 intact-crc:BC03369E81AA270A|rigid:Q524rhwKe+6HtZH+cbF8Do4BjHI false - - 1 - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O54972 uniprotkb:P70662 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007229|mint:MINT-2571326|imex:IM-10947-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)")|mint:MINT-2571327(identity) ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-2571337(identity) - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein|comment:"Stoichiometry: 1.0" - figure legend:F1B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090 intact-crc:3611D27E86A686B8|rigid:jVEjApf4eMp602MnPD8Zd3xG5yY false - - 1 - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O54972 uniprotkb:P70662 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007199|mint:MINT-2570998|imex:IM-10947-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)")|mint:MINT-2570999(identity) ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-2571005(identity) - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein|comment:"Stoichiometry: 1.0" - figure legend:F1B|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090 intact-crc:97EB02EF413297F1|rigid:jVEjApf4eMp602MnPD8Zd3xG5yY false - - 1 - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O54972 uniprotkb:Q60722 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-310070|uniprotkb:Q60721|uniprotkb:Q62211|uniprotkb:Q64072|uniprotkb:Q80UE8|ensembl:ENSMUSP00000077577|ensembl:ENSMUSP00000110631|ensembl:ENSMUSP00000110636 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:itf2_mouse(display_long)|uniprotkb:Tcf4(gene name)|psi-mi:Tcf4(display_short)|uniprotkb:Itf2(gene name synonym)|uniprotkb:Sef2(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:Class A helix-loop-helix transcription factor ME2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8007141|mint:MINT-2570708|imex:IM-10947-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)")|mint:MINT-2570715(identity) refseq:NP_001077436.1|refseq:NP_038713.1|refseq:XP_006525809.1|refseq:XP_006525810.1|refseq:XP_006525813.1|refseq:XP_006525825.1|ensembl:ENSMUSG00000053477(gene)|ensembl:ENSMUST00000078486(transcript)|ensembl:ENSMUST00000114980(transcript)|ensembl:ENSMUST00000114985(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q60722|reactome:R-MMU-525793|go:"GO:0016525"(negative regulation of angiogenesis)|refseq:XP_017173346.1|dip:DIP-42841N|mint:MINT-2570709(identity) - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mel-1)|taxid:10090(Mus musculus) - 2006/06/14 2014/10/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:o8X4UFFW9S6TNL/Ur0E/WC+b/8010090 intact-crc:10A51597FB910032|rigid:hjTCsVeaD/HjKFKMu/69/RFi7X0 false - - 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P22091 uniprotkb:Q61286 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-8006499|intact:MINT-2567849|uniprotkb:E9QPN4|ensembl:ENSMUSP00000139364|ensembl:ENSMUSP00000139365 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:htf4_mouse(display_long)|uniprotkb:Tcf12(gene name)|psi-mi:Tcf12(display_short)|uniprotkb:Alf1(gene name synonym)|uniprotkb:Meb(gene name synonym)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:Class A helix-loop-helix transcription factor ME1(gene name synonym) psi-mi:"MI:0096"(pull down) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8007349|mint:MINT-2571713|imex:IM-10947-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2571719(identity) refseq:NP_035674.2|refseq:NP_001240794.1|refseq:XP_006511057.1|refseq:XP_006511060.1|dip:DIP-42840N|ensembl:ENSMUSG00000032228(gene)|ensembl:ENSMUST00000183404(transcript)|ensembl:ENSMUST00000184783(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q61286|reactome:R-MMU-525793|reactome:R-MMU-8939236|mint:MINT-2571714(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:mint|function:Binds specifically to oligomers of E-box motifs. May play important roles during development of the nervous system as well as in other organ systems|comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:RaQpcfOvnDIORBP08og33dK901w10090 intact-crc:BBB2E771048200B8|rigid:LTnZ2RORqozBZCU/4AIOZwoepVg false glutathione s tranferase tag:?-?(MINT-2571721) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O54972 uniprotkb:P15806 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-81370|uniprotkb:Q3U153|uniprotkb:Q8CAH9|uniprotkb:Q8VCY4|uniprotkb:Q922S2|uniprotkb:Q99MB8|uniprotkb:Q9CYJ4|ensembl:ENSMUSP00000100983 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:tfe2_mouse(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym) psi-mi:"MI:0096"(pull down) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8007297|mint:MINT-2571347|imex:IM-10947-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)")|mint:MINT-2571354(identity) rcsb pdb:2QL2|reactome:R-MMU-525793|reactome:R-MMU-8939236|refseq:NP_001157620.1|refseq:NP_001157621.1|refseq:NP_001157623.1|refseq:NP_035678.3|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048468"(cell development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15806|ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105346(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|dip:DIP-30940N|mint:MINT-2571348(identity) - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/06/14 2014/10/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:aMvLmcfudacIqIAxOSmbNPNjsc810090 intact-crc:329195B0D73955BD|rigid:T0vI1IyG7OAecotbVQqlvzsYYMs false glutathione s tranferase tag:?-?(MINT-2571426) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O54972 uniprotkb:Q61286 intact:EBI-8006703|uniprotkb:Q7TND6|intact:MINT-2568147|uniprotkb:Q8BZS0 intact:EBI-8006499|intact:MINT-2567849|uniprotkb:E9QPN4|ensembl:ENSMUSP00000139364|ensembl:ENSMUSP00000139365 psi-mi:mtg16_mouse(display_long)|uniprotkb:Cbfa2t3(gene name)|psi-mi:Cbfa2t3(display_short)|uniprotkb:Cbfa2t3h(gene name synonym)|uniprotkb:Mtgr2(gene name synonym)|uniprotkb:Protein ETO-2(gene name synonym)|uniprotkb:Eight twenty one protein 2(gene name synonym)|uniprotkb:MTG8-related protein 2(gene name synonym) psi-mi:htf4_mouse(display_long)|uniprotkb:Tcf12(gene name)|psi-mi:Tcf12(display_short)|uniprotkb:Alf1(gene name synonym)|uniprotkb:Meb(gene name synonym)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:Class A helix-loop-helix transcription factor ME1(gene name synonym) psi-mi:"MI:0096"(pull down) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8007332|mint:MINT-2571502|imex:IM-10947-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001103343.1|refseq:NP_796263.1|refseq:NP_033954.2|interpro:IPR014896(NHR2-like)|mint:O54972|interpro:IPR037249|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|interpro:IPR013292("Myeloid transforming gene on chromosome 16 (MTG16)")|mint:MINT-2571509(identity) refseq:NP_035674.2|refseq:NP_001240794.1|refseq:XP_006511057.1|refseq:XP_006511060.1|dip:DIP-42840N|ensembl:ENSMUSG00000032228(gene)|ensembl:ENSMUST00000183404(transcript)|ensembl:ENSMUST00000184783(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:Q61286|reactome:R-MMU-525793|reactome:R-MMU-8939236|mint:MINT-2571504(identity) - comment:mint|function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein|comment:"Stoichiometry: 1.0" comment:mint|function:Binds specifically to oligomers of E-box motifs. May play important roles during development of the nervous system as well as in other organ systems|comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/06/14 2014/10/16 rogid:svOvncuPBKXlH2C98N/H3qfIV/g10090 rogid:RaQpcfOvnDIORBP08og33dK901w10090 intact-crc:9D1F5E1525E9F9FF|rigid:ZPBYPf3igQl6iaXgyh/EbXhRe28 false glutathione s tranferase tag:?-?(MINT-2571513) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P22091 uniprotkb:P15806 intact:EBI-8006437|intact:MINT-2567683|ensembl:ENSMUSP00000030489|ensembl:ENSMUSP00000124983|ensembl:ENSMUSP00000125202 intact:EBI-81370|uniprotkb:Q3U153|uniprotkb:Q8CAH9|uniprotkb:Q8VCY4|uniprotkb:Q922S2|uniprotkb:Q99MB8|uniprotkb:Q9CYJ4|ensembl:ENSMUSP00000100983 psi-mi:tal1_mouse(display_long)|uniprotkb:Tal1(gene name)|psi-mi:Tal1(display_short)|uniprotkb:Scl(gene name synonym)|uniprotkb:Tal-1(gene name synonym)|uniprotkb:Stem cell protein(gene name synonym) psi-mi:tfe2_mouse(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym) psi-mi:"MI:0096"(pull down) Goardon et al. (2006) pubmed:16407974|imex:IM-10947|mint:MINT-5218217 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8007366|mint:MINT-2571752|imex:IM-10947-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035657.1|refseq:NP_001274317.1|refseq:XP_006502973.1|refseq:XP_006502975.1|refseq:XP_006502976.1|refseq:XP_006502977.1|refseq:XP_006502978.1|refseq:XP_006502979.1|dip:DIP-42839N|ensembl:ENSMUSG00000028717(gene)|ensembl:ENSMUST00000030489(transcript)|ensembl:ENSMUST00000161601(transcript)|ensembl:ENSMUST00000162489(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007626"(locomotory behavior)|go:"GO:0019899"(enzyme binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045799"(positive regulation of chromatin assembly or disassembly)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048699"(generation of neurons)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060217"(hemangioblast cell differentiation)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060375"(regulation of mast cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040238|mint:P22091|reactome:R-MMU-8939236|mint:MINT-2571753(identity) rcsb pdb:2QL2|reactome:R-MMU-525793|reactome:R-MMU-8939236|refseq:NP_001157620.1|refseq:NP_001157621.1|refseq:NP_001157623.1|refseq:NP_035678.3|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048468"(cell development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15806|ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105346(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|dip:DIP-30940N|mint:MINT-2571760(identity) - comment:mint|function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation|function:Involved in chromosomal translocation in leukemic stem-cells|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/06/14 2014/10/16 rogid:lFDGEWJ65/G4+uXxjEQ/gMZbKq010090 rogid:aMvLmcfudacIqIAxOSmbNPNjsc810090 intact-crc:4F4BACBCC3C9E3F5|rigid:Dsr+1yEQaVf8snTGpNlVT0BJhtA false glutathione s tranferase tag:?-?(MINT-2571757) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)