#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q01638	uniprotkb:O95760	intact:EBI-993762|uniprotkb:Q53TU7|uniprotkb:Q8NEJ3|uniprotkb:Q9ULV7|uniprotkb:Q9UQ44|uniprotkb:A8K6B3|ensembl:ENSP00000233954|uniprotkb:B4E0I3	intact:EBI-724057|ensembl:ENSP00000370842|ensembl:ENSP00000507310|uniprotkb:D3DRI5|uniprotkb:Q2YEJ5|uniprotkb:B4E1Q9|uniprotkb:B2R8L1|uniprotkb:E7EAX4|uniprotkb:B4DJ35	psi-mi:ilrl1_human(display_long)|uniprotkb:Protein ST2(gene name synonym)|uniprotkb:IL1RL1(gene name)|psi-mi:IL1RL1(display_short)|uniprotkb:DER4(gene name synonym)|uniprotkb:ST2(gene name synonym)|uniprotkb:T1(gene name synonym)	psi-mi:il33_human(display_long)|uniprotkb:Interleukin-1 family member 11(gene name synonym)|uniprotkb:Nuclear factor from high endothelial venules(gene name synonym)|uniprotkb:IL33(gene name)|psi-mi:IL33(display_short)|uniprotkb:C9orf26(gene name synonym)|uniprotkb:IL1F11(gene name synonym)|uniprotkb:NFHEV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Schmitz et al. (2005)	pubmed:16286016|imex:IM-19150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-993803|imex:IM-19150-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712902.1|refseq:XP_011510453.1|ensembl:ENSG00000115602(gene)|ensembl:ENST00000233954(transcript)|go:"GO:0002113"(interleukin-33 binding)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:4KC3|reactome:R-HSA-1257604|reactome:R-HSA-6811558|reactome:R-HSA-9014843|refseq:NP_003847.2|refseq:NP_057316.3|refseq:NP_001269337.1|dip:DIP-37861N	refseq:NP_001186569.1|refseq:NP_001186570.1|refseq:NP_254274.1|ensembl:ENSG00000137033(gene)|ensembl:ENST00000381434(transcript)|ensembl:ENST00000682010(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0010186"(positive regulation of cellular defense response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030133"(transport vesicle)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0038172"(interleukin-33-mediated signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0120042"(negative regulation of macrophage proliferation)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150142"(positive regulation of CD86 production)|go:"GO:0150145"(positive regulation of CD80 production)|interpro:IPR026145|mint:O95760|rcsb pdb:2KLL|rcsb pdb:4KC3|reactome:R-HSA-1257604|reactome:R-HSA-5689880|reactome:R-HSA-6811558|reactome:R-HSA-9014843|refseq:NP_001300973.1|refseq:NP_001300974.1|refseq:NP_001300975.1|refseq:NP_001300976.1|refseq:NP_001300977.1|dip:DIP-37862N	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/21	2014/10/16	rogid:eclKff34jc9DFSGpdp8CSvRj3949606	rogid:i5+nKwGFVwA7KHOPlynsuUeAU1M9606	intact-crc:C368B4A5016C0C9C|rigid:XYRgNHTqowWt0PKEh8pO3SIKmhM	false	fusion protein:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01638	uniprotkb:O95760	intact:EBI-993762|uniprotkb:Q53TU7|uniprotkb:Q8NEJ3|uniprotkb:Q9ULV7|uniprotkb:Q9UQ44|uniprotkb:A8K6B3|ensembl:ENSP00000233954|uniprotkb:B4E0I3	intact:EBI-724057|ensembl:ENSP00000370842|ensembl:ENSP00000507310|uniprotkb:D3DRI5|uniprotkb:Q2YEJ5|uniprotkb:B4E1Q9|uniprotkb:B2R8L1|uniprotkb:E7EAX4|uniprotkb:B4DJ35	psi-mi:ilrl1_human(display_long)|uniprotkb:Protein ST2(gene name synonym)|uniprotkb:IL1RL1(gene name)|psi-mi:IL1RL1(display_short)|uniprotkb:DER4(gene name synonym)|uniprotkb:ST2(gene name synonym)|uniprotkb:T1(gene name synonym)	psi-mi:il33_human(display_long)|uniprotkb:Interleukin-1 family member 11(gene name synonym)|uniprotkb:Nuclear factor from high endothelial venules(gene name synonym)|uniprotkb:IL33(gene name)|psi-mi:IL33(display_short)|uniprotkb:C9orf26(gene name synonym)|uniprotkb:IL1F11(gene name synonym)|uniprotkb:NFHEV(gene name synonym)	psi-mi:"MI:0096"(pull down)	Schmitz et al. (2005)	pubmed:16286016|imex:IM-19150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-994012|imex:IM-19150-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712902.1|refseq:XP_011510453.1|ensembl:ENSG00000115602(gene)|ensembl:ENST00000233954(transcript)|go:"GO:0002113"(interleukin-33 binding)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:4KC3|reactome:R-HSA-1257604|reactome:R-HSA-6811558|reactome:R-HSA-9014843|refseq:NP_003847.2|refseq:NP_057316.3|refseq:NP_001269337.1|dip:DIP-37861N	refseq:NP_001186569.1|refseq:NP_001186570.1|refseq:NP_254274.1|ensembl:ENSG00000137033(gene)|ensembl:ENST00000381434(transcript)|ensembl:ENST00000682010(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0010186"(positive regulation of cellular defense response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030133"(transport vesicle)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0038172"(interleukin-33-mediated signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0120042"(negative regulation of macrophage proliferation)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150142"(positive regulation of CD86 production)|go:"GO:0150145"(positive regulation of CD80 production)|interpro:IPR026145|mint:O95760|rcsb pdb:2KLL|rcsb pdb:4KC3|reactome:R-HSA-1257604|reactome:R-HSA-5689880|reactome:R-HSA-6811558|reactome:R-HSA-9014843|refseq:NP_001300973.1|refseq:NP_001300974.1|refseq:NP_001300975.1|refseq:NP_001300976.1|refseq:NP_001300977.1|dip:DIP-37862N	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/21	2014/10/16	rogid:eclKff34jc9DFSGpdp8CSvRj3949606	rogid:i5+nKwGFVwA7KHOPlynsuUeAU1M9606	intact-crc:B265631E92C265EB|rigid:XYRgNHTqowWt0PKEh8pO3SIKmhM	false	fusion protein:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01638	uniprotkb:Q99836	intact:EBI-993762|uniprotkb:Q53TU7|uniprotkb:Q8NEJ3|uniprotkb:Q9ULV7|uniprotkb:Q9UQ44|uniprotkb:A8K6B3|ensembl:ENSP00000233954|uniprotkb:B4E0I3	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:ilrl1_human(display_long)|uniprotkb:Protein ST2(gene name synonym)|uniprotkb:IL1RL1(gene name)|psi-mi:IL1RL1(display_short)|uniprotkb:DER4(gene name synonym)|uniprotkb:ST2(gene name synonym)|uniprotkb:T1(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schmitz et al. (2005)	pubmed:16286016|imex:IM-19150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-997149|imex:IM-19150-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712902.1|refseq:XP_011510453.1|ensembl:ENSG00000115602(gene)|ensembl:ENST00000233954(transcript)|go:"GO:0002113"(interleukin-33 binding)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:4KC3|reactome:R-HSA-1257604|reactome:R-HSA-6811558|reactome:R-HSA-9014843|refseq:NP_003847.2|refseq:NP_057316.3|refseq:NP_001269337.1|dip:DIP-37861N	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:3D|agonist:Interaction has been detected after stimulation with C9orf26/Il-33  interleukin-1-like cytokine.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/08/21	2014/10/16	rogid:eclKff34jc9DFSGpdp8CSvRj3949606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	intact-crc:0BBC92CC46050F72|rigid:sJAvRibYeZSzYXTc1gsBMEv29Ks	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01638	uniprotkb:Q9Y4K3	intact:EBI-993762|uniprotkb:Q53TU7|uniprotkb:Q8NEJ3|uniprotkb:Q9ULV7|uniprotkb:Q9UQ44|uniprotkb:A8K6B3|ensembl:ENSP00000233954|uniprotkb:B4E0I3	intact:EBI-359276|uniprotkb:Q8NEH5|uniprotkb:A6NKI7|uniprotkb:A8KAB3|ensembl:ENSP00000337853|ensembl:ENSP00000433623|uniprotkb:D3DR16	psi-mi:ilrl1_human(display_long)|uniprotkb:Protein ST2(gene name synonym)|uniprotkb:IL1RL1(gene name)|psi-mi:IL1RL1(display_short)|uniprotkb:DER4(gene name synonym)|uniprotkb:ST2(gene name synonym)|uniprotkb:T1(gene name synonym)	psi-mi:traf6_human(display_long)|uniprotkb:TRAF6(gene name)|psi-mi:TRAF6(display_short)|uniprotkb:RNF85(gene name synonym)|uniprotkb:Interleukin-1 signal transducer(gene name synonym)|uniprotkb:RING finger protein 85(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schmitz et al. (2005)	pubmed:16286016|imex:IM-19150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-997176|imex:IM-19150-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712902.1|refseq:XP_011510453.1|ensembl:ENSG00000115602(gene)|ensembl:ENST00000233954(transcript)|go:"GO:0002113"(interleukin-33 binding)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:4KC3|reactome:R-HSA-1257604|reactome:R-HSA-6811558|reactome:R-HSA-9014843|refseq:NP_003847.2|refseq:NP_057316.3|refseq:NP_001269337.1|dip:DIP-37861N	refseq:NP_004611.1|refseq:NP_665802.1|ensembl:ENSG00000175104(gene)|ensembl:ENST00000348124(transcript)|ensembl:ENST00000526995(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:Q9Y4K3|rcsb pdb:1LB4|rcsb pdb:1LB5|go:"GO:0070534"(protein K63-linked ubiquitination)|rcsb pdb:1LB6|rcsb pdb:2ECI|rcsb pdb:2JMD|rcsb pdb:3HCS|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:4Z8M|rcsb pdb:5ZUJ|rcsb pdb:6A33|go:"GO:0070555"(response to interleukin-1)|rcsb pdb:7L3L|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-205043|go:"GO:0071222"(cellular response to lipopolysaccharide)|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-2871837|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975163|reactome:R-HSA-975871|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|dip:DIP-27515N	-	-	-	figure legend:3D|agonist:Interaction has been detected after stimulation with C9orf26/Il-33 interleukin-1-like cytokine.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/08/21	2014/10/16	rogid:eclKff34jc9DFSGpdp8CSvRj3949606	rogid:m0TTXwlrtXnnjXWbg0MsEULlq0I9606	intact-crc:97447B0794259096|rigid:Ni9IfIHlsh5aD3K+vLcGZ0k0NSI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01638	uniprotkb:Q9NWZ3	intact:EBI-993762|uniprotkb:Q53TU7|uniprotkb:Q8NEJ3|uniprotkb:Q9ULV7|uniprotkb:Q9UQ44|uniprotkb:A8K6B3|ensembl:ENSP00000233954|uniprotkb:B4E0I3	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	psi-mi:ilrl1_human(display_long)|uniprotkb:Protein ST2(gene name synonym)|uniprotkb:IL1RL1(gene name)|psi-mi:IL1RL1(display_short)|uniprotkb:DER4(gene name synonym)|uniprotkb:ST2(gene name synonym)|uniprotkb:T1(gene name synonym)	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schmitz et al. (2005)	pubmed:16286016|imex:IM-19150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-997187|imex:IM-19150-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712902.1|refseq:XP_011510453.1|ensembl:ENSG00000115602(gene)|ensembl:ENST00000233954(transcript)|go:"GO:0002113"(interleukin-33 binding)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:4KC3|reactome:R-HSA-1257604|reactome:R-HSA-6811558|reactome:R-HSA-9014843|refseq:NP_003847.2|refseq:NP_057316.3|refseq:NP_001269337.1|dip:DIP-37861N	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	-	-	-	figure legend:3D|agonist:Interaction has been detected after stimulation with C9orf26/Il-33 interleukin-1-like cytokine.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/08/21	2014/10/16	rogid:eclKff34jc9DFSGpdp8CSvRj3949606	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	intact-crc:D77B74362BE47394|rigid:bMotrtNY3xrN+nyJJ/sgYD7fYSU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)