#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q69ZI1	uniprotkb:P61092	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	intact:EBI-446761|uniprotkb:Q06984|ensembl:ENSMUSP00000044123	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:sia1a_mouse(display_long)|uniprotkb:Seven in absentia homolog 1a(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1A(gene name synonym)|uniprotkb:Siah1a(gene name)|psi-mi:Siah1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957393|imex:IM-14493-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	refseq:NP_033198.1|refseq:XP_006530847.2|dip:DIP-29100N|ensembl:ENSMUSG00000036840(gene)|ensembl:ENSMUST00000045296(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005886"(plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|rcsb pdb:1K2F|rcsb pdb:2AN6|reactome:R-MMU-373752|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/16	2014/10/16	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	rogid:C7i3ubOqLVDW4MzmA6OLDZq2TM810090	intact-crc:BC937F5AE8A96187|rigid:Ui0U0GBbwUedw04pZNkG7UA6B/8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06985	uniprotkb:Q69ZI1	intact:EBI-957400|uniprotkb:Q7TPV6	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	psi-mi:sia1b_mouse(display_long)|uniprotkb:Siah1b(gene name)|psi-mi:Siah1b(display_short)|uniprotkb:Seven in absentia homolog 1b(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1B(gene name synonym)	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957397|imex:IM-14493-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|refseq:NP_033199.1|interpro:IPR004162(Seven in absentia protein)|interpro:IPR018121|interpro:IPR008974(TRAF-like)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013010(Zinc finger, SIAH-type)|refseq:NP_001295314.1|refseq:NP_001295315.1	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/16	2014/10/16	rogid:+fGhB+SOOXUbjF3AEClnY3Nmv6A10090	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	intact-crc:8994B8FAB03C27EF|rigid:MfltQ63HqGkR55zzh9TqXEgcyec	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06986	uniprotkb:Q69ZI1	intact:EBI-957413|ensembl:ENSMUSP00000067496	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	psi-mi:siah2_mouse(display_long)|uniprotkb:Siah2(gene name)|psi-mi:Siah2(display_short)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym)	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957425|imex:IM-14493-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033200.2|ensembl:ENSMUSG00000036432(gene)|ensembl:ENSMUST00000070368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q06986|reactome:R-MMU-373752|reactome:R-MMU-5689880|reactome:R-MMU-983168	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/16	2014/10/16	rogid:Rdbim60OD4dIj1xn7RpUoPAvD5010090	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	intact-crc:FC4FD567D3C02862|rigid:0nonIqcdlwOmp18D34Kn4pOb6XQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8IUQ4	uniprotkb:Q69ZI1	intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957438|imex:IM-14493-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:1A|caution:RING finger domain of Sh3md2 deleted and shown not to be essential for interaction. Domain boundaries of deletion mutant not given, therefore estimated using ProSite domain boundaries.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/06/16	2014/10/16	rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	intact-crc:457989FB950287FC|rigid:A/mzIUF/IGWav7I2Ug/DUTfv6OI	false	mutation decreasing interaction:41-41,44-44|flag tag:?-?	myc tag:?-?|sufficient binding region:37..37-892,1-28..28	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q69ZI1	uniprotkb:Q8IUQ4	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957450|imex:IM-14493-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N	psi-mi:"MI:0469"(intact)	-	-	figure legend:1B|caution:RING finger domain of Sh3md2 deleted and shown not to be essential for interaction. Domain boundaries of deletion mutant not given, therefore estimated using ProSite domain boundaries.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/06/16	2014/10/16	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606	intact-crc:988A549B685C722E|rigid:A/mzIUF/IGWav7I2Ug/DUTfv6OI	false	myc tag:?-?|sufficient binding region:37..37-892,1-28..28	flag tag:?-?|mutation decreasing interaction:41-41,44-44	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IUQ4	uniprotkb:Q69ZI1	intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957473|imex:IM-14493-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:1C|comment:"Exact amino acid residues removed from deltaRING construct of POSH (O70254) not given in entry, so taken from ProSite pattern PS00518."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/06/16	2014/10/16	rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	intact-crc:1B6BEC6B93AED49B|rigid:A/mzIUF/IGWav7I2Ug/DUTfv6OI	false	ha tag:?-?|necessary binding region:230-282	sufficient binding region:38..38-892,1-27..27|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IUQ4	uniprotkb:Q69ZI1	intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-959341|imex:IM-14493-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:1C|comment:"Exact amino acid residues removed from deltaRING construct of POSH (O70254) not given in entry, so taken from ProSite pattern PS00518."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/06/16	2014/10/16	rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	intact-crc:50947ABCB7E1B4C8|rigid:A/mzIUF/IGWav7I2Ug/DUTfv6OI	false	necessary binding region:230-282|ha tag:?-?	sufficient binding region:38..38-892,1-27..27|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IUQ4	uniprotkb:Q69ZI1	intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421	intact:EBI-957380|uniprotkb:Q3UG42|uniprotkb:Q6P9M8|uniprotkb:Q8BR66|uniprotkb:Q8C2T5|uniprotkb:O70254	psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:sh3r1_mouse(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Kiaa1494(gene name synonym)|uniprotkb:Posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957494|imex:IM-14493-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N	refseq:NP_067481.2|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-MMU-9013424|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/16	2014/10/16	rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606	rogid:IlJ8Jo/3jz3+wqZGb++Bgb5pkWk10090	intact-crc:048CDE12C079D7D6|rigid:A/mzIUF/IGWav7I2Ug/DUTfv6OI	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|necessary binding region:437-892	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q920M9	uniprotkb:Q71F54	intact:EBI-957514|uniprotkb:Q06984|ensembl:ENSRNOP00000020329	intact:EBI-957526|ensembl:ENSRNOP00000013815	psi-mi:siah1_rat(display_long)|uniprotkb:Siah1(gene name)|psi-mi:Siah1(display_short)|uniprotkb:Siah1a(gene name synonym)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:sh3r1_rat(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Posh(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957537|imex:IM-14493-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000015143(gene)|ensembl:ENSRNOT00000020329(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-RNO-373752|reactome:R-RNO-983168|refseq:XP_008770567.1|rgd:620449|refseq:NP_543181.2|dip:DIP-35686N	ensembl:ENSRNOG00000010358(gene)|ensembl:ENSRNOT00000013816(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-RNO-9013424|reactome:R-RNO-983168|rgd:735154|refseq:NP_942059.1|refseq:XP_017455595.1	go:"GO:0006915"(apoptotic process)	-	-	figure legend:1E|agonist:Camptothecin - a pro-apoptotic signal|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2006/06/16	2014/10/16	rogid:C7i3ubOqLVDW4MzmA6OLDZq2TM810116	rogid:iYq6emcmMWquj8B6fXpyeOYyJT410116	intact-crc:7F18050DCFA8F0C2|rigid:p88FRqi96wEndjJcSta8qkqVvhY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q920M9	uniprotkb:Q71F54	intact:EBI-957514|uniprotkb:Q06984|ensembl:ENSRNOP00000020329	intact:EBI-957526|ensembl:ENSRNOP00000013815	psi-mi:siah1_rat(display_long)|uniprotkb:Siah1(gene name)|psi-mi:Siah1(display_short)|uniprotkb:Siah1a(gene name synonym)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym)	psi-mi:sh3r1_rat(display_long)|uniprotkb:Posh1(gene name synonym)|uniprotkb:Sh3rf1(gene name)|psi-mi:Sh3rf1(display_short)|uniprotkb:Posh(gene name synonym)|uniprotkb:Sh3md2(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:SH3 multiple domains protein 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xu et al. (2006)	imex:IM-14493|pubmed:16230351	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957547|imex:IM-14493-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000015143(gene)|ensembl:ENSRNOT00000020329(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-RNO-373752|reactome:R-RNO-983168|refseq:XP_008770567.1|rgd:620449|refseq:NP_543181.2|dip:DIP-35686N	ensembl:ENSRNOG00000010358(gene)|ensembl:ENSRNOT00000013816(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030027"(lamellipodium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035795|interpro:IPR035816|interpro:IPR036028|reactome:R-RNO-9013424|reactome:R-RNO-983168|rgd:735154|refseq:NP_942059.1|refseq:XP_017455595.1	go:"GO:0006915"(apoptotic process)	-	-	figure legend:1E|agonist:Camptothecin - a pro-apoptotic signal|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2006/06/16	2014/10/16	rogid:C7i3ubOqLVDW4MzmA6OLDZq2TM810116	rogid:iYq6emcmMWquj8B6fXpyeOYyJT410116	intact-crc:F09DFACC44593C58|rigid:p88FRqi96wEndjJcSta8qkqVvhY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)