#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06786	uniprotkb:P24583	intact:EBI-19352|uniprotkb:D6W191|ensemblfungi:YNL088W	intact:EBI-9860|ensemblfungi:YBL105C|uniprotkb:D6VPP8	psi-mi:top2_yeast(display_long)|uniprotkb:TOP2(gene name)|psi-mi:TOP2(display_short)|uniprotkb:TOR3(gene name synonym)|uniprotkb:YNL088W(locus name)|uniprotkb:N2244(orf name)|uniprotkb:DNA topoisomerase II(gene name synonym)	psi-mi:kpc1_yeast(display_long)|uniprotkb:PKC1(gene name)|psi-mi:PKC1(display_short)|uniprotkb:HPO2(gene name synonym)|uniprotkb:STT1(gene name synonym)|uniprotkb:YBL105C(locus name)|uniprotkb:YBL0807(orf name)	psi-mi:"MI:0399"(two hybrid fragment pooling approach)	Mouchel et al. (2006)	pubmed:16364307|imex:IM-11189|mint:MINT-5218149	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7967222|mint:MINT-74891|imex:IM-11189-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005032|ensemblfungi:YNL088W(gene)|ensemblfungi:YNL088W_mRNA(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031055"(chromatin remodeling at centromere)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0097046"(replication fork progression beyond termination site)|go:"GO:0097047"(DNA replication termination region)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|rcsb pdb:1BGW|rcsb pdb:1BJT|rcsb pdb:1PVG|rcsb pdb:1QZR|rcsb pdb:2RGR|rcsb pdb:3L4J|rcsb pdb:3L4K|rcsb pdb:4GFH|reactome:R-SCE-4615885|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|refseq:NP_014311.3|dip:DIP-2300N|mint:P06786|mint:MINT-1503356(identity)	refseq:NP_009445.2|sgd:S000000201|ensemblfungi:YBL105C(gene)|ensemblfungi:YBL105C_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032165"(prospore septin filament array)|go:"GO:0032186"(cellular bud neck septin ring organization)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0060211"("regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060237"(regulation of fungal-type cell wall organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037312|interpro:IPR037778|reactome:R-SCE-114508|reactome:R-SCE-114516|reactome:R-SCE-1169091|reactome:R-SCE-1489509|reactome:R-SCE-202424|reactome:R-SCE-2029485|reactome:R-SCE-2179392|reactome:R-SCE-2871837|reactome:R-SCE-399997|reactome:R-SCE-4419969|reactome:R-SCE-5218921|reactome:R-SCE-5607764|reactome:R-SCE-5625740|reactome:R-SCE-5668599|reactome:R-SCE-6798695|reactome:R-SCE-76005|reactome:R-SCE-8980692|reactome:R-SCE-9013026|reactome:R-SCE-9634635|dip:DIP-1516N|mint:P24583|mint:MINT-1503368(identity)	-	crc64:0E29EB8B89AA1387|comment:"Stoichiometry: 1.0"	crc64:8200EC2A2C6E649E|comment:"Stoichiometry: 1.0"	figure legend:F1A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/01/17	2014/10/16	rogid:XKHvaF2HxChXbspQofpg5T6iZ+g559292	rogid:ajnsIv2ZUh0GzDRqYAJTKsbr7hg559292	intact-crc:8E31AFB328D84571|rigid:0iJmZf6y+Jz0zD8QvVv4jHgtg00	false	mutation decreasing interaction:9-10(MINT-1503360)|binding-associated region:3-310(MINT-1503357)|tag:?-?(MINT-1503362)	tag:?-?(MINT-1503371)|binding-associated region:206-700(MINT-1503369)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06786	uniprotkb:P24583	intact:EBI-19352|uniprotkb:D6W191|ensemblfungi:YNL088W	intact:EBI-9860|ensemblfungi:YBL105C|uniprotkb:D6VPP8	psi-mi:top2_yeast(display_long)|uniprotkb:TOP2(gene name)|psi-mi:TOP2(display_short)|uniprotkb:TOR3(gene name synonym)|uniprotkb:YNL088W(locus name)|uniprotkb:N2244(orf name)|uniprotkb:DNA topoisomerase II(gene name synonym)	psi-mi:kpc1_yeast(display_long)|uniprotkb:PKC1(gene name)|psi-mi:PKC1(display_short)|uniprotkb:HPO2(gene name synonym)|uniprotkb:STT1(gene name synonym)|uniprotkb:YBL105C(locus name)|uniprotkb:YBL0807(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mouchel et al. (2006)	pubmed:16364307|imex:IM-11189|mint:MINT-5218149	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7967264|mint:MINT-74892|imex:IM-11189-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005032|ensemblfungi:YNL088W(gene)|ensemblfungi:YNL088W_mRNA(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031055"(chromatin remodeling at centromere)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0097046"(replication fork progression beyond termination site)|go:"GO:0097047"(DNA replication termination region)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|rcsb pdb:1BGW|rcsb pdb:1BJT|rcsb pdb:1PVG|rcsb pdb:1QZR|rcsb pdb:2RGR|rcsb pdb:3L4J|rcsb pdb:3L4K|rcsb pdb:4GFH|reactome:R-SCE-4615885|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|refseq:NP_014311.3|dip:DIP-2300N|mint:P06786|mint:MINT-1503383(identity)	refseq:NP_009445.2|sgd:S000000201|ensemblfungi:YBL105C(gene)|ensemblfungi:YBL105C_mRNA(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0009272"(fungal-type cell wall biogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032165"(prospore septin filament array)|go:"GO:0032186"(cellular bud neck septin ring organization)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0060211"("regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060237"(regulation of fungal-type cell wall organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037312|interpro:IPR037778|reactome:R-SCE-114508|reactome:R-SCE-114516|reactome:R-SCE-1169091|reactome:R-SCE-1489509|reactome:R-SCE-202424|reactome:R-SCE-2029485|reactome:R-SCE-2179392|reactome:R-SCE-2871837|reactome:R-SCE-399997|reactome:R-SCE-4419969|reactome:R-SCE-5218921|reactome:R-SCE-5607764|reactome:R-SCE-5625740|reactome:R-SCE-5668599|reactome:R-SCE-6798695|reactome:R-SCE-76005|reactome:R-SCE-8980692|reactome:R-SCE-9013026|reactome:R-SCE-9634635|dip:DIP-1516N|mint:P24583|mint:MINT-1503390(identity)	-	crc64:0E29EB8B89AA1387|comment:"Stoichiometry: 1.0"	crc64:8200EC2A2C6E649E|comment:"Stoichiometry: 1.0"	figure legend:F1C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/01/17	2014/10/16	rogid:XKHvaF2HxChXbspQofpg5T6iZ+g559292	rogid:ajnsIv2ZUh0GzDRqYAJTKsbr7hg559292	intact-crc:81A66577092CB417|rigid:0iJmZf6y+Jz0zD8QvVv4jHgtg00	false	myc tag:?-?(MINT-1503384)	binding-associated region:206-700(MINT-1503391)|ha tag:?-?(MINT-1503393)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)