#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32389	uniprotkb:P39014	intact:EBI-10757|uniprotkb:D6W176	intact:EBI-11507|uniprotkb:D6VVN6|ensemblfungi:YIL046W	psi-mi:met4_yeast(display_long)|uniprotkb:MET4(gene name)|psi-mi:MET4(display_short)|uniprotkb:YNL103W(locus name)|uniprotkb:N2177(orf name)|uniprotkb:Methionine-requiring protein 4(gene name synonym)	psi-mi:met30_yeast(display_long)|uniprotkb:YIL046W(locus name)|uniprotkb:MET30(gene name)|psi-mi:MET30(display_short)|uniprotkb:Methionine-requiring protein 30(gene name synonym)|uniprotkb:"E3 ubiquitin ligase complex SCF(Met30) subunit MET30"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Brunson et al. (2005)	pubmed:15883825|imex:IM-18986	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-896368|imex:IM-18986-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005047|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0089713"(Cbf1-Met4-Met28 complex)|go:"GO:0000096"(sulfur amino acid metabolic process)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0042802"(identical protein binding)|refseq:NP_014296.4|mint:P32389|dip:DIP-2241N	ensemblfungi:YIL046W_mRNA(transcript)|ensemblfungi:YIL046W(gene)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|refseq:NP_012218.1|sgd:S000001308|mint:P39014|dip:DIP-1439N	-	crc64:D65745E1FA40C09D	crc64:5135D4BCA2E1EB97	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/10	2014/10/16	rogid:SpxM+SnEmiw+uQlCEGZSto/zduw559292	rogid:B138OcWsG8zW/eFMselD2pFyy5c559292	intact-crc:44054943C8A3FBAB|rigid:wI0BBJhBGohBhUh282FVK/ON83Y	false	myc tag:?-?	glutathione s tranferase tag:?-?|necessary binding region:300-640	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32389	uniprotkb:P39014	intact:EBI-10757|uniprotkb:D6W176	intact:EBI-11507|uniprotkb:D6VVN6|ensemblfungi:YIL046W	psi-mi:met4_yeast(display_long)|uniprotkb:MET4(gene name)|psi-mi:MET4(display_short)|uniprotkb:YNL103W(locus name)|uniprotkb:N2177(orf name)|uniprotkb:Methionine-requiring protein 4(gene name synonym)	psi-mi:met30_yeast(display_long)|uniprotkb:YIL046W(locus name)|uniprotkb:MET30(gene name)|psi-mi:MET30(display_short)|uniprotkb:Methionine-requiring protein 30(gene name synonym)|uniprotkb:"E3 ubiquitin ligase complex SCF(Met30) subunit MET30"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Brunson et al. (2005)	pubmed:15883825|imex:IM-18986	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-896396|imex:IM-18986-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005047|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0089713"(Cbf1-Met4-Met28 complex)|go:"GO:0000096"(sulfur amino acid metabolic process)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0042802"(identical protein binding)|refseq:NP_014296.4|mint:P32389|dip:DIP-2241N	ensemblfungi:YIL046W_mRNA(transcript)|ensemblfungi:YIL046W(gene)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043224"(nuclear SCF ubiquitin ligase complex)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|refseq:NP_012218.1|sgd:S000001308|mint:P39014|dip:DIP-1439N	-	crc64:D65745E1FA40C09D	crc64:5135D4BCA2E1EB97	comment:The mutations asn425ala and leu530asp together inhibit interaction of Met30 with Met4. Also mutations leu386asp, asn425ala and gln476ala  together inhibit this interaction. Indicates that the Met30 employs multiple residues that work in concert to interact with Met4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/10	2014/10/16	rogid:SpxM+SnEmiw+uQlCEGZSto/zduw559292	rogid:B138OcWsG8zW/eFMselD2pFyy5c559292	intact-crc:BA76938F0C77A18B|rigid:wI0BBJhBGohBhUh282FVK/ON83Y	false	myc tag:?-?	glutathione s tranferase tag:?-?|mutation decreasing interaction:467-467,386-386,530-530,425-425	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)