#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JJ19	uniprotkb:O35240	intact:EBI-982391|ensembl:ENSRNOP00000004351	intact:EBI-982374|ensembl:ENSRNOP00000011300	psi-mi:nhrf1_rat(display_long)|uniprotkb:Nherf1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)|uniprotkb:Slc9a3r1(gene name)|psi-mi:Slc9a3r1(display_short)|uniprotkb:Nherf(gene name synonym)	psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Deval et al. (2006)	imex:IM-14489|pubmed:16234233	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-982387|imex:IM-14489-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0005576"(extracellular region)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0044782"(cilium organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|ensembl:ENSRNOG00000003232(gene)|ensembl:ENSRNOT00000004351(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|rgd:708538|refseq:NP_067605.1	ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/08/07	2014/10/16	rogid:G5I7bIzbx2WYbIPRtysKKswyjh410116	rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116	intact-crc:AA1A969FED8A8075|rigid:tTcQ1rYH/uVC69GuHo6R0Ip8TNU	false	-	sufficient binding region:465-533	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q920G2	uniprotkb:O35240	intact:EBI-982439|uniprotkb:Q91Y70	intact:EBI-982374|ensembl:ENSRNOP00000011300	psi-mi:nhrf2_rat(display_long)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)|uniprotkb:Slc9a3r2(gene name)|psi-mi:Slc9a3r2(display_short)|uniprotkb:Nherf2(gene name synonym)	psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Deval et al. (2006)	imex:IM-14489|pubmed:16234233	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-982460|imex:IM-14489-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048839"(inner ear development)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR036034|rgd:620380|refseq:NP_446263.2|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR031197	ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/08/07	2014/10/16	rogid:xNJliuaXqUUSD1yBpwA2qtPXIDI10116	rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116	intact-crc:C43FD4F4A0BE9DA2|rigid:3fTjwdATjrQFAyyNhsN2k/Xw3sU	false	-	sufficient binding region:465-533	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JJ19	uniprotkb:O35240	intact:EBI-982391|ensembl:ENSRNOP00000004351	intact:EBI-982374|ensembl:ENSRNOP00000011300	psi-mi:nhrf1_rat(display_long)|uniprotkb:Nherf1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)|uniprotkb:Slc9a3r1(gene name)|psi-mi:Slc9a3r1(display_short)|uniprotkb:Nherf(gene name synonym)	psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Deval et al. (2006)	imex:IM-14489|pubmed:16234233	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-982575|imex:IM-14489-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0005576"(extracellular region)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0044782"(cilium organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|ensembl:ENSRNOG00000003232(gene)|ensembl:ENSRNOT00000004351(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|rgd:708538|refseq:NP_067605.1	ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N	psi-mi:"MI:0469"(intact)	-	-	caution:The coordiates of the deleted PDZ region for NHERF-1 are not given in the text. The coordinates for the PDZ region were taken from the UniProt entry Q9JJ19.|figure legend:Figure 1A Figure 2|agonist:"phorbol 12-myristate 13-acetate (PMA)"|antagonist:chelerythrine|comment:"The authors note that \"All of  these data strongly suggest that PKC phosphorylation of serine 523  in the COOH-terminal region of ASIC3 positively modulates the  interaction between ASIC3 and NHERF-1.\""|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/07	2014/10/16	rogid:G5I7bIzbx2WYbIPRtysKKswyjh410116	rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116	intact-crc:905F4CD6AA52A1B5|rigid:tTcQ1rYH/uVC69GuHo6R0Ip8TNU	false	ha tag:n-n|necessary binding region:14..14-94..94(IPR001478)	necessary binding region:531-533|myc tag:n-n|mutation decreasing interaction:523-523|mutation increasing interaction:523-523	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q920G2	uniprotkb:O35240	intact:EBI-982439|uniprotkb:Q91Y70	intact:EBI-982374|ensembl:ENSRNOP00000011300	psi-mi:nhrf2_rat(display_long)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)|uniprotkb:Slc9a3r2(gene name)|psi-mi:Slc9a3r2(display_short)|uniprotkb:Nherf2(gene name synonym)	psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Deval et al. (2006)	imex:IM-14489|pubmed:16234233	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-982647|imex:IM-14489-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048839"(inner ear development)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR036034|rgd:620380|refseq:NP_446263.2|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR031197	ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N	psi-mi:"MI:0469"(intact)	-	-	caution:The coordiates of the deleted PDZ region for NHERF-1 are not given in the text. The coordinates for the PDZ region were taken from the UniProt entry  Q920G2.|figure legend:Figure 1 B|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/07	2014/10/16	rogid:xNJliuaXqUUSD1yBpwA2qtPXIDI10116	rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116	intact-crc:BF7CFF9B1F11B19A|rigid:3fTjwdATjrQFAyyNhsN2k/Xw3sU	false	necessary binding region:11..11-91..91|ha tag:n-n	necessary binding region:531-533|myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JJ19	uniprotkb:O35240	intact:EBI-982391|ensembl:ENSRNOP00000004351	intact:EBI-982374|ensembl:ENSRNOP00000011300	psi-mi:nhrf1_rat(display_long)|uniprotkb:Nherf1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)|uniprotkb:Slc9a3r1(gene name)|psi-mi:Slc9a3r1(display_short)|uniprotkb:Nherf(gene name synonym)	psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Deval et al. (2006)	imex:IM-14489|pubmed:16234233	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-982875|imex:IM-14489-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0005576"(extracellular region)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0044782"(cilium organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|ensembl:ENSRNOG00000003232(gene)|ensembl:ENSRNOT00000004351(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|rgd:708538|refseq:NP_067605.1	ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 4E|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2006/08/07	2014/10/16	rogid:G5I7bIzbx2WYbIPRtysKKswyjh410116	rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116	intact-crc:8CB3160CCD644D73|rigid:tTcQ1rYH/uVC69GuHo6R0Ip8TNU	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9JJ19	uniprotkb:O35240	intact:EBI-982391|ensembl:ENSRNOP00000004351	intact:EBI-982374|ensembl:ENSRNOP00000011300	psi-mi:nhrf1_rat(display_long)|uniprotkb:Nherf1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)|uniprotkb:Slc9a3r1(gene name)|psi-mi:Slc9a3r1(display_short)|uniprotkb:Nherf(gene name synonym)	psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Deval et al. (2006)	imex:IM-14489|pubmed:16234233	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-982904|imex:IM-14489-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0005576"(extracellular region)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0044782"(cilium organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|ensembl:ENSRNOG00000003232(gene)|ensembl:ENSRNOT00000004351(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|rgd:708538|refseq:NP_067605.1	ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 5F|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/07	2014/10/16	rogid:G5I7bIzbx2WYbIPRtysKKswyjh410116	rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116	intact-crc:F200A991337CD2D6|rigid:tTcQ1rYH/uVC69GuHo6R0Ip8TNU	false	ha tag:n-n|necessary binding region:14..14-94..94	necessary binding region:531-533|myc tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O35240	intact:EBI-1008215	intact:EBI-982374|ensembl:ENSRNOP00000011300	-	psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym)	psi-mi:ezri_cerae_protein(display_short)|psi-mi:EBI-1008215(display_long)	psi-mi:"MI:0416"(fluorescence microscopy)	Deval et al. (2006)	imex:IM-14489|pubmed:16234233	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1008242|imex:IM-14489-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N	intact:EBI-982904(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:The protein was detected using in situ hybridisation using an anti-ezrin antibody. The source and prooduction details used in production of this assay are not provided in the corresponding paper.	figure legend:Figure 6|comment:No UniProt accession number is available for Ezrin at this time.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/07	2014/10/16	rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116	-	intact-crc:2B15980D340B6BD4	false	myc tag:n-n	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O35240	uniprotkb:Q9JJ19	intact:EBI-982374|ensembl:ENSRNOP00000011300	intact:EBI-982391|ensembl:ENSRNOP00000004351	psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym)	psi-mi:nhrf1_rat(display_long)|uniprotkb:Nherf1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)|uniprotkb:Slc9a3r1(gene name)|psi-mi:Slc9a3r1(display_short)|uniprotkb:Nherf(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Deval et al. (2006)	imex:IM-14489|pubmed:16234233	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1008242|imex:IM-14489-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N	go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0005576"(extracellular region)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0044782"(cilium organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|ensembl:ENSRNOG00000003232(gene)|ensembl:ENSRNOT00000004351(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|rgd:708538|refseq:NP_067605.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 6|comment:No UniProt accession number is available for Ezrin at this time.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/08/07	2014/10/16	rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116	rogid:G5I7bIzbx2WYbIPRtysKKswyjh410116	intact-crc:2B15980D340B6BD4	false	myc tag:n-n	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)