#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P63168	uniprotkb:P26367	intact:EBI-349121|uniprotkb:Q15701|ensembl:ENSMUSP00000107720|ensembl:ENSMUSP00000009157|uniprotkb:Q3UGE7	intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109	psi-mi:dyl1_mouse(display_long)|uniprotkb:Dynll1(gene name)|psi-mi:Dynll1(display_short)|uniprotkb:Dlc1(gene name synonym)|uniprotkb:Dnclc1(gene name synonym)|uniprotkb:Dncl1(gene name synonym)|uniprotkb:Dynein light chain LC8-type 1(gene name synonym)|uniprotkb:8 kDa dynein light chain(gene name synonym)|uniprotkb:Protein inhibitor of neuronal nitric oxide synthase(gene name synonym)	psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cooper et al. (2005)	pubmed:16098226|imex:IM-18993	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851748|imex:IM-18993-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062656.3|ensembl:ENSMUST00000009157(transcript)|ensembl:ENSMUST00000112090(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000009013(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030286"(dynein complex)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:P63168|reactome:R-MMU-111446|reactome:R-MMU-141444|reactome:R-MMU-1632852|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/13	2014/10/16	rogid:Bra4LfaqYPMyo6xX9RD6G7Rdv8010090	rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606	intact-crc:704894FFDFE6D0CA|rigid:WsrijMHtbSnFeMRQcva/Z+L5drc	false	-	sufficient binding region:278-422	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NSC5	uniprotkb:P26367	intact:EBI-748420|uniprotkb:O14580|uniprotkb:O95350|uniprotkb:Q9NSB9|uniprotkb:Q9NSC0|intact:EBI-2557809|uniprotkb:E9PCW9|uniprotkb:Q9NSC1|intact:EBI-28972925|ensembl:ENSP00000376162|ensembl:ENSP00000439937|ensembl:ENSP00000446026|intact:EBI-10175777|uniprotkb:B2RA10	intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109	psi-mi:home3_human(display_long)|uniprotkb:HOMER3(gene name)|psi-mi:HOMER3(display_short)	psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cooper et al. (2005)	pubmed:16098226|imex:IM-18993	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851752|imex:IM-18993-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000221222|ensembl:ENSP00000221222|ensembl:ENSP00000376162|ensembl:ENST00000433218|ensembl:ENSP00000396154|ensembl:ENSP00000439937|ensembl:ENSP00000446026|ensembl:ENST00000594439|ensembl:ENSP00000471835|refseq:XP_006723006.1|refseq:XP_006723007.1|refseq:NP_001139193.1|refseq:NP_001139194.1|refseq:NP_004829.3|refseq:NP_001139196.1|ensembl:ENSG00000051128(gene)|ensembl:ENST00000392351(transcript)|ensembl:ENST00000539827(transcript)|ensembl:ENST00000542541(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9NSC5|rcsb pdb:2P8V|rcsb pdb:3CVF|reactome:R-HSA-6794361	refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/13	2014/10/16	rogid:U1y/y52nnf7zQUCNQlqk7JDgXi49606	rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606	intact-crc:27B4E741437A33FC|rigid:Z6vWhEN2ZYY4y7lKM+vOLr8LyBg	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63168	uniprotkb:P26367	intact:EBI-349121|uniprotkb:Q15701|ensembl:ENSMUSP00000107720|ensembl:ENSMUSP00000009157|uniprotkb:Q3UGE7	intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109	psi-mi:dyl1_mouse(display_long)|uniprotkb:Dynll1(gene name)|psi-mi:Dynll1(display_short)|uniprotkb:Dlc1(gene name synonym)|uniprotkb:Dnclc1(gene name synonym)|uniprotkb:Dncl1(gene name synonym)|uniprotkb:Dynein light chain LC8-type 1(gene name synonym)|uniprotkb:8 kDa dynein light chain(gene name synonym)|uniprotkb:Protein inhibitor of neuronal nitric oxide synthase(gene name synonym)	psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cooper et al. (2005)	pubmed:16098226|imex:IM-18993	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851771|imex:IM-18993-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062656.3|ensembl:ENSMUST00000009157(transcript)|ensembl:ENSMUST00000112090(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000009013(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030286"(dynein complex)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:P63168|reactome:R-MMU-111446|reactome:R-MMU-141444|reactome:R-MMU-1632852|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/13	2014/10/16	rogid:Bra4LfaqYPMyo6xX9RD6G7Rdv8010090	rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606	intact-crc:E54BD7C1252736A6|rigid:WsrijMHtbSnFeMRQcva/Z+L5drc	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26367	uniprotkb:Q9NSC5	intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109	intact:EBI-748420|uniprotkb:O14580|uniprotkb:O95350|uniprotkb:Q9NSB9|uniprotkb:Q9NSC0|intact:EBI-2557809|uniprotkb:E9PCW9|uniprotkb:Q9NSC1|intact:EBI-28972925|ensembl:ENSP00000376162|ensembl:ENSP00000439937|ensembl:ENSP00000446026|intact:EBI-10175777|uniprotkb:B2RA10	psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)	psi-mi:home3_human(display_long)|uniprotkb:HOMER3(gene name)|psi-mi:HOMER3(display_short)	psi-mi:"MI:0018"(two hybrid)	Cooper et al. (2005)	pubmed:16098226|imex:IM-18993	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851803|imex:IM-18993-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N	ensembl:ENST00000221222|ensembl:ENSP00000221222|ensembl:ENSP00000376162|ensembl:ENST00000433218|ensembl:ENSP00000396154|ensembl:ENSP00000439937|ensembl:ENSP00000446026|ensembl:ENST00000594439|ensembl:ENSP00000471835|refseq:XP_006723006.1|refseq:XP_006723007.1|refseq:NP_001139193.1|refseq:NP_001139194.1|refseq:NP_004829.3|refseq:NP_001139196.1|ensembl:ENSG00000051128(gene)|ensembl:ENST00000392351(transcript)|ensembl:ENST00000539827(transcript)|ensembl:ENST00000542541(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9NSC5|rcsb pdb:2P8V|rcsb pdb:3CVF|reactome:R-HSA-6794361	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/13	2014/10/16	rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606	rogid:U1y/y52nnf7zQUCNQlqk7JDgXi49606	intact-crc:B2B7A47FB9BBD590|rigid:Z6vWhEN2ZYY4y7lKM+vOLr8LyBg	false	sufficient binding region:278-422	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26367	uniprotkb:Q96F44	intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109	intact:EBI-851809|uniprotkb:B2RB82|uniprotkb:B3KUS3|uniprotkb:B4DX88|uniprotkb:Q8NCA6|uniprotkb:Q9C022|uniprotkb:A6NKE2|uniprotkb:Q5VSU1|ensembl:ENSP00000284551	psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)	psi-mi:tri11_human(display_long)|uniprotkb:RING finger protein 92(gene name synonym)|uniprotkb:Protein BIA1(gene name synonym)|uniprotkb:TRIM11(gene name)|psi-mi:TRIM11(display_short)|uniprotkb:RNF92(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM11(gene name synonym)|uniprotkb:Tripartite motif-containing protein 11(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cooper et al. (2005)	pubmed:16098226|imex:IM-18993	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851832|imex:IM-18993-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N	refseq:NP_660215.1|refseq:XP_016857901.1|ensembl:ENSG00000154370(gene)|ensembl:ENST00000284551(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR043136|mint:Q96F44|reactome:R-HSA-983168	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/13	2014/10/16	rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606	rogid:cE4Lcnp0zSSEpo3e9Kr940Vdit89606	intact-crc:BAAC53DF62D07207|rigid:gfmSIOaOBKivc4oul4zH5Mo4HO8	false	sufficient binding region:278-422	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26367	uniprotkb:P63168	intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109	intact:EBI-349121|uniprotkb:Q15701|ensembl:ENSMUSP00000107720|ensembl:ENSMUSP00000009157|uniprotkb:Q3UGE7	psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)	psi-mi:dyl1_mouse(display_long)|uniprotkb:Dynll1(gene name)|psi-mi:Dynll1(display_short)|uniprotkb:Dlc1(gene name synonym)|uniprotkb:Dnclc1(gene name synonym)|uniprotkb:Dncl1(gene name synonym)|uniprotkb:Dynein light chain LC8-type 1(gene name synonym)|uniprotkb:8 kDa dynein light chain(gene name synonym)|uniprotkb:Protein inhibitor of neuronal nitric oxide synthase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cooper et al. (2005)	pubmed:16098226|imex:IM-18993	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851847|imex:IM-18993-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N	refseq:NP_062656.3|ensembl:ENSMUST00000009157(transcript)|ensembl:ENSMUST00000112090(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000009013(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030286"(dynein complex)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:P63168|reactome:R-MMU-111446|reactome:R-MMU-141444|reactome:R-MMU-1632852|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	omim:106210(see-also)	-	-	comment:"The following mutations in PAX6 disrupt the interaction with Dcln1: 1629insT mutation changing the stop codon by a Leucine at the c-terminus of PAX6 (X423L) generating a 35 amino acids extension, 1615del10 mutation, a PAX6 frameshift mutation causing replacement of the last 5 amino-acids by a 103 amino acid extension."|disease:"Mutations found in aniridia (OMIM:106210) disrupts the interaction."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/13	2014/10/16	rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606	rogid:Bra4LfaqYPMyo6xX9RD6G7Rdv8010090	intact-crc:34C26214647E99C7|rigid:WsrijMHtbSnFeMRQcva/Z+L5drc	false	necessary binding region:?-?|sufficient binding region:278-422	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26367	uniprotkb:Q9NSC5	intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109	intact:EBI-748420|uniprotkb:O14580|uniprotkb:O95350|uniprotkb:Q9NSB9|uniprotkb:Q9NSC0|intact:EBI-2557809|uniprotkb:E9PCW9|uniprotkb:Q9NSC1|intact:EBI-28972925|ensembl:ENSP00000376162|ensembl:ENSP00000439937|ensembl:ENSP00000446026|intact:EBI-10175777|uniprotkb:B2RA10	psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)	psi-mi:home3_human(display_long)|uniprotkb:HOMER3(gene name)|psi-mi:HOMER3(display_short)	psi-mi:"MI:0018"(two hybrid)	Cooper et al. (2005)	pubmed:16098226|imex:IM-18993	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851938|imex:IM-18993-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N	ensembl:ENST00000221222|ensembl:ENSP00000221222|ensembl:ENSP00000376162|ensembl:ENST00000433218|ensembl:ENSP00000396154|ensembl:ENSP00000439937|ensembl:ENSP00000446026|ensembl:ENST00000594439|ensembl:ENSP00000471835|refseq:XP_006723006.1|refseq:XP_006723007.1|refseq:NP_001139193.1|refseq:NP_001139194.1|refseq:NP_004829.3|refseq:NP_001139196.1|ensembl:ENSG00000051128(gene)|ensembl:ENST00000392351(transcript)|ensembl:ENST00000539827(transcript)|ensembl:ENST00000542541(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9NSC5|rcsb pdb:2P8V|rcsb pdb:3CVF|reactome:R-HSA-6794361	omim:106210(see-also)	-	-	comment:"The following mutations in PAX6 disrupt the interaction with Dcln1: 1629insT mutation changing the stop codon by a Leucine at the c-terminus of PAX6 (X423L) generating a 35 amino acids extension, 1615del10 mutation, a PAX6 frameshift mutation causing replacement of the last 5 amino-acids by a 103 amino acid extension."|disease:"Mutations found in aniridia (OMIM:106210) disrupts the interaction."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/13	2014/10/16	rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606	rogid:U1y/y52nnf7zQUCNQlqk7JDgXi49606	intact-crc:8D5A2B53FC7995D1|rigid:Z6vWhEN2ZYY4y7lKM+vOLr8LyBg	false	sufficient binding region:278-422|necessary binding region:?-?	sufficient binding region:71-356	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96F44	uniprotkb:P26367	intact:EBI-851809|uniprotkb:B2RB82|uniprotkb:B3KUS3|uniprotkb:B4DX88|uniprotkb:Q8NCA6|uniprotkb:Q9C022|uniprotkb:A6NKE2|uniprotkb:Q5VSU1|ensembl:ENSP00000284551	intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109	psi-mi:tri11_human(display_long)|uniprotkb:RING finger protein 92(gene name synonym)|uniprotkb:Protein BIA1(gene name synonym)|uniprotkb:TRIM11(gene name)|psi-mi:TRIM11(display_short)|uniprotkb:RNF92(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM11(gene name synonym)|uniprotkb:Tripartite motif-containing protein 11(gene name synonym)	psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cooper et al. (2005)	pubmed:16098226|imex:IM-18993	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-851951|imex:IM-18993-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660215.1|refseq:XP_016857901.1|ensembl:ENSG00000154370(gene)|ensembl:ENST00000284551(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR043136|mint:Q96F44|reactome:R-HSA-983168	refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/13	2014/10/16	rogid:cE4Lcnp0zSSEpo3e9Kr940Vdit89606	rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606	intact-crc:94D97EEEEC8176DB|rigid:gfmSIOaOBKivc4oul4zH5Mo4HO8	false	-	sufficient binding region:278-390	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)