#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P39060-PRO_0000005794	uniprotkb:P39060-PRO_0000005794	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	He et al. (2006)	imex:IM-14487|pubmed:16269408	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-981341|imex:IM-14487-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-981314(chain-parent)	intact:EBI-981314(chain-parent)	go:"GO:0042802"(identical protein binding)	chain-seq-start:1572|chain-seq-end:1754	chain-seq-start:1572|chain-seq-end:1754	figure legend:Figure 1 Figure 7|comment:In the case of  endo-WT, no increased fluorescence was  observed regardless of various pH values. The fluorescence for endo-all-  Ala, however, increased rapidly from pH 4.3 to 6.0 and reached a maximum  at pH 6.0.|comment:The coordinates for the mutated cysteine residues were taken from the UniProt entry Q8WXI5|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/04	2015/10/13	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	intact-crc:8C6A77937B141DA5|rigid:EdfNWM7gJ1ZpIob91u39Y0dwoMY	false	mutation:165-165,33-33,173-173,135-135	mutation:165-165,33-33,173-173,135-135	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39060-PRO_0000005794	uniprotkb:P39060-PRO_0000005794	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:"MI:0040"(electron microscopy)	He et al. (2006)	imex:IM-14487|pubmed:16269408	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-981519|imex:IM-14487-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-981314(chain-parent)	intact:EBI-981314(chain-parent)	go:"GO:0042802"(identical protein binding)	chain-seq-start:1572|chain-seq-end:1754	chain-seq-start:1572|chain-seq-end:1754	figure legend:Figure 2|comment:The coordinates for the mutated cysteine residues were taken from the UniProt entry Q8WXI5|complex-properties:"It was shown that amorphous granular  aggregates composed of spherical particles predominated immediately after the pH was adjusted (Fig. 2A). Eleven hours later, short fibrils  emanated from the globular granules, which indicated that fibrillar protein  aggregates were beginning to form (Fig. 2B). In a similar sample  recovered at 41 h, the fibrillar material was clearly evident, and the fibril  extension continued (Fig. 2C). This fibrillar type resembles the protofilaments  observed in other fibrillogenic systems, according to the size  and characteristics of the aggregates (33). After prolonged incubation  for 81 h, the AFM image showed that the fibrils produced were long,  smooth, and unbranched and possessed a rope-like structure with a  width of 30�40 nm (Fig. 2D)."|comment:"When endo-WT  was incubated under the same conditions for 81 h, there were only small  spherical particles, which were probably the protein monomer molecules  in appearance, with no evidence for extended fibrils characteristic  of fibril formation (Fig. 2E)."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/04	2015/10/13	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	intact-crc:F9F6C9127A21FFE4|rigid:EdfNWM7gJ1ZpIob91u39Y0dwoMY	false	mutation:165-165,33-33,173-173,135-135	mutation:165-165,33-33,173-173,135-135	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39060-PRO_0000005794	uniprotkb:P39060-PRO_0000005794	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:"MI:0040"(electron microscopy)	He et al. (2006)	imex:IM-14487|pubmed:16269408	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-981636|imex:IM-14487-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-981314(chain-parent)	intact:EBI-981314(chain-parent)	go:"GO:0042802"(identical protein binding)	chain-seq-start:1572|chain-seq-end:1754	chain-seq-start:1572|chain-seq-end:1754	figure legend:Figure 4|comment:The coordinates for the mutated cysteine residues were taken from the UniProt entry Q8WXI5|comment:Fibril formation was seen in in 30% TFE and endostatin  displayed long, twisted, and rope-like fibrils|stimulant:"2, 2, 2 Trifluoroethanol (TFE)"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/04	2015/10/13	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	intact-crc:389685B7B1338DEA|rigid:EdfNWM7gJ1ZpIob91u39Y0dwoMY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39060-PRO_0000005794	uniprotkb:P39060-PRO_0000005794	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:"MI:0016"(circular dichroism)	He et al. (2006)	imex:IM-14487|pubmed:16269408	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-981580|imex:IM-14487-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-981314(chain-parent)	intact:EBI-981314(chain-parent)	go:"GO:0042802"(identical protein binding)	chain-seq-start:1572|chain-seq-end:1754	chain-seq-start:1572|chain-seq-end:1754	figure legend:Figure 3|comment:The coordinates for the mutated cysteine residues were taken from the UniProt entry Q8WXI5|complex-properties:The difference of the spectra between endo-all-  Ala before and after being incubated for 81 h showed a negative peak at  215 nm, which is a diagnostic mark for the presence of beta-structure|comment:The secondary structure of  endo-WT did not alter after the incubation.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/04	2015/10/13	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	intact-crc:3392BD3520FD2BD3|rigid:EdfNWM7gJ1ZpIob91u39Y0dwoMY	false	mutation:165-165,33-33,173-173,135-135	mutation:165-165,33-33,173-173,135-135	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39060-PRO_0000005794	uniprotkb:P39060-PRO_0000005794	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:"MI:0016"(circular dichroism)	He et al. (2006)	imex:IM-14487|pubmed:16269408	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-981652|imex:IM-14487-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-981314(chain-parent)	intact:EBI-981314(chain-parent)	go:"GO:0042802"(identical protein binding)	chain-seq-start:1572|chain-seq-end:1754	chain-seq-start:1572|chain-seq-end:1754	figure legend:Figure 8A|comment:The coordinates for the mutated cysteine residues were taken from the UniProt entry Q8WXI5|comment:Alpha-helical  structure of endo-WT increased with TFE concentrations from 0 to 30%  at pH 6.0, according to the two negative peaks at 208 and 222 nm in the  spectra.|stimulant:"2, 2, 2 Trifluoroethanol (TFE)"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/04	2015/10/13	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	intact-crc:7107F3438BA4C536|rigid:EdfNWM7gJ1ZpIob91u39Y0dwoMY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39060-PRO_0000005794	uniprotkb:P39060-PRO_0000005794	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	intact:EBI-2566375|intact:EBI-9076876|intact:EBI-9028624	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:p39060-pro_0000005794(display_long)|uniprotkb:COL18A1(gene name)|psi-mi:COL18A1(display_short)	psi-mi:"MI:0013"(biophysical)	He et al. (2006)	imex:IM-14487|pubmed:16269408	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-981607|imex:IM-14487-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-981314(chain-parent)	intact:EBI-981314(chain-parent)	go:"GO:0042802"(identical protein binding)	chain-seq-start:1572|chain-seq-end:1754	chain-seq-start:1572|chain-seq-end:1754	figure legend:Figure 4|comment:The coordinates for the mutated cysteine residues were taken from the UniProt entry Q8WXI5|caution:Stoichiometry was not determined in this assay|comment:The FTIR spectrum of endo-WT after the  incubation did not make any change compared with that of the protein  incubated before|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/04	2015/10/13	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	rogid:/GEv8hNT/FBUcv637M4OgwJcP709606	intact-crc:786B60EB56F3E4E2|rigid:EdfNWM7gJ1ZpIob91u39Y0dwoMY	false	mutation:165-165,33-33,173-173,135-135	mutation:165-165,33-33,173-173,135-135	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)