#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:17489"	intact:EBI-983902	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	-	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:ccpmelr(display_short)|psi-mi:EBI-983902(display_long)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Youn et al. (2006)	pubmed:16260780	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983878	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	kinetics:Values were different for 0.1mM cAMP and 1 mM cAMP. Reported value are for 0.1 mM cAMP.  T127L&S128M gave a Kd of  276 nM and  T127L&S1281&L61V gave a Kd of 100 nM|figure legend:table 3 figure 2	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2014/10/16	-	crc64:B3812C3DCEC93D66	intact-crc:B42929DE2AEBF006	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:P0ACJ8	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-547513|uniprotkb:P03020|uniprotkb:Q2M723|ensemblbacteria:AAC76382|ensemblbacteria:BAE77933	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:crp_ecoli(display_long)|uniprotkb:Catabolite activator protein(gene name synonym)|uniprotkb:crp(gene name)|psi-mi:crp(display_short)|uniprotkb:cap(gene name synonym)|uniprotkb:csm(gene name synonym)|uniprotkb:b3357(locus name)|uniprotkb:cAMP regulatory protein(gene name synonym)|uniprotkb:JW5702(locus name)|uniprotkb:cAMP receptor protein(gene name synonym)|uniprotkb:Catabolite gene activator(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Youn et al. (2006)	pubmed:16260780	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983878	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_417816.1|refseq:WP_000242755.1|ensemblbacteria:AAC76382(transcript)|ensemblbacteria:b3357(gene)|ensemblbacteria:BAE77933(gene)|ensemblbacteria:BAE77933(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0030552"(cAMP binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045013"(carbon catabolite repression of transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR012318(Helix-turn-helix motif, Crp-type)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018335|interpro:IPR018488|interpro:IPR018490|interpro:IPR036388|interpro:IPR036390|rcsb pdb:1CGP|rcsb pdb:1G6N|rcsb pdb:1HW5|rcsb pdb:1I5Z|rcsb pdb:1I6X|rcsb pdb:1J59|go:"GO:0042802"(identical protein binding)|rcsb pdb:1LB2|rcsb pdb:1O3Q|rcsb pdb:1O3R|rcsb pdb:1O3S|rcsb pdb:1O3T|rcsb pdb:1RUN|rcsb pdb:1RUO|rcsb pdb:1ZRC|rcsb pdb:1ZRD|rcsb pdb:1ZRE|rcsb pdb:1ZRF|rcsb pdb:2CGP|rcsb pdb:2GAP|rcsb pdb:2GZW|rcsb pdb:2WC2|rcsb pdb:3FWE|rcsb pdb:3HIF|rcsb pdb:3IYD|rcsb pdb:3N4M|rcsb pdb:3QOP|rcsb pdb:3RDI|rcsb pdb:3ROU|rcsb pdb:3RPQ|rcsb pdb:3RYP|rcsb pdb:3RYR|rcsb pdb:4BH9|rcsb pdb:4BHP|rcsb pdb:4FT8|rcsb pdb:4HZF|rcsb pdb:4I01|mint:P0ACJ8|rcsb pdb:4I02|rcsb pdb:4I09|rcsb pdb:3KCC|rcsb pdb:4I0A|rcsb pdb:4I0B|rcsb pdb:4R8H|rcsb pdb:5CIZ|dip:DIP-29232N	-	-	crc64:DCBC24FA46C61B3D	kinetics:Values were different for 0.1mM cAMP and 1 mM cAMP. Reported value are for 0.1 mM cAMP.  T127L&S128M gave a Kd of  276 nM and  T127L&S1281&L61V gave a Kd of 100 nM|figure legend:table 3 figure 2	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2014/10/16	-	rogid:U7WWKRnBGxivTuoNzQ0Sb4rcuFU83333	intact-crc:B42929DE2AEBF006	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	intact:EBI-983902	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	-	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:ccpmelr(display_short)|psi-mi:EBI-983902(display_long)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Youn et al. (2006)	pubmed:16260780	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983918	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	kinetics:"T127L/S128I CRP showed a significant decrease in DNA affinity at 0.1 mM cGMP (Kd = 165 nM) and a very dramatic decrease at 1 mM cGMP (Kd = 2006 nM)."|figure legend:2	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2014/10/16	-	crc64:B3812C3DCEC93D66	intact-crc:22350A164E9EA7F1	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:P0ACJ8	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-547513|uniprotkb:P03020|uniprotkb:Q2M723|ensemblbacteria:AAC76382|ensemblbacteria:BAE77933	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:crp_ecoli(display_long)|uniprotkb:Catabolite activator protein(gene name synonym)|uniprotkb:crp(gene name)|psi-mi:crp(display_short)|uniprotkb:cap(gene name synonym)|uniprotkb:csm(gene name synonym)|uniprotkb:b3357(locus name)|uniprotkb:cAMP regulatory protein(gene name synonym)|uniprotkb:JW5702(locus name)|uniprotkb:cAMP receptor protein(gene name synonym)|uniprotkb:Catabolite gene activator(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Youn et al. (2006)	pubmed:16260780	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-983918	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_417816.1|refseq:WP_000242755.1|ensemblbacteria:AAC76382(transcript)|ensemblbacteria:b3357(gene)|ensemblbacteria:BAE77933(gene)|ensemblbacteria:BAE77933(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0030552"(cAMP binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045013"(carbon catabolite repression of transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR012318(Helix-turn-helix motif, Crp-type)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018335|interpro:IPR018488|interpro:IPR018490|interpro:IPR036388|interpro:IPR036390|rcsb pdb:1CGP|rcsb pdb:1G6N|rcsb pdb:1HW5|rcsb pdb:1I5Z|rcsb pdb:1I6X|rcsb pdb:1J59|go:"GO:0042802"(identical protein binding)|rcsb pdb:1LB2|rcsb pdb:1O3Q|rcsb pdb:1O3R|rcsb pdb:1O3S|rcsb pdb:1O3T|rcsb pdb:1RUN|rcsb pdb:1RUO|rcsb pdb:1ZRC|rcsb pdb:1ZRD|rcsb pdb:1ZRE|rcsb pdb:1ZRF|rcsb pdb:2CGP|rcsb pdb:2GAP|rcsb pdb:2GZW|rcsb pdb:2WC2|rcsb pdb:3FWE|rcsb pdb:3HIF|rcsb pdb:3IYD|rcsb pdb:3N4M|rcsb pdb:3QOP|rcsb pdb:3RDI|rcsb pdb:3ROU|rcsb pdb:3RPQ|rcsb pdb:3RYP|rcsb pdb:3RYR|rcsb pdb:4BH9|rcsb pdb:4BHP|rcsb pdb:4FT8|rcsb pdb:4HZF|rcsb pdb:4I01|mint:P0ACJ8|rcsb pdb:4I02|rcsb pdb:4I09|rcsb pdb:3KCC|rcsb pdb:4I0A|rcsb pdb:4I0B|rcsb pdb:4R8H|rcsb pdb:5CIZ|dip:DIP-29232N	-	-	crc64:DCBC24FA46C61B3D	kinetics:"T127L/S128I CRP showed a significant decrease in DNA affinity at 0.1 mM cGMP (Kd = 165 nM) and a very dramatic decrease at 1 mM cGMP (Kd = 2006 nM)."|figure legend:2	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2014/10/16	-	rogid:U7WWKRnBGxivTuoNzQ0Sb4rcuFU83333	intact-crc:22350A164E9EA7F1	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)