#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9WTV5	uniprotkb:P52947	intact:EBI-7626072|intact:MINT-1894545	intact:EBI-7626093|intact:MINT-1894530|ensembl:ENSRNOP00000066935	psi-mi:psmd9_rat(display_long)|uniprotkb:Psmd9(gene name)|psi-mi:Psmd9(display_short)|uniprotkb:26S proteasome regulatory subunit p27(gene name synonym)|uniprotkb:Transactivating protein Bridge-1(gene name synonym)	psi-mi:pdx1_rat(display_long)|uniprotkb:Pdx1(gene name)|psi-mi:Pdx1(display_short)|uniprotkb:Ipf1(gene name synonym)|uniprotkb:Islet/duodenum homeobox 1(gene name synonym)|uniprotkb:Insulin promoter factor 1(gene name synonym)|uniprotkb:Somatostatin-transactivating factor 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Stanojevic et al. (2005)	pubmed:15885879|mint:MINT-5217723	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7626068|mint:MINT-1894557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9WTV5|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR035269|interpro:IPR041489|rgd:621110|refseq:NP_569114.1|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070682"(proteasome regulatory particle assembly)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168|go:"GO:0046676"(negative regulation of insulin secretion)|interpro:IPR036034|interpro:IPR040815|mint:MINT-1894559(identity)	refseq:NP_074043.3|rgd:62387|go:"GO:0030154"(cell differentiation)|go:"GO:0031016"(pancreas development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033273"(response to vitamin)|go:"GO:0033993"(response to lipid)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043201"(response to leucine)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0030073"(insulin secretion)|go:"GO:0051594"(detection of glucose)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070542"(response to fatty acid)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR017995|interpro:IPR020479|mint:P52947|ensembl:ENSRNOG00000046458(gene)|ensembl:ENSRNOT00000071942(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010157"(response to chlorate)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016607"(nuclear speck)|go:"GO:0006355"(regulation of transcription, DNA-templated)|mint:MINT-1894558(identity)	-	function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'|comment:"Stoichiometry: 1.0"	figure legend:T1|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/05/04	2014/10/16	rogid:wUHgvsJqaOBBP9N7ZD/MqulyM9E10116	rogid:hpTkSwiqgwMkgt5FPabPm9nsX8E10116	intact-crc:D36785A6CE326440|rigid:Q2C8kT1hKQ3Bu+FMGWLTFpQ3X+k	false	tag:?-?(MINT-1894570)	tag:?-?(MINT-1894578)|binding-associated region:160-283(MINT-1894585)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WTV5	uniprotkb:P52947	intact:EBI-7626072|intact:MINT-1894545	intact:EBI-7626093|intact:MINT-1894530|ensembl:ENSRNOP00000066935	psi-mi:psmd9_rat(display_long)|uniprotkb:Psmd9(gene name)|psi-mi:Psmd9(display_short)|uniprotkb:26S proteasome regulatory subunit p27(gene name synonym)|uniprotkb:Transactivating protein Bridge-1(gene name synonym)	psi-mi:pdx1_rat(display_long)|uniprotkb:Pdx1(gene name)|psi-mi:Pdx1(display_short)|uniprotkb:Ipf1(gene name synonym)|uniprotkb:Islet/duodenum homeobox 1(gene name synonym)|uniprotkb:Insulin promoter factor 1(gene name synonym)|uniprotkb:Somatostatin-transactivating factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Stanojevic et al. (2005)	pubmed:15885879|mint:MINT-5217723	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7626247|mint:MINT-1894588	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9WTV5|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR035269|interpro:IPR041489|rgd:621110|refseq:NP_569114.1|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070682"(proteasome regulatory particle assembly)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168|go:"GO:0046676"(negative regulation of insulin secretion)|interpro:IPR036034|interpro:IPR040815|mint:MINT-1894599(identity)	refseq:NP_074043.3|rgd:62387|go:"GO:0030154"(cell differentiation)|go:"GO:0031016"(pancreas development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033273"(response to vitamin)|go:"GO:0033993"(response to lipid)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043201"(response to leucine)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0030073"(insulin secretion)|go:"GO:0051594"(detection of glucose)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070542"(response to fatty acid)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR017995|interpro:IPR020479|mint:P52947|ensembl:ENSRNOG00000046458(gene)|ensembl:ENSRNOT00000071942(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010157"(response to chlorate)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016607"(nuclear speck)|go:"GO:0006355"(regulation of transcription, DNA-templated)|mint:MINT-1894589(identity)	-	function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'|comment:"Stoichiometry: 1.0"	figure legend:F2B|figure legend:F1|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/04	2014/10/16	rogid:wUHgvsJqaOBBP9N7ZD/MqulyM9E10116	rogid:hpTkSwiqgwMkgt5FPabPm9nsX8E10116	intact-crc:5F836B96653C5C78|rigid:Q2C8kT1hKQ3Bu+FMGWLTFpQ3X+k	false	glutathione s tranferase tag:?-?(MINT-1894605)	binding-associated region:1-143(MINT-1894590)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52947	uniprotkb:Q9WTV5	intact:EBI-7626093|intact:MINT-1894530|ensembl:ENSRNOP00000066935	intact:EBI-7626072|intact:MINT-1894545	psi-mi:pdx1_rat(display_long)|uniprotkb:Pdx1(gene name)|psi-mi:Pdx1(display_short)|uniprotkb:Ipf1(gene name synonym)|uniprotkb:Islet/duodenum homeobox 1(gene name synonym)|uniprotkb:Insulin promoter factor 1(gene name synonym)|uniprotkb:Somatostatin-transactivating factor 1(gene name synonym)	psi-mi:psmd9_rat(display_long)|uniprotkb:Psmd9(gene name)|psi-mi:Psmd9(display_short)|uniprotkb:26S proteasome regulatory subunit p27(gene name synonym)|uniprotkb:Transactivating protein Bridge-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Stanojevic et al. (2005)	pubmed:15885879|mint:MINT-5217723	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7626265|mint:MINT-1894622	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_074043.3|rgd:62387|go:"GO:0030154"(cell differentiation)|go:"GO:0031016"(pancreas development)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033273"(response to vitamin)|go:"GO:0033993"(response to lipid)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043201"(response to leucine)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0030073"(insulin secretion)|go:"GO:0051594"(detection of glucose)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070542"(response to fatty acid)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR017995|interpro:IPR020479|mint:P52947|ensembl:ENSRNOG00000046458(gene)|ensembl:ENSRNOT00000071942(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010157"(response to chlorate)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016607"(nuclear speck)|go:"GO:0006355"(regulation of transcription, DNA-templated)|mint:MINT-1894630(identity)	mint:Q9WTV5|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR035269|interpro:IPR041489|rgd:621110|refseq:NP_569114.1|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070682"(proteasome regulatory particle assembly)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168|go:"GO:0046676"(negative regulation of insulin secretion)|interpro:IPR036034|interpro:IPR040815|mint:MINT-1894623(identity)	-	comment:mint|function:Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'|comment:"Stoichiometry: 1.0"	function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins|comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F2C|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/04	2014/10/16	rogid:hpTkSwiqgwMkgt5FPabPm9nsX8E10116	rogid:wUHgvsJqaOBBP9N7ZD/MqulyM9E10116	intact-crc:13F1A7DE41A35303|rigid:Q2C8kT1hKQ3Bu+FMGWLTFpQ3X+k	false	binding-associated region:1-206(MINT-1894631)|glutathione s tranferase tag:?-?(MINT-1894641)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)