#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P36381	uniprotkb:P28238	intact:EBI-867402|uniprotkb:Q92144	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:"MI:0096"(pull down)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867396	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/28	2014/10/16	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	intact-crc:E80ED4776EBC7C70|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	-	his tag:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36381	uniprotkb:P28238	intact:EBI-867402|uniprotkb:Q92144	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867421	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	-	-	-	-	taxid:9031(chick-embryonic_fibroblast)|taxid:9031(Chick embryonic fibroblasts)	-	2006/02/28	2014/10/16	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	intact-crc:AD123865C327D0C1|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	-	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36381	uniprotkb:P28238	intact:EBI-867402|uniprotkb:Q92144	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	-	-	-	-	taxid:9031(chick-embryonic_fibroblast)|taxid:9031(Chick embryonic fibroblasts)	-	2006/02/28	2014/10/16	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	intact-crc:83A825DBAF120218|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	-	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P28238	uniprotkb:P36381	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	intact:EBI-867402|uniprotkb:Q92144	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:"MI:0096"(pull down)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867439	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	-	-	-	inhibition:"The protein Cx45.6 seems to undergo a development-associated cleavage at its intracellular loop domains which prevents binding of MIP(AQP0) as shown with day 8 embryonic lens lysate."|comment:"The interaction between Cx45.6 and MIP(AQP0) gradually disappear with late stages of lens development and the degree of lens cell differentiation into mature fibers."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/28	2014/10/16	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	intact-crc:E37057DC07A5FC8B|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	-	his tag:?-?|sufficient binding region:98-148	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36381	uniprotkb:P28238	intact:EBI-867402|uniprotkb:Q92144	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867460	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	-	-	-	comment:"The last amino acid (Threonine 147) was mutated into Cysteine in order to permit the thiol coupling immobilization on the chip."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/28	2014/10/16	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	intact-crc:9FD226EFA96B4D7F|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	sufficient binding region:98-147|his tag:?-?|tag:c-c	glutathione s tranferase tag:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36381	uniprotkb:P28238	intact:EBI-867402|uniprotkb:Q92144	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-867818	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	-	-	-	comment:A Cysteine was added at the n-terminus of the Cx45.6 peptide in order to permit the thiol coupling immobilization on the chip.|comment:"MIP(AQP0) interacts both with front peptide and a rear peptide of the intracellular loop of Cx45.6."|inhibition:"The rear peptide (131-147)of Cx45.6 competes with the front peptide (97-115)  for MIP(AQP0) c-terminus binding."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/28	2014/10/16	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	intact-crc:EA0FC34F3F97D043|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	sufficient binding region:98-116|tag:n-n	glutathione s tranferase tag:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28238	uniprotkb:P36381	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	intact:EBI-867402|uniprotkb:Q92144	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-868595	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	-	-	-	comment:A Cysteine was added at the n-terminus of the Cx45.6 peptide in order to permit the thiol coupling immobilization on the chip.|comment:"MIP(AQP0) interacts both with the front and the rear portions of the intracellular loop of Cx45.6."|inhibition:"The front peptide (97-115) of Cx45.6 competes with the rear peptide (131-147) for MIP(AQP0) c-terminus binding."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/28	2014/10/16	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	intact-crc:C5133A1807ACEEBB|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	sufficient binding region:?-?|glutathione s tranferase tag:?-?	sufficient binding region:132-148|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28238	uniprotkb:P36381	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	intact:EBI-867402|uniprotkb:Q92144	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-870995	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	-	-	-	comment:"The last amino acid (Threonine 147) was mutated into Cysteine in order to permit the thiol coupling immobilization on the chip."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/28	2014/10/16	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	intact-crc:F83F5410B855626C|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	sufficient binding region:?-?|his tag:?-?	sufficient binding region:98-147|his tag:?-?|tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28238	uniprotkb:P36381	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	intact:EBI-867402|uniprotkb:Q92144	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-871011	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	-	-	-	comment:A Cysteine was added at the n-terminus of the Cx45.6 peptide in order to permit the thiol coupling immobilization on the chip.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/28	2014/10/16	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	intact-crc:9C45BC3DE074B23A|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	his tag:?-?|sufficient binding region:?-?	tag:n-n|sufficient binding region:98-116	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28238	uniprotkb:P36381	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	intact:EBI-867402|uniprotkb:Q92144	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-871025	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	-	-	-	comment:A Cysteine was added at the n-terminus of the Cx45.6 peptide in order to permit the thiol coupling immobilization on the chip.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/28	2014/10/16	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	intact-crc:D0341E219F2540AE|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	his tag:?-?|sufficient binding region:?-?	sufficient binding region:132-148|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28238	uniprotkb:P36381	intact:EBI-867385|uniprotkb:Q8QFW8|ensembl:ENSGALP00000049696	intact:EBI-867402|uniprotkb:Q92144	psi-mi:mip_chick(display_long)|uniprotkb:Aquaporin-0(gene name synonym)|uniprotkb:MIP26(gene name synonym)|uniprotkb:MIP(gene name)|psi-mi:MIP(display_short)	psi-mi:cxa8_chick(display_long)|uniprotkb:Connexin-45.6(gene name synonym)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Yu et al. (2005)	pubmed:15802270	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-874610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_989597.1|ensembl:ENSGALG00000042119(gene)|ensembl:ENSGALT00000050001(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005921"(gap junction)|go:"GO:0006833"(water transport)|go:"GO:0007601"(visual perception)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1990349"(gap junction-mediated intercellular transport)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023254|interpro:IPR023271|interpro:IPR034294	refseq:NP_990328.1|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)	go:"GO:0005921"(gap junction)	-	-	comment:they colocalize in fiber gap junctions	taxid:9031(chick-embryonic_fibroblast)|taxid:9031(Chick embryonic fibroblasts)	-	2006/02/28	2014/10/16	rogid:TJzg0aikGytMuEO2Xf7tgGTlPBQ9031	rogid:2YjiB3eRckxBkc8iLFXG4LdRy9o9031	intact-crc:AC1C423C193B62F0|rigid:3DJ2rVfsUiCrZ13IIRSFJ+5WL2s	false	flag tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)